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Telencephalic stab wound injury induces regenerative angiogenesis and neurogenesis in zebrafish:unveiling the role of vascular endothelial growth factor signaling and microglia

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Neural Regeneration Research 2025年第10期20卷 2938-2954页

作者： Danielle Fernezelian philippe Rondeau Laura Gence Nicolas Diotel Universitéde La Réunion INSERMUMR 1188Diabète athérothrombose Thérapies Réunion Océan Indien(DéTROI)Saint PierreLa RéunionFrance

After brain damage,regenerative angiogenesis and neurogenesis have been shown to occur simultaneously in mammals,suggesting a close link between these ***,the mechanisms by which these processes interact are not well *** this work,we aimed to study the correlation between angiogenesis and neurogenesis after a telencephalic stab wound *** this end,we used zebrafish as a relevant model of neuroplasticity and brain repair ***,using the Tg(fli1:EGFP×mpeg1.1:mCherry)zebrafish line,which enables visualization of blood vessels and microglia respectively,we analyzed regenerative angiogenesis from 1 to 21 days *** parallel,we monitored brain cell proliferation in neurogenic niches localized in the ventricular zone by using *** found that after brain damage,the blood vessel area and width as well as expression of the fli1 transgene and vascular endothelial growth factor(vegfaa and vegfbb)were *** the same time,neural stem cell proliferation was also increased,peaking between 3 and 5 days post-lesion in a manner similar to angiogenesis,along with the recruitment of ***,through pharmacological manipulation by injecting an anti-angiogenic drug(Tivozanib)or Vegf at the lesion site,we demonstrated that blocking or activating Vegf signaling modulated both angiogenic and neurogenic processes,as well as microglial ***,we showed that inhibition of microglia by clodronate-containing liposome injection or dexamethasone treatment impairs regenerative neurogenesis,as previously described,as well as injury-induced *** conclusion,we have described regenerative angiogenesis in zebrafish for the first time and have highlighted the role of inflammation in this *** addition,we have shown that both angiogenesis and neurogenesis are involved in brain repair and that microglia and inflammation-dependent mechanisms activated by Vegf signaling are important contributors to

关键词： angiogenesis cerebral damage inflammation neurogenesis stab wound telencephalon vascular endothelial growth factor zebrafish

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面向有机污染物消除的“微生物、植物、电”多效耦合作用机制及低能耗型修复技术

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生物工程学报 2021年第10期37卷 3405-3410页

作者：刘双江 philippe F.-X.corvini Korneel Rabaey 中国科学院微生物研究所微生物资源国家重点实验室北京100101 山东大学微生物技术国家重点实验室山东青岛266237 School of Life Sciences University of Applied Sciences and Arts Northwestern SwitzerlandMuttenz 4132Switzerland 南京大学环境学院江苏南京210023 Center for Microbial Ecology and Technology(CMET) Ghent UniversityGhentBelgium

中欧合作项目“面向有机污染物消除的‘微生物、植物、电’多效耦合作用机制及低能耗型修复技术”是由中国国家自然科学基金委和欧盟共同资助的重大国际合作项目。该项目研究领域属于环境生物技术,研究团队包括5个中方单位和17个欧方单... 详细信息

中欧合作项目“面向有机污染物消除的‘微生物、植物、电’多效耦合作用机制及低能耗型修复技术”是由中国国家自然科学基金委和欧盟共同资助的重大国际合作项目。该项目研究领域属于环境生物技术,研究团队包括5个中方单位和17个欧方单位,项目主要围绕新有机污染物的生物降解过程和机制、低能耗生物修复技术开展研究工作。项目执行2年来,在降解污染物的微生物资源、弱电介入增效生物降解和强化电子传递、微生物3D打印等方面取得了阶段性成果的同时,项目团队还开展了有效的交流和实质性合作。未来,项目团队将克服新冠疫情影响,强化中欧双方团队内部和团队之间的合作交流,全面实现项目科学目标,圆满完成国际合作任务。

关键词：中国-欧盟合作环境生物技术新有机污染物生物降解弱电低能耗生物修复技术

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Effects of Cu^(2+)and humic acids on degradation and fate of TBBPA in pure culture of Pseudomonas *** CDT

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Journal of Environmental Sciences 2017年第12期29卷 60-67页

