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Baicalin attenuates blood-spinal cord barrier disruption and apoptosis through pi3K/Akt signaling pathway after spinal cord injury

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Neural Regeneration Research 2022年第5期17卷 1080-1087页

作者： Rui Zhao xue Wu xue-Yuan Bi Hao Yang Qian Zhang College of Pharmacy Shaanxi University of Chinese MedicineXi’anShaanxi ProvinceChina Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest ChinaCollege of Life SciencesShaanxi Normal UniversityXi’anShaanxi ProvinceChina Translational Medicine Center Hong Hui HospitalXi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Pharmacy Hong Hui HospitalXi’an Jiaotong UniversityXi’anShaanxi ProvinceChina

Baicalin is a natural active ingredient isolated from Scutellariae Radix that can cross the blood-brain barrier and exhibits neuroprotective effects on multiple central nervous system ***,the mechanism behind the neuroprotective effects remains *** this study,rat models of spinal cord injury were established using a modified Allen's impact method and then treated with intraperitoneal injection of *** results revealed that Baicalin greatly increased the Basso,Beattie,Bresnahan Locomotor Rating Scale score,reduced blood-spinal cord barrier permeability,decreased the expression of Bax,Caspase-3,and nuclear factorκB,increased the expression of Bcl-2,and reduced neuronal apoptosis and pathological spinal cord ***-SY5 Y cell models of excitotoxicity were established by application of 10 m M glutamate for 12 hours and then treated with 40μM Baicalin for 48 hours to investigate the mechanism of action of *** results showed that Baicalin reversed tight junction protein expression tendencies(occludin and ZO-1)and apoptosis-related protein expression(Bax,Bcl-2,Caspase-3,and nuclear factor-κB),and also led to up-regulation of pi3 K and Akt *** effects on Bax,Bcl-2,and Caspase-3 were blocked by pretreatment with the pi3 K inhibitor *** findings suggest that Baicalin can inhibit bloodspinal cord barrier permeability after spinal cord injury and reduce neuronal apoptosis,possibly by activating the pi3 K/Akt signaling *** study was approved by Animal Ethics Committee of Xi'an Jiaotong University on March 6,2014.

关键词： apoptosis baicalin blood-spinal cord barrier natural products neuron pi3K/Akt signaling pathway spinal cord injury tight junction

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Fractional Moments of Automorphic L-Functions on GL(m)

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Chinese Annals of Mathematics,Series B 2011年第4期32卷 631-642页

作者： Qinghua pi School of Mathematics Shandong University Jinan 250100 China.

Let πr be an irreducible unitary cuspidal representation of GL,^（AQ）, m ≥ 2. Assume that π is self-contragredient. The author gets upper and lower bounds of the same order for fractional moments of automorphic L-function L（s, π） on the critical line under Generalized Ramanujan Conjecture; the upper bound being conditionally subject to the truth of Generalized Riemann Hypothesis.

关键词： Moments Automorphic L-functions GRC

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Improved insensitive to input parameters trajectory clustering algorithm

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Journal of Systems Engineering and Electronics 2013年第5期24卷 852-861页

作者： Jiashun Chen Dechang pi College of Computer Science and Technology Nanjing University of Aeronautics and Astronautics College of Computer Science and Technology Huaihai Institute of Technology

The existing trajectory clustering （TRACLUS） is sensitive to the input parameters c and MinLns. The parameter value is changed a little, but cluster results are entirely different. Aiming at this vulnerability, a shielding parameters sensitivity trajectory cluster （SPSTC） algorithm is proposed which is insensitive to the input parameters. Firstly, some definitions about the core distance and reachable distance of line segment are presented, and then the algorithm generates cluster sorting according to the core dis- tance and reachable distance. Secondly, the reachable plots of line segment sets are constructed according to the cluster sorting and reachable distance. Thirdly, a parameterized sequence is extracted according to the reachable plot, and then the final trajectory cluster based on the parameterized sequence is acquired. The parameterized sequence represents the inner cluster structure of trajectory data. Experiments on real data sets and test data sets show that the SPSTC algorithm effectively reduces the sensitivity to the input parameters, meanwhile it can obtain the better quality of the trajectory cluster.

关键词： clustering trajectory sensitivity input parameter.

