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High-current pulsed electron beam modification on microstructure and performance of Cu/CuW diffusion bonding joints

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Rare metals 2024年第6期43卷 2819-2831页

作者： na-na Tian Cong-Lin Zhang Peng Lyu Jin-Tong Guan Jie Cai Qing-Feng Guan Shun Guo School of materials Science and Engineering Jiangsu UniversityZhenjiang 212013China School of material Science and Engineering Yancheng Institute of TechnologyYancheng 221051China Engineering Institute of Advanced manufacturing and modern Equipment Technology Jiangsu UniversityZhenjiang 212013China

This study investigates the influence of high-current pulsed electron beam(HCPEB)modification on the microstructure and shear strength of Cu/CuW *** solid-state diffusion bonding of modified-Cu(mCu)and modified-CuW(m-CuW)was achieved by HCPEB modification pretreatment at a temperature of 800-900℃and a pressure of 5 mPa for 10-50 *** demonstrate that HCPEB modification facilitates the dissolution of W and Cu,resulting in the formation of a Cu_(0.4)W_(0.6)solid solution and thus enhancing the uniform distribution of ***,HCPEB-induced defects play a beneficial role in promoting the diffusion process by providing fast diffusion paths for *** optimal joints with the maximum shear strength of 213.7 mPa were obtained through bonding m-Cu and m-CuW at 900℃and 5 mPa for 30 min,which attributes to the combined effects of fine-grained strengthening and solid solution ***,the application of HCPEB modification showcases its effectiveness in promoting element diffusion and enhancing the mechanical performance of the joints.

关键词： HCPEB Element diffusion Shear strength Crystal defects Surface modification

The Adjustment Analysis method of the Active Surface Antenna Based on Convolutional Neural Network

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Research in Astronomy and Astrophysics 2024年第6期24卷 294-306页

作者： You Ban Shang Shi na Wang Qian Xu Shufei Feng School of mechanical Engineering Xinjiang UniversityUrumqi 830017China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China School of mechanical Engineering Dongguan University of TechnologyDongguan 523808China

Active surface technique is one of the key technologies to ensure the reflector accuracy of the millimeter/submillimeter wave large reflector *** antenna is complex,large-scale,and high-precision equipment,and its active surfaces are affected by various factors that are difficult to comprehensively deal *** this paper,based on the advantage of the deep learning method that can be improved through data learning,we propose the active adjustment value analysis method of large reflector antenna based on deep *** method constructs a neural network model for antenna active adjustment analysis in view of the fact that a large reflector antenna consists of multiple panels spliced *** on the constraint that a single actuator has to support multiple panels(usually 4),an autonomously learned neural network emphasis layer module is designed to enhance the adaptability of the active adjustment neural network *** classical 8-meter antenna is used as a case study,the actuators have a mean adjustment error of 0.00252 mm,and the corresponding antenna surface error is0.00523 *** active adjustment result shows the effectiveness of the method in this paper.

关键词： techniques:radar astronomy telescopes methods:analytical methods:numerical

Effectiveness of magnetic resonance imaging and spiral computed tomography in the staging and treatment prognosis of colorectal cancer

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2135-2144页

作者： Lu-na Bai Lu-Xian Zhang Department of Radiology Zhongshan Hospital Xiamen UniversityXiamen 361004Fujian ProvinceChina

