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Synthesis and characterization of NaYF4:Yb3+,Er3+@silica-N=folic acid nanocomplex for bioimaginable detecting MCF-7 breast cancer cells

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Journal of Rare Earths 2019年第11期37卷 1183-1187页

作者： Ha thi phuong Tran Thu Huong Le thi Vinh Hoang thi Khuyen Do thi Thao Nguyen Thanh Huong Pham thi Lien Le Quoc Minh Institute of Materials Science Vietnam Academy of Science and Technology18 Hoang Quoc VietCau GiayHanoiViet Nam Graduate University of Science and Technology-Vietnam Academy of Science and Technology 18 Hoang Quoc VietCau GiayHanoiViet Nam Department of Chemistry Hanoi Medical University1-Ton That TungDong DaHanoiViet Nam Department of Chemistry Hanoi University of Mining and Geology18-Pho LienBac Tu LiemHanoiViet Nam Institute of Biotechnology Vietnam Academy of Science and Technology18-Hoang Quoc VietCau GiayHanoiViet Nam Duy Tan University K7/25 Quang TrungDa NangViet Nam

Upconversion nanophosphors are new promising nanomaterials to be used as biolabels for detection and imaging of cancer *** nanophosphors absorb long-wavelength excitation radiation in the infrared or near infrared region and emit shorter wavelength,higher energy radiation from ultraviolet to *** this paper,we studied the hydrothermal method and optical properties of the functionalized NaYF4:Yb^3+,Er^3+for biomedical *** synthesis,these NaYF4:Yb^3+,Er^3+nanophosphors were functionalized with aminosilanes and folic *** acid binds to the folate receptor on the surface of MCF-7 breast cancer cells and this binding promotes internalization of the nanophosphors via *** sizes of the functionalized NaYF4:Yb^3+,Er^3+@silica-N=FA(folic acid)nanophosphors can be controlled with length of the rod about 300-800 nm and diameter of the rod about 100-200 *** structure of NaYF4:Yb^3+,Er^3+is in hexagonal crystal *** photo luminescence(PL)spectra of the functionalized NaYF4:Yb^3+,Er^3+@silica-N=FA nanophosphors were *** nanophosphors emit in red color with the strongest band at 650 nm under 980 nm *** result can provide NaYF4:Er^3+,Yb^3+@silica-N=FA complex for developing fluorescence label and image tool in cancer biology and medicine.

关键词： Upconversion luminescence NaYF4:Yb^3+,Er^3+ Nanophosphors Bioimaging Cancer cell Rare earths

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Injectable reactive oxygen and nitrogen species-controlling hydrogels for tissue regeneration:current status and future perspectives

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Regenerative Biomaterials 2022年第1期9卷 1106-1130页

作者： phuong Le thi Dieu Linh Tran Thai Thanh Hoang thi Yunki Lee Ki Dong Park Institute of Applied Materials Science Vietnam Academy of Science and TechnologyHo Chi Minh City 700000Vietnam Department of Orthopaedics Emory University School of MedicineAtlantaGA 30329USA Department of Molecular Science and Technology Ajou UniversitySuwon 443-749Republic of Korea

The dual role of reactive oxygen and nitrogen species(RONS)in physiological and pathological processes in biological systems has been widely *** has been recently suggested that the regulation of RONS levels under physiological and pathological conditions is a potential therapy to promote health and treat diseases,*** hydrogels have been emerging as promising biomaterials for RONS-related biomedical applications owing to their excellent biocompatibility,three-dimensional and extracellular matrix-mimicking structures,tunable properties and easy *** hydrogels have been developed as advanced injectable platforms for locally generating or scavenging RONS,depending on the specific conditions of the target *** this review article,the design principles and mechanism by which RONS are generated/scavenged from hydrogels are outlined alongside a discussion of their in vitro and in vivo ***,we highlight the advantages and recent developments of these injectable RONS-controlling hydrogels for regenerativemedicines and tissue engineering applications.

关键词： reactive oxygen/nitrogen species oxidative stress-related diseases injectable hydrogels reactive oxygen/nitrogen species-scavenging/releasing/responsive properties tissue regeneration

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The COVID-19 pandemic in the ASEAN: A preliminary report on the spread, burden and medical capacities

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Asian Pacific Journal of Tropical Medicine 2020年第6期13卷 247-251页

作者： Minh Van Hoang phuong thi ngoc Nguyen Thao thi phuong Tran Long Quynh Khuong An thi Minh Dao Huy Van Nguyen Riyanti Djalante Hanh thi Tuyet Tran Hanoi University of Public Health HanoiVietnam Hanoi Medical University HanoiVietnam Graduate School of Public Health St.Luke's International UniversityTokyoJapan United Nations University-Institute for the Advanced Study of Sustainability(UNU-IAS) TokyoJapan