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NANOGrav hints on planet-mass primordial black holes

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Science China(Physics,Mechanics & Astronomy) 2022年第3期65卷 26-32页

作者： Guillem Domenech Shi pi INFN Sezione di Padova Padova 1-35131Italy CAS Key'Laboratory of Theoretical Physics.Institute of Theoretical Physics ChinesAcademy of SciencesBeijing 100190China Kavli Institute for the Physics and Mathematics of the Universe(Wpi) The University of Tokyo Institutes for Advanced StudyThe University of TokyoKashiwaChiba 277-8583Japan

Recently, the North American Nanohertz Observatory for Gravitational Waves(NANOGrav) claimed the detection of a stochastic common-spectrum process of the pulsar timing array(PTA) time residuals from their 12.5 year data, which might be the first detection of the stochastic background of gravitational waves(GWs). We show that the amplitude and the power index of such waves imply that they could be the secondary GWs induced by the peaked curvature perturbation with a dust-like post inflationary era with-0.091 ≤ w ≤ 0.048. Such stochastic background of GWs naturally predicts substantial existence of planet-mass primordial black holes(PBHs), which can be the lensing objects for the ultrashort-timescale microlensing events observed by the Optical Gravitational Lensing Experiment(OGLE).

关键词： pulsar timing array stochastic gravitational waves the early universe

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DOES INVESTOR SENTIMENT PREDICT STOCK RETURNS? THE EVIDENCE FROM CHINESE STOCK MARKET

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Journal of Systems Science & Complexity 2014年第1期27卷 130-143页

作者： BU Hui pi Li School of Economics and Management Beihang University

This paper examines the proxy variables of investor sentiment in Chinese stock market carefully, and tries to construct an investor sentiment index indirectly. We use cross correlation analysis to examine lead-lag relationship between the proxy variables and HS300 index. The results show that net added accounts （NAA）, SSE share turnover （TURN）, and closed-end fund discount （CEFD） are leading variables to stock market. The average first day return of IPOs （RIPO） and relative degree of active trading in equity market （RDAT） are contemporary variables, while number of IPOs （NIPO） is a lagging variable of stock market. Using the sentiment proxy variables with most possible leading order, and forward selection stepwise regression method, the empirical results on monthly stock returns reveal that three leading proxy variables can be used to form a sentiment index. And the out of sample tests prove that this sentiment index has good predictive power of Chinese stock market, and it is robust.

关键词： Chinese stock market investor sentiment return predictability.

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SAR tomography imaging via higher-order spectrum analysis

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Journal of Systems Engineering and Electronics 2009年第4期20卷 748-754页

作者： Wang Jinfeng pi Yiming School of Electronic Engineering Univ. of Electronic Science and Technology of China Chengdu 610054 P. R. China

To deal with the non-Caussian noise in standard 2-D SAR images, the deramped signal in imaging plane, and the possible symmetric distribution of complex noise, the fourth-order cumulant of complex process is introduced into SAR tomography. With the estimated AR parameters of ARMA model of noise through Yule-Walker equation, the signal series of height is pre-filtered. Then, through ESPRIT, the spectrum is obtained and the aperture in height direction is synthesized. Finally, the SAR tomography imaging of scene is achieved. The results of processing on signal with non-Gaussian noise demonstrate the robustness of the proposed method. The tomography imaging of the scenes shows that the higher-order spectrum analysis is feasible in the application.

关键词： synthetic aperture radar 3-D imaging tomography high-order spectrum analysis nongaussian

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Phase noise filtering and phase unwrapping method based on unscented Kalman filter

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Journal of Systems Engineering and Electronics 2011年第3期22卷 365-372页

作者： Xianming Xie Yiming pi School of Electronic Engineering University of Electronic Science and Technology of ChinaChengdu 611731P.R.China

This paper presents a new phase unwrapping algorithm based on the unscented Kalman filter（UKF） for synthetic aperture radar（SAR） *** method is the result of combining an UKF with path-following strategy and an omni-directional local phase slope *** technique performs simultaneously noise filtering and phase unwrapping along the high-quality region to the low-quality region,which is also able to avoid going directly through the noisy *** addition,phase slope is estimated directly from the sample frequency spectrum of the complex interferogram,by which the underestimation of phase slope is *** and real data processing results validate the effectiveness of the proposed method,and show a significant improvement with respect to the extended Kalman filtering（EKF） algorithm and some conventional phase unwrapping algorithms in some situations.