作者： Yini Ma Yingying Zhao Yongfeng Wang Xiangzhen Li Feifei Sun Phillippe Francois-Xavier corvini Rong Ji State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210023China Key Laboratory of Environmental and Applied Microbiology Chengdu Institute of BiologyChinese Academy of SciencesChengdu 610041China Institute for Ecopreneurship School of Life SciencesUniversity of Applied Sciences and Arts Northwestern SwitzerlandGrundenstrasse 40Muttenz CH-4132Switzerland

Soil contamination with tetrabromobisphenol A（TBBPA） has caused great concerns;however, the presence of heavy metals and soil organic matter on the biodegradation of TBBPA is still unclear. We isolated Pseudomonas sp. strain CDT, a TBBPA-degrading bacterium, from activated sludge and incubated it with ^（14）C-labeled TBBPA for 87 days in the absence and presence of Cu^（2＋）and humic acids（HA）. TBBPA was degraded to organic-solvent extractable（59.4% ± 2.2%） and non-extractable（25.1% ± 1.3%） metabolites,mineralized to CO_2（4.8% ± 0.8%）, and assimilated into cells（10.6% ± 0.9%） at the end of incubation. When Cu^（2＋）was present, the transformation of extractable metabolites into non-extractable metabolites and mineralization were inhibited, possibly due to the toxicity of Cu^（2＋）to cells. HA significantly inhibited both dissipation and mineralization of TBBPA and altered the fate of TBBPA in the culture by formation of HA-bound residues that amounted to 22.1% ± 3.7% of the transformed TBBPA. The inhibition from HA was attributed to adsorption of TBBPA and formation of bound residues with HA via reaction of reactive metabolites with HA molecules, which decreased bioavailability of TBBPA and metabolites in the culture. When Cu^（2＋）and HA were both present, Cu^（2＋）significantly promoted the HA inhibition on TBBPA dissipation but not on metabolite degradation. The results provide insights into individual and interactive effects of Cu^（2＋）and soil organic matter on the biotransformation of TBBPA and indicate that soil organic matter plays an essential role in determining the fate of organic pollutants in soil and mitigating heavy metal toxicity.

关键词： Tetrabromobisphenol-A Biodegradation Soil organic matter Heavy metals Fate

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土壤中四溴双酚A不可提取态残留的降解转化

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科学通报 2019年第33期64卷 3458-3466页

作者：王松凤吴玄王麒麟王永峰王联红 philippe Fran?ois-Xavier corvini 孙棐斐季荣南京大学环境学院污染控制与资源化研究国家重点实验江苏省中国科学院植物研究所 Institute for Ecopreneurship School of Life Sciences University of Applied Sciences and Arts Northwestern Switzerland

四溴双酚A(tetrabromobisphenol A, TBBPA)在各种氧化还原状态土壤中均可形成大量的不可提取态残留(nonextractable residues, TBBPA-NER).然而TBBPA-NER在环境中的稳定性和生物可利用性目前还鲜见报道.本研究以TBBPA在淹水条件和有氧... 详细信息

四溴双酚A(tetrabromobisphenol A, TBBPA)在各种氧化还原状态土壤中均可形成大量的不可提取态残留(nonextractable residues, TBBPA-NER).然而TBBPA-NER在环境中的稳定性和生物可利用性目前还鲜见报道.本研究以TBBPA在淹水条件和有氧条件下分别形成的不可提取态残留(即flooded-nonextractable residues, F-NER和oxicnonextractable residues, O-NER)为研究对象,分析了有氧条件下F-NER的归趋,以及土壤氧化还原状态改变下, FNER和O-NER环境行为的差异;同时研究了水稻根系分泌物对上述过程的影响.结果显示,有氧条件连续培养231 d中, F-NER在土壤中发生了缓慢的生物转化.尽管F-NER在土壤中释放出的可提取态量很低(1%~6%),但是矿化>10%,且酯键和醚键结合部分有所消减.土壤氧化还原状态的改变(即0~50 d有氧, 50~103 d淹水, 103~231 d有氧)对F-NER的矿化影响很小;而TBBPA-NER在土壤中的降解转化受形成条件影响较大,表现为有氧-淹水-有氧培养下F-NER的矿化量,以及释放量均显著高于O-NER. F-NER受环境因素的影响更大,水稻根系分泌物抑制了FNER在有氧环境下的矿化,而淹水条件促进了F-NER的释放产物在土壤中的累积.结果证明,土壤中添加根系分泌物以及氧化还原状态转变等,在不同程度上影响了两种NER在土壤中的生物转化.