Objective:To provide preliminary descriptions of the spread,burden and related medical capacity characteristics of the ASEAN ***:We utilized the data from four main official databases,including WHO reports,the Statistics and Research of the Coronavirus Disease,and the Southeast Asia Program of the Center for Strategic and International *** spread of the COVID-19 pandemic,current burden and the COVID-19 medical response capacities were extracted before April 11,***:As of April 13,2020,the ASEAN countries reported19547 COVID-19 positive cases with 817 deaths(case-facility rate of 4.2%).Thailand was the first country in the region that reported having the COVID-19 cases,while Laos was the last to report confirmed COVID-19 *** for the number of deaths to double were between 8-12 *** the testing and treatment capacities,the number of PCR tests provided to the populations was the highest in Vietnam,followed by Singapore,Malaysia,and ***,the percentage of the population being tested was the highest in Brunei(2.31%),followed by Singapore(1.30%).Conclusions:A wide range of interventions were taken into practice in response to the outbreak with an effort of curbing the rise of this ***,special care should not be overlooked as the pandemic is placing a huge impact on the population and becomes increasingly *** tackle the spread of the pandemic in the region,the ASEAN countries should work together as one community to provide better responses to future pandemics and other transboundary public health challenges.

关键词： COVID-19 SARS-CoV-2 ASEAN South-East Asia Epidemiology

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Successful containment of a COVID-19 outbreak in Bach Mai Hospital by prompt and decisive responses

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Asian Pacific Journal of Tropical Medicine 2021年第5期14卷 234-235页

作者： Van Minh Hoang thi phuong Thao Tran thi ngoc phuong Nguyen thi Hai Yen Nguyen Quang Tuan Nguyen Hanoi University of Public Health HanoiVietnam Bach Mai Hospital HanoiVietnam

In low-and middle-income countries,tertiary care hospitals frequently face an extremely heavy workload and shoulder an even heavier burden during the COVID-19 *** Mai Hospital(BMH),one of the leading tertiary hospitals in Vietnam,is on the frontline in the fierce battle against *** letter aims to describe how BMH tackles the COVID-19 outbreak in the hospitallevel battle,which could support policymakers in time-management and well-preparation for this unpredictable pandemic.

关键词： prompt income policy

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Morphology and kinematics of the gas envelope of the Mira binary W Aquilae

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Research in Astronomy and Astrophysics 2016年第7期16卷 47-54页

作者： Do thi Hoai Pham Tuyet Nhung Pham ngoc Diep Nguyen thi phuong Pham Tuan-Anh Nguyen thi Thao Pierre Darriulat Department of Astrophysics Vietnam National Satellite CenterVAST

We analyse ALMA observations of the12CO（3-2） emission of the circumstellar envelope（CSE）of the Mira variable binary star W Aql. These provide, for the first time, spatially resolved Doppler velocity spectra of the CSE up to angular distances to the central star ofy nature of the observations（only five minutes in each of～5′′（meaning some 2000 AU）. The explorator two different configurations） does not allow for a detailed modelling of the properties of the CSE but provides important qualitative information on its morphology and kinematics. Emission is found to be enhanced along an axis moving from east/west to north-east/south-west when the angular distance from the central star projected on the plane of the sky increases from zero to four arcseconds. In parallel, the Doppler velocity distribution displays asymmetry along an axis moving from east/west to north-west/south-east. The results are discussed in the context of earlier observations, in particular of the dust morphology.

关键词： stars AGB and post-AGB (stars ) circumstellar matter stars individual(W Aql) stars mass-loss radio lines stars

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Operator Splitting and Local Time-Stepping Methods for Transport Problems in Fractured Porous Media

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Communications in Computational Physics 2023年第10期34卷 1215-1246页

作者： Phuoc-Toan Huynh Yanzhao Cao thi-Thao-phuong Hoang Department of Mathematics and Statistics Auburn UniversityAuburn 36849AlabamaUSA

this paper is concerned with efficient numerical methods for the advectiondiffusion equation in a heterogeneous porous medium containing fractures.A dimensionally reduced fracture model is considered,in which the fracture is represented as an interface between subdomains and is assumed to have larger permeability than the surrounding *** develop three global-in-time domain decomposition methods coupled with operator splitting for the reduced fracture model,where the advection and the diffusion are treated separately by different numerical schemes and with different time ***,smaller time steps can be used in the fracture-interface than in the *** first two methods are based on the physical transmission conditions,while the third one is based on the optimized Schwarz waveform relaxation approach with Ventcel-Robin transmission conditions.A discrete space-time interface system is formulated for each method and is solved iteratively and globally in *** results for two-dimensional problems with various P′eclet numbers and different types of fracture are presented to illustrate and compare the convergence and accuracy in time of the proposed methods with local time stepping.

关键词： Domain decomposition reduced fracture model operator splitting nonconforming time grids time-dependent Steklov-Poincare operator optimized Schwarz waveform relaxation

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Application Prospects for the Innovation of Defined Fungal Starter in Rice Wine Fermentation

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Journal of Life Sciences 2011年第4期5卷 255-263页

作者： ngo thi phuong Dung Huynh Xuan Phong Biotechnology Research and Development Institute Can Tho University Can Tho Ci.tv 92000 Vetnam

The feasibility of pilot-scale manufacture of defined fungal starter and its application in rice wine production from different local starchy materials were investigated. Starter consisting of Arnylomyces rouxii and Saccharomyces cerevisiae gave high performance in winemaking when prepared in conditions of rice flour 80% and cassava flour 20% with 4 incubation days. The starter level at 20% was favourably employed for manufacture with the initial amount of I0 kg mixed-flours, Dry starter granules which were vacuum packed could adapt ambient temperature （approx. 28-32℃） during 8 months of storage. The defined starter performed as superior inoculum for winemaking from different agricultural starchy resources. The undesirable bacteria were found at approx. 2 Log CFU/g of dry starter. By morphology, biochemical and physiological growth and the genetic partial 16S analyses, three bacterial isolates were characterized as Bacillus subtilis/amvloliquefaciens which may contaminate tbod but not cause food poisoning and not considered as a human pathogen.