BACKGROUND Colorectal cancer(CRC)is a prevalent cancer type in clinical settings;its early signs can be difficult to detect,which often results in late-stage diagnoses in many *** early detection and diagnosis of CRC are crucial for improving treatment success and patient survival ***,imaging techniques have been hypothesized to be essential in managing CRC,with magnetic resonance imaging(mRI)and spiral computed tomography(SCT)playing a significant role in enhancing diagnostic and treatment *** To explore the effectiveness of mRI and SCT in the preoperative staging of CRC and the prognosis of laparoscopic *** Ninety-five individuals admitted to Zhongshan Hospital Xiamen University underwent mRI and SCT and were diagnosed with *** precision of mRI and SCT for the presurgical classification of CRC was assessed,and pathological staging was used as a *** operating characteristic curves were used to evaluate the diagnostic efficacy of blood volume,blood flow,time to peak,permeability surface,blood reflux constant,volume transfer constant,and extracellular extravascular space volume fraction on the prognosis of patients with *** Pathological biopsies confirmed the following CRC stages:23,23,32,and 17 at T1,T2,T3,and T4,*** were 39 cases at the N0 stage,22 at N1,34 at N2,44 at m0 stage,and 51 at *** pathological findings as the benchmark,the combined use of mRI and SCT for preoperative TNm staging in patients with CRC demonstrated superior sensitivity,specificity,and accuracy compared with either modality alone,with a statistically significant difference in accuracy(Pnalysis revealed the predictive values for laparoscopic treatment prognosis,as indicated by the areas under the curve for blood volume,blood flow,time to peak,and permeability surface,blood reflux constant,volume transfer constant,and extracellular extravascular space volu

关键词： magnetic resonance imaging Spiral computed tomography Colorectal cancer Prognosis Receiver operating characteristic curve Retrospective study

Improvement of mechanical properties and investigation of strengthening mechanisms on the Ti_(3)AlC_(2) ceramic with nanosized WC addition

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Journal of Advanced Ceramics 2024年第6期13卷 861-876页

作者： Yi Zhong Ying Liu Qinkai Jiang na Jin Zifeng Lin Jinwen Ye School of materials Science&Engineering Sichuan UniversityChengdu 610065China Yibin R&D Park Yibin Industrial Technology Research InstituteSichuan UniversityYibin 644005China

Ti_(3)AlC_(2) (TAC) has great potential for use as an ablation material in aerospace applications due to its great oxidation/ablation resistance, but its high-temperature strength and thermal shock resistance still have much room for simultaneous improvement under fast temperature variation conditions. Herein, we used Ti_(3)AlC_(2) and WC powders as raw materials and successfully fabricated textured (Ti,W)_(3)AlC_(2) ceramic with small amounts of TiC and Al_(2)O_(3), and room temperature mechanical properties such as flexural strength (1146±46.9 mPa), fracture toughness (11.78±0.44 mPa·m^(1/2)), and hardness (5.81±0.11 GPa) at 5 wt% WC addition were achieved. The high-temperature strength of the ceramic was significantly improved, and better thermal shock resistance from 298 to 1173 K was simultaneously acquired together with the regulation of the elastic modulus, thermal conductivity, and thermal expansion coefficient, providing (Ti,W)_(3)AlC_(2) with more possibilities for fast-temperature variation applications. Strengthening and toughening mechanisms were proposed. Scanning transmission electron microscopy high-angle annular dark-field imaging (STEm-HADDF) showed that W randomly replaced the Ti1 and Ti2 sites of Ti_(3)AlC_(2), providing a good reference for establishing crystal models, and further density functional theory (DFT) calculations based on these models indicated a higher fracture energy of (Ti,W)_(3)AlC_(2) along different crystal planes, providing superior resistance to transgranular fracture;a lower mismatch degree of (Ti,W)_(3)AlC_(2)/Al_(2)O_(3) resulted in stronger interface bonding, resulting in greater resistance to intergranular fracture as well as more balanced stress distributions at different interfaces.

关键词： mechanical properties solid solution mAX phase transmission electron microscopy(TEm) ceramic atomic structure

Insights into sensitizing and eliciting capacity of gastric and gastrointestinal digestion products of shrimp(Penaeus vannamei)proteins in BALB/c mice

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Food Science and Human Wellness 2024年第1期13卷 339-348页

作者： Yao Liu Songyi Lin Kexin Liu Shan Wang Wang Li na Sun national Engineering Research Center of Seafood School of Food Science and TechnologyDalian Polytechnic UniversityDalian 116034China Collaborative Innovation Center of Seafood Deep Processing Dalian Polytechnic UniversityDalian 116034China

