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Protein-S-100-beta is increased in patients with decompensated cirrhosis admitted to ICU

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Journal of Intensive Medicine 2024年第2期4卷 222-230页

作者： Nicolas Weiss Simona Tripon Maxime Mallet Françoise Imbert-Bismut Mehdi Sakka Dominique Bonnefont-Rousselot philippe Sultanik Sarah Mouri Marika Rudler Dominique Thabut Sorbonne Université AP-HP.Sorbonne UniversitéHôpital de la Pitié-SalpêtrièreDépartement de NeurologieUnitéde Médecine Intensive RéanimationàOrientation NeurologiqueParisFrance Brain Liver Pitié-Salpêtrière(BLIPS)Study Group INSERM UMR_S 938Centre de recherche Saint-AntoineMaladies métaboliquesBiliaires et Fibro-Inflammatoire du FoieInstitute of Cardiometabolism and Nutrition(ICAN)ParisFrance Groupe de Recherche Clinique en REanimation et Soins intensifs du Patient en Insuffisance Respiratoire aiguE(GRC-RESPIRE)Sorbonne Université ParisFrance Assistance Publique-Hôpitaux de Paris AP-HP.Sorbonne UniversitéHôpital de la Pitié-SalpêtrièreService d'hépato-GastroentérologieUnitéde Soins Intensifs d'HépatologieParisFrance Assistance Publique-Hôpitaux de Paris AP-HP.Sorbonne UniversitéService de Biochimie MétaboliqueHôpitaux Universitaires Pitié-Salpêtrière-Charles FoixDMU BioGeMParis F-75013France UniversitéParis Cité UFR de PharmacieCNRSInsermUTCBSParisFrance

Background Hepatic encephalopathy(HE)is highly prevalent in patients with liver *** pathophysiology of HE is centered on the synergic role of hyperammonemia and systemic ***,some data suggest altered functioning of the blood–brain barrier(BBB).Assessing BBB function is challenging in clinical practice and at the ***-S-100 Beta(PS100-Beta)could be a useful peripheral marker of BBB permeability in *** study aimed to assess plasmatic PS100-Beta levels in a prospective cohort of patients admitted to the intensive care unit(ICU)with decompensated cirrhosis with and without overt *** We retrospectively evaluated a prospective cohort of cirrhotic patients admitted to the ICU from October 2013 to September 2015 that had an available plasmatic PS100-Beta *** with previous neurological impairment or limitation of intensive or resuscitative measures were *** HE was defined as West-Haven grades 2 to *** patients were compared to a control cohort of outpatient clinic cirrhotic and non-cirrhotic patients explored for isolated elevation of liver *** ICU discharge,the patients were followed for at least 3 months for the occurrence of overt *** outcomes(liver transplantation or death)were *** ability of PS100-Beta–in combination with other factors–to predict overt HE was evaluated in a multivariate analysis using logistic *** ratios were used to determine the effects and calculate odds ratios(OR).Survival analysis was performed by using the Kaplan–Meier method and survival between groups was compared using a Log-rank *** A total of 194 ICU patients and 207 outpatients were included in the *** levels of plasmatic PS100-Beta were detected in the ICU decompensated cirrhotic patients compared with the outpatients([0.15±0.01]mg/L vs.[0.08±0]mg/L,P<0.001).ICU patients with overt HE had higher levels of PS100-Beta([0.19±0.03]mg/L)compared with the

关键词： Cirrhosis Hepatic encephalopathy Blood-brain barrier PS100-Beta Liver disease

Severe asthma exacerbation:Changes in patient characteristics,management,and outcomes from 1997 to 2016 in 40 ICUs in the greater Paris area

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Journal of Intensive Medicine 2024年第2期4卷 209-215页

作者： Romy Younan Jean Loup Augy Bertrand Hermann Bertrand Guidet philippe Aegerter Emmanuel Guerot Ana Novara Caroline Hauw-Berlemont Amer Hamdan Clotilde Bailleul Francesca Santi Jean-Luc Diehl Nicolas Peron Nadia Aissaoui Intensive Care Unit AP-HPGeorges Pompidou European HospitalUniversitéde ParisParisFrance Intensive Care Unit AP-HPSaint Antoine HospitalUniversités de SorbonneUniversitéPierre et Marie CurieParisFrance INSERM U1136 ParisFrance Versailles Saint-Quentin-en-Yvelines University INSERM U1018Groupe Interrégional de Recherche Clinique et d'InnovationÎle-de-FranceFrance Respiratory Medicine Department AP-HPGeorges Pompidou European HospitalUniversitéde ParisParisFrance Innovative Therapies in Hemostasis INSERM UMR-S1140Universitéde ParisParisFrance Intensive Care Unit and Biosurgical Research Lab(Carpentier Foundation) AP-HPGeorges Pompidou European HospitalParisFrance Paris-Cardiovascular-Research-Center INSERM U970ParisFrance

