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Liver resection versus liver transplantation for hepatocellular carcinoma within Milan criteria:a meta-analysis of 18,421 patients

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 78-93,I0009-I0013页

作者： Jin Hean Koh Darren Jun Hao Tan Yuki Ong wen Hui Lim Cheng Han Ng phoebe wen lin tay Jie Ning Yong Mark D.Muthiah Eunice X.Tan Ning Qi Pang Beom Kyung Kim Nicholas Syn Alfred Kow Brian K.P.Goh Daniel Q.Huang Yong Loo lin School of Medicine National University of SingaporeSingaporeSingapore Division of Gastroenterology and Hepatology Department of MedicineNational University HospitalSingaporeSingapore National University Centre for Organ Transplantation National University Health SystemSingaporeSingapore Division of Hepatobiliary&Pancreatic Surgery Department of SurgeryNational University HospitalSingaporeSingapore Department of Internal Medicine Yonsei University College of MedicineSeoulRepublic of Korea Yonsei Liver Center Severance HospitalYonsei University Health SystemSeoulRepublic of Korea Biostatistics and Modelling Domain Saw Swee Hock School of Public HealthNational University of Singapore and National University Health SystemSingaporeSingapore Department of Hepato-Pancreato-Biliary and Transplant Surgery Division of SurgerySingapore General HospitalSingaporeSingapore Liver Transplant Service SingHealth Duke-NUS Transplant CentreSingaporeSingapore

Background:Outcomes after liver resection(LR)and liver transplantation(LT)for hepatocellular carcinoma(HCC)are heterogenous and may vary by region,over time periods and disease *** aimed to compare overall survival(OS)and disease-free survival(DFS)between LT versus LR for HCC within the Milan ***:Two authors independently searched Medline and Embase databases for studies comparing survival after LT and LR for patients with HCC meeting the Milan ***-analyses and meta-regression were conducted using random-effects ***:We screened 2,278 studies and included 35 studies with 18,421 *** was associated with poorer OS[hazard ratio(HR)=1.44;95%confidence interval(CI):1.14-1.81;Pwent enhanced surveillance had comparable OS after LT and LR(P=0.33),but cohorts undergoing usual surveillance had worse OS after LR(HR=1.95;95%CI:1.24-3.07;P<0.01).Conclusions:Mortality after LR for HCC is nearly 50%higher compared to *** between LR and LT were similar in uninodular *** risk of recurrence after LR is threefold that of LT.

关键词： Hepatocellular carcinoma(HCC) liver resection(LR) liver transplant survival recurrence

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Foregut bypass *** bariatric procedures for nonalcoholic fatty liver disease:a meta-analysis of 3,355 individuals

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 658-670,I0001-I0003页

作者： wen Hui Lim Snow Yunni lin Cheng Han Ng Darren Jun Hao Tan Jieling Xiao Jie Ning Yong phoebe wen lin tay Nicholas Syn Yip Han Chin Kai En Chan Chin Meng Khoo Nicholas Chew Roger S.Y.Foo Asim Shabbir Eunice X.Tan Daniel Q.Huang Mazen Noureddin Arun J.Sanyal Mohammad Shadab Siddiqui Mark D.Muthiah Yong Loo lin School of Medicine National University of SingaporeSingaporeSingapore Division of Endocrinology Department of MedicineNational University HospitalSingaporeSingapore Department of Cardiology National University Heart CentreNational University HospitalSingaporeSingapore Division of General Surgery(Upper Gastrointestinal Surgery) Department of SurgeryNational University HospitalSingaporeSingapore Division of Gastroenterology and Hepatology Department of MedicineNational University HospitalSingaporeSingapore National University Centre for Organ Transplantation National University Health SystemSingaporeSingapore Cedars-Sinai Fatty Liver Program Division of Digestive and Liver DiseasesDepartment of MedicineComprehensive Transplant CenterCedars-Sinai Medical CentreLos AngelesCAUSA Division of Gastroenterology Hepatology and NutritionDepartment of Internal MedicineVirginia Commonwealth UniversityRichmondVAUSA