Shrimp(Penaeus vannamei)proteins have been shown an allergenic potential;however,little information is available on the sensitizing and eliciting capacity of shrimp protein digestion *** this study,a BALB/c mice model was used to explore the allergenicity of shrimp protein sample(SPS)and their gastric and gastrointestinal digestion products(GDS/GIDS).As compared with the SPS groups,the GDS/GIDS groups caused lower specific immunoglobulins(Ig E/Ig G1)levels(Pmouse mast cell protease-1(m mCP-1)concentration and proportion of degranulated mast cells were significantly reduced in the GDS/GIDS groups(Pmultaneously,allergic symptoms,vascular permeability and histopathological changes of tissues were ***,the allergenicity of digestion products cannot be eliminated and still cause systemic allergic reactions in *** study showed that the digestion products of shrimp still had high sensitizing and eliciting capacity.

关键词： Penaeus vannamei Allergenicity Digestion BALB/c mice model

Neutrophil peptide 1 accelerates the clearance of degenerative axons during Wallerian degeneration by activating macrophages after peripheral nerve crush injury

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Neural Regeneration Research 2024年第8期19卷 1822-1827页

作者： Yuhui Kou Yusong Yuan Qicheng Li Wenyong Xie Hailin Xu na Han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina national Center for Trauma medicine BeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina Department of Central Laboratory and Institute of Clinical molecular Biology Peking University People’s HospitalBeijingChina

macrophages play an important role in peripheral nerve regeneration,but the specific mechanism of regeneration is still *** preliminary findings indicated that neutrophil peptide 1 is an innate immune peptide closely involved in peripheral nerve ***,the mechanism by which neutrophil peptide 1 enhances nerve regeneration remains *** study was designed to investigate the relationship between neutrophil peptide 1 and macrophages in vivo and in vitro in peripheral nerve crush *** functions of RAW 264.7 cells we re elucidated by Cell Counting Kit-8 assay,flow cytometry,migration assays,phagocytosis assays,immunohistochemistry and enzyme-linked immunosorbent *** debris phagocytosis was observed using the CUBIC(Clear,Unobstructed Brain/Body Imaging Cocktails and Computational analysis)optical clearing technique during Wallerian *** inflammatory factor expression in different polarization states was detected using a protein *** results showed that neutrophil peptide 1 promoted the prolife ration,migration and phagocytosis of macrophages,and CD206 expression on the surfa ce of macrophages,indicating m2 *** axonal debris clearance rate during Wallerian degeneration was enhanced after neutrophil peptide 1 *** peptide 1 also downregulated inflammatory factors interleukin-1α,-6,-12,and tumor necrosis factor-αin invo and in ***,the results suggest that neutrophil peptide 1 activates macrophages and accelerates Wallerian degeneration,which may be one mechanism by which neutrophil peptide 1 enhances peripheral nerve regeneration.

关键词： axonal debris inflammatory factors macrophages neutrophil peptide 1 peripheral nerve injury peripheral nerve regeneration RAW 264.7 cells sciatic nerve Wallerian degeneration

Astronomical forcing and sedimentary noise modeling of lake-level changes in the middle Eocene Chezhen Sag,Bohai Bay Basin,eastern China

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Frontiers of Earth Science 2024年第2期18卷 446-459页

作者： Xuwei LUAN Jinliang ZHANG na LI Tao CHEN Long SUN Xuecai ZHANG Faculty of Geographical Science Beijing Normal UniversityBeijing 100875China College of Geosciences China University of Petroleum(Beijing)Beijing 102249China management Center of Oil and Gas Exploration Sinopec Shengli OilfieldDongying 257000China

