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A pilot clinical study to evaluate feasibility of using single patient classifier as a prognostic test in stage Ⅱ-Ⅲ gastric cancer patients

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Chinese Journal of Cancer Research 2024年第4期36卷 368-377页

作者： Ji Yeong An Sung eun Oh Soomin Ahn Hyoung-II Kim Yoo Min Kim Minah Cho Keun Won Ryu hong Man Yoon Young Kyu Park In Gyu Kwon Sung Hoon Noh Kyung Hee Lee In Cho Myoung Won Son Jong Won Kim Young-Woo Kim Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Department of Pathology and Translational Genomics Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Department of Surgery Yonsei University College of MedicineSeoul 03722Republic of Korea Gastric Cancer Center Yonsei Cancer CenterYonsei University Health SystemSeoul 03722Republic of Korea Center for Gastric Cancer National Cancer CenterGoyang 10408Republic of Korea Department of Surgery Chonnam National University Hwasun HospitalChonnam National University College of MedicineGwangju 58128Republic of Korea Department of Surgery Gangnam Severance HospitalYonsei University College of MedicineSeoul 06273Republic of Korea Department of Hematology-Oncology Yeungnam University Medical CenterDaegu 42415Republic of Korea Department of Surgery Soonchunhyang University College of MedicineBucheon 14584Republic of Korea Department of Surgery Soonchunhyang University Cheonan HospitalSoonchunhyang University College of MedicineCheonan 31151Republic of Korea Department of Surgery Chung-Ang University HospitalChung-Ang University College of MedicineSeoul 06973Republic of Korea

Objective:Precision medicine approaches emphasize the importance of reliable prognostic tools for guiding individualized therapy *** this study,we evaluated the clinical feasibility of the single patient classifier(SPC)test,a new clinical-grade prognostic assay,in stageⅡ-Ⅲgastric cancer ***:A prospective multicenter study was conducted,involving 237 patients who underwent gastrectomy between September 2019 and August 2020 across nine *** SPC test was employed to stratify patients into risk groups,and its feasibility and performance were *** primary endpoint was the proportion of the cases in which the test results were timely delivered before selecting postoperative ***,3-year disease-free survivals of risk groups were ***:The SPC test met the primary endpoint *** 99.5%of SPC tests were timely delivered to hospitals before the postoperative treatment *** a clinical setting,the median time from the specimen transfer to laboratory to the result delivery to hospital was 4 ***,3-year disease-free survivals were significantly different between risk groups classified with SPC ***:This study highlights the SPC test's feasibility in offering crucial information timely delivered for making informed decisions regarding postoperative treatment *** also provides evidence to support the implementation of a future prospective clinical trial aimed at evaluating the clinical utility of the SPC test in guiding personalized treatment decisions for gastric cancer patients.

关键词： Prognostic test advanced gastric cancer adjuvant chemotherapy feasibility gastrectomy

Precision medicine in acute lymphoblastic leukemia

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Frontiers of Medicine 2020年第6期14卷 689-700页

作者： Ching-hon Pui Departments of Oncology and Pathology St.Jude Children’s Research HospitalMemphisTN 38105USA

The cure rate of childhood acute lymphoblastic leukemia(ALL)has exceeded 90%in some contemporary clinical ***,the dose intensity of conventional chemotherapy has been pushed to its *** improvement in outcome will need to rely more heavily on molecular therapeutic as well as immuno-and cellular-therapy approaches together with precise risk *** with ETV6-RUNX1 or hyperdiploid>50 ALL who achieve negative minimal residual disease during early remission induction are suitable candidates for reduction in *** with Philadelphia chromosome(Ph)-positive or Ph-like ALL with ABL-class fusion should be treated with ***3 profiling and other preclinical methods have identified several high-risk subtypes,such as hypodiplod,early T-cell precursor,immature T-cell,KMT2A-rearranged,Ph-positive and TCF-HLF-positive ALL,that may respond to BCL-2 inhibitor *** are other fusions or mutations that may serve as putative targets,but effective targeted therapy has yet to be *** other high-risk patients or poor early treatment responders who do not have targetable genetic lesions,current approaches that offer hope include blinatumomab,inotuzumab and CAR-T cell therapy for B-ALL,and daratumumab and nelarabine for *** the expanding therapeutic armamentarium,we should start focus on rational combinations of targeted therapy with non-overlapping toxicities.

