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Mucopolysaccharidosis typeⅢB:a curren. review an. exploration.of the AAV therapy lan.scape

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n.ural Regen.ration.Research 2024年第2期19卷 355-359页

作者： Courtn.y J.Rouse Victoria n.Jen.en.Coy d.Heldermon Lacerta Therapeutics AlachuaFLUSA Un.versity of Florida College of Medicin. GainesvilleFLUSA

Mucopolysaccharidoses typeⅢB is a rare gen.tic disorder caused by mutation. in.the gen. that en.odes for *** results in.the aggregation.of heparan.sulfate polysaccharides within.cell lysosomes that leads to progressive an. severe debilitatin. n.urological *** treatmen. option. are expen.ive,limited,an. presen.ly there are n. approved cures for mucopolysaccharidoses typeⅢ***-associated virus gen. therapy has sign.fican.ly advan.ed the field forward,allowin. researchers to successfully design.en.an.e,an. improve poten.ial *** group recen.ly published an.effective treatmen. usin. a codon.optimized triple mutan. aden.-associated virus 8 vector that restores n.acetyl-alpha-glucosamin.dase levels,auditory fun.tion.an. lifespan.in.the murin. model for mucopolysaccharidoses typeⅢB to that seen.in.healthy ***,we review the curren. state of the field in.relation.to the capsid lan.scape,aden.-associated virus gen. therapy an. its successes an. challen.es in.the clin.c,an. how n.vel aden.associated virus capsid design. have evolved research in.the mucopolysaccharidoses typeⅢB field.

关键词： aden.-associated virus cen.ral n.rvous system gen. therapy heparan.sulfate immun. respon.e mucopolysaccharidoses type IIIB n.acetyl-alpha-glucosamin.dase n.wborn.screen.n.

Hon.y vesicle-like n.n.particles protect aged liver from n.n.alcoholic steatohepatitis

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Acta pharmaceutica Sin.ca B 2024年第8期14卷 3661-3679页

作者： Baolon. Liu phuong Lin. n.uyen.Han.Yu Xin.zhi Li Huiren.Wan. Tram Gia Bao n.uyen.Prakash Kumar Sahoo Meghn. Sur Jay Reddy Sarah Sillman.Stephen.d.Kachman.Bara Altartouri Guoqin. Lu Sathish Kumar n.tarajan.Mahesh Pattabiraman.Jiujiu Yu departmen. of n.trition.an. Health Scien.es University of Nebraska-LincolnLincolnNE 68583USA Shaan.i Key Laboratory of Molecular Biology for Agriculture College of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China departmen. of n.trition Case Western Reserve UniversityClevelandOH 44106USA School of Veterin.ry Medicin. an. Biomedical Scien.es University of Nebraska-LincolnLincolnNE 68583USA departmen. of Statistics University of Nebraska-LincolnLincolnNE 68583USA Cen.er for Biotechn.logy University of Nebraska-LincolnLincolnNE 68588USA departmen. of Biology University of Nebraska OmahaOmahaNE 68182USA departmen. of Chemistry University of Nebraska-KearneyKearneyNE 68849USA

n.n.alcoholic steatohepatitis(n.SH),an.advan.ed form of n.n.alcoholic fatty liver disease(n.FLd),has emerged as the leadin. cause of liver failure an. related ***,n. medication.is specifically approved to treat n.FLd or *** we report that oral admin.stration.of hon.y vesiclelike n.n.particles(H-VLn.)to n.turally aged mice protects the liver from n.SH developmen..H-VLn. are domin.n.ly taken.up by Kupffer cells in.the liver an. suppress hepatic chron.c in.lammation.an. further developmen. of fibrosis an. n.dule formation.in.aged *** their reported an.iin.lammasome fun.tion.H-VLn. are foun. to in.ibit the tran.cription.l activities of C-JUn.an. n.clear factor-kappa B(n.-κB).MicroRn.s miR5119 an. miR5108 an. phen.lic compoun. luteolin.in.H-VLn. are iden.ified in.suppressin. both the C-JUn.an. n.-kB ***,oral in.ake of H-VLn. represen.s a promisin. n.w user-frien.ly modality to preven. the developmen. of n.SH.

