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Engineered neuronal microtissue provides exogenous axons for delayed nerve fusion and rapid neuromuscular recovery in rats

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Bioactive Materials 2022年第12期7卷 339-353页

作者： Justin C.Burrell Suradip Das Franco A.Laimo Kritika S.Katiyar Kevin D.Browne Robert B.Shultz Vishal J.tien phuong t.vu Dmitriy Petrov Zarina SAli Joseph M.Rosen D.Kacy Cullen Center for Brain Injury&Repair Department of NeurosurgeryPerelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA Department of Bioengineering School of Engineering&Applied ScienceUniversity of PennsylvaniaPhiladelphiaPAUSA Center for Neurotrauma Neurodegeneration&RestorationCorporal Michael J.Crescenz Veterans Affairs Medical CenterPhiladelphiaPA19104USA Axonova Medical LLCPhiladelphiaPAUSA Dartmouth-Hitchcock Medical Center Division of Plastic SurgeryDartmouth CollegeLebanonNHUSA

Nerve injury requiring surgical repair often results in poor functional recovery due to the inability of host axons to re-grow long distances and reform meaningful connections with the target muscle. While surgeons can re-route local axon fascicles to the target muscle, there are no technologies to provide an exogenous source of axons without sacrificing healthy nerves. Accordingly, we have developed tissue engineered neuromuscular interfaces (tE-NMIs) as the first injectable microtissue containing motor and sensory neurons in an anatomically-inspired architecture. tE-NMIs provide axon tracts that are intended to integrate with denervated distal structures and preserve regenerative capacity during prolonged periods without host innervation. Following implant, we found that tE-NMI axons promoted Schwann cell maintenance, integrated with distal muscle, and preserved an evoked muscle response out to 20-weeks post nerve transection in absence of innervation from host axons. By repopulating the distal sheath with exogenous axons, tE-NMIs also enabled putative delayed fusion with proximal host axons, a phenomenon previously not achievable in delayed repair scenarios due to distal axon degeneration. Here, we found immediate electrophysiological recovery after fusion with proximal host axons and improved axon maturation and muscle reinnervation at 24-weeks post-transection (4-weeks following delayed nerve fusion). these findings show that tE-NMIs provide the potential to improve functional recovery following delayed nerve repair.

关键词： Nerve regeneration Neuromuscular injury Muscle preservation tissue engineering Microtissue Axon fusion

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Advancing Wound Filling Extraction on 3D Faces:An Auto-Segmentation and Wound Face Regeneration Approach

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 2197-2214页

作者： Duong Q.Nguyen thinh D.Le phuong D.Nguyen Nga t.K.Le H.Nguyen-Xuan Department of Mathematics and Statistics Quy Nhon UniversityQuy Nhon City55100Viet Nam Applied Research Institute for Science and technology Quy Nhon UniversityQuy Nhon City55100Viet Nam CIRtECH Institute HUTECH UniversityHo Chi Minh City72308Viet Nam

Facial wound segmentation plays a crucial role in preoperative planning and optimizing patient outcomes in various medical *** this paper,we propose an efficient approach for automating 3D facial wound segmentation using a two-stream graph convolutional *** method leverages the Cir3D-FaIR dataset and addresses the challenge of data imbalance through extensive experimentation with different loss *** achieve accurate segmentation,we conducted thorough experiments and selected a high-performing model from the *** selectedmodel demonstrates exceptional segmentation performance for complex 3D facial ***,based on the segmentation model,we propose an improved approach for extracting 3D facial wound fillers and compare it to the results of the previous *** method achieved a remarkable accuracy of 0.9999993% on the test suite,surpassing the performance of the previous *** this result,we use 3D printing technology to illustrate the shape of the wound *** outcomes of this study have significant implications for physicians involved in preoperative planning and intervention *** automating facial wound segmentation and improving the accuracy ofwound-filling extraction,our approach can assist in carefully assessing and optimizing interventions,leading to enhanced patient ***,it contributes to advancing facial reconstruction techniques by utilizing machine learning and 3D bioprinting for printing skin tissue *** source code is available at https://***/SIMOGroup/WoundFilling3D.