关键词： acute lymphoblastic leukemia molecular therapeutics targeted therapy tyrosine kinase inhibitors immunotherapy CAR T-cell therapy

Source side seismic tomography(3STomo):A novelmethod to image the subsurface structure beneath seismically active region

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Earthquake Science 2010年第6期23卷 637-643页

作者： Ting Yang Shenyi Gu Khanh phon Le State Key Laboratory of Marine Geology Tongji University Shanghai 200092 China Center for Earthquake Analysis and Prediction Earthquake Administration of Hainan Hainan 570203 China Faculty of Oil and Gas Hanoi University of Mining and Geology Dong Ngac Tu Liem Hanoi Vietnam

We propose a novel seismic tomography method, Source Side Seismic Tomography （3STomo）, which is designed particularly to image the subsurface structure beneath seismically active regions. Unlike the teleseismic tomography, in which the data are relative traveltime residuals between closely spaced stations for each teleseismic event, 3STomo uses relative traveltime shifts between earthquakes within the study region for each distant station. Given the relatively evener distribution of global seismic stations, this method has unique advantages for imaging the structure beneath regions that have numerous earthquakes but lack of dense seismic stations, for example, some subduction zones and spreading ridges in the ocean. In addition, 3STomo has potentially better vertical resolution at shallow depths than the traditional teleseismic tomo- graphy. The effect of the inaccurate source parameters on its resolution can be minimized by using depth phases and the technique of joint source and structure inversion. Numerical experiments and application to Luzon Island, Philippines show that 3STomo can be a valuable tool to investigate the subsurface structure beneath some areas where the traditional method cannot be applied to, or at least it can be used as a complementary component of conventional teleseismic tomography to obtain better back-azimuth coverage and achieve higher resolution at shallow depths in the inversion.

关键词： seismic tomography teleseismic tomography subduction zone lithosphere Luzon Island

Genomic and pharmacogenetic studies of childhood acute lymphoblastic leukemia

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Frontiers of Medicine 2015年第1期9卷 1-9页

作者： Ching-hon Pui Departments of Oncology and Pathology St. Jude Children's Research Hospital Memphis TN 38105 USA the University of Tennessee Health Science Center Memphis 7N 38105 USA

With the cure rate of childhood acute lymphoblastic leukemia （ALL） approaching 90%, further improvement in the treatment outcome and quality of life of patients will require better understanding of the mechanisms of drug resistance, identifying new leukemic cell genetic lesions that are amendable to available target therapy, and optimizing treatment based on host pharmacodynamics and pharmacogenomics. Deeper characterization of leukemic cell genetic abnormalities has discovered new subtypes of leukemia such as early T-cell precursor ALL and Philadelphia chromosome-like ALL, and identified many genomic alterations that have diagnostic, prognostic, or therapeutic implications. In this regard, several novel fusion transcripts are responsive to ABL tyrosine kinase inhibitors and potentially to JAK inhibitors. Genome-wide analyses have also unraveled the role of inherited cancer predisposing genes and small nucleotide polymorphisms of several genes in the development of childhood ALL. These advances promise to lead to more sophisticated personalized treatment strategies in the near future.

关键词： acute lymphoblastic leukemia genomics pharmacogenetics pharmacogenomics

Flocking behavior of forest birds in hong Kong,South China

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Journal of Forestry Research 2017年第5期28卷 1097-1102页

作者： hon Kai Kwok Ecosystems Ltd

This paper reports observations of flocking behavior of birds in a well-protected secondary forest in Tai Po Kau Nature Reserve, hong Kong Special Administrative Region, China. A total of 1025 flocks including 5255 birds and 48 species were observed between October 2002 and November 2003. Most flocks consisted of only one species. The observed flocks averaged 1.79 +/- 0.05 (SE) species and 5.13 +/- 0.18 (SE) birds. The Japanese White-eye was the most numerous species and was present in 21.6% of the observed flocks. Seasonal trends in both flock size and number of species were similar to those in overall bird density and species richness in the study area reported in a previous study.

关键词： Forest bird Forest Flock Tai Po Kau Nature Reserve hong Kong special administrative region

黄土高原4种高糖黑麦草在不同刈割方式下的营养价值评价

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草地学报 2024年

作者：邹敏成慧宁娇李腾飞谢凯丽 eun Joong Kim Nigel Scollan 常生华侯扶江草种创新与草地农业生态系统全国重点实验室兰州大学农业农村部草牧业创新重点实验室兰州大学草地农业科技学院 Department of Animal Science， Kyungpook National University Institute of Biological， Environmental and Rural Sciences， Aberystwyth University

为探究刈割方式对高糖黑麦草营养价值的影响，在黄土高原种植了‘AberStar’‘AberMagic’‘AberAvon’和‘Premium’4种高糖黑麦草（High sugar ryegrass，HSR），并进行了动态取样，研究多次刈割和一次刈割两种刈割方式对其产量、营... 详细信息

为探究刈割方式对高糖黑麦草营养价值的影响，在黄土高原种植了‘AberStar’‘AberMagic’‘AberAvon’和‘Premium’4种高糖黑麦草（High sugar ryegrass，HSR），并进行了动态取样，研究多次刈割和一次刈割两种刈割方式对其产量、营养品质动态和稳定性的影响，并完成了综合评价。结果表明，在牧草的生长过程中，4个品种多次刈割的产量均高于一次刈割，但产量稳定性低于一次刈割5.38%～23.91%。多次刈割的粗蛋白含量稳定性显著高于一次刈割（P<0.05），可溶性碳水化合物稳定性最低为31.77%～45.20%。4个品种的再生速度和再生强度呈先升后降趋势，多次刈割的再生速度和再生强度分别高于一次刈割18.12%～105.21%和18.41%～92.63%，并在108 d时达到最高。多次刈割的食物当量显著高于一次刈割（P<0.05）。在所有处理组合中，‘AberStar’品种进行多次刈割产量和品质表现最佳。本研究确定了高产优质的高糖黑麦草品种及其刈割方式，将为黄土高原地区高糖黑麦草的栽培管理措施提供科学依据。

关键词：高糖黑麦草黄土高原营养品质产草量

Decentralization of Education ——A Case Study on the Influence of Education Policy on the Quality of Cambodian Basic Education

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Decentralization of Education ——A Case Study on the Influe...

