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Epidemiological, Clinical and Therapeutic Aspects of Bladder Tumors in a Schistosomiasis-Endemic Country

Open Journal of Urology 2024年第3期14卷 151-159页

作者： Amadou Kassogue Idrissa Sissoko Alkadri Diarra Moussa Salifou Diallo Daouda Sangare Boureima Coulibaly philippe togo Albacaye Sember Mahamadou Traore Salia Coulibaly Mamadou Lamine Diakite Urology Department Pr Bocar Sidy Sall University Hospital Kati Mali Urology Department Luxembourg University Hospital Bamako Mali Medical Imaging Department Pr Bocar Sidy Sall University Hospital Kati Mali Urology Department Point G University Hospital Bamako Mali

Introduction: Bladder tumors are common in our country;Mali is a bilharzial endemic country. In our context, urinary bilharzia is common, and bladder tumors arouse particular interest in the field of urological oncology, because of their frequency, their diagnosis, their difficulty in management and their histological particularity. The objective of our work was to study the epidemiological, clinical and therapeutic aspects of bladder tumors. Materials and Methods: This is a cross-sectional, descriptive study with a retrospective and prospective collection that took place over 3 years from January 1, 2020 to December 31, 2022. Results: We identified 316 cases of bladder tumors during this period. Bladder tumors are a common pathology representing