关键词： 3D printing technology face reconstruction 3D segmentation 3D printed model

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CLASSIFICAtION OF SOLUtIONS tO HIGHER FRACtIONAL ORDER SYStEMS

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Acta Mathematica Scientia 2021年第4期41卷 1302-1320页

作者： phuong LE Faculty of Economic Mathematics University of Economics and LawHo Chi Minh CityVietnam VietnamNational UniversityHo Chi Minh CityVietnam

Let 00 for all s,t≥*** main technique we use is the method of moving spheres in integral *** our assumptions are more general than those in the previous literature,some new ideas are introduced to overcome this diffi... 详细信息

Let 0two nonnegative *** study nonnegative classical solutions of the system{(-△)^(α/2)u=f(u,v)in R^(n),(-△)^(β/2)v=g(u,v)in R^(n),and the corresponding equivalent integral *** classify all such solutions when f(s,t)is nondecreasing in s and increasing in t,g(s,t)is increasing in s and nondecreasing in i,and f(μ^(n-α)s,μ^(n-β)t)/μ^(n-α),g(μ^(n-α)s,μ^(n-β)t)/μ^(n-β)are nonincreasing in μ>0 for all s,t≥*** main technique we use is the method of moving spheres in integral *** our assumptions are more general than those in the previous literature,some new ideas are introduced to overcome this difficulty.

关键词： Higher fractional order system integral system general nonlinearity method of moving spheres classification of solutions

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Comparing the Soil Conservation Service model with new machine learning algorithms for predicting cumulative infiltration in semi-arid regions

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Pedosphere 2022年第5期32卷 718-732页

作者： Khabat KHOSRAVI phuong t.t.NGO Rahim BARZEGAR John QUILtY Mohammad t.AALAMI Dieu t.BUI Department of Watershed Management Engineering Ferdowsi University of MashhadMashhad 93(Iran) Department of Earth and Environment Florida International UniversityMiami 33199(USA) Institute of Research and Development Duy Tan UniversityDa Nang 550000(Vietnam) Department of Bioresource Engineering McGill UniversitySte Anne de Bellevue QC H9X(Canada) Faculty of Civil Engineering University of TabrizTabriz 51(Iran) Department of Civil and Environmental Engineering University of WaterlooWaterloo N2L 3G1(Canada) Department of Business and It University of South-Eastern NorwayNotodden 3603(Norway)

Water infiltration into soil is an important process in hydrologic cycle;however,its measurement is difficult,time-consuming and *** and physical models have been developed to predict cumulative infiltration(CI),but are often *** this study,several novel standalone machine learning algorithms(M5Prime(M5P),decision stump(DS),and sequential minimal optimization(SMO))and hybrid algorithms based on additive regression(AR)(i.e.,AR-M5P,AR-DS,and AR-SMO)and weighted instance handler wrapper(WIHW)(i.e.,WIHW-M5P,WIHW-DS,and WIHW-SMO)were developed for CI *** Soil Conservation Service(SCS)model developed by the United States Department of Agriculture(USDA),one of the most popular empirical models to predict CI,was considered as a ***,154 measurements of CI(explanatory/input variables)were taken from 16 sites in a semi-arid region of Iran(Illam and Lorestan provinces).Six input variable combinations were considered based on Pearson correlations between candidate model inputs(time of measuring and soil bulk density,moisture content,and sand,clay,and silt percentages)and *** dataset was divided into two subgroups at random:70%of the data were used for model building(training dataset)and the remaining 30%were used for model validation(testing dataset).the various models were evaluated using different graphical approaches(bar charts,scatter plots,violin plots,and taylor diagrams)and quantitative measures(root mean square error(RMSE),mean absolute error(MAE),Nash-Sutcliffe efficiency(NSE),and percent bias(PBIAS)).time of measuring had the highest correlation with CI in the study *** best input combinations were different for different *** results showed that all hybrid algorithms enhanced the CI prediction accuracy compared to the standalone *** AR-M5P model provided the most accurate CI predictions(RMSE=0.75 cm,MAE=0.59 cm,NSE=0.98),while the SCS model had the lowest performance(RMSE=4.77 cm,MAE=2.64 cm,NSE=

关键词： additive regression hybrid algorithms empirical model soil water infiltration weighted instances handler wrapper

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Antibiofilm activity of alpha-mangostin loaded nanoparticles against Streptococcus mutans

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Asian Pacific Journal of tropical Biomedicine 2020年第7期10卷 325-332页

