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The COVID-19 pandemic in the ASEAN: A preliminary report on the spread, burden and medical capacities

Asian Pacific Journal of Tropical Medicine 2020年第6期13卷 247-251页

作者： Minh Van Hoang phuong thi Ngoc Nguyen Thao thi phuong tran Long Quynh Khuong An thi Minh Dao Huy Van Nguyen Riyanti Djalante Hanh thi Tuyet tran Hanoi University of Public Health HanoiVietnam Hanoi Medical University HanoiVietnam Graduate School of Public Health St.Luke's International UniversityTokyoJapan United Nations University-Institute for the Advanced Study of Sustainability(UNU-IAS) TokyoJapan

Objective:To provide preliminary descriptions of the spread,burden and related medical capacity characteristics of the ASEAN ***:We utilized the data from four main official databases,including WHO reports,the Statistics and Research of the Coronavirus Disease,and the Southeast Asia Program of the Center for Strategic and International *** spread of the COVID-19 pandemic,current burden and the COVID-19 medical response capacities were extracted before April 11,***:As of April 13,2020,the ASEAN countries reported19547 COVID-19 positive cases with 817 deaths(case-facility rate of 4.2%).Thailand was the first country in the region that reported having the COVID-19 cases,while Laos was the last to report confirmed COVID-19 *** for the number of deaths to double were between 8-12 *** the testing and treatment capacities,the number of PCR tests provided to the populations was the highest in Vietnam,followed by Singapore,Malaysia,and ***,the percentage of the population being tested was the highest in Brunei(2.31%),followed by Singapore(1.30%).Conclusions:A wide range of interventions were taken into practice in response to the outbreak with an effort of curbing the rise of this ***,special care should not be overlooked as the pandemic is placing a huge impact on the population and becomes increasingly *** tackle the spread of the pandemic in the region,the ASEAN countries should work together as one community to provide better responses to future pandemics and other transboundary public health challenges.

关键词： COVID-19 SARS-CoV-2 ASEAN South-East Asia Epidemiology

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Successful containment of a COVID-19 outbreak in Bach Mai Hospital by prompt and decisive responses

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Asian Pacific Journal of Tropical Medicine 2021年第5期14卷 234-235页

作者： Van Minh Hoang thi phuong Thao tran thi Ngoc phuong Nguyen thi Hai Yen Nguyen Quang Tuan Nguyen Hanoi University of Public Health HanoiVietnam Bach Mai Hospital HanoiVietnam

In low-and middle-income countries,tertiary care hospitals frequently face an extremely heavy workload and shoulder an even heavier burden during the COVID-19 *** Mai Hospital(BMH),one of the leading tertiary hospitals in Vietnam,is on the frontline in the fierce battle against *** letter aims to describe how BMH tackles the COVID-19 outbreak in the hospitallevel battle,which could support policymakers in time-management and well-preparation for this unpredictable pandemic.

关键词： prompt income policy

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Influence of Foliar Fertilizers on Growth and Development of Petunia hybrida in Winter-Spring 2015-2016 in Thua thien Hue

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Journal of Agricultural Science and Technology(A) 2017年第B10期7卷 40-47页

作者： The thi Dieu Nguyen phuong thi Xuan tran Hai thi Hong Truong Khoa Dang tran Hue University 03 Le Loi StreetHue City 530000Vietnam Institute of Biotechnology Hue UniversityTinh Lo 10 StreetHue City 530000Vietnam Agronomy Faculty University of Agriculture and ForestryHue University102 Phung Hung StreetHue City 530000Vietnam

The experiment was conducted in winter-spring 2015-2016 in Thua thien Hue to identify different foliar fertilizer for Petunia hybrida having good growth and development,beautiful colors and long lifetime under local *** experiment included four treatments with three kinds of forliar fertilizers—Dau Trau MK 30-10-5,gibberellin 25-10-10 and abscisic *** control treatment(T0)used sterilized water without foliar *** results showed that all the foliar fertilizers influenced well on growth and development of Petunia *** Trau MK 30-10-5 helped Petunia hybrida have high quality and high value/cost ratio than the others.