Background:Bariatric surgery represents an important treatment option for severely obese patients with nonalcoholic fatty liver disease(NAFLD).However,there remains inadequate data regarding the effects of different bariatric procedures on various NAFLD parameters,especially for histological ***,this meta-analysis aimed to compare the effects of restrictive bariatric procedures and foregut bypass on the metabolic,biochemical,and histological parameters for patients with ***:Medline and Embase were searched for articles relating to bariatric procedures and *** meta-analysis was conducted to compare efficacy of bariatric procedures ***-procedure with subgroup analysis to further compare restrictive against foregut bypass ***:Thirty-one articles involving 3,355 patients who underwent restrictive bariatric procedures(n=1,460)and foregut bypass(n=1,895)were *** foregut bypass(Pline non-significant decrease in fibrosis score(P=0.06)and significantly lower steatosis score(Pline phosphatase(P=0.61).However,foregut bypass resulted in significantly lower gamma-glutamyl transferase than restrictive procedures(P=0.01)while restrictive procedures resulted in significantly lower alanine transaminase than foregut bypass(P=0.02).Conclusions:The significant histological and metabolic advantages and comparable improvements in biochemical outcomes support the choice of foregut bypass over restrictive bariatric procedures in NAFLD management.

关键词： Bariatric surgery non-alcoholic fatty liver disease(NAFLD) obesity fibrosis endoscopy

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Efficacy and safety of sofosbuvir/velpatasvir with or without ribavirin in hepatitis C genotype 3 compensated cirrhosis:A meta-analysis

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World Journal of Hepatology 2022年第6期14卷 1248-1257页

作者： Jing Hong Loo wen Xin Flora Xu Jun Teck Low Wei Xuan tay Le Shaun Ang Yew Chong Tam Prem Harichander Thurairajah Rahul Kumar Yu Jun Wong Yong Loo lin School of Medicine National University of SingaporeSingapore 119077Singapore Education Resource Center Medical BoardSingapore General HospitalSingapore 100059Singapore Department of Gastroenterology and Hepatology National University HospitalSingapore 119077Singapore Department of Gastroenterology and Hepatology Changi General HospitalSingapore 529889Singapore Duke-NUS Medicine Academic Clinical Program Singapore 100059Singapore

BACKGROUND Hepatitis C virus(HCV)is a leading cause of liver cirrhosis and hepatocellular carcinoma ***/velpatasvir(SOF/VEL)is an effective pangenotypic direct-acting antiviral combination for treatment of chronic HCV *** the addition of ribavirin(RBV)to SOF/VEL improved sustained virological response(SVR12)in genotype 3(GT3)decompensated cirrhosis patients,the benefits of RBV in GT3 compensated cirrhosis patients receiving SOF/VEL remains *** To evaluate the efficacy and safety of SOF/VEL,with or without RBV in GT3 compensated cirrhosis *** We searched four electronic databases(PubMed/Medline,Embase,Cochrane Library and Web of Science)from inception up to June 2021 using both free text and MeSH *** was no restriction on language,geography,publication dates and publication status(full text or abstracts).All GT3 compensated cirrhosis patients treated with 12 wk of SOF/VEL,with or without RBV,were included,regardless of age,gender or prior treatment *** primary outcome was sustained virological response 12-wk posttreatment(SVR12).The secondary outcome was treatment-related adverse events,as defined by symptomatic anemia requiring transfusion or a drop in hemoglobin beyond 2 g/*** pooled relative risk(RR),95%CI and heterogeneity(I^(2))were estimated using Review Manager version *** From 1752 citations,a total of seven studies(2 randomized controlled trials,5 cohort studies)with 1088 subjects were *** SVR12 was similar in GT3 compensated cirrhosis patients,regardless of the use of RBV,for both the intention-to-treat RR 1.03,95%CI:0.99-1.07;I^(2)=0%)and the per-protocol analysis(RR:1.03,95%CI:0.99-1.07;I^(2)=48%).The overall pooled rate of treatment-related adverse events was 7.2%.Addition of RBV increased the pooled risk of treatment-related adverse events in GT3 compensated cirrhosis patients receiving SOF/VEL(RR:4.20,95%CI:1.29-13.68;I^(2)=0%).Subgroup analysis showed that RBV wa

关键词： Direct-acting antiviral Hepatitis C Cirrhosis Sofosbuvir/velpatasvir

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Dental trauma in endoscopy:A systematic review and experience of a tertiary endoscopy centre