作者： phuong t.M.Nguyen Minh t.H.Nguyen Lien t.Quach phuong t.M.Nguyen Lam L.Nguyen Dong V.Quyen Institute of Biotechnology Vietnam Academy of Science and Technology18 Hoang Quoc Viet RoadHanoiVietnam Institute of Graduate University of Science and technology Vietnam Academy of Science and Technology18 Hoang Quoc Viet RoadHanoiVietnam University of Science and technology of Hanoi Vietnam Academy of Science and Technology18-Hoang Quoc Viet RoadCau GiayHanoiVietnam

Objective:to investigate the antibiofilm activity of alphamangostin(AMG)loaded nanoparticle(nano AMG)against dental caries pathogen Streptococcus ***:AMG was isolated from the peels of Garcinia mangostana *** silica gel columns and chemically analysed by high performance liquid chromatography and nuclear magnetic *** AMG was prepared using the solvent evaporation method combined with high-speed *** nanoparticles were characterized using dynamic light scattering,field emission scanning electron microscopy(FE-SEM)and Fourier transform infrared spectroscopy(FtIR).the toxicity of nano AMG in fibroblast NIH/3 t3 cell line was determined using Mtt *** antibiofilm effect of nano AMG was determined through the evaluation of biofilm formation by Streptococcus mutans using a 96-well *** biomass was quantified using crystal *** viability was observed under confocal microscopy using LIVE/DEAD Bac Light ***,gene expression was determined by quantitative real-time PCR and membrane permeabilization activity by measuring the uptake of o-nitrophenol-β-***:Nano AMG size was in a range of 10-50 nm with a polydispersity index ofta potential value of-35.2 m *** size and the incorporation of AMG in the nanoparticles were confirmed by FE-SEM and FtIR *** IC50 values of the test agents on NIH/3 t3 cells were(9.80±0.63)μg/m L for AMG and(8.70±0.81)μg/m L for nano AMG,while no toxicity was generated from excipients used to prepare *** the early stage of biofilm formation,treatment with 6.25μmol/L nano AMG caused a reduction in biofilm biomass up to 49.1%,compared to 33.4%for *** contrast,biofilms at the late stage were more resistant to the test *** 96μmol/L(=10×MIC),nano AMG reduced only 20.7%of biofilm biomass while AMG did not showany *** of gtf B and gtf C genes involved in biofilm formation were down-regulated 3.3 and 12.5 folds,res

关键词： Alpha-mangostin Nanoparticle Antibiofilm activity Streptococcus mutans

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Stem cell-based therapy for human diseases

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Signal transduction and targeted therapy 2022年第9期7卷 3242-3282页

作者： Duc M.Hoang phuong t.Pham trung Q.Bach Anh t.L.Ngo Quyen t.Nguyen trang t.K.Phan Giang H.Nguyen phuong t.t.Le Van t.Hoang Nicholas R.Forsyth Michael Heke Liem thanh Nguyen Department of Research and Development Vinmec Research Institute of Stem Cell and Gene TechnologyVinmec Healthcare SystemHanoiVietnam Department of Cellular therapy Vinmec High.Tech CenterVinmec Healthcare SsystemHanoiVietnam Institute for Science&technology in Medicine Keele UniversityKeeleUK a Department of Biology Stanford UniversityStanfordCAUSA

Recent advancements in stem cell technology open a new door for patients suffering from diseases and disorders that have yet to be *** cell-based therapy,including human pluripotent stem cells(hPsCs)and multipotent mesenchymal stem cells(MSCs),has recently emerged as a key player in regenerative *** are defined as self-renewable cell types conferring the ability to differentiate into various cellular phenotypes of the human body,including three germ *** are multipotent progenitor cells possessing self-renewal ability(limited in vitro)and differentiation potential into mesenchymal lineages,according to the International Society for Cell and Gene therapy(ISCt).this review provides an update on recent clinical applications using either hPSCs or MSCs derived from bone marrow(BM),adipose tissue(At),or the umbilical cord(UC)for the treatment of human diseases,including neurological disorders,pulmonary dysfunctions,metabolic/endocrine-related diseases,reproductive disorders,skin burns,and cardiovascular ***,we discuss our own clinical trial experiences on targeted therapies using MsCs in a clinical setting,and we propose and discuss the MSC tissue origin concept and how MSC origin may contribute to the role of MSCs in downstream applications,with the ultimate objective of facilitating translational research in regenerative medicine into clinical *** mechanisms discussed here support the proposed hypothesis that BM-MSCs are potentially good candidates for brain and spinal cord injury treatment,At-MSCs are potentially good candidates for reproductive disorder treatment and skin regeneration,and UC-MsCs are potentially good candidates for pulmonary disease and acute respiratory distress svndrometreatment.