关键词： Foliar fertilizer Petunia hybrida growth Thua thien Hue

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ROR2 regulates the survival of murine osteosarcoma cells in lung capillaries

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Journal of Cancer Metastasis and Treatment 2020年第1期6卷 611-621页

作者： Diem thi phuong tran Takahiro Kuchimaru Mongkol Pongsuchart Kha The Nguyen John Clyde Co Soriano Tetsuya Kadonosono Shinae Kizaka-Kondoh School of Life Science and Technology Tokyo Institute of TechnologyYokohama 226-8501Japan Center for Molecular Medicine Jichi Medical UniversityTochigi 329-0498Japan

Aim:Lung metastasis is a leading cause of death in patients with osteosarcoma(OS).No effective therapy exists that improves the five-year overall survival rate of OS patients with ***,finding novel therapeutic targets will help develop new treatment strategies for OS patients with lung ***:Based on analysis of gene expression profiles between sublines of the Dunn OS LM8 cell line with high(LM8-H)and low(LM8-L)metastatic ability,we have identified Wnt signal-related genes that play an important role in lung metastasis of *** of the genes was investigated by establishing sublines of gene knockout and assessing their metastatic ability using a mouse lung metastasis *** molecular mechanism underlying the function of the genes was further investigated by in vitro ***:We have identified that receptor tyrosine kinase-like orphan receptor 2(ROR2),a receptor of the non-canonical Wnt signaling pathway,was involved in OS cell survival in lung capillaries during ***8-H knocked out of Ror2(H/Ror2-KO)significantly reduced lung metastasis by decreasing the viability in lung capillaries 48 h after intravenous *** vitro study revealed that ROR2 increased anoikis resistance through AKT *** of ROR2 expression in H/Ror2-KO cells restored their metastatic ability and viability in lung ***:The results demonstrate a novel ROR2 function in OS lung metastasis and may inform new treatment strategies for OS patients.

关键词： Osteosarcoma lung metastasis cell survival lung capillary ROR2

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Drought and conflicts at the local level: Establishing a water sharing mechanism for the summer-autumn rice production in Central Vietnam

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International Soil and Water Conservation Research 2019年第4期7卷 362-375页

作者： Chuong Van Huynh Catharien Terwisscha van Scheltinga Ty Huu Pham Non Quoc Duong phuong thi tran Linh Hoang Khanh Nguyen Tung Gia Pham Ngoc Bich Nguyen Jos Timmerman Hue University Viet Nam Climate Change and Adaptive Land and Water Management Group Wageningen Environmental ResearchNetherlands University of Agriculture and Forestry Hue UniversityViet Nam

In recent years,water for agricultural production gradually became a significant challenge in the context of climate change in *** solutions are required,which consider the use of resources for both human needs and ecology,and that account for the equitable distribution and the livelihood of the farmers now and in the *** particular,the farmers in the province of Quang Nam faring water shortage in the cultivation of paddy in the summer-autumn *** arise regarding the sharing of the water between the farmers,the drinking water company and the hydropower *** the context of climate change,the water shortage is expected to increase in the *** article presents the results of participatory action research (PAR) approach to develop a local level mechanism for water sharing,in which stakeholders actively *** sharing mechanism was developed,envisioning a sustainable solution for inclusive water *** mechanism was successfully implemented in two cases,one at commune level (Tho stream) and one at the district level (Mo stream).The participatory approach proved to be successful in setting up a broadly acceptable mechanism that will need to be further incorporated in the institutional set-up.

关键词： Adaptation Agriculture Climate change Governance Rice production Water sharing

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Novel enzymatically crosslinked chitosan hydrogels with free-radical-scavenging property and promoted cellular behaviors under hyperglycemia

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Progress in Natural Science:Materials International 2020年第5期30卷 661-668页

作者： Dieu Linh tran phuong Le thi Thai Thanh Hoang thi Ki Dong Park Department of Molecular Science and Technology Ajou University Biomaterials and Nanotechnology Research Group Faculty of Applied Sciences Ton Duc Thang University

