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Protein induced by vitamin K absence or antagonist-Ⅱ versus alpha-fetoprotein in the diagnosis of hepatocellular carcinoma: A systematic review with meta-analysis

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Hepatobiliary & Pancreatic Diseases International 2018年第6期17卷 487-495页

作者： Hao Xing Yi-Jie Zheng Jun Han Han Zhang Zhen-Li Li Wan-yee lau Feng Shen Tian Yang Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Naval Medical University Medical Scientific Affairs Abbott Diagnostics Faculty of Medicine The Chinese University of Hong Kong

Background: As a promising biomarker of hepatocellular carcinoma(HCC), protein induced by vitamin K absence or antagonist-Ⅱ(PIVKA-Ⅱ) has been studied extensively. However, its diagnostic capability varies across HCC studies. This study aimed to compare the performance of PIVKA-Ⅱ with alpha-fetoprotein(AFP) in the diagnosis of HCC. Data sources: A systematic literature search was conducted to identify the studies from MEDLINE, Embase and Cochrane Library Databases, which were published up to December 20, 2017 to compare the diagnostic capability of PIVKA-Ⅱ and AFP for HCC. The data were pooled using random effects model. Pooled sensitivity and specificity were calculated. Summary receiver operating characteristic curve(ROC) was employed to evaluate the diagnostic accuracy of each marker. Results: Thirty-one studies were included. The pooled sensitivity(95% CI) of PIVKA-Ⅱ and AFP was 0.66(0.65–0.68) and 0.66(0.65–0.67), respectively in diagnosis of HCC; and the corresponding pooled specificity(95% CI) was 0.89(0.88–0.90) and 0.84(0.83–0.85), respectively. The area under the ROC curve(AUC) of PIVKA-Ⅱ and AFP was 0.856(0.817–0.895) and 0.770(0.728–0.811), respectively. Subgroup analysis showed that PIVKA-Ⅱ was superior to AFP in terms of the AUC for both small HCC( < 3 cm) [0.863(0.825–0.901) vs 0.717(0.658–0.776)] and large HCC( ≥ 3 cm) [0.854(0.811–0.897) vs 0.729(0.682–0.776)]; for American [0.926(0.897–0.955) vs 0.698(0.594–0.662)], European [0.772(0.743–0.801) vs 0.628(0.594–0.662)], Asian [0.838(0.812–0.864) vs 0.785(0.764–0.806)] and African [0.812(0.794–0.840) vs 0.721(0.675–0.767)] HCC patients; and for HBV-related [0.909(0.866–0.951) vs 0.714(0.673–0.755)] and mixed-etiology [0.847(0.821–0.873) vs 0.794(0.772–0.816)] HCC. Conclusion: This meta-analysis indicates that PIVKA-Ⅱ is better than AFP in terms of the accuracy for diagnosing HCC, regardless of tumor size, patient ethnic group, or HCC etiology.

关键词： Hepatocellular carcinoma Meta-analyses Protein induced by vitamin K absence or antagonist-Ⅱ Alpha-fetoprotein

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Typing of biliary tumor thrombus influences the prognoses of patients with hepatocellular carcinoma

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Cancer Biology & Medicine 2021年第3期18卷 808-815页

作者： Juxian Sun Jiayi Wu Chang Liu Jie Shi Yonggang Wei Jianyin Zhou Zhibo Zhang Wan yee lau Maolin Yan Shuqun Cheng Department of Hepatic SurgeryⅥ The Eastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200433China Shengli Clinical Medical College Fujian Medical UniversityFuzhou 350001China Department of Hepatobiliary Surgery Fujian Provincial HospitalFuzhou 350001China Department of Hepatobiliary Surgery West China HospitalSichuan UniversityChengdu 610041China Department of Hepatobiliary Surgery Zhongshan HospitalXiamen UniversityXiamen 361004China Department of Hepatobiliary Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350002China Faculty of Medicine The Chinese University of Hong KongHong Kong 999077China