关键词： phase unwrapping unscented Kalman filter(UKF) path-following strategy.

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Improving Thermal-oxidative Aging Resistance of Styrene-butadiene Rubber by Antioxidant Loaded Silica Aerogel

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Chinese Journal of Polymer Science 2024年第8期42卷 1198-1209页

作者： xue-Fei ping Yu Wang Lu Liu Fu-Yong Liu Hong-Wei He pi Wang Wen-Wen Yu Qiang Zheng College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030032China Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310058China

The antioxidant N-isopropyl-N'-phenyl-p-phenylenediamine(4010NA)was dissolved in ethanol and impregnated into silica aerogel(SAG)via vacuum-pressure cycles,yielding composite particles(A-N)with enhanced sustained-release and reinforcing *** effect of A-N on the mechanical properties and thermal-oxidative aging resistance of styrene-butadiene rubber(SBR)vulcanizates was *** and BET assessments indicated that the loading efficiency of 4010NA in SAG reached 14.26%within ethanol's solu bility *** A-N into SBR vulcanizates significantly elevated tensile strength by 17.5%and elongation at break by 41.9%over those with fumed silica and ***,A-N notably enhanced the thermal-oxidative aging resistance of *** aging for 96 h at 100℃,the tensile strength and elongation at break of SBR with A-N sustained 70.09%and 58.61%of their initial values,respectively,with the retention rate of elongation at break being 62.8%higher than that of SBR with fumed silica and free *** study revealed that A-N composite particles significantly inhibited the crosslinking in SBR's molecular chains,reducing hardening and embrittlement during later thermal-oxidative aging stages.

关键词： Styrene-butadiene rubber Silica aerogel Loading modification Thermal-oxidative aging

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On the Characterization of Maximal Planar Graphs with a Given Signed Cycle Domination Number

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Acta Mathematica Sinica,English Series 2018年第5期34卷 911-920页

作者： Xiao Ming pi Department of Mathematics Harbin Normal University

Let G = （V, E） be a simple graph. A function f ： E → {＋1,-1} is called a signed cycle domination function （SCDF） of G if ∑e∈E（C） f（e） ≥ 1 for every induced cycle C of G. The signed cycle domination number of G is defined as γ′sc（G） = min{∑e∈E f（e）｜ f is an SCDF of G}. This paper will characterize all maxima] planar graphs G with order n ≥ 6 and γ′sc（G） =n.

关键词： Domination number signed cycle domination function signed cycle domination number planar graph maximal planar graph

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Rice Blast Resistance of Transgenic Rice Plants with pi-d2 Gene

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Rice science 2010年第3期17卷 179-184页

作者： CHEN De-xi CHEN xue-wei lei Cai-lin MA Bing-tian WANG Yu-ping LI Shi-gui Institute of Plant Protection Sichuan Academy of Agricultural Sciences Chengdu 610066 China Rice Research Institute SichuanAgricultural University Chengdu 611130 China Institute of Crop Sciences Chinese Academy of Agricultural Sciences Beijing100081 China

Resistance to rice blast of transgenic rice lines harboring rice blast resistance gene pi-d2 transformed from three different expression vectors of pCB6.3kb, pCB5.3kb and pZH01-2.72kb were analyzed. Nine advanced-generation transgenic rice lines with pi-d2 gene displayed various resistance to 39 rice blast strains, and the highest disease-resistant frequency reached 91.7%. Four early-generation homozygous transgenic lines with pi-d2 gene exhibited resistance to more than 81.5% of 58 rice blast strains, showing the characteristic of wide-spectrum resistance. The transgenic embryonic calli selected by the crude toxin of rice blast fungus showed that the callus induction rate of immature embryo from transgenic rice plants decreased as the concentration of crude toxin in the culture medium increased. When the concentration of crude toxin reached 40%, the callus induction rate of immature embryo from transgenic lines was 49.3%, and that of the receptor control was 5%. The disease incidence of neck blast of the transgenic rice lines in fields under induction was 0% to 50%, indicating that the rice blast resistance of transgenic rice lines is much higher than that of the receptor control.

关键词： transgenic rice disease resistance gene rice blast resistant spectrum crude toxin callus induction

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