The impairment of regenerative processes induced by high blood-glucose level(hyperglycemia) and excessive reactive oxygen species(ROS) contributes to the diabetic complication progression and development. In this study, an injectable, in situ crosslinkable chitosan hydrogel with ROS-scavenging capability was developed by conjugating gallic acid onto the chitosan backbone(CGA). We hypothesized that gallic acid serves as both antioxidant and crosslinking moieties to form hydrogel in situ by means of enzymatic crosslinking with horseradish peroxidase(HRP). The rapid gelation(from 30 s) was observed by vial tilting. The mechanical properties and microstructures of CGA hydrogels can be well controlled by varying the concentrations of H2O2. The ROSscavenging ability of these CGA hydrogels was demonstrated against DPPH radical, hydroxyl radical, and total reducing power. Notably, in an in vitro hyperglycemia environment, CGA hydrogels significantly improved the proliferation and migration of human dermal fibroblast cells, which are closely related to diabetic wound healing. These results suggest that CGA hydrogels have potential as advanced materials for the treatment of diabetes-related diseases via attenuating the excessive ROS production and improving cellular behaviors.

关键词： Chitosan Gallic acid Injectable hydrogel Hyperglycemia Free-radical-scavenging

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Injectable reactive oxygen and nitrogen species-controlling hydrogels for tissue regeneration:current status and future perspectives

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Regenerative Biomaterials 2022年第1期9卷 1106-1130页

作者： phuong Le thi Dieu Linh tran Thai Thanh Hoang thi Yunki Lee Ki Dong Park Institute of Applied Materials Science Vietnam Academy of Science and TechnologyHo Chi Minh City 700000Vietnam Department of Orthopaedics Emory University School of MedicineAtlantaGA 30329USA Department of Molecular Science and Technology Ajou UniversitySuwon 443-749Republic of Korea

The dual role of reactive oxygen and nitrogen species(RONS)in physiological and pathological processes in biological systems has been widely *** has been recently suggested that the regulation of RONS levels under physiological and pathological conditions is a potential therapy to promote health and treat diseases,*** hydrogels have been emerging as promising biomaterials for RONS-related biomedical applications owing to their excellent biocompatibility,three-dimensional and extracellular matrix-mimicking structures,tunable properties and easy *** hydrogels have been developed as advanced injectable platforms for locally generating or scavenging RONS,depending on the specific conditions of the target *** this review article,the design principles and mechanism by which RONS are generated/scavenged from hydrogels are outlined alongside a discussion of their in vitro and in vivo ***,we highlight the advantages and recent developments of these injectable RONS-controlling hydrogels for regenerativemedicines and tissue engineering applications.

关键词： reactive oxygen/nitrogen species oxidative stress-related diseases injectable hydrogels reactive oxygen/nitrogen species-scavenging/releasing/responsive properties tissue regeneration

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Synthesis and characterization of NaYF4:Yb3+,Er3+@silica-N=folic acid nanocomplex for bioimaginable detecting MCF-7 breast cancer cells

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Journal of Rare Earths 2019年第11期37卷 1183-1187页

作者： Ha thi phuong tran Thu Huong Le thi Vinh Hoang thi Khuyen Do thi Thao Nguyen Thanh Huong Pham thi Lien Le Quoc Minh Institute of Materials Science Vietnam Academy of Science and Technology18 Hoang Quoc VietCau GiayHanoiViet Nam Graduate University of Science and Technology-Vietnam Academy of Science and Technology 18 Hoang Quoc VietCau GiayHanoiViet Nam Department of Chemistry Hanoi Medical University1-Ton That TungDong DaHanoiViet Nam Department of Chemistry Hanoi University of Mining and Geology18-Pho LienBac Tu LiemHanoiViet Nam Institute of Biotechnology Vietnam Academy of Science and Technology18-Hoang Quoc VietCau GiayHanoiViet Nam Duy Tan University K7/25 Quang TrungDa NangViet Nam