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World Journal of Gastrointestinal Endoscopy 2023年第8期15卷 518-527页

作者： Chelsea Qiu lin Tan Gabrielle Yi wen Loh tay Wei Rong Benjamin Calvin Jianyi Koh John Shao Rong Mok Juanda Leo Hartono Kai Ting Cheryl Chua Hee Hon Tan Kewin Tien Ho Siah Yong Loo lin School of Medicine National University of SingaporeSingapore 117594Singapore Division of Gastroenterology and Hepatology National University Health SystemSingapore 119074Singapore Department of Medicine Ng Teng Fong General HospitalSingapore Division of Prosthodontics National University Centre for Oral HealthSingapore 119074Singapore

BACKGROUND Dental injury is the leading cause of litigation in anaesthesia but an underrecognized preventable complication of *** To determine frequency and effects of dental injury in endoscopy,we present findings from an audit of outpatient endoscopy procedures conducted at a tertiary university hospital and a systematic review of *** Retrospective review of 11265 outpatient upper endoscopy procedures over the period of 1 June 2019 to 31 May 2021 identified dental related complications in 0.284%of *** of literature identified a similar rate of 0.33%.RESULTS Pre-existing dental pathology or the presence of prostheses makes damage more likely but sound teeth may be ***-endoscopic history and tooth examination are key for risk stratification and may be conducted succinctly with limited time *** retrieval should be prioritized in the event of dental injury to minimize aspiration and be followed by prompt dental consultation for specific *** Dental complications occur in approximately 1 in 300 of upper endoscopy *** are easily preventable by pre-endoscopy *** to mitigate dental injury are also suggested.

关键词： Teeth Dental trauma Endoscopy Digestive system

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A Class Effect Network Meta-analysis of Lipid Modulation in Non-alcoholic Steatohepatitis for Dyslipidemia

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Journal of Clinical and Translational Hepatology 2022年第6期10卷 1042-1049页

作者： Jieling Xiao Cheng-Han Ng Yip-Han Chin Darren Jun Hao Tan wen-Hui Lim Grace Lim Jingxuan Quek Ansel Shao Pin Tang Kai-En Chan Rou-Yi Soong Nicholas Chew Benjamin tay Daniel Q.Huang Nobuharu Tamaki Roger Foo Mark Y.Chan Mazen Noureddin Mohammad Shadab Siddiqui Arun J.Sanyaland Mark D.Muthiah Yong Loo lin School of Medicine National University of SingaporeSingapore Lee Kong Chian School of Medicine Nan-yang Technological UniversitySingapore Department of Cardiology National University Heart CenterNational University HospitalSingapore Division of Gastroenterology and Hepatology Department of MedicineNational University HospitalSingaporeSingapore National University Center for Organ Transplantation National University Health SystemSingapore NAFLD Research Center Division of Gastroenterology and HepatologyDepartment of MedicineUniversity of California at San DiegoLa JollaCAUSA Department of Gastroenterology and Hepatology Musashino Red Cross HospitalTokyoJapan Cedars-Sinai Fatty Liver Program Division of Digestive and Liver DiseasesDepartment of MedicineComprehen-sive Transplant CenterCedars-Sinai Medical CenterLos AngelesCAUSA Division of Gastroenterology Hepatology and NutritionDepartment of Internal MedicineVirginia Commonwealth UniversityRichmondVAUSA

