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Osteoporosis and People with Down Syndrome: A Preliminary Descriptive Examination of the Intellectual Disability Supplement to the Irish Longitudinal Study on Ageing Wave 1 Results

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Health 2018年第9期10卷 1233-1249页

作者： éilish A. Burke Rachael Carroll Máire O’Dwyer j. bernard Walsh Philip McCallion Mary McCarron School of Nursing and Midwifery Trinity College Dublin Dublin Ireland School of Pharmacy and Pharmaceutical Sciences Trinity College Dublin Dublin Ireland Department of Medical Gerontology Trinity College Dublin Dublin Ireland College of Public Health Temple University Philadelphia PA USA Faculty of Health Sciences Trinity College Dublin Dublin Ireland

Background: People with Down syndrome (DS) are a high “at risk” group to develop osteoporosis. Increased morbidity associated with older age, higher prevalence of Alzheimer dementia, hypotonia, hypogonadism, and thyroid disease, are all features of DS and predispose this cohort to musculoskeletal complications. Methods: The Intellectual Disability Supplement to The Irish Longitudinal Study on Ageing (IDS-TILDA) is a representative study of the aging of adults with intellectual disability in Ireland. The sample (N = 753) included 147 people with DS. Data was gathered on participants’ health status, behavioural health, health screenings and activities of daily living. The prevalence of osteoporosis and related risk factors among people with DS was specifically examined. Findings: Of the 147 participants with DS, 9.4% reported a doctor’s diagnosis of osteoporosis;a much lower figure than prevalence of risk factors would suggest. Predisposing factors identified included higher than general population rates of thyroid disease (37.4%), epilepsy (19.3%), sedentary lifestyle (51.7%) and the majority of the females reporting having experienced menopause (61%). Bone health screening was low at (8%) despite the presence of such high levels of risk factors in this population. Conclusion: Given the risk factor findings and the hidden nature of osteoporosis, underreported incidence among people with Down syndrome seems probable. Further investigations and systematic screening are required.

关键词： Intellectual Disability Down Syndrome Osteoporosis Bone Health Bone Fragility Risk

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Ar^+和He^+离子与C_(60)碰撞后富勒希离子的激发机制

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原子与分子物理学报 2004年第B4期21卷 213-215页

作者：魏宝仁 L.Chen j.bernard R.Bredy S.Martin 中国科学院近代物理研究所兰州730000 Laboratoire de Spectrométrie Ionique et Moléculaire Université Lyon1

C60 在与重离子作用下的激发机制与入射离子能量、质量及电荷态有关。核阻止主要出现在低能重离子与C60 的碰撞中 ;而高能轻离子作用下 ,电子阻止迅速增强 ,成为主要的激发方式。本文中直接观察到由弹性碰撞引起的C+ 峰 ,及其丰度依赖... 详细信息

C60 在与重离子作用下的激发机制与入射离子能量、质量及电荷态有关。核阻止主要出现在低能重离子与C60 的碰撞中 ;而高能轻离子作用下 ,电子阻止迅速增强 ,成为主要的激发方式。本文中直接观察到由弹性碰撞引起的C+ 峰 ,及其丰度依赖于入射离子的质量。同时我们还发现电子阻止随入射离子能量 (7～ 2 0keV)增大相应增加 ,这与绝热量子分子动力学计算的结果一致。

关键词：核阻止电子阻止激发机制

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重磁资料的人机联作处理

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国外地质勘探技术 1987年第5期 31-31页

作者： j.bernard 刘心铸法国B.G.M和C.F.P

对于一个给定的位场,一般无法求得场源分布的唯一解,除非再利用其他一些信息。因此模拟和反演都应考虑与地质环境有关的约束条件,例如构造上的对比及几何形态。应该根据解释人员的意愿,采用各种方法以得到特定的解答。在资料处理过程中... 详细信息

对于一个给定的位场,一般无法求得场源分布的唯一解,除非再利用其他一些信息。因此模拟和反演都应考虑与地质环境有关的约束条件,例如构造上的对比及几何形态。应该根据解释人员的意愿,采用各种方法以得到特定的解答。在资料处理过程中,求剩余场,场的分离及转换等技术常常是需要的。GMI程序包是法国C.F.P和B.R.G.M联合研制的一个功能齐全的重磁资料解释系统,它在资料的处理与模拟中采用图像显示与人机联作的新技术。我们将通过矿产与

关键词：重磁资料图像显示功能程序包 GMI 人机联作交互解释联合反演

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今天无纺织布用的粘合剂和化学品

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产业用纺织品 1983年第3期 27-29+41页

作者： bernard j.Obenski ,俞镇慌

很多采用湿法或者干法生产的无纺织布,其中粘合剂的含量占到整个布重的1/4～1/2,因此最好将无纺织布称作粘合布更合适。实际上粘合剂对纤维的比例一般位于5～300%之间。由于这些粘合型无纺织布在纺织品市场上占了很大的一个部分,因此化... 详细信息