The accurate determination of geological age is a key to understanding the history and process of paleolake evolution and oil and gas exploration in continental lake ***,improving the accuracy of geological age has always been a difficult scientific problem.A 609-m-thick,continuous lacustrine mudstone and sandstone succession in Chezhen Sag(eastern China)provides an ideal middle Eocene sedimentary record for establishing a high-resolution stratigraphic chronology *** on spectrum analysis and sliding window spectrum analysis of the natural gamma(GR)logging data of well Che 271(C271)in Chezhen Sag,the periods of 405 kyr and 40.1 kyr were filtered by a Gaussian bandpass filter,and a“floating”astrochronological time scale(ATS)was *** total number of 405 kyr eccentricity cycles were 13.6 and 40.1 kyr obliquity cycles were 138 which recorded from the upper member 4(Es4U)to the member 3(Es3)of the Eocene Shahejie Formation,and the depositional duration was 5.53 *** Coefficient(COCO)analysis and evolutionary Correlation Coefficient(eCoCo)analysis found that the optimal sedimentary rate of different *** noise simulation revealed the history of paleolake water changes in the middle Eocene in the Chezhen Sag,according to which four sequences are *** study shows that the lake level change of Chezhen Sag in the middle Eocene shows prominent 1.2 myr cycles and an antiphase well-coupled relationship with obliquity ***,we propose a model to explain the relationship between the orbital cycle and lake level change in the continental lake *** the obliquity of the earth increases,the middle and high latitudes of the earth will be closer to the sun,the direct sunlight will be higher,and the meridional sunshine will increase,thus accelerating the evaporation process of lake basin *** the seasonal changes are obvious(maximum period of 1.2 myr ultra-long obliquity),this effect is more signific

关键词： Chezhen Sag cyclostratigraphy astrochronological time scale sedimentary noise

The infection kinetics and transmission potential of two Guaico Culex viruses in Culex quinquefasciatus mosquitoes

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Virologica Sinica 2024年第2期39卷 228-234页

作者： Ru-Yi Chen Teng Zhao Jing-Jing Guo Feng Zhu na-na Zhang Xiao-Feng Li Hai-Tao Liu Fei Wang Yong-Qiang Deng Cheng-Feng Qin College of Bioscience and Bioengineering Jiangxi Agricultural UniversityNanchang330045China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyAMMSBeijing100071China School of Life Sciences Southwest Forestry UniversityKunming650224China

Guaico Culex virus(GCXV)is a newly identified segmented Jingmenvirus from Culex *** in Central and South *** genome of GCXV is composed of four or five single-stranded positive Rna ***,the infection kinetics and transmission capability of GCXV in mosquitoes remain *** this study,we used reverse genetics to rescue two GCXVs(4S and 5S)that contained four and five Rna segments,respectively,in C6/36 *** in vitro characterization revealed that the two GCXVs exhibited comparable replication kinetics,protein expression and viral ***,GCXV Rnas were detected in the bodies,salivary glands,midguts and ovaries of Culex quinquefasciatus at 4–10 days after oral *** addition,two GCXVs can colonize *** eggs,resulting in positive rates of 15%–35%for the second gonotrophic *** conclusion,our results demonstrated that GCXVs with four or five Rna segments can be detected in *** eggs during the first and second gonotrophic cycles after oral infection.

关键词： Guaico Culex virus(GCXV) Jingmenvirus Culex quinquefasciatus Vertical transmission

Discovery of GluN2A subtype-selective N-methyl-d-aspartate(NmDA)receptor ligands

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Acta Pharmaceutica Sinica B 2024年第5期14卷 1987-2005页

作者： Liyang Jiang na Liu Fabao Zhao Boshi Huang Dongwei Kang Peng Zhan Xinyong Liu Department of medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China

The N-methyl-d-aspartate(NmDA)receptors,which belong to the ionotropic Glutamate receptors,constitute a family of ligand-gated ion *** the various subtypes of NmDA receptors,the GluN1/2A subtype plays a significant role in central nervous system(CNS)*** present article aims to provide a comprehensive review of ligands targeting GluN2A-containing NmDA receptors,encompassing negative allosteric modulators(nams),positive allosteric modulators(PAms)and competitive ***,the ligands’structure–activity relationships(SARs)and the binding models of representative ligands are also discussed,providing valuable insights for the clinical rational design of effective drugs targeting CNS diseases.

关键词： NmDA receptors GluN2A subtype Subtype-selective ligands SARs Protein ligand interactions