关键词：四溴双酚A 不可提取态残留根系分泌物氧化还原条件释放

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中欧环境和微生物科学家:共同担当起保护地球家园的责任

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生物工程学报 2021年第10期37卷 3401-3404页

作者：刘双江季荣 philippe F.-X.corvini Korneel Rabaey 山东大学微生物技术国家重点实验室山东青岛266237 中国科学院微生物研究所微生物资源国家重点实验室北京100101 南京大学环境学院江苏南京210023 School of Life Sciences University of Applied Sciences and Arts Northwestern SwitzerlandMuttenz 4132Switzerland Center for Microbial Ecology and Technology(CMET) Ghent UniversityGhentBelgium

国际科技合作是促进科技进步和人类社会文明发展的重要举措,在环境保护和维护地球生态系统良好运行的目标下,最容易达成共识。中国国家自然科学基金委员会和欧盟委员会2018年和2019年分别发布了在环境生物技术领域合作的项目指南,共同... 详细信息

国际科技合作是促进科技进步和人类社会文明发展的重要举措,在环境保护和维护地球生态系统良好运行的目标下,最容易达成共识。中国国家自然科学基金委员会和欧盟委员会2018年和2019年分别发布了在环境生物技术领域合作的项目指南,共同支持环境生物修复技术和塑料降解微生物菌群相关领域的基础研究和成果转化。本专刊邀请了相关项目负责人介绍合作框架内项目的设计思想、主要内容以及获得的进展,并收录了在环境生物修复技术领域的基础研究和成果转化方面的论文23篇。

关键词：生物修复环境保护中国欧盟国际合作

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3D生物打印技术在微生物修复中的应用（英文）

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生物工程学报 2021年第10期37卷 3475-3486页

作者：柯壮 Osagie Obamwonyi Boris Kolvenbach 季荣刘双江蒋建东 philippe F.-X.corvini 南京农业大学生命科学学院农业部农业环境微生物重点实验室 Institute for Ecopreneurship University of Applied Sciences and Arts Northwestern Switzerland (FHNW)School of Life Sciences 南京大学环境学院污染控制与资源化利用国家重点实验室中国科学院微生物研究所微生物资源前期开发国家重点实验室

排放到环境中的各种农药、多环芳烃、卤代芳烃等有机污染物以及阻燃剂等新兴污染物,对环境污染、农产品质量和环境安全造成了沉重负担。因此,有效去除环境中的有机污染物已成为迫在眉睫的挑战。3D生物打印技术已经在医学材料、制药等行... 详细信息

排放到环境中的各种农药、多环芳烃、卤代芳烃等有机污染物以及阻燃剂等新兴污染物,对环境污染、农产品质量和环境安全造成了沉重负担。因此,有效去除环境中的有机污染物已成为迫在眉睫的挑战。3D生物打印技术已经在医学材料、制药等行业中发挥着重要作用。现在,越来越多的微生物被确定适合通过3D生物打印生产具有复杂结构和功能的生物材料。微生物的3D生物打印越来越受到环境微生物学家和生物技术专家的关注。本文综述了用于污染物微生物去除的不同3D生物打印技术的原理和优缺点,及用于微生物生物修复技术的可行性,并指出了可能遇到的限制和挑战。

关键词：有机污染物微生物修复技术 3D生物打印技术多细胞3D生物打印

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A review of numerical analyses and experimental characterization methods for forming of textile reinforcements

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Chinese Journal of Aeronautics 2021年第8期34卷 143-163页

作者： Biao LIANG philippe BOISSE School of Mechanical Engineering Northwestern Polytechnical UniversityXi'an 710072China Universitede Lyon CNRSINSA-LyonLaMCoSF69621France

The forming of textile reinforcements is an important stage in the manufacturing of textile composite parts with Liquid Composite Molding *** orientations and part geometry obtained from this stage have significant impact on the subsequent resin injection and final mechanical properties of composite *** simulation of textile reinforcement forming is in strong demand as it can greatly reduce the time and cost in the determination of the optimized processing parameters,which is the foundation of the low-cost application of composite *** review presents the state of the art of forming modeling methods for textile reinforcement and the corresponding experimental characterization methods developed in this *** microscopic,mesoscopic and macroscopic models are *** concerning the simulation of wrinkling are also presented since it is the most common defect occurred in the textile reinforcement ***,challenges and recommendations on the future research directions for textile reinforcement modeling and experimental characterization are provided.

