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作者： Kyle A.Smith Tiffany M.z.ñiga Forrest L.Baker Helena Batatinha Charles R.Pedlar Shane C.Burgess Michael P.Gustafson Emmanuel Katsanis Richard J.Simpson School of Nutritional Sciences and Wellness The University of ArizonaTucsonAZ 85721USA Department of Pediatrics The University of ArizonaTucsonAZ 85724USA Faculty of Sport Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Institute of Sport Exercise and Health University College LondonLondon WC1E 7HUUK Department of Animal and Comparative Biomedical Sciences The University of ArizonaTucsonAZ 85721USA The University of Ariz.na Cancer Center The University of ArizonaTucsonAZ 85719USA Laboratory Medicine and Pathology Mayo Clinic ArizonaPhoenixAZ 85054USA Department of Immunobiology The University of ArizonaTucsonAZ 85724USA Department of Medicine The University of ArizonaTucsonAZ 85724USA Department of Pathology The University of ArizonaTucsonAZ 85724USA

Background:The mobiliz.tion and redistribution of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)specific T-cells and neutraliz.ng antibodies(nAbs)during exercise is purported to increase immune surveillance and protect against severe coronavirus disease 2019(COVID-19).We sought to determine if COVID-19 vaccination would elicit exercise-responsive SARS-CoV-2 T-cells and transiently alter nAb ***:Eighteen healthy participants completed a 20-min bout of graded cycling exercise before and/or after receiving a COVID-19 *** major leukocyte subtypes were enumerated before,during,and after exercise by flow cytometry,and immune responses to SARS-CoV-2 were determined using whole blood peptide stimulation assays,T-cell receptor(TCR)-βsequencing,and SARS-CoV-2 nAb ***:COVID-19 vaccination had no effect on the mobiliz.tion or egress of major leukocyte subsets in response to intensity-controlled graded ***,non-infected participants had a significantly reduced mobiliz.tion of CD4+and CD8+naive T-cells,as well as CD4+central memory T-cells,after vaccination(synthetic immunity group);this was not seen after vaccination in those with prior SARS-CoV-2 infection(hybrid immunity group).Acute exercise after vaccination robustly mobiliz.d SARS-CoV-2 specific T-cells to blood in an intensity-dependent *** groups mobiliz.d T-cells that reacted to spike protein;however,only the hybrid immunity group mobiliz.d T-cells that reacted to membrane and nucleocapsid *** increased significantly during exercise only in the hybrid immunity ***:These data indicate that acute exercise mobiliz.s SARS-CoV-2 specific T-cells that recogniz. spike protein and increases the redistribution of nAbs in individuals with hybrid immunity.

关键词： Anti-viral COVID-19 Exercise immunology SARS-CoV-2 T-Cells Vaccine

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Is tenecteplase ready to replace alteplase to treat acute ischaemic stroke? The knowns and unknowns

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Stroke & Vascular Neurology 2022年第1期7卷 1-5页

作者： Yi Dong Yi Sui Xin Cheng David z.Wang Department of Neurology Huashan Hospital Fudan UniversityShanghaiChina Department of Neurology Shenyang Brain HospitalShenyang Medical CollegeShenyangChina Department of Neurology The First People's Hospital of ShenyangShenyangChina Department of Neurology Barrow Neurological InstitutePhoenixArizonaUSA

Tenecteplase(TNKase,TNK-tPA or TNK)is a thrombolytic agent derived from the tissue plasminogen activator(tPA).It is a 527-amino acid glycoprotein developed by replacing three amino acids at the T,N and K positions of the glycoprotein structure of tPA under genetic recombinant *** replacing threonine 103 with asparagine,asparagine 117 with glutamine and a tetra-alanine at amino acids 296–299,TNK is about eightfold more potent in dissolving clot,80-fold higher resistance to plasminogen activator inhibitor-1 and 14-fold enhanced relative fibrin specificity,and with a longer half-life(20 min).1 Hence,TNK is administered as a single intravenous bolus.