Upconversion nanophosphors are new promising nanomaterials to be used as biolabels for detection and imaging of cancer *** nanophosphors absorb long-wavelength excitation radiation in the infrared or near infrared region and emit shorter wavelength,higher energy radiation from ultraviolet to *** this paper,we studied the hydrothermal method and optical properties of the functionalized NaYF4:Yb^3+,Er^3+for biomedical *** synthesis,these NaYF4:Yb^3+,Er^3+nanophosphors were functionalized with aminosilanes and folic *** acid binds to the folate receptor on the surface of MCF-7 breast cancer cells and this binding promotes internalization of the nanophosphors via *** sizes of the functionalized NaYF4:Yb^3+,Er^3+@silica-N=FA(folic acid)nanophosphors can be controlled with length of the rod about 300-800 nm and diameter of the rod about 100-200 *** structure of NaYF4:Yb^3+,Er^3+is in hexagonal crystal *** photo luminescence(PL)spectra of the functionalized NaYF4:Yb^3+,Er^3+@silica-N=FA nanophosphors were *** nanophosphors emit in red color with the strongest band at 650 nm under 980 nm *** result can provide NaYF4:Er^3+,Yb^3+@silica-N=FA complex for developing fluorescence label and image tool in cancer biology and medicine.

关键词： Upconversion luminescence NaYF4:Yb^3+,Er^3+ Nanophosphors Bioimaging Cancer cell Rare earths

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Static and dynamic analysis of functionally graded fluidinfiltrated porous skew and elliptical nanoplates using an isogeometric approach

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Frontiers of Structural and Civil Engineering 2023年第3期17卷 477-502页

作者： tran thi Thu THUY Faculty of Mechanical Engineering Hanoi University of IndustryHanoi 100000Vietnam

The analysis of static bending and free and forced vibration responses of functionally graded fluidinfiltrated porous(FGFP)skew and elliptical nanoplates placed on Pasternak’s two-parameter elastic foundation is performed for the first time using isogeometric analysis(IGA)based on the non-uniform rational B-splines(NURBSs)basis *** types of porosity distributions affect the mechanical characteristics of materials:symmetric distribution,upper asymmetric distribution,and lower asymmetric *** stress–strain relationship for Biot porous materials was determined using the elastic *** general equations of motion of the nanoplates were established using the four-unknown shear deformation plate theory in conjunction with the nonlocal elastic theory and Hamilton’s principle.A computer program that uses IGA to determine the static bending and free and forced vibration of a nanoplate was developed on MATLAB software *** accuracy of the computational program was validated via numerical comparison with confidence *** set of programs presents the influence of the following parameters on the static bending and free and forced vibrations of nanoplates:porosity distribution law,porosity coefficient and geometrical parameters,elastic foundation,deviation angle,nonlocal coefficient,different boundary conditions,and Skempton *** numerical findings demonstrated the uniqueness of the FGFP plate’s behavior when the porosities are saturated with liquid compared with the case without *** findings of this study have significant implications for engineers involved in the design and fabrication of the aforementioned type of ***,this can form the basis for future research on the mechanical responses of the structures.

关键词： static bending free and forced vibrations nonlocal theory isogeometric analysis fluid-infiltrated porous nanoplates

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A Deep Learning Model of Traffic Signs in Panoramic Images Detection

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Intelligent Automation & Soft Computing 2023年第7期37卷 401-418页

作者： Kha Tu Huynh thi phuong Linh Le Muhammad Arif thien Khai tran International University Ho Chi Minh CityVietnam-Vietnam National UniversityHo Chi Minh City700000Vietnam Department of Computer Science The Superior UniversityLahorePakistan Ho Chi Minh City University of Foreign Languages and Information Technology Ho Chi Minh City700000Vietnam

To pursue the ideal of a safe high-tech society in a time when traffic accidents are frequent,the traffic signs detection system has become one of the necessary topics in recent years and in the *** ultimate goal of this research is to identify and classify the types of traffic signs in a panoramic *** accomplish this goal,the paper proposes a new model for traffic sign detection based on the Convolutional Neural Network for com-prehensive traffic sign classification and Mask Region-based Convolutional Neural Networks(R-CNN)implementation for identifying and extracting signs in panoramic *** augmentation and normalization of the images are also applied to assist in classifying better even if old traffic signs are degraded,and considerably minimize the rates of discovering the extra *** proposed model is tested on both the testing dataset and the actual images and gets 94.5%of the correct signs recognition rate,the classification rate of those signs discovered was 99.41%and the rate of false signs was only around 0.11.

关键词： Deep learning convolutional neural network Mask R-CNN traffic signs detection

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