关键词： Hon.y Extracellular vesicles Exosomes n.n.particles microRn.s Agin. In.lammation n.n.alcoholic steatohepatitis

Polio eradication.surveillan.e in.Sri Lan.a,2019-2023

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Asian.Pacific Journ.l of Tropical Medicin. 2024年第6期17卷 268-272页

作者： M.A.Y.Fern.n.o n.S.Madarasin.he C.Ran.an. n.Weerasin.he d.C.U.d.Weligamage J.I.Abeyn.yake departmen. of Medical Microbiology an. Immun.logy Faculty of MedicineUniversity of ColomboSri Lanka departmen. of Virology Medical Research InstituteColombo 08Sri Lanka Medical Research In.titute Colombo 08Sri Lanka

Objective:To evaluate the polio laboratory surveillan.e carried out from Jan.ary,2019 to May,2023 by the Polio Region.l Referen.e Laboratory,Sri ***:This retrospective study an.lyzed all stool samples received un.er the acute flaccid paralysis(AFP)an. immun.deficien. vaccin.-derived poliovirus(VdPV)surveillan.e at Polio Region.l Referen.e Laboratory,Sri Lan.a from Jan.ary,2019 to May,*** results of the testin. methodologies were extracted from the laboratory data system,i.e.,poliovirus virus isolation.in.ra-typic differen.iation.VdPV real time reverse tran.criptase polymerase chain.reaction.ITd/VdPV rRTPCR)an. sequen.in.,alon. with the data on.timin. of reportin. results,stool adequacy an. *** was an.lyzed usin. descriptive ***:A total of 2141 stool samples from 1644 cases were received for AFP surveillan.e from Sri Lan.a(93.61%),Maldives(1.52%),an. immun.deficien. VdPV(4.86%)*** polioviruses(19/1644,1.15%)an. n.n.polio en.eroviruses(73/1644,4.44%)were isolated,while Sabin.like 3 virus was detected in.majority(12/19,63.15%)amon. the poliovirus *** polioviruses or circulatin. VdPVs were n.t detected amon. the *** all years of the study,the n.n.polio AFP detection.rate was>1/100000 in.children.aged less than.15 years,whereas stool adequacy rate was>80%.All results were reported within.14 days of receipt,en.urin. timely reportin. as per global ***:The Polio Region.l Referen.e Laboratory,Sri Lan.a plays a vital role in.main.ain.n. the polio-free status in.the coun.ry through its robust laboratory surveillan.e,while adherin. to the surveillan.e ***-detection.of wild polioviruses an. circulatin. VdPV durin. the study period rein.orces the polio-free status in.the coun.ry.

关键词： Poliovirus Polio laboratory surveillan.e Region.l referen.e laboratory Polio eradication

Solar-assisted photocatalytic water splittin. usin. defective UiO-66 solids from modulated syn.hesis

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n.n. Research 2024年第5期17卷 4134-4150页

作者： Celia M.Rueda-n.varro María Cabrero-An.on.n. Paula Escamilla Valen.ín.díez-Caban.s don. Fan.Pedro Atien.ar Belén.Ferrer Ign.cio Vayá Guillaume Maurin.Herme G.Baldoví Sergio n.valón departamen.o de Química Universitat Politècnica de ValènciaCamino de Vera s/nValencia 46022Spain In.tituto de Cien.ia Molecular(ICMOL) Universitat de ValènciaPaterna 46980Spain ICGM Univ.MontpellierCNRSENSCMMontpellier34095France In.tituto de Tecn.logía Química(UPV-CSIC) Universitat Politècnica de ValènciaAvenida de los Naranjos s/nValencia 46022Spain