Background and Aims:Pharmaceutical therapy for NASH is associated with lipid modulation,but the consensus on drug treatment is limited and lacks comparative analysis of effectiveness.A network meta-analysis was conducted to compare NASH drug classes in lipid ***:Online databases were searched for randomized controlled trails(RCTs)evaluating NASH treatments in biopsy-proven NASH *** were classified into four groups:(1)inflammation,(2)energy,(3)bile acids,and(4)fibro-sis based on the mechanism of action.A Bayesian network analysis was conducted with outcome measured by mean difference(MD)with credible intervals(Crl)and surface un-der the cumulative ranking curve(SUCRA).Results:Forty-four RCTs were included in the *** acid modulat-ing treatments(MD:0.05,Crl:0.03-0.07)were the best treatment for improvement in high-density lipid(HDL)cho-lesterol,followed by treatments modulating energy(MD:0.03,Crl:0.02-0.04)and fibrosis(MD:0.01,Crl:−0.12 to 0.14)compared with *** top three treatments for reduction in triglycerides were treatments modulating energy(MD:−0.46,Crl:−0.49 to−0.43),bile acids(MD:−0.22,Crl:−0.35 to−0.09),and inflammation(MD:−0.08,Crl:−0.13 to−0.03)compared with *** found treatment modulating fibrosis(MD:−1.27,Crl:−1.76 to−0.79)was the best treatment for reduction in low-density lipid(LDL)cholesterol followed by treatment modulating in-flammation(MD:−1.03,Crl:−1.09 to−0.97)and energy(MD:−0.37,Crl:−0.39 to−0.34)compared with placebo,but LDL cholesterol was worsened by treatments modulat-ing bile ***:Network analysis comparing the class effects of dyslipidemia modulation in NASH found that treatment targets can include optimization of athero-genic *** studies are required to evaluate the cardiovascular outcomes.

关键词： Lipid modulation NASH Dyslipidemia

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Gene expression profile of peripheral blood in colorectal cancer

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World Journal of Gastroenterology 2014年第39期20卷 14463-14471页

作者： Yu-Tien Chang Chi-Shuan Huang Chung-tay Yao Sui-Lung Su Harn-Jing Terng Hsiu-ling Chou Yu-Ching Chou Kang-Hua Chen Yun-wen Shih Chian-Yu Lu Ching-Huang Lai Chen-En Jian Chiao-Huang lin Chien-Ting Chen Yi-Syuan Wu Ke-Shin lin Thomas Wetter Chi-wen Chang Chi-Ming Chu Division of Biomedical Statistics and Informatics School of Public Health National Defense Medical Center Division of Colorectal Surgery Cheng Hsin Rehabilitation Medical Center Department of Surgery Cathay General Hospital Department of Epidemiology School of Public Health National Defense Medical Center Advpharma Inc. Department of Nursing Far Eastern Memorial Hospital and Oriental Institute of Technology Department of Nursing School of Medicine Chang Gung University Air Force Combatant Command National Defense Ministry Institute of Medical Biometry and Informatics Heidelberg University Germany Department of Biomedical Informatics and Medical Education University of Washington Seattle United States

AIM:Optimal molecular markers for detecting colorectal cancer(CRC)in a blood-based assay were ***:A matched(by variables of age and sex)case-control design(111 CRC and 227 non-cancer samples)was *** RNAs isolated from the338 blood samples were reverse-transcribed,and the relative transcript levels of candidate genes were *** training set was made of 162 random samples of the total 338 samples.A logistic regression analysis was performed,and odds ratios for each gene were determined between CRC and *** samples(n=176)in the testing set were used to validate the logistic model,and an inferred performance(generality)was *** pooling 12 public microarray datasets(GSE 4107,4183,8671,9348,10961,13067,13294,13471,14333,15960,17538,and 18105),which included 519 cases of adenocarcinoma and 88 controls of normal mucosa,we were able to verify the selected genes from logistic models and estimate their external ***:The logistic regression analysis resulted in the selection of five significant genes(P<0.05;MDM2,DUSP6,CPEB4,MMD,and EIF2S3),with odds ratios of 2.978,6.029,3.776,0.538 and 0.138,*** five-gene model performed stably for the discrimination of CRC cases from controls in the training set,with accuracies ranging from 73.9%to 87.0%,a sensitivity of 95%and a specificity of 95%.In addition,a good performance in the test set was obtained using the discrimination model,providing 83.5%ac-curacy,66.0%sensitivity,92.0%specificity,a positive predictive value of 89.2%and a negative predictive value of 73.0%.Multivariate logistic regressions analyzed 12 pooled public microarray data sets as an external *** that provided similar expected and observed event rates in subgroups were termed well calibrated.A model in which MDM2,DUSP6,CPEB4,MMD,and EIF2S3 were selected showed the result in logistic regression analysis(H-L P=0.460,R2=0.853,AUC=0.978,accuracy=0.949,specificity=0.818 and sensitivity=0