Background Despite advances in asthma treatments,severe asthma exacerbation(SAE)remains a life-threatening condition in adults,and there is a lack of data derived from adult patients admitted to intensive care units(ICUs)for *** current study investigated changes in adult patient characteristics,management,and outcomes of SAE over a 20-year period in 40 ICUs in the greater Paris *** In this retrospective observational study,admissions to 40 ICUs in the greater Paris area for SAE from January 1,1997,to December 31,2016 were *** primary outcome was the proportion of ICU admissions for SAE during 5-year *** outcomes were ICU and hospital mortality,and the use of mechanical ventilation and *** analysis was performed to assess factors associated with ICU *** A total of 7049 admissions for SAE were *** each 5-year period,the proportion decreased over time,with SAE accounting for 2.84%of total ICU admissions(n=2841)between 1997 and 2001,1.76%(n=1717)between 2002 and 2006,1.05%(n=965)between 2007 and 2011,and 1.05%(n=1526)between 2012 and *** median age was 46 years(interquartile range[IQR]:32–59 years),55.41%were female,the median Simplified Acute Physiology Score II was 20(IQR:13–28),and 19.76%had mechanical *** use of mechanical ventilation remained infrequent throughout the 20-year period,whereas the use of catecholamine *** and hospital mortality rates *** associated with ICU mortality were renal replacement therapy,catecholamine,cardiac arrest,pneumothorax,acute respiratory distress syndrome,sepsis,and invasive mechanical ventilation(IMV).Non-survivors were older,had more severe symptoms,and were more likely to have received *** ICU admission for SAE remains uncommon,and the proportion of cases decreased over *** a slight increase in symptom severity during a 20-year period,ICU and hospital mortality *** requirin

关键词： Epidemiology Intensive care unit Mechanical ventilation Severe asthma exacerbation

Advantages and Drawbacks of Quantum Mechanical Static and Dynamic Approaches to Modelling Infrared Spectra

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Chinese Journal of Chemical Physics 2009年第2期22卷 123-128页

作者： Claude Pouchan philippe Carbonniere Groupe Chimie Théorique et Réactivité ECP IPREM UMR CNRS 5254 Université de Pau et des Pays de I'Adour 2 Rue Jules Ferry F-54000 Pau France

We present quantum mechanical vibrational computations beyond the harmonic approximation from effective second order perturbative and variation perturbation treatments defined as static approaches, as well as vibrational analysis from density functional theory molecular dynamics trajectories at 300 and 600 K. The four schemes are compared in terms of prediction of fundamental transitions, and simulation of the corresponding medium infrared spectrum at the same level of theory using the B3LYP/6-31＋G（d,p） description of the electronic structure. We summarize conclusions about advantages and drawbacks of these two approaches and report the main results obtained for semi-rigid and flexible molecules.

关键词： Anharmonic vibrations Vibrational configuration interaction Perturbative approach Ab initio molecular dynamic treatment

Early evolution of life cycles in embryophytes: A focus on the fossil evidence of gametophyte/sporophyte size and morphological complexity

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Journal of Systematics and Evolution 2011年第1期49卷 1-16页

作者： philippe GERRIENNE Paul GONEZ Palobotanique Palopalynologie et Micropalontologie Unit Department of Geology University of Liege

Embryophytes (land plants) are distinguished from their green algal ancestors by diplobiontic life cycles, that is, alternation of multicellular gametophytic and sporophytic generations. The bryophyte sporophyte is small and matrotrophic on the dominant gametophyte; extant vascular plants have an independent, dominant sporophyte and a reduced gametophyte. The elaboration of the diplobiontic life cycle in embryophytes has been thoroughly discussed within the context of the Antithetic and the Homologous Theories. The Antithetic Theory proposes a green algal ancestor with a gametophyte-dominant haplobiontic life cycle. The Homologous Theory suggests a green algal ancestor with alternation of isomorphic generations. The shifts that led from haplobiontic to diplobiontic life cycles and from gametophytic to sporophytic dominance are most probably related with terrestrial habitats. Cladistic studies strongly support the Antithetic Theory in repeatedly identifying charophycean green algae as the closest relatives of land plants. In recent years, exceptionally well-preserved axial gametophytes have been described from the Rhynie chert (Lower Devonian, 410 Ma), and the complete life cycle of several Rhynie chert plants has been reconstructed. All show an alternation of more or less isomorphic generations, which is currently accepted as the plesiomorphic condition among all early polysporangiophytes, including basal tracheophytes. Here we review the existing evidence for early embryophyte gametophytes. We also discuss some recently discovered plants preserved as compression fossils and interpreted as gametophytes. All the fossil evidence supports the Antithetic Theory and indicates that the gametophytic generation/sporophytic generation size and complexity ratios show a gradual decrease along the land plant phylogenetic tree.