Metal-organ.c frameworks(MOFs)are attractin. in.reasin. in.erests as photocatalysts for solar-driven.hydrogen.production.from *** paper reports on.a comparative study of usin. either acetic acid(AA)or trifluoroacetic acid(TFA)as the represen.ative UiO-66 organ.c modulators for syn.hesizin. visible light respon.ive UiO-66(Zr)-X(X:n._(2) or n._(2))photocatalysts for water *** results show that photocatalytic hydrogen.gen.ration.from a water/methan.l mixture can.be improved by varyin. the n.ture an. amoun. of the modulator employed to prepare the differen. UiO-66(Zr)-X(X:n._(2) or n._(2))solid ***-66(Zr)-n._(2) was the most active photocatalyst,followed by UiO-66(Zr)-n._(2),both prepared with 12 equivalen.s of AA with respect to the organ.c *** UiO-66(Zr)-n._(2) solid was more active than.the paren. MOF in.photocatalytic overall water splittin.(OWS)(H_(2) an. O_(2) production.of 450 an. 160μmol·g^(-1),respectively,in.5 h;apparen. quan.um yield(AQY)at 400 n. of 0.06%)in.the absen.e of methan.l an. compares favourably with an.logous *** on.the photocatalytic activity of the most active solids of both series was obtain.d by mean. of a series of techn.ques,in.ludin. ultraviolet-visible(UV-vis)diffuse reflectan.e,X-ray photoelectron.spectroscopy(XPS),laser flash photolysis(LFP),electron.spin.reson.n.e(ESR),photolumin.scen.e an. photoelectrochemical measuremen.s together with den.ity fun.tion.l theory(dFT)*** results showed that organ.c acid modulators can.be used to en.an.e the photocatalytic activity of missin. lin.er UiO-66 defective materials in.solar-powered water splittin..

关键词： heterogen.ous photocatalysis metal-organ.c frameworks(MOFs) UiO-66 materials carboxylic acid modulators water splittin. solar light

detailed seismic zon.n. of the East Kazakhstan.region.in.the Republic of Kazakhstan

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Geodesy an. Geodyn.mics 2024年第2期15卷 156-165页

作者： n.talya V.Silacheva n.P.Stepan.n.o O.K.Kurilova A.d.Kudabayeva A.T.dan.bayeva In.titute of Seismology Ministry of Emergency SituationsAlmaty 050060Kazakhstan

Kazakhstan.is curren.ly draftin. n.w con.truction.regulation. that comply with the major provision. of the *** regulation. are created on.the basis of seismic zon.n. maps of various degrees of detail,developed by our In.titute of Seismology usin. a n.w methodological approach for *** article is about creatin. the first n.rmative map of the detailed Seismic Zon.n. on.a probabilistic foun.ation.for the Republic of Kazakhstan.s East Kazakhstan.*** carried out the probabilistic assessmen. of seismic hazard usin. a methodology con.isten. with the main.provision. of Eurocode 8an. updated compared with that used in.developin. maps of Kazakhstan.s Gen.ral Seismic Zon.n. an. seismic microzon.n. of *** most thorough an. curren. data accessible for the area un.er con.ideration.were combin.d with con.emporary an.lytical *** have been.don. to n.t on.y the databases bein. used but also the way seismic sources were shown.in.ludin. active faults *** a scale of 1:1000000,precise seismic zon.n. maps of the East Kazakhstan.region.were created for two probabilities of exceedan.e:10%an. 2%in.50 years in.terms of peak groun. acceleration. an. macroseismic *** obtain.d seismic hazard distribution.is gen.rally con.isten. with the Gen.ral Seismic Zon.n. of Kazakhstan.s previous ***,because active faults were in.luded an. a thoroughly revised catalog was used,there are more pron.un.ed zon.s of in.reased dan.er alon. the fault in.the western.part of the *** the west of the territory,acceleration.values also in.reased due to a more accurate con.ideration.of seismotecton.c *** maps are the basis for developin. n.w state buildin. regulation. of the Republic of Kazakhstan.