关键词： Colorectal cancer Gene expression Micro-array Inte

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中亚热带4种林分类型土壤微生物生物量碳氮特征及季节变化

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应用生态学报 2019年第6期30卷 1901-1910页

作者：刘宝吴文峰林思祖林开敏福建农林大学林学院

以中亚热带常绿阔叶林及由其改造而来的闽楠、毛竹及杉木人工林为研究对象,采用氯仿熏蒸浸提法测定了4种林分类型表层(0~10 cm)和深层(40~60 cm)土壤微生物生物量碳(MBC)和氮(MBN),并分析了其季节变化及与土壤理化性质之间的关系.结果表... 详细信息

以中亚热带常绿阔叶林及由其改造而来的闽楠、毛竹及杉木人工林为研究对象,采用氯仿熏蒸浸提法测定了4种林分类型表层(0~10 cm)和深层(40~60 cm)土壤微生物生物量碳(MBC)和氮(MBN),并分析了其季节变化及与土壤理化性质之间的关系.结果表明:4种林分类型表层土壤MBC和MBN均以常绿阔叶林最高,其次为闽楠人工林、毛竹人工林和杉木人工林,且前三者显著高于后者;各林分深层土壤MBC和MBN无显著差异.4种林分类型的表层土壤MBC和MBN均显著高于深层土壤,且各土层MBC和MBN均具有明显的季节变化,总体呈现出'夏高冬低'单峰曲线变化模式.相关分析表明,4种林分类型土壤MBC和MBN与土壤有机碳、全氮及土壤温度呈显著正相关关系,与土壤容重呈显著负相关关系.表明常绿阔叶林改造成人工林30多年后,表层土壤MBC和MBN呈下降趋势,其中杉木人工林下降幅度最大(分别下降39.0%和49.8%),而对深层土壤MBC和MBN的影响较小.凋落物数量和质量、土壤有机碳和总氮含量及土壤温度是导致各林分类型土壤微生物生物量碳氮差异和季节变化的主要因素.

关键词：森林转换土壤微生物生物量碳氮土层季节变化土壤理化性质

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指数施磷后闽楠幼苗诊断施肥综合法营养诊断研究

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西部林业科学 2023年第2期52卷 121-131页

作者：倪艳林杨丽丽彭君文仕知龙大鑫何功秀及利中南林业科技大学林学院湖南长沙410000 湖南省地质实验测试中心湖南长沙410000

为研究闽楠幼苗对指数施磷的响应,利用DRIS营养诊断法对闽楠幼苗营养状态进行分析,以1 a生闽楠幼苗为试验材料,设定对照(0 mg/株)、不同指数施肥水平(过磷酸钙,400、800、1200、1600、2000、2400、2800 mg/株)和常规施肥(1600 mg/株)共... 详细信息

为研究闽楠幼苗对指数施磷的响应,利用DRIS营养诊断法对闽楠幼苗营养状态进行分析,以1 a生闽楠幼苗为试验材料,设定对照(0 mg/株)、不同指数施肥水平(过磷酸钙,400、800、1200、1600、2000、2400、2800 mg/株)和常规施肥(1600 mg/株)共9个处理,采用DRIS图解法求得闽楠幼苗叶片营养元素诊断参数最适比范围,初步制定闽楠幼苗DRIS指数分级标准,划分其养分浓度诊断范围,并判断指数施肥后闽楠幼苗养分状态。结果显示:(1)DRIS图解法结果表明,指数施肥后,闽楠幼苗叶片氮/磷(N/P)在16.549~18.492之间,钾/磷(K/P)在6.179~7.084之间,氮/钾(N/K)在2.543~2.759之间时,闽楠幼苗叶片N、P、K养分含量平衡。(2)DRIS指数法的结果发现,低产组需肥顺序为K>P>N>Ca>Mg;高产组需肥顺序为K>P>Ca>Mg>N。此外,指数施肥后闽楠幼苗DRIS指数平衡区N为-0.775~31.805、P为-9.901~-1.770、K为-18.734~-2.159、Ca为-21.489~9.27、Mg为1.012~15.450。(3)营养诊断临界标准平衡区N为24.773~27.964 mg/g、P为1.465~1.624 mg/g、K为9.250~9.995 mg/g、Ca为9.168~9.653 mg/g、Mg为0.453~0.796 mg/g。可得结论:闽楠幼苗指数施肥较常规施肥养分更为平衡,指数施磷肥总量为1600~2400 mg/株时,闽楠幼苗N、P、K、Ca、Mg养分含量基本处于平衡状态。