Objective:To establish a new classification of biliary tumor thrombus(BTT).Methods:Overall survival of patients with BTT was first used to determine whether it correlated with current hepatocellular carcinoma staging *** and multivariate analyses were used to determine factors affecting the overall survival(OS)to form the basis of our new classification for ***:All 6 international staging systems showed overlapping survival *** followed by multivariate analyses showed that total bilirubin and intrahepatic/extrahepatic BTT were significant risk factors of *** on these data,a new BTT classification was defined as:TypeⅠ:intrahepatic BTT;and TypeⅡ:extrahepatic BTT involving a common bile duct or common hepatic ***Ⅰwas further subdivided into type Ia:BTT involving a second-order intrahepatic duct or above,and type Ib:BTT involving a first-order intrahepatic ***Ⅱwas further subdivided into typeⅡa and typeⅡb using a cut-off total bilirubin(TB)>300μmol/*** numbers(percentages)of patients with typesⅠandⅡBTT were 69(34.2%)and 133(65.8%),*** median OS of typeⅠpatients was significantly higher than that of typeⅡpatients(37.5 months vs.23.2 months;P=0.002).Using subgroup analyses,OS outcomes were significantly different between the subgroups of typeⅡb and type IIa,although there was no significant difference between the type Ia and type Ib subgroups(P=0.07).Conclusions:A new BTT classification was established to predict prognoses of HCC patients with BTT who underwent liver resection.

关键词： Hepatocellular carcinoma biliary tumor thrombus staging system surgery prognosis

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Root exclusion methods for partitioning of soil respiration:Review and methodological considerations

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Pedosphere 2023年第5期33卷 683-699页

作者： Mei-yee CHIN Sharon Yu Ling lau Frazer MIDOT Mui Sie JEE Mei Lieng LO Faustina E.SANGOK Lulie MELLING Sarawak Tropical Peat Research Institute Lot 6035Kuching-Kota Samarahan ExpresswayKota SamarahanSarawak 94300Malaysia

Soil respiration is a vital process in all terrestrial ecosystems,through which the soil releases carbon dioxide(CO_(2))into the atmosphere at an estimated annual rate of 68–101 Pg carbon,making it the second highest terrestrial contributor to carbon *** soil respiration consists of autotrophic and heterotrophic constituents,methods for accurately determining the contribution of each constituent to the total soil respiration are critical for understanding their differential responses to environmental factors and aiding the reduction of CO_(2)*** to its low cost and simplicity,the root exclusion(RE)technique,combined with manual chamber measurements,is frequently used in field studies of soil respiration ***,RE treatments alter the soil environment,leading to potential bias in respiration *** review aims to elucidate the current understanding of RE,i.e.,trenching(Tr)and deep collar(DC)insertion techniques,by examining soil respiration partitioning studies performed in several ***,we discuss methodological considerations when using RE and the combinations of RE with stable isotopic and modeling ***,future research directions for improving the Tr and DC insertion methods in RE are suggested.

关键词： autotrophic respiration deep collar insertion heterotrophic respiration microbial respiration root trenching soil microbial community soil respirationcomponent

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Portal venous gas and thrombosis in a Chinese patient with fulminant Crohn’s colitis: A case report with literature review

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World Journal of Gastroenterology 2006年第34期12卷 5582-5586页

作者： Simon Siu-Man Ng Raymond Ying-Chang Yiu Janet Fung-yee Lee Jimmy Chak-Man Li Ka-lau Leung Department of Surgery The Chinese University of Hong Kong Prince of Wales Hospital Shatin Hong Kong SAR China