很多采用湿法或者干法生产的无纺织布,其中粘合剂的含量占到整个布重的1/4～1/2,因此最好将无纺织布称作粘合布更合适。实际上粘合剂对纤维的比例一般位于5～300%之间。由于这些粘合型无纺织布在纺织品市场上占了很大的一个部分,因此化学品制造厂,有时

关键词：无纺织布纺织品市场纤维网粘合剂丁苯胶乳化学品

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Dobutamine Infusion and Absence of Pulmonary Hypertension Are Associated with Decreased Mortality in a Cohort of 249 Patients with Cardiogenic Shock

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Health 2014年第18期6卷 2408-2415页

作者： Sébastien Champion bernard A. Gaüzère David Vandroux Bruno j. Bouchet Didier Drouet Yannick Lefort Réanimation Polyvalente CHU de la Réunion H&ocirc pital Félix Guyon Saint Denis France

Objective: Prognostic analysis of 249 patients admitted for cardiogenic shock (CS) of various origins. Background: Little is known about prognosis of CS from non-ischemic cardiomyopathy. Methods: Retrospective monocentric study of patients referred to an ICU during 2 years. Results: Despite aggressive management including intra-aortic balloon pump (31%), extra-renal replacement therapy (36%), extra-corporeal life support (8%), and catecholamine infusion (97%), in-hospital mortality was 46%. Toxic CS or CS related to deficiency carried a better outcome (mortality 5%). Post-myocardial infarction or post-cardiac arrest CS was associated with higher mortality. In the multivariate analyses, only SAPS II (OR 1.037;1.013 - 1.056;p = 0.0001), pulmonary hypertension (OR 4.8;1.3 - 17;p = 0.02), extra-renal replacement therapy (OR 2.9;1.3 - 6;p = 0.006), and dobutamine infusion (OR 0.44;0.2 - 0.96;p = 0.04) were significantly associated with in-hospital mortality. Conclusion: Dobutamine infusion was associated with a better outcome. Higher SAPS II, pulmonary hypertension, and extra-renal replacement therapy were associated with increased in-hospital mortality.

关键词： Cardiogenic Shock Myocardial Infarction Catecholamine Pulmonary Hypertension Dobutamine Critically Ill

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Chromosome Based Strategies to Decipher the Structure and Evolution of the Hexaploid Wheat Genome: Chromosome 3B,a Case Study

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分子植物育种 2007年第2期5卷 167-168页

作者： E. Paux P. Sourdille j. Salse P. Leroy j. Dolezel M. bernard C. Feuillet Genetics and Plant Breeding UMR INRA-UBP Domaine de Crouelle 234 Ave du Brezet Clermont-Ferrand 63100 France Laboratory of Molecular Cytogenetics and Cytometry IEB Sokolovska 6 CZ-77200 Olomouc Czech Republic

With 17% of all crop area, wheat is the staple food for 40% of the world’s population. Improvement in bread wheat quality and yield in the context of sustainable agriculture is needed in the next decades to meet human

关键词：六倍体小麦基因染色体

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Early pregnancy maternal cardiovascular profiling in the prediction of hypertensive disease in pregnancy

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Open journal of Obstetrics and Gynecology 2014年第2期4卷 61-65页

作者： jennifer Hogan Vicky O’Dwyer Nadine Farah Mairead M. Kennelly Michael j. Turner bernard Stuart UCD Centre for Human Reproduction Coombe Women and Infants University Hospital Dublin Ireland

Prediction of hypertensive disease in pregnancy remains challenging. Risk factor based screening utilizing history, physical characteristics, uterine artery Doppler and serum markers have been used with varying success. As hypertension in pregnancy appears to be associated with changes in the maternal vasculature, we have investigated the utility of maternal arterial elasticity measurement, prior to 20 weeks gestation, in the prediction of hypertensive disease in pregnancy. A HDI/Pulsewave CR2000 Research Cardiovascular Profiling System was used to obtain radial artery pulse pressure waveforms from 623 Caucasian women at the time of their first antenatal visit. Outcome data were available in 610 cases and these comprised the study group. The results showed that women who subsequently developed gestational hypertension (n = 20) had higher baseline systolic, diastolic and pulse pressure values (though within the normal range) but similar arterial elasticity to those patients who did not develop hypertension. Women who later developed pre-eclampsia (n = 23) had, in addition, reduced large artery elasticity and increased systemic vascular resistance compared with women who did not develop hypertension. The measurement of maternal radial artery elasticity in early pregnancy may provide an additional refinement in screening for hypertensive disease, particularly pre-eclampsia, in pregnancy.

关键词： Pre-Eclampsia Gestational Hypertension Arterial Wall Elasticity Pulse Pressure Wave Analysis

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