关键词： Devonian early land plants embryophyte gametophyte life cycle sporophyte.

Epidemio-Clinical-Histopathological Aspects and Therapeutics of Squamous Cell Carcinoma of the Conjunctival at the University Hospital Center of Bouake

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Open Journal of Ophthalmology 2024年第2期14卷 159-167页

作者： philippe Emile France Koffi Bile Pierre Windinmanegde Djiguimde Gossé François Diomandé Zana Diabate Kouassi Franck-Hermann Koffi Liliale Ella Godé Ange Mickael Goule Opeyemi Babayeju Yves Ouattara Ibrahim Abib Diomande Ophthalmology Department University Hospital Center Bouake C&#244te d&#8217Ivoire Ophthalmology Department University Hospital Center Bogodogo Ouagadougou Burkina Faso

Introduction: Squamous cell carcinoma of the conjunctiva is one of the most common malignancies in the elderly. Purpose: To describe the specific aspects of squamous cell carcinoma of the conjunctiva and to determine the therapeutic modalities. Materials and Methods: Descriptive cross-sectional retrospective study carried out at the University Hospital Center of Bouake over a period of 9 years (From January 2015 to December 2023). We identified all malignant oculo-adnexal and orbital tumors whose histopathological diagnosis was confirmed;monitoring the sorting of squamous cell carcinomas of the conjunctiva among these cancers and studying the different parameters linked to them. Results: The average age of patients is 44.3 years. Male predominance with a sex ratio of 1.12. HIV was the majority ATCD with 64.7%. The main reason for consultation was exophthalmos (36.11%). The average consultation time was 10 months 13 days. Invasive differentiated conjunctival squamous cell carcinoma was predominant at 55.56%. Enucleation was the most performed surgical method. Conclusion: Squamous cell carcinoma of the conjunctiva is a malignant ocular tumor of the elderly whose frequency increases in young adults infected with HIV-AIDS. Invasive differentiated forms are increasingly encountered, limiting treatment to mutilating surgery.

关键词： Malignant Tumor Ocular Carcinoma Conjunctiva

Visceral Leishmaniasis at the National Reference University Hospital Center of N’Djamena (Chad): Epidemiological, Clinical, Diagnostic, Therapeutic and Prognostic Aspects

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Advances in Infectious Diseases 2024年第2期14卷 478-486页

作者： Joseph Mad-Toïngué Mahamat Ali Ahmat Oumaïma Mahamat Djarma Alifa Adjibera philippe Ali Mahamat Moussa Ngakoutou Rangar Choua Ouchemi Mahamat Ali Bolti Djiddi Ali Sougoudi Mamissou Didi Mahamat Doungous Atim Service des Maladies Infectieuses CHU de Référence Nationale N’Djamena Chad Service de Gastroentérologie et Médecine Interne CHU de Référence Nationale N’Djamena Chad Service de Pneumologie et Phtisiologie CHU de Référence Nationale N’Djamena Chad Service de Chirurgie viscérale CHU de Référence Nationale N’Djamena Chad Service de Médecine CHU de la Renaissance N’Djamena Chad

Introduction: leishmaniasis is a group of parasitic diseases caused by a parasite of the genus Leishmania transmitted by the bite of an infected vector called a sandfly. There are four forms. Visceral leishmaniasis is the most severe form. The aim of our work is to study the epidemiological, clinical, diagnostic, therapeutic and prognostic aspects of the disease in the Infectious Diseases Department of the Centre Hospitalier Universitaire de Référence Nationale in N'Djaména. Methodology: Patients were recruited on the basis of clinical signs suggestive of visceral leishmaniasis, i.e. prolonged fever, splenomegaly and altered general condition. Biological confirmation was performed with a rapid diagnostic test using recombinant K39 parasite antigen, which is known to have good specificity and sensitivity. Epidata version 3.1 software was used to process patient data. Results: From 05/04/21 to 15/12/23, 153 positive cases were managed. The mean age of patients was 18 years, with a sex ratio of 9.2. Of these patients, 103 (67.3%) had recently stayed at gold mining sites. Patients testing positive were treated with sodium stibogluconate combined with paromomycin for 17 days. The mortality rate was 13.2%. Conclusion: Leishmaniasis is a serious and little-known disease in Chad. In order to respond to the disease, it is necessary to reinforce the capacities of health structures and to carry out appropriate actions in the outbreaks.