Ever since its earliest reports, portal venous gas (PVG) has been associated with numerous intraabdominal catastrophes and has served as an indication for urgent surgical exploration. It is traditionally regarded to be an ominous finding of impending death, with highest mortality reported in patients with underlying bowel ischemia. Today, computed tomography has demonstrated a wider range of clinical conditions associated with PVG, some of which are ‘benign’ and do not necessarily require surgery, unless when there are signs of intraabdominal catastrophe or systemic toxicity. One of these ‘benign’ conditions is Crohn’s disease. The present report describes a 19-year-old Chinese boy with Crohn’s pancolitis who presented with septic shock associated with PVG and portal vein thrombosis, and was successfully managed surgically. To our knowledge, this is the fi rst report of PVG and portal vein thrombosis associated with Crohn’s disease in a Chinese patient. In addition, we have also reviewed the reports of another 18 Crohn’s patients with PVG previously described in the English literature. Specifi c predisposing factors for PVG were identified in 8 patients, including barium enema, colonoscopy, blunt abdominal trauma, and enterovenous f istula. The patients who developed PVG following barium enema and blunt trauma were all asymptomatic and no specifi c treatment was necessary. Eleven patients (58%) who presented with signs of intraabdominal catastrophe or systemic toxicity required either immediate or eventual surgery. The overall mortality rate among the 19 patients was only 11%. The present literature review has shown that the f inding of PVG associated with Crohn’ s disease does not always mandate surgical intervention. It is the clinical features and the related complications that ultimately determine the treatment approaches. The overall outcome of PVG associated with Crohn’s disease has been favourable.

关键词： Portal venous gas Portal vein thrombosis Pylephlebitis Crohn's disease Chinese

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Laparoscopic duodenum-preserving total pancreatic head resection, current status and future trends

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Laparoscopic, Endoscopic and Robotic Surgery 2019年第4期2卷 81-82页

作者： Wan yee lau Faculty of Medicine The Chinese University of Hong Kong Prince of Wales Hospital Shatin Hong Kong Special Administrative Region Faculty of Medicine The Chinese University of Hong Kong Prince of Wales Hospital Shatin Hong Kong

A recent article published in Surgical Endoscopy entitled“Laparoscopic duodenum-preserving total pancreatic head resection:a novel surgical approach for benign or low-grade malignant tumors”(Surgical Endoscopy 2019;33:633e638)is probably the main reason why Professor Xiujun Cai,Editor-in-Chief of Laparoscopic,Endoscopic and Robotic Surgery sent an email to me on July 8,2019,requesting me to write an Editorial related to this *** readers of this journal may wonder why this topic is so important in the eyes of Professor Cai who himself is a world-renowned laparoscopic hepatopancreaticobiliary surgeon?Why is this published article so important in my eyes that I am willing to spend time in my busy daily schedule to write this Editorial?

关键词： Laparoscopic Surgery preserving

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Combined FOLFOX4 with all-trans retinoic acid versus FOLFOX4 with placebo in treatment of advanced hepatocellular carcinoma with extrahepatic metastasis: a randomized, double-blind comparative study

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Signal Transduction and Targeted Therapy 2023年第10期8卷 5096-5105页

作者： Juxian Sun Feifei Mao Chang Liu Fan Zhang Dafeng Jiang Weixing Guo Lei Huo Liping Zhou Wan yee lau Jie Shi Shuqun Cheng Department of Hepatic Surgery VI Third Affliated Hospital of Naval Medical UniversityShanghaiChina Tongji University Cancer Center Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghaiChina Department of General Surgery Fujian Cancer HospitalFujan Medical UniversityFuzhouChina Department of Oncology Zhejiang Sian International HospitalJiaxingChina Department of Radiology Third Affliated Hospital of Naval Medical UniversityShanghaiChina Faculty of Medicine The Chinese University of Hong KongPrince of Wales HospitalShatinNew TerritoriesHong Kong SARChina

The majority of hepatocellular carcinoma(HCC)cases are diagnosed at an advanced ***,there are only a few therapeutic methods available for patients with advanced HCC and extrahepatic metastasis(EHM).Systemic chemotherapy,such as FOLFOX4(infusions of fluorouracil,leucovorin,and oxaliplatin),has been reported for treating advanced HCC with EHM,but its effectiveness is very poor.