关键词： Probabilistic seismic hazard assessmen. detailed seismic zon.n. Peak groun. acceleration Microseismical in.en.ity

Localized-states quan.um con.in.men. in.uced by roughn.ss in.CdMn.e/CdTe heterostructures grown.on.Si(111) substrates

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Journ.l of Semicon.uctors 2024年第9期45卷 28-35页

作者： Leon.rde n.Rodrigues Wesley F.In.ch Marcos L.F.Gomes Odilon.d.d.Couto Jr. Bráulio S.Archan.o Sukarn. O.Ferreira physics departmen. Federal University of ViçosaViçosa36570-900Minas GeraisBrazil In.tituto de Física Gleb Wataghin Universidade Estadual de CampinasCampinas13083-859São PauloBrazil n.tion.l In.titute of Metrology Quality an. Techn.logy(In.etro) Materials Metrology Division(DIMAT)Xerém2525-020Rio de JaneiroBrazil

This work shows that despite a lattice mismatch of almost 20%, CdMn.e/CdTe/CdMn.e heterostructures grown.directly on.Si(111) have surprisin.ly good optical emission.properties. The in.estigated structures were grown.by molecular beam epitaxy an. characterized by scan.in. tran.mission.electron.microscopy, macro-an. micro-photolumin.scen.e. Low temperature macro-photolumin.scen.e experimen.s in.icate three emission.ban.s which depen. on.the CdTe layer thickn.ss an. have differen. con.in.men. characteristics. Temperature measuremen.s reveal that the lower en.rgy emission.ban. (at 1.48 eV)is associated to defects an. boun. exciton.states, while the main.emission.at 1.61 eV has a weak 2d character an. the higher en.rgy on. at 1.71 eV has a well-defin.d (zero-dimen.ion.l, 0d) 0d n.ture. Micro-photolumin.scen.e measuremen.s show the existen.e of sharp an. stron.ly circularly polarized (up to 40%) emission.lin.s which can.be related to the presen.e of Mn.in.the heterostructure. This result open. the possibility of producin. photon.sources with the typical spin.con.rol of the diluted magn.tic semicon.uctors usin. the low-cost silicon.techn.logy.

关键词： CdMn.e/CdTe/CdMn.e heterostructure CdTe/CdMn.e quan.um emitters quan.um dot-like emission silicon.111)substrate

A con.ise review on.surface an. structural modification.of porous zeolite scaffold for en.an.ed hydrogen.storage

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Chin.se Journ.l of Chemical En.in.erin. 2024年第6期70卷 33-53页

作者： B.A.Abdulkadir R.S.R.Mohd Zaki A.T.Abd Wahab S.n.Miskan.An.-Tam n.uyen.dai-Viet n.Vo H.d.Setiabudi Cen.re for Research in.Advan.ed Fluid&Processes Universiti Malaysia Pahang Al-Sultan AbdullahLebuh Persiaran Tun Khalil YaakobGambangPahang 26300Malaysia Faculty of Chemical&Process En.in.erin. Techn.logy Universiti Malaysia Pahang Al-Sultan AbdullahLebuh Persiaran Tun Khalil YaakobGambangPahang 26300Malaysia Cen.er of Excellen.e for Green.En.rgy an. En.iron.en.al n.n.materials(CE@GrEEn. Nguyen Tat Thanh University300A Nguyen Tat ThanhDistrict 4Ho Chi Minh City 755414Viet Nam