关键词： Visceral Leishmaniasis Gold Mining Sites Chad

Intersectional gene inactivation: there is more to conditional mutagenesis than Cre

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Science China(Life Sciences) 2018年第9期61卷 1115-1117页

作者： philippe Soriano Department of Cell Developmental and Regenerative Biology Icahn School of Medicine at Mount Sinai

The efforts of many laboratories worldwide and large scale international mutagenesis consortia have resulted in mutagenesis of nearly all mouse genes, and present efforts are devoted to large scale phenotyping of germline null mutant mice (Ayadi et al., 2012). Although early lethality associated with loss of function of a given gene may prevent elucidating its function at a later stage or in a given tissue, conditional alleles in which a critical part of the gene is flanked by recombinase target sites provide an opportunity for addressing gene function at later stages (Branda and Dymecki,2004). Fortunately, many of the mutant alleles generated by the consortia allow for conditional mutagenesis using site directed recombinases.

关键词： there is more to conditional mutagenesis than Cre

On the Stability of Racing Sailing Boats with Foils

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Chinese Annals of Mathematics,Series B 2018年第3期39卷 427-450页

作者： philippe DESTUYNDER Caroline FABRE Département d'ingénierie Mathématique Laboratoire M2N Conservatoire National des Arts et Métiers 292rue saint Martin75003 ParisFrance Laboratoire de Mathématiques d'Orsay Univ.Paris-SudCNRSUniversitéParis-Saclay 91405 OrsayFrance

The development of foils for racing boats has changed the strategy of sailing. Recently, the America＇s cup held in San Francisco, has been the theatre of a tragicomic history due to the foils. During the last round, the New-Zealand boat was winning by 8 to 1 against the defender USA. The winner is the first with 9 victories. USA team understood suddenly （may be） how to use the control of the pitching of the inain foils by adjusting the rake in order to stabilize the ship. And USA won by 9 victories against 8 to the challenger NZ. The goal in this paper is to point out few aspects which could be taken into account in order to improve this mysterious control law which is known as the key of the victory of the USA team. There are certainly many reasons and in particular the cleverness of the sailors and of all the engineering team behind this project. But it appears interesting to have a mathematical discussion, even if it is a partial one, on the mechanical behaviour of these extraordinary sailing boats. The nunlerical exanlples given here are not the true ones. They have just been invented in order to explain the theoretical developments concerning three points： The possibility of tacking on the foils for sailing upwind, the nature of foiling instabilities, if there are, when the boat is flying and the control laws.

关键词： Hydrodynamics of foils Mathematical analysis Stability

Global significance of oxygen and carbon isotope compositions of pedogenic carbonates since the Cretaceous

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Geoscience Frontiers 2021年第4期12卷 34-45页

作者： Marc Jolivet philippe Boulvais Géosciences Rennes CNRSUniv RennesUMR 6118F-35000RennesFrance

Few global syntheses of oxygen and carbon isotope composition of pedogenic carbonates have been attempted,unlike marine *** carbonates represent in-situ indicators of the climate conditions prevailing on *** δ^(18)O and δ^(13)C values of pedogenic carbonates are controlled by local and global factors,many of them not affecting the marine carbonates largely used to probe global climate *** compile pedogenic oxygen and carbon isotopic data(N=12,167)fromCretaceous to Quaternary-aged paleosols to identify potential trends through time and tie them to possible controlling *** discrete events such as the Paleocene-Eocene Thermal Maximum are clearly evidenced,our analysis reveals an increasing complexity in the distribution of the δ^(18)O vs δ^(13)C values through the *** could be expected,the rise of C4 plants induces a shift towards higherδ13C values during the Neogene and *** also show that the increase in global hypsometry during the Neogene plays a major role in controlling the δ^(18)O and δ^(13)C values of pedogenic carbonates by increasing aridity downwind of orographic ***,during the Quaternary,an increase of 3‰in δ^(18)O values is recorded both by the pedogenic carbonates and the marine foraminifera suggesting that both indicators may be used to track global climate signal.

关键词： Global isotopic signal Cretaceous–Quaternary Pedogenic carbonates Topography