关键词： Defined starter rice wine alcoholic fermentation pilot-scale manufacture undesirable bacteria.

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^(12)CO emission from the Red Rectangle

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Research in Astronomy and Astrophysics 2015年第12期15卷 2213-2228页

作者： Pham Tuan Anh Pham ngoc Diep Do thi Hoai Pham Tuyet Nhung Nguyen thi phuong Nguyen thi Thao Pierre Darriulat Department of Astrophysics Vietnam National Satellite CenterVAST

Observations of an unprecedented quality made by ALMA on the Red Rectangle of CO（3-2） and CO（6-5） emissions are analysed jointly with the aim of obtaining as simple as possible a description of the gas morphology and kinematics. Evidence is found for polar conical outflows and for a broad equatorial torus in rotation and expansion. Simple models of both are proposed. Comparing CO（6-5） and CO（3-2） emissions provides evidence for a strong temperature enhancement over the polar outflows. Continuum emission （dust） is seen to be enhanced in the equatorial region. Observed asymmetries are briefly discussed.

关键词： stars: AGB and post-AGB -- circumstellar matter -- radio-lines: stars-- planetary nebulae: individual (Red Rectangle)

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Morphology and kinematics of the gas envelope of the variable AGB star π^1 Gruis

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Research in Astronomy and Astrophysics 2016年第7期16卷 97-104页

作者： Pham Tuyet Nhung Do thi Hoai Pham ngoc Diep Nguyen thi phuong Nguyen thi Thao Pham Tuan Anh Pierre Darriulat Department of Astrophysics Vietnam National Satellite CenterVAST

Observations of the ^12CO（3–2） emission from the circumstellar envelope（CSE） of the variable star π1Gru using the compact array of the ALMA observatory have been recently made accessible to the public. An analysis of the morphology and kinematics of the CSE is presented with a result very similar to that obtained earlier for ^12CO（2–1） emission using the Submillimeter Array. A quantitative comparison is made using their flared disk model. A new model is presented that provides a significantly better description of the data, using radial winds and smooth evolutions of the radio emission and wind velocity from the stellar equator to the poles.

关键词： stars AGB and post-AGB circumstellar matter star individual(π1Gru) stars massloss radio lines stars

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An Effective Integrated Machine Learning Framework for Identifying Severity of Tomato Yellow Leaf Curl Virus and Their Experimental Validation

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Research 2023年第3期2023卷 91-104页

作者： Nattanong Bupi Vinoth Kumar Sangaraju Le thi Phan Aamir Lal Thuy thi Bich Vo phuong thi Ho Muhammad Amir Qureshi Marjia Tabassum Sukchan Lee Balachandran Manavalan Department of Integrative Biotechnology College of Biotechnology and BioengineeringSungkyunkwan UniversitySuwon 16419.Gyeonggi-doRepublic of Korea Computational Biology and Bioinformatics Laboratory Department of Integrative BiotechnologyCollege of Biotechnology and Bioengineering.Sungkyunkwan UniversitySuwon 16419Gyeonggi-doRepublic of Korea

Tomato yellow leaf curl virus(TYLCV)dispersed across different countries,specifically to subtropical regions,associated with more severe *** TYLCV was first isolated in 1931,it has been a menace to tomato industrial production worldwide over the past *** groups were newly isolated from TYLCV-resistant tomatoes in 2022;however,their functions are *** development of machine learning(ML)-based models using characterized sequences and evaluating blind predictions is one of the major challenges in interdisciplinary *** purpose of this study was to develop an integrated computational framework for the accurate identification of symptoms(mild or severe)based on TYLCV sequences(isolated in Korea).For the development of the framework,we first extracted 11 different feature encodings and hybrid features from the training data and then explored 8 different classifiers and developed their respective prediction models by using randomized 10-fold ***,we carried out a systematic evaluation of these 96 developed models and selected the top 90 models,whose predicted class labels were combined and considered as reduced *** the basis of these features,a multilayer perceptron was applied and developed the final prediction model(IML-TYLCVs).We conducted blind prediction on 3 groups using IML-TYLCVs,and the results indicated that 2 groups were severe and 1 group was ***,we confirmed the prediction with virus-challenging experiments of tomato plant phenotypes using infectious clones from 3 *** virologists and plant breeding professionals can access the user-friendly online IML-TYLCVs web server at https://***/IML-TYLCVs,which can guide them in developing new protection strategies for newly emerging viruses.

关键词： breeding fir prediction

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