关键词： FOLFOX4 metastasis chemotherapy

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Impact of pathological response after preoperative transcatheter arterial chemoembolization(TACE)on incidences of microvascular invasion and early tumor recurrence in hepatocellular carcinoma:a multicenter propensity score matching analysis

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Hepatobiliary Surgery and Nutrition 2022年第3期11卷 386-399页

作者： Yun Yang Zheng Dang Peng Lu Youwen Qian Kongying Lin Zeya Pan Wan yee lau Weiping Zhou The Third Department of Hepatic Surgery Eastern Hepatobiliary Surgery HospitalShanghaiChina Department of Hepatobiliary Surgery 940 Hospital of PLA Joint Logistic Support ForceLanzhouChina Department of Hepatobiliary Surgery Hainan Hospital of Chinese PLA General HospitalSanyaChina Department of Pathology Eastern Hepatobiliary Surgery HospitalShanghaiChina Department of Hepatopancreatobiliary Surgery Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhouChina Faculty of Medicine the Chinese University of Hong KongHong KongChina Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer(SMMU) Ministry of EducationShanghaiChina Shanghai Key Laboratory of Hepatobiliary Tumor Biology(EHBH) ShanghaiChina

Background:To study the influence of pathological responses(PR)after transcatheter arterial chemoembolization(TACE)on incidences of microvascular invasion(MVI)and early recurrence in hepatocellular carcinoma(HCC)***:Between 2013 to 2015,consecutive HCC patients who underwent liver resection with“curative”intent at three hospitals were enrolled in this *** with different areas of PR after preoperative TACE were compared with those without preoperative TACE on the incidences of MVI,early recurrence rates and patterns of recurrence before and after propensity score matching(PSM).Results:Of 1,970 patients,737 patients who received preoperative TACE were divided into three groups according to the areas of PR:≥90%(n=226),60-90%(n=447),and<60%(n=64).PR≥90%was an independent protective factor of incidences of MVI[odds ratio(OR),0.144;95%confidence interval(CI),0.082-0.245,P<0.001)and early recurrence(HR,0.742;95%CI,0.561-0.963,P=0.032);while PR<60%was an independent risk factor of incidences of MVI(OR,6.076;95%CI,3.004-11.728,P<0.001)and early recurrence(HR,1.428;95%CI,1.095-1.929;P=0.009).Furthermore,patients with PR<60%were significantly more likely to develop multiple intrahepatic recurrences involving multiple hepatic segments when compared with patients without preoperative ***:This study indicated the area of PR after TACE was closely associated with the incidences of MVI and early tumor *** with PR<60%were at significantly higher risks of having more MVI,early and multiple tumor recurrences.

关键词： Hepatocellular carcinoma(HCC) transcatheter arterial chemoembolization(TACE) pathological response microvascular invasion(MVI) early recurrence

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Evaluating the emotion regulation of positive mood states among people with bipolar disorder using hierarchical clustering

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World Journal of Psychiatry 2021年第9期11卷 619-634页

作者： Sunny Ho-Wan Chan Chong Ho Yu Ken Ho Kan Liu Charlie lau Anna On yee Fung Samson Tse Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong KongChina School of Behavioral and Applied Science Azusa Pacific UniversityAzusaCA 91702United States Department of Social Work and Social Administration The University of Hong KongHong KongChina

BACKGROUND People with bipolar disorder(BD)frequently struggle with the recurrence of affective ***,the interplay between coping mechanism and positive mood state remains *** To explore the associations among behavioral approach system(BAS)sensitivity level,coping,and positive mood states among people with *** Using a cross-sectional study design,90 participants with BD were presented with four BAS-activating life event scenarios and assessed with regard to their BAS trait sensitivity,coping flexibility,and mood states.A hierarchical clustering method was used to identify different groups with different styles of *** hierarchical regression analyses were conducted to examine the mediating and moderating roles of different components of coping on mood *** A three-cluster solution was found to best fit the present data *** findings showed that a low mass of coping combined with low BAS sensitivity level protects people with BD from detrimentally accentuating mood states when they encounter BAS-activating life ***,coping flexibility is demonstrated to mediate and moderate the relationships between BAS sensitivity level and mood ***,subduing the perceived controllability and reducing the use of behavioral-activation/emotion-amplifying coping strategies could help buffer the effect of positive *** The judicious use of coping in emotion regulation for people with BD when encountering BAS-activating life events was *** applications and theoretical implications are highlighted.