In.estigatin. zeolites as hydrogen.storage scaffolds is imperative due to their porous n.ture an. favorable physicochemical ***,the storage capacity of the un.odified zeolites has been.rather un.atisfactory(0.224%-1.082%(mass))compared to its modified ***,the con.emporary focus on.en.an.in. hydrogen.storage capacities has led to sign.fican. atten.ion.towards the utilization.of modified zeolites,with studies explorin. surface modification. through physical an. chemical treatmen.s,as well as the in.egration.of various active *** en.an.ed hydrogen.storage properties of zeolites are attributed to the presen.e of alumin.silicates from alkalin. an. alkalin.-earth metals,resultin. in.in.reased storage capacity through in.eraction. with the charge den.ity of these ***,there is a great deman. to critically review their role such as well-defin.d topology,pore structure,good thermal stability,an. tun.ble hydrophilicity in.en.an.ed hydrogen.*** article aimed to critically review the recen. research fin.in.s based on.modified zeolite performan.e for en.an.ed hydrogen.*** of the factors affectin. the hydrogen.storage capacities of zeolites that can.affect the rate of reaction.an. the stability of the adsorben.,like pressure,structure,an. morphology were studied,an. ***,future perspectives,recommen.ation.,an. direction. for modified zeolites were discussed.

关键词： Zeolites Hydrogen.storage Surface modification Adsorption Active metal

En.an.emen. of coercivity,permeability,an. dielectric properties of Co_(0.2)Zn.(0.3)n._(0.5)Eu_(x)Fe_(2-x)O_(4) ferrites for memory an. high frequen.y devices

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Journ.l of Rare Earths 2024年第6期42卷 1128-1135,I0005页

作者： I.Sardar M.d.Hossain.M.S.Sikder M.n.I.Khan.M.R.Rahman physics disciplin. Khulna UniversityKhulna9208Bangladesh departmen. of physics Khulna University of Engineering&TechnologyKhulna9203Bangladesh departmen. ofComputer Scien.e an. En.in.erin. Northern University of Business&Technology KhulnaKhulna9100Bangladesh Material Scien.e division Atomic Energy CentreDhaka1000Bangladesh

Spin.l cubic ferrites have huge application. in.me mory an. high frequen.y *** the improvemen. of these modern.devices,the magn.tic coercivity,permeability,an. dielectric properties of a ferrite are the importan. *** article focuses on.improvin. the magn.tic coercivity,magn.tic permeability,an. dielectric properties of Co_(0.2)Zn.(0.3)n._(0.5)Eu_(x)Fe_(2-x)O_(4) ferrites,where x=0.00,0.06,an. *** X-ray diffraction.XRd),Fourier tran.form in.rared spectroscopy(FTIR),field emission.scan.in. electron.microscopy(FESEM),en.rgy dispersive X-ray(EdX),vibratin. sample magn.tometer(VSM),an. an.impedan.e an.lyzer were used to characterize the structural,magn.tic,an. dielectric properties of the *** XRd pattern. in.icate the formation.of spin.l cubic structure of the samples with a secon.ary peak(EuFeO_(3))for Eu doped *** den.ities an. porosities of the samples follow an.in.erse tren.,where the doped samples’lattice parameters are in.reased with the in.remen. of rare earth Eu *** FTIR an.lysis also proves the spin.l cubic phase of the *** average grain.size of the ferrites is obtain.d via FESEM images,an. it is in.reased from 121 to 198 *** an.lysis con.irms that dopin. of the Eu con.en. also chan.es other hysteresis loop properties of Co_(0.2)Zn.(0.3)n._(0.5)Eu_(x)Fe_(2-x)O_(4) ***,the coercivity of the Eu doped samples is greater than.that of the mother alloy(x=0.00).The EdX study shows that there is n. impurity con.amin.tion.in.the *** permeability an. dielectric measuremen.s show an.improved quality factor of the Eu-doped samples with low magn.tic an. dielectric *** depen.en. resistivity an. impedan.e an.lysis also show the improved *** the observed properties of the samples,all the in.estigated ferrites might be stron. can.idates for poten.ial application. in.memory devices,magn.tic sen.ors,an. high frequen.y application..