关键词： technology replace replacing

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Treating supratentorial intracerebral haemorrhage: hopeless? Or rethink our strategy

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Stroke & Vascular Neurology 2021年第2期6卷 158-159页

作者： David z.Wang Liping Liu Guohua Xi Yongjun Wang Neurovascular Division Department of NeurologyBarrow Neurological InstitutePhoenixArizonaUSA Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Department of Neurosurgery University of MichiganAnn ArborMichiganUSA

Intracerebral haemorrhage(ICH)is the deadliest(40%)among all strokes.1 There are about 2 million ICHs annually worldwide,but effective treatment is still *** ICH volume of<30 cm3 may have a 30-day mortality of 19%.2 Clinical research on treating ICH has been focusing on blood pressure control,haemostatic therapy,surgical evacuation of the clot and effective drainage of intraven-tricular blood.

关键词： mortality cerebral Clinical

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终于是大明星了:凯特·布兰切特

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明日风尚 2009年第2期 196-196页

作者：阿侠 phoenix z

在一部大制作的电影内演一个白痴的角色,几乎是所有好莱坞大明星的事业指标。凯特·布兰切特在《夺宝奇兵4之水晶骷髅之谜》中饰演一个俄罗斯女军人,形象突出,完全不必演技。证明她终于成了大明星!

关键词：夺宝奇兵布兰部大通天塔托德英国女王本杰明史蒂文斯皮尔伯格光芒四射

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死亡最快乐

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明日风尚 2009年第1期 196-196页

作者：阿侠 phoenix z

黑暗,透出震动的气息,愈黑暗,震动的频率就更激烈,愈接近死亡,心脏的跳动就更快,肾上腺素增加,害怕的严寒让整个人结了冰。但我很喜欢把所有的灯都熄了,面对在漆黑背后似乎随时有东西扑出来的快感。

关键词：你我克里斯托弗希斯诺兰石漆男演员尼科尔森黑暗世界令人魔镜

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Stem cell treatment improves post stroke neurological outcomes:a comparative study in male and female rats

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Stroke & Vascular Neurology 2021年第4期6卷 519-527,I0005-I0010页

作者： Koteswara Rao Nalamolu Bharath Chelluboina Casimir A Fornal Siva Reddy Challa David M Pinson David z.Wang Jeffrey D Klopfenstein Krishna Kumar Veeravalli Cancer Biology and Pharmacology College of MedicineUniversity of IllinoisPeoriaIllinoisUSA Pharmaceutical and Biomedical Sciences California Health Sciences UniversityClovisCaliforniaUSA Neurological Surgery University of Wisconsin-MadisonMadisonWisconsinUSA Health Sciences Education College of MedicineUniversity of IllinoisPeoriaIllinoisUSA Neurology College of MedicineUniversity of IllinoisPeoriaIllinoisUSA Neurology Barrow Neurological InstitutePhoenixArizonaUSA Neurosurgery College of MedicineUniversity of IllinoisPeoriaIllinoisUSA OSF HealthCare Illinois Neurological Institute PeoriaIllinoisUSA Pediatrics College of MedicineUniversity of IllinoisPeoriaIllinoisUSA

Background and purpose The therapeutic potential of different stem cells for ischaemic stroke treatment is intriguing and somewhat *** results from our laboratory have demonstrated the potential benefits of human umbilical cord blood-derived mesenchymal stem cells(MSC)in a rodent stroke *** hypothesised that MSC treatment would effectively promote the recovery of sensory and motor function in both males and females,despite any apparent sex differences in post stroke brain *** Transient focal cerebral ischaemia was induced in adult Sprague-Dawley rats by occlusion of the middle cerebral *** the procedure,male and female rats of the untreated group were euthanised 1 day after reperfusion and their brains were used to estimate the resulting infarct volume and tissue *** groups of stroke-induced male and female rats were treated with MSC or vehicle and were subsequently subjected to a battery of standard neurological/neurobehavioral tests(Modified Neurological Severity Score assessment,adhesive tape removal,beam walk and rotarod).The tests were administered at regular intervals(at days 1,3,5,7 and 14)after reperfusion to determine the time course of neurological and functional recovery after *** The infarct volume and extent of swelling of the ischaemic brain were similar in males and *** similar pathological stroke lesions,the clinical manifestations of stroke were more pronounced in males than females,as indicated by the neurological scores and other *** treatment significantly improved the recovery of sensory and motor function in both sexes,and it demonstrated efficacy in both moderate stroke(females)and severe stroke(males).Conclusions Despite sex differences in the severity of post stroke outcomes,MSC treatment promoted the recovery of sensory and motor function in male and female rats,suggesting that it may be a promising treatment for stroke.

关键词： neurological female rats

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