关键词： Experimental characterization Forming Liquid Composite Molding Numerical analysis Textile reinforcements

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Advantages and Drawbacks of Quantum Mechanical Static and Dynamic Approaches to Modelling Infrared Spectra

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Chinese Journal of Chemical Physics 2009年第2期22卷 123-128页

作者： Claude Pouchan philippe Carbonniere Groupe Chimie Théorique et Réactivité ECP IPREM UMR CNRS 5254 Université de Pau et des Pays de I'Adour 2 Rue Jules Ferry F-54000 Pau France

We present quantum mechanical vibrational computations beyond the harmonic approximation from effective second order perturbative and variation perturbation treatments defined as static approaches, as well as vibrational analysis from density functional theory molecular dynamics trajectories at 300 and 600 K. The four schemes are compared in terms of prediction of fundamental transitions, and simulation of the corresponding medium infrared spectrum at the same level of theory using the B3LYP/6-31＋G（d,p） description of the electronic structure. We summarize conclusions about advantages and drawbacks of these two approaches and report the main results obtained for semi-rigid and flexible molecules.

关键词： Anharmonic vibrations Vibrational configuration interaction Perturbative approach Ab initio molecular dynamic treatment

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Ba promoter effect on cobalt-catalyzed ammonia decomposition kinetics: A theoretical analysis

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Journal of Energy Chemistry 2024年第12期99卷 182-192页

作者： Zahra Almisbaa philippe Sautet Department of Chemical and Biomolecular Engineering University of CaliforniaLos AngelesCA 90095United States Department of Chemistry and Biochemistry University of CaliforniaLos AngelesCA 90095United States

Ammonia decomposition is a key reaction in the context of hydrogen storage, transport, and release. This study combines density functional theory(DFT) calculations with microkinetic modeling to address the promotion mechanism of Ba species for ammonia decomposition on Co catalysts. The modified adsorption properties of Co upon the addition of metallic Ba or BaO suggest that the promoters play a role in alleviating the competitive adsorption of H. Calculating the full reaction pathway of ammonia decomposition shows that limiting the investigation to the N–N association step, as done previously, overlooks the effect of the promoter on the energy barriers of the NHxdehydrogenation steps. Challenges of modeling the ammonia decomposition reaction are addressed by understanding that the NH_(2) intermediate is stabilized on the step sites rather than the terrace sites. When the effect of H-coverage on the adsorption of NH_(3) is not considered in the microkinetic simulations, the results conflict with the ***, accounting for the effect of H-coverage, as performed here, shows that BaO-doped Co has higher rates than pristine Co and Ba-doped Co at the reaction temperature of 723.15 K. When H is adsorbed on the Ba-doped Co, the adsorption of ammonia becomes significantly endergonic, which makes the rates relatively slow. The superiority of the BaO-promoted catalyst is attributed to a lower energy for the transition state of the rate-determining step, coupled with a reduced impact of the hydrogen coverage on weakening the ammonia adsorption. The kinetic analysis of the influence of Ba and BaO on the Co surface shows that BaO-doped Co aligns more closely with experimental observations than Badoped Co. This implies that Ba on the Co surface is likely to be in an oxide form under reaction *** the kinetics of the ammonia decomposition reaction provides a foundation for developing highly effective catalysts to accelerate the industrial utilizatio

关键词： Cobalt catalyst Ammonia decomposition Hydrogen carrier DFT Microkinetic

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Intersectional gene inactivation: there is more to conditional mutagenesis than Cre

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Science China(Life Sciences) 2018年第9期61卷 1115-1117页

作者： philippe Soriano Department of Cell Developmental and Regenerative Biology Icahn School of Medicine at Mount Sinai

The efforts of many laboratories worldwide and large scale international mutagenesis consortia have resulted in mutagenesis of nearly all mouse genes, and present efforts are devoted to large scale phenotyping of germline null mutant mice (Ayadi et al., 2012). Although early lethality associated with loss of function of a given gene may prevent elucidating its function at a later stage or in a given tissue, conditional alleles in which a critical part of the gene is flanked by recombinase target sites provide an opportunity for addressing gene function at later stages (Branda and Dymecki,2004). Fortunately, many of the mutant alleles generated by the consortia allow for conditional mutagenesis using site directed recombinases.

关键词： there is more to conditional mutagenesis than Cre

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