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Wan-yee Joseph lau:the promoter of modernization and internationalization of Chinese surgery

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Oncology and Translational Medicine 2024年第1期10卷 1-3页

作者： Wan-yee Joseph lau Faculty of Medicine The Chinese University of Hong KongHong KongChina

To my knowledge,there have been 3 books[1–3]and 2 book chapters written about me.[4–5]For those who are interested in the details of my life,please refer to these books/book *** title of this article is an English translation of the title of the book I refer to as reference 1,which I find appropriate to describe the role that I play in China.

关键词： please details translation

Current controversies and challenges for resection of pancreatic ductal adenocarcinoma in pancreatic head aiming at cure

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Hepatobiliary & Pancreatic Diseases International 2023年第2期22卷 111-112页

作者： Wan yee lau Faculty of Medicine the Chinese University of Hong KongPrince of Wales HospitalShatinHong Kong SARChina

Pancreatic ductal adenocarcinoma(PDAC) is a very common but a highly lethal malignancy due to its biological aggressive behavior. PDAC more commonly affects the head than other parts of the pancreas. As PDAC in the head of pancreas is located at an anatomical position with a lot of adjacent vital structures, and the cornerstone of treatment aiming at cure is pancreaticoduodenectomy(PD).

关键词： adenocarcinoma ductal pancreas

Reply to the commentary on “The efficiency of pathological response after preoperative transcatheter arterial chemoembolization for microvascular invasion and early tumor recurrence in hepatocellular carcinoma”

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Hepatobiliary Surgery and Nutrition 2023年第1期12卷 144-147页

作者： Yun Yang Weiping Zhou Wan yee lau Eastern Hepatobiliary Surgery Hospital ShanghaiChina Faculty of Medicine The Chinese University of Hong KongHong KongChina

We thank He et *** their interest in our recent article(1)and for their thoughtful *** first question raised by He et *** on the total number of patients in the PSM cohort in Table 1,which they considered *** this study,we first analyzed the incidences of MVI in the groups of patients with or without preoperative *** PSM,there were 737 patients who received preoperative TACE,and 1,233 patients who did not receive preoperative TACE.

关键词： preoperative invasion

Root exclusion methods for partitioning of soil respiration:Review and methodological considerations

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Pedosphere 2023年第5期33卷 683-699页

作者： Mei-yee CHIN Sharon Yu Ling lau Frazer MIDOT Mui Sie JEE Mei Lieng LO Faustina E.SANGOK Lulie MELLING Sarawak Tropical Peat Research Institute Lot 6035Kuching-Kota Samarahan ExpresswayKota SamarahanSarawak 94300Malaysia

Soil respiration is a vital process in all terrestrial ecosystems,through which the soil releases carbon dioxide(CO_(2))into the atmosphere at an estimated annual rate of 68–101 Pg carbon,making it the second highest terrestrial contributor to carbon *** soil respiration consists of autotrophic and heterotrophic constituents,methods for accurately determining the contribution of each constituent to the total soil respiration are critical for understanding their differential responses to environmental factors and aiding the reduction of CO_(2)*** to its low cost and simplicity,the root exclusion(RE)technique,combined with manual chamber measurements,is frequently used in field studies of soil respiration ***,RE treatments alter the soil environment,leading to potential bias in respiration *** review aims to elucidate the current understanding of RE,i.e.,trenching(Tr)and deep collar(DC)insertion techniques,by examining soil respiration partitioning studies performed in several ***,we discuss methodological considerations when using RE and the combinations of RE with stable isotopic and modeling ***,future research directions for improving the Tr and DC insertion methods in RE are suggested.

关键词： autotrophic respiration deep collar insertion heterotrophic respiration microbial respiration root trenching soil microbial community soil respirationcomponent

Early control of short hepatic portal veins in isolated or combined hepatic caudate lobectomy

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Hepatobiliary & Pancreatic Diseases International 2012年第4期11卷 377-382页

作者： Wan-yee lau Faculty of Medicine The Chinese University of Hong KongShatinNew TerritoriesHong Kong SARChina

BACKGROUND:Caudate lobectomy has long been considered technically *** study aimed to elaborate the significance of early control of short hepatic portal veins(SHPVs) in isolated hepatic caudate lobectomy or in hepatic caudate lobectomy combined with major partial hepatectomy,and to describe the anatomical characteristics of ***:The data of 117 patients who underwent either isolated or combined caudate lobectomy by the same team of surgeons from 2005 to 2009 were retrospectively *** 2005 to 2007(group A,n=55),we carried out early control of short hepatic veins(SHVs) only;from 2008 to 2009(group B,n=62),we carried out early control of both SHVs and *** two groups were compared to evaluate which surgical procedure was better.A detailed anatomical study was then carried out on the last 25 consecutive patients in group B to study the number and distribution of SHPVs during ***:Patients in group B had less intra-operative blood loss,less impairment of liver function,shorter postoperative hospital stay,fewer postoperative complications and required less blood transfusion(P<0.05).The number of SHPVs in the 25 patients was 183,with 7.3±2.7 per *** diameters of SHPVs were 1 to 4 *** average,3.4 SHPVs/patient came from the left portal vein,2.2 from the bifurcation,1.4 from the right portal vein,and 0.3 from the main portal *** average,3.3 SHPVs/patient supplied segment I of the liver,0.4 for segment II,2.1 for segment IV,1.4 for segment V and 0.1 for segment ***:Early control of SHPVs in isolated or combined hepatic caudate lobectomy may be a useful method to decrease surgical risk and improve postoperative recovery.

关键词： short hepatic portal vein caudate lobe anatomy

Modified conventional clamp-crushing technique in liver parenchymal transection

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Hepatobiliary & Pancreatic Diseases International 2012年第4期11卷 442-445页

作者： Wan-yee lau Faculty of Medicine The Chinese University of Hong KongShatinHong Kong SARChina

Significant intraoperative bleeding and injuries to vital structures in the liver remnant can occur during liver parenchymal transection using the conventional clampcrushing *** performed liver resection on 242 patients using a mosquito clamp-crushing technique combined with a self-assembled saline-linked diathermy for liver parenchymal *** mean blood loss was 215 mL(range 20-1100).There was no damage to the vital structures in the liver *** mean liver transection time was 53 minutes(range 15-125).Our technique has the advantages of reducing blood loss,exposing vessles clearly and being simple,cheap and efficacious.

关键词： hepatectomy hepatocellular carcinoma liver neoplasm

A novel chemotherapy strategy for advanced hepatocellular carcinoma: a multicenter retrospective study

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Chinese Medical Journal 2022年第19期135卷 2338-2343页

作者： Juxian Sun Chang Liu Jie Shi Nanya Wang Dafeng Jiang Feifei Mao Jingwen Gu Liping Zhou Li Shen Wan yee lau Shuqun Cheng Department of Hepatic Surgery VI Eastern Hepatobiliary Surgery HospitalThe Second Military Medical UniversityShanghai 200433China Department of Integrative Oncology Eastern Hepatobiliary Surgery HospitalThe Second Military Medical UniversityShanghai 200433China Department of Outpatient Department Eastern Hepatobiliary Surgery HospitalThe Second Military Medical UniversityShanghai 200433China Department of Oncology First Hospital of Jlin UniversityChangchunJlin 1300China Department of Oncology Zhejiang Sian International Hospital JiaxingZhejang 314000China Tongji University Cancer Center Shanghai Tenth People's HospitaSchool of MedicineTongji UniversitShanghai 200040China Faculty of Medicine The Chinese University of Hong KongPrince of Wales HospitalShatinNew TerritoriesHong Kong SAR 999077China.

Background:Chemotherapy is a common treatment for advanced hepatocellular carcinoma,but the effect is not *** study aimed to retrospectively evaluate the effects of adding all-trans-retinoic acid(ATRA)to infusional fluorouracil,leucovorin,and oxaliplatin(FOLFOX4)for advanced hepatocellular carcinoma(HCC).Methods:We extracted the data of patients with advanced HCC who underwent systemic chemotherapy using FOLFOX4 or ATRA plus FOLFOX4 at the Eastern Hepatobiliary Surgery Hospital,First Hospital of Jilin University,and Zhejiang Sian International Hospital and retrospectively compared for overall *** Cox proportional hazards model was used to calculate the hazard ratios for overall survival and disease progression after controlling for age,sex,and disease ***:From July 2013 to July 2018,111 patients with HCC were included in this *** median survival duration was 14.8 months in the ATRA plus FOLFOX4 group and 8.2 months in the FOLFOX4 only group(P<0.001).The ATRA plus FOLFOX4 group had a significantly longer median time to progression compared with the FOLFOX4 group(3.6 monthsvs.1.8 months,P<0.001).Hazard ratios for overall survival and disease progression were 0.465(95%confidence interval:0.298–0.726;P=0.001)and 0.474(0.314–0.717;P<0.001)after adjusting for potential confounders,***:ATRA plus FOLFOX4 significantly improves the overall survival and time to disease progression in patients with advanced HCC.

关键词： Hepatocellular carcinoma ATRA plus FOLFOX4 Overall survival All-trans-retinoic acid Fluorouracil Leucovorin Oxaliplatin

Combined FOLFOX4 with all-trans retinoic acid versus FOLFOX4 with placebo in treatment of advanced hepatocellular carcinoma with extrahepatic metastasis: a randomized, double-blind comparative study

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Signal Transduction and Targeted Therapy 2023年第10期8卷 5096-5105页

作者： Juxian Sun Feifei Mao Chang Liu Fan Zhang Dafeng Jiang Weixing Guo Lei Huo Liping Zhou Wan yee lau Jie Shi Shuqun Cheng Department of Hepatic Surgery VI Third Affliated Hospital of Naval Medical UniversityShanghaiChina Tongji University Cancer Center Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghaiChina Department of General Surgery Fujian Cancer HospitalFujan Medical UniversityFuzhouChina Department of Oncology Zhejiang Sian International HospitalJiaxingChina Department of Radiology Third Affliated Hospital of Naval Medical UniversityShanghaiChina Faculty of Medicine The Chinese University of Hong KongPrince of Wales HospitalShatinNew TerritoriesHong Kong SARChina

The majority of hepatocellular carcinoma(HCC)cases are diagnosed at an advanced ***,there are only a few therapeutic methods available for patients with advanced HCC and extrahepatic metastasis(EHM).Systemic chemotherapy,such as FOLFOX4(infusions of fluorouracil,leucovorin,and oxaliplatin),has been reported for treating advanced HCC with EHM,but its effectiveness is very poor.

关键词： FOLFOX4 metastasis chemotherapy

Impact of pathological response after preoperative transcatheter arterial chemoembolization(TACE)on incidences of microvascular invasion and early tumor recurrence in hepatocellular carcinoma:a multicenter propensity score matching analysis

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Hepatobiliary Surgery and Nutrition 2022年第3期11卷 386-399页

作者： Yun Yang Zheng Dang Peng Lu Youwen Qian Kongying Lin Zeya Pan Wan yee lau Weiping Zhou The Third Department of Hepatic Surgery Eastern Hepatobiliary Surgery HospitalShanghaiChina Department of Hepatobiliary Surgery 940 Hospital of PLA Joint Logistic Support ForceLanzhouChina Department of Hepatobiliary Surgery Hainan Hospital of Chinese PLA General HospitalSanyaChina Department of Pathology Eastern Hepatobiliary Surgery HospitalShanghaiChina Department of Hepatopancreatobiliary Surgery Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhouChina Faculty of Medicine the Chinese University of Hong KongHong KongChina Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer(SMMU) Ministry of EducationShanghaiChina Shanghai Key Laboratory of Hepatobiliary Tumor Biology(EHBH) ShanghaiChina

Background:To study the influence of pathological responses(PR)after transcatheter arterial chemoembolization(TACE)on incidences of microvascular invasion(MVI)and early recurrence in hepatocellular carcinoma(HCC)***:Between 2013 to 2015,consecutive HCC patients who underwent liver resection with“curative”intent at three hospitals were enrolled in this *** with different areas of PR after preoperative TACE were compared with those without preoperative TACE on the incidences of MVI,early recurrence rates and patterns of recurrence before and after propensity score matching(PSM).Results:Of 1,970 patients,737 patients who received preoperative TACE were divided into three groups according to the areas of PR:≥90%(n=226),60-90%(n=447),and<60%(n=64).PR≥90%was an independent protective factor of incidences of MVI[odds ratio(OR),0.144;95%confidence interval(CI),0.082-0.245,P<0.001)and early recurrence(HR,0.742;95%CI,0.561-0.963,P=0.032);while PR<60%was an independent risk factor of incidences of MVI(OR,6.076;95%CI,3.004-11.728,P<0.001)and early recurrence(HR,1.428;95%CI,1.095-1.929;P=0.009).Furthermore,patients with PR<60%were significantly more likely to develop multiple intrahepatic recurrences involving multiple hepatic segments when compared with patients without preoperative ***:This study indicated the area of PR after TACE was closely associated with the incidences of MVI and early tumor *** with PR<60%were at significantly higher risks of having more MVI,early and multiple tumor recurrences.

关键词： Hepatocellular carcinoma(HCC) transcatheter arterial chemoembolization(TACE) pathological response microvascular invasion(MVI) early recurrence