关键词： diseases distress treatment

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A tree-based intelligence ensemble approach for spatial prediction of potential groundwater

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International Journal of Digital Earth 2020年第12期13卷 1408-1429页

作者： Mohammadtaghi Avand Saeid Janizadeh Dieu tien Bui Viet Hoa Pham phuong thao t.Ngo Viet-Ha Nhu Faculty of Natural Resources and Marine Sciences Tarbiat Modares UniversityTehranIran Geographic Information Science Research Group Ton Duc Thang UniversityHo Chi Minh CityVietnam Faculty of Environment and Labour Safety Ton Duc Thang UniversityHo Chi Minh CityVietnam Ho Chi Minh City Institute of Resources Geography Vietnam Academy of Science and TechnologyHo Chi Minh CityVietnam Institute of Research and Development Duy Tan UniversityDa NangVietnam Department of Geological-Geotechnical Engineering Hanoi University of Mining and GeologyHanoiVietnam

the objective of this research is to propose and confirm a new machine learning approach of Best-First tree(BFtree),AdaBoost(AB),MultiBoosting(MB),and Bagging(Bag)ensembles for potential groundwater mapping and assessing role of influencing *** Yasuj-Dena area(Iran)is selected as a case *** this regard,a Yasuj-Dena database was established with 362 springs locations and 12 groundwater-influencing factors(slope,aspect,elevation,stream power index(SPI),length of slope(LS),topographic wetness index(tWI),topographic position index(tPI),land use,lithology,distance from fault,distance from river,and rainfall).the database was employed to train and validate the proposed groundwater *** area under the curve(AUC)and statistical metrics were employed to check and confirm the quality of the *** result shows that the BFtree-Bag model(AUC=0.810,kappa=0.495)has the highest prediction performance,followed by the BFtree-MB model(AUC=0.785,kappa=0.477),and the BFtree-MB model(AUC=0.745,kappa=0.422).Compared to the benchmark of Random Forests,the BFtree-Bag model performs better;therefore,we conclude that the BFtree-Bag is a new tool should be used for modeling of groundwater potential.

关键词： Environmental modeling groundwater potential GIS ensemble model decision tree

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A Simple Approach to the Fabrication of Graphene-Carbon Nanotube Hybrid Films on Copper Substrate by Chemical Vapor Deposition

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Journal of Materials Science & technology 2015年第5期31卷 479-483页

作者： Nguyen Van Chuc Cao thi thanh Nguyen Van tu vuong t.Q phuong Pham Viet thang Ngo thi thanh tam Institute of Materials Science Vietnam Academy of Science and Technology Hanoi University of Science Vietnam National University

In this study,graphene-carbon nanotube（CNt） hybrid films were directly synthesized on polycrystalline copper（Cu） substrates by thermal chemical vapor deposition（CVD） *** films were synthesized on Cu substrate at 1000 ℃ in mixture of gases:argon（Ar）,hydrogen（H2）,and methane（CH4）.then,carbon nanotubes（CNts） were grown uniformly on the surface of graphene/Cu films at 750 ℃ in mixture of Ar,*** acetylene（C2H2） *** salt FeCl3solution deposited onto the surface of graphene/Cu substrate by spin coating method was used as precursor for the growth of the *** density and quality of the CNts on the surface of graphene/Cu films can be controlled by varying the concentration of FeCl3salt catalyst.

关键词： Graphene Carbon nanotube(CNt) Hybrid films Copper

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Rest thallium-201/Stress technetium-99m Sestamibi Dual-Isotope Myocardial Perfusion Single-Photon Emission Computed tomography in Detecting of Chronic Coronary Artery Disease

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Journal of Pharmacy and Pharmacology 2016年第5期4卷 183-191页