关键词： Bipolar disorder Mood regulation Cluster analysis Coping style Positive emotions

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Effects of Epstein-Barr virus infection on the development of multiple myeloma after liver transplantation

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Science China(Life Sciences) 2012年第8期55卷 735-743页

作者： ZHANG YeWei ZHAO HeWei HE Xia ZHENG SuWen WANG TaiHong YAN DongLiang SUN JingFeng LU Xiang WEN JianFei lau Wan yee Department of Hepatobiliary and Pancreatic Surgery Affiliated Jiangsu Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of Radiotherapy Affiliated Jiangsu Caneer Hospital of Nanjlng Medical University Nanjing 210009China Department of General surgery The Second Affiliated Hospital of Nantong University Nantong 226001China Departimen of Geriatrics The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011China Faculty of Medicine The Chinese University of Hong KongPrince of Wales HospitalShatinHong KongChina

Reduced cellular immune function in patients after liver transplantation easily results in many types of viral infections,such as Epstein-Barr ***-Barr virus is a γ-herpesvirus and is related to many malignant diseases,especially epithelial and lymph *** abnormal interaction of cluster of differentiation 40 with cluster of differentiation 40 ligand and expression of cluster of differentiation 40 ligand are considered closely related to the development of myeloma *** study explored the influence and mechanism of Epstein-Barr virus infection on the phenotype and biological behavior of myeloma cells after liver *** cytometry was used to detect coexpression of cluster of differentiation 40 and cluster of differentiation 40 ligand in 10 samples of freshly isolated multiple myeloma *** of differentiation 40 and cluster of differentiation 40 ligand were coexpressed in sample Nos.5,8,9,and 10,particularly in sample *** blot analysis was used to detect the expression of the Epstein-Barr virus antigens latent membrane protein 1 and Epstein-Barr virus nuclear antigen 2 in the multiple myeloma cell line RPMI 8226 infected with Epstein-Barr *** antigen expression indicated that Epstein-Barr virus can infect multiple myeloma virus cells in *** transcription-polymerase chain reaction revealed upregulated expression of cluster of differentiation 40 ligand on the infected RPMI 8226 cells,which may be involved in the anti-apoptosis activity of the infected *** microscopy showed that pairs of molecules of cluster of differentiation 40,cluster of differentiation 40 ligand,and latent membrane protein 1 were colocalized on the surface of the infected *** chemokine receptor 4 was upregulated on the RPMI 8226 cells after Epstein-Barr virus *** migratory ability of the infected cells improved in the presence of the chemokine stromal cell-derived factor-1α.Anti-apoptosis and migration are k

关键词： liver transplantation CD40 CD40L multiple myeloma EBV

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Novel liver vein deprivation technique that promotes increased residual liver volume(with video):A case report

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World Journal of Clinical Cases 2022年第31期10卷 11579-11584页

作者： Gang Wu Ji-Peng Jiang Dong-Hui Cheng Chong Yang Dong-Xu Liao Yu-Bo Liao Wan-yee lau Yu Zhang Department of Hepatobiliary Surgery Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina Organ Transplantation Center Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina Faculty of Medicine The Chinese University of Hong KongPrince of Wales HospitalHongkong 999077China

BACKGROUND Inadequate volume of future liver remnant(FLR)is a major challenge for hepatobiliary surgeons treating large or multiple liver *** an alternative to associating liver partition and portal vein ligation(ALPPS)for staged hepatectomy and liver venous deprivation(LVD)using stage 1 interventional radiology for vascular embolization combined with stage 2 open liver resection have been *** SUMMARY A novel modified LVD technique was performed in a patient with pancreatic neuroendocrine tumor with liver metastases by using stage 1 laparoscopic ligation of the right hepatic vein,right posterior portal vein,and short hepatic veins combined with local excision of three liver metastases in the left *** operation was followed three days later by interventional radiology to embolize an anomalous right anterior portal vein to complete LVD.A stage 2 laparoscopic right hemihepatectomy and pancreaticosplenectomy were then carried *** The minimally invasive technique promoted a rapid increase,comparable to ALPPS,in volume of the FLR after the stage 1 operation to allow the laparoscopic stage 2 resection to be performed.

关键词： Laparoscopic Liver venous deprivation Future liver remnant Case report

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