关键词：闽楠幼苗指数施肥综合营养诊断指数法图解法

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The phoebe genome sheds light on the evolution of magnoliids

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Horticulture Research 2020年第1期7卷 876-888页

作者： Shi-Pin Chen Wei-Hong Sun Yuan-Fang Xiong Yu-Ting Jiang Xue-Die Liu Xing-Yu Liao Di-Yang Zhang Shu-Zhen Jiang Yu Li Bin Liu Liang Ma Xia Yu Li He Bao Liu Jin-lin Feng Li-Zhen Feng Zhi-wen Wang Shuang-Quan Zou Si-Ren Lan Zhong-Jian Liu College of Forestry Fujian Agriculture and Forestry University350002 FuzhouChina Key Laboratory of National Forestry and Grassland Administration for Orchid Conservation and Utilization at the College of Landscape Architecture Fujian Agriculture and Forestry University350002 FuzhouChina PubBio-Tech 430070 WuhanChina Zhejiang Institute of Subtropical Crops Zhejiang Academy of Agricultural Sciences325005 WenzhouChina Institute of Vegetable and Flowers Shandong Academy of Agricultural Sciences250100 JinanChina

Lauraceae includes the genus phoebe,and the family is linked to the evolution of *** sequenced the genome of phoebe bournei *** assembled genome size was 989.19 Mb,with a contig N50 value of 2.05 Mb.A total of 28,198 protein-coding genes were annotated in ***-genome duplication(WGD)analysis showed that Lauraceae has experienced two WGD events;the older WGD event occurred just before the divergence of Lauraceae and Magnoliales,and the more recent WGD was shared by all lineages of *** phylogenetic tree showed that magnoliids form a sister clade to monocots and *** also identified 63 MADS-box genes,including AGL12-like genes that may be related to the regulation of *** roots and FIN219-like genes encoding GH3 proteins,which are involved in ***50-like genes involved in light signal-mediated pedicel or stem development were also *** ATMYB46-and three PtrEPSP-homologous genes related to lignin biosynthesis were *** genes may be associated with the formation of straight trunks in ***,the *** reference genome provides insight into the origin,evolution,and diversification of phoebe and other magnoliids.

关键词： Whole evolution light

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闽楠木荷混交幼林生长规律及生物量分布特征研究

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中南林业科技大学学报 2019年第4期39卷 79-84,98页

作者：林立彬李铁华文仕知杨柳中南林业科技大学林学院湖南长沙410004

以金洞林场14年生闽楠木荷人工混交林为研究对象,采用树干解析和分层收获法对闽楠与木荷的生长规律以及生物量分配特征进行研究。结果表明:1)闽楠与木荷胸径的速生期均为8～12 a,胸径的连年生长量分别在10 a和12 a时达到最大值;2)闽楠... 详细信息

以金洞林场14年生闽楠木荷人工混交林为研究对象,采用树干解析和分层收获法对闽楠与木荷的生长规律以及生物量分配特征进行研究。结果表明:1)闽楠与木荷胸径的速生期均为8～12 a,胸径的连年生长量分别在10 a和12 a时达到最大值;2)闽楠与木荷树高的连年生长量分别在第12 a与第10 a时达到最大值,随后急速下降,闽楠树高连年、平均生长量在13 a左右相交;3)0～8 a时,闽楠与木荷的材积生长速度缓慢,8 a以后生长速度上升,14 a时仍处于材积增长的速生期;4)闽楠与木荷单株材积生物量分别为61.43 kg和83.29 kg,各个器官生物量大小顺序均为:树干>树根>树枝>树叶>树皮;5)林分总单位面积生物量为136.29 t·hm^(-2),其中乔木层所占比值高达93.09%,各层次单位面积生物量由大到小排列顺序为:乔木层>半分解枯落物层>未分解枯落物层>草本层。

关键词：闽楠木荷人工混交林生长规律生物量分配特征

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