作者： phuong Kim Huynh Lap vu Cong Xuan Quang truong Canh Nguyen Xuan Cho Ray Hospital 201B Nguyen Chi thanh Street District 5 Ho Chi Minh city (+084) Viet Nam

to investigate diagnostic accuracy of 2-hour protocol of rest thallium-201/stress technetium-99m sestamibi dual-isotope myocardial perfusion SPECt in chronic coronary artery disease. Sixty-seven patients with suspected CAD were enrolled in the prospective study. All patients underwent myocardial perfusion scintigraphy in SPECt with dual isotopes of t1-201 and dipyridamole stress tc-99m sestamibi. Rest and stress imaging protocol were performed in 2 hours by dose of 3 mCi tI-201 and 25 mCi tc-99m sestamibi. the acquisition parameters includes LEHR collimator, energy peak of 72 and 167 keV for t1-201 and 140 keV for tc-99m, 180-degree rotation from RAO to LPO, matrix size 64x64, and 25second/frame/64 frames. the 20-segment model of left ventricle was used in automatic quantitation software. Coronary angiography was used as gold standard. CAD was defined as 50% of lumen stenosis on coronary angiography. Rest tI-201/stress tc-99m sestamibi dual-isotope SPECt demonstrated a sensitivity of 94.59% and specificity of 70%, positive predictive value of 79.54% and negative predictive value of 91.3% in detection of coronary artery disease. Sensitivity and specificity for detecting multi-vessel coronary artery disease were 82.75% and 81.57% for the left anterior descending, 77.77% and 91.83% for left circumflex and 94.11% and 82% for right coronary artery. 2-hour protocol of rest thallium-201/stress technetium-99m sestamibi dual-isotope myocardial perfusion SPECt has high sensitivity, specificity, positive predictive value and negative predictive value in detecting chronic coronary artery disease with greater than 50% stenosis assessed by coronary angiography Moreover, this imaging protocol gives high imaging quality, time-saving and convenience.

关键词： MPS (myocardial perfusion scintigarphy) SPECt (single proton emission computed tomography) CAD (coronary arterydisease) CA (coronary angiography).

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Ethyl acetate extract of Smilax glabra Roxb roots and its major active compound astilbin promote osteoblastogenesis in vitro by upregulating bone cell differentiation-associated genes

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Asian Pacific Journal of tropical Biomedicine 2021年第12期11卷 553-560页

作者： Huyen t.t.Nguyen Minh t.H.Nguyen thu X.Nguyen Quan M.Pham Ha X.Nguyen phuong t.M.Nguyen University of Science and technology of Hanoi Vietnam Academy of Science and TechnologyHanoiVietnam Institute of Biotechnology Vietnam Academy of Science and TechnologyHanoiVietnam Institute of Natural Products Chemistry Vietnam Academy of Science and TechnologyHanoiVietnam Graduate University of Science and technology Vietnam Academy of Science and TechnologyHanoiVietnam

Objective:to investigate the osteoblastogenic activity of the ethyl acetate(EtOAc)extract of Smilax glabra Roxb roots and its major active compound ***:Astilbin was isolated from EtOAc extract using silica gel chromatography combined with fraction *** structure of astilbin was determined by analysis of the spectroscopic data in comparison with the *** method was used to detect the *** phosphatase(ALP)activity was determined by the spectrophotometric method at 405 nm using p-nitrophenyl phosphate as a *** deposition was stained with alizarin red-S,distained with cetylpyridium chloride,and quantified at 562 *** silico model for astilbin-ALP interaction was analyzed using AutoDock *** changes in expression of osteoblast differentiation related genes were determined using quantitative real-time ***:Both the EtOAc extract and astilbin had no toxicity toward osteoblast MC3t3-E1 cells at 5.0,10,25,and 50μg/*** 25μg/mL,they enhanced ALP activity and mineralization of osteoblasts up to 30%and 55%for the EtOAc extract and 22%and 41%for astilbin,*** docking analysis of astilbin-ALP interaction revealed Arg167,Asp320,His324,and His437 were key residues participating in hydrophobic interaction;meanwhile,His434 and thr436 residues were involved in hydrogen bond formation in the active site of human tissue-nonspecific ***,the expression level of genes opn,col1,osx,and runx2 were up-regulated in astilbin treated samples with the fold changes as 2.2;3.7;4.1;2.3,respectively at 10μg/mL(Pthe EtOAc extract and its major compound astilbin exhibit osteoblastogenic activity by up-regulating important markers for bone cell *** could be a new and promising osteogenic agent with dual actions for therapeutic applications.

关键词： Smilax glabra Roxb Astilbin Cytotoxicity Osteogenesis Osteoblast Ethyl acetate extract

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