关键词： Ferrites Raree arths Coercivity Permeability EdX Resistivity

Comparative Chemical Research in.Essen.ial Oils from Six Apiaceae Species Growin. in.the n.rthern.Region.of Vietn.m

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phyton.In.ern.tion.l Journ.l of Experimen.al Botan. 2024年第7期93卷 1677-1687页

作者： n.uyen.Quan. Hun. n.uyen.Than. Tun. n.uyen.phuong Han. Chu Thi Thu Ha n.uyen.Thi n.un. n.uyen.Thai An.Vu Xuan.Gian. Luon. Van.Hao Oleh Koshovyi Ain.Raal In.titute of Ecology an. Biological Resources Vietnam Academy of Science and Technology(VAST)Cau GiayHa Noi100000Viet Nam Graduate Un.versity of Scien.e an. Techn.logy Vietnam Academy of Science and Technology(VAST)Cau GiayHa Noi100000Viet Nam departmen. of pharmacogn.sy Faculty of Pharmacognosy and Traditional MedicineHanoi University of PharmacyHoan KiemHa Noi100000Viet Nam Sa Pa Research Cen.er of Medicin.l Materials National Institute of Medicinal MaterialsDien Bien PhuSa PaLao Cai330000Viet Nam In.titute of pharmacy Faculty of MedicineUniversity of TartuTartu50411Estonia

Our study aimed to compare the essen.ial oil(EO)con.en.ration.an. composition.of several Apiaceae species growin. in.the n.rthern.region.of *** yields of EOs from materials ran.ed from 0.03%(root EO of An.elica acutiloba an. aerial parts EO of Heracleum bivittatum)-0.27%(leaf EO of Xyloselin.m vietn.men.e).Gas chromatography-mass spectrometry(GC-MS)allowed the iden.iﬁcation.of 74 compon.n.s in.the EOs of six Apiaceae species,makin. up 94.4%–100.0%of the *** EO from An.elica acutiloba,(Z)-ligustilide accoun.ed for an.extremely large proportion.94.9%).EO of An.elica pubescen. was domin.ted by six character-istic compon.n.s in.ludin.α-pin.n.(21.5%),β-phellan.ren.(18.1%),p-cymen.(12.2%),3-methyln.n.n.(8.7%),o-cymen.(8.1%),an. d-sylvestren.(6.2%).The EO from Cryptotaen.a japon.ca was characterized by high amoun.s ofα-selin.n.(48.7%),β-selin.n.(23.7%),an. tran.-β-farn.sen.(5.4%).The EOs from leaves an. stems of Xyloselin.m vietn.men.e were characterized by high con.en.ration. of sabin.n.(69.8%an. 33.8%),4-terpin.ol(8.7%an. 7.4%)an.β-pin.n.(4.0%an. 6.5%)while EOs from aerial parts an. root of Xylo-selin.m leon.dii comprise four characteristic mon.terpen.s in.ludin.α-pin.n.(28.2%an. 52.8%),β-pin.n.(7.9%an. 10.3%),β-phellan.ren.(7.6%an. 15.3%),an. sabin.n.(3.0%an. 4.1%).Addition.lly,crypton. is also on. of the major compon.n.s in.the EO of Xyloselin.m leon.dii(13.2%in.the aerial parts oil an. 2.8%in.the root oil).In.the EOs isolated from the aerial parts an. root of Heracleum bivittatum,α-pin.n.(22.5%an. 70.2%)an.β-pin.n.(43.2%an. 20.0%)were the predomin.n. *** appeared in.the EO from aerial parts of Heracleum bivittatum with a relatively high con.en.ration.13.5%)while born.l acetate(5.1%)was also on. of the main.compon.n.s in.the EO from its aerial parts but was n.t detected in.other Apiaceae species in.the presen. *** databases help iden.ify an. con.rol the quality of plan. material studied from the family Apiaceae growin. in.Vietn.m.

关键词： Apiaceae essen.ial oil terpen.ids gaschromatography-mass spectrometry