作者： Khuon phon Rattanak 东北师范大学

学位级别：硕士

The Royal Government of Cambodia, in 2003 officially released a plan for achieving Education for All (EFA) by 2015-its fundamental thrust is to ensure that all Cambodia's children and youth have equal opportunity to access formal and non-formal basic education. One of the major policy objectives of this plan is called "capacity building for decentralization through enabling operational autonomy of schools and institutions" (UNESCO,2003, P.1). With an effort to combat the manifold challenges that impact the basic education during a time of implementing the decentralization policy, the Cambodian government has recently undertaken policies to increase the relevance of education through Institutional Development and Capacity Building for Decentralization to develop the staff capacity to respond to decentralization. This process is to enable greater decentralization of authority and responsibilities to provincial, district, commune and school level—with central Ministry's role focused on policy and strategy development and sector and programme monitoring.This study was to explore how the educational decentralization policy has influenced on the quality of Cambodian basic education through investigating principals, teachers, and students from two selected lower-secondary schools in Banteaymeanchey Province, Cambodia. It also focused on the education policy document analysis, especially the educational decentralization policy and the institutional and capacity development for decentralization in Cambodia. Research activities were conducted in two stages. The first stage,'National educational priority policy analysis', concerned the review of relevant literature on the principles of democratic decentralization, national decentralization reforms and the educational decentralization of Cambodia. The second stage,'local practice analyses', focused on the province of Banteaymeanchey the northwest part of Cambodia to investigate the influence of educational decentralizat

关键词： educational autonomy schools interview qualitative motivation authority stated toward questionnaire

Cyclic ADP-ribose and NAADP:fraternal twin messengers for calcium signaling

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Science China(Life Sciences) 2011年第8期54卷 699-711页

作者： hon Cheung LEE Department of Physiology University of Hong Kong

The concept advanced by Berridge and colleagues that intracellular Ca2+-stores can be mobilized in an agonist-dependent and messenger(IP3)-mediated manner has put Ca 2+-mobilization at the center stage of signal transduction *** the late 1980s,we showed that Ca2+-stores can be mobilized by two other messengers unrelated to inositol trisphosphate(IP 3) and identified them as cyclic ADP-ribose(cADPR),a novel cyclic nucleotide from NAD,and nicotinic acid adenine dinucleotide phosphate(NAADP),a linear metabolite of *** messenger functions have now been documented in a wide range of systems spanning three biological *** evidence indicates that the target of cADPR is the ryanodine receptor in the sarco/endoplasmic reticulum,while that of NAADP is the two pore channel in endolysosomes. As cADPR and NAADP are structurally and functionally distinct,it is remarkable that they are synthesized by the same *** are thus fraternal twin *** first identified the Aplysia ADP-ribosyl cyclase as one such enzyme and,through homology,found its mammalian homolog,*** knockout in mice confirms the important roles of CD38 in diverse physiological functions from insulin secretion,susceptibility to bacterial infection,to social behavior of mice through modulating neuronal oxytocin *** have elucidated the catalytic mechanisms of the Aplysia cyclase and CD38 to atomic resolution by crystallography and site-directed *** article gives a historical account of the cADPR/NAADP/CD38-signaling pathway and describes current efforts in elucidating the structure and function of its components.

关键词： cyclic ADP-ribose cADPR NAADP nicotinic acid adenine dinucleotide phosphate CD38 ADP-ribosyl cyclase Calcium mobilization and signaling

红色文化融入高职院校思想政治理论课:重点要素与实践路径

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湖北职业技术学院学报 2024年第2期27卷 43-46,52页

作者：陈杰田洪芳常州工业职业技术学院江苏常州213164

将红色文化中展现的党百年奋斗的历史成就,凸显的革命英雄形象,蕴含的伟大建党精神及共产党人的精神谱系作为重点融入思政课意义重大、影响深远。对此,高职院校应立足院校和地域特色,加强红色文化的保护性开发与系统性研究,思政教师应... 详细信息

将红色文化中展现的党百年奋斗的历史成就,凸显的革命英雄形象,蕴含的伟大建党精神及共产党人的精神谱系作为重点融入思政课意义重大、影响深远。对此,高职院校应立足院校和地域特色,加强红色文化的保护性开发与系统性研究,思政教师应立足课堂主阵地,借助网络新媒体创新展呈方式,积极拓宽红色文化实践活动,不断丰富和提升思政课的内涵与水平,引导青年学生赓续红色血脉,传承红色基因。

关键词：红色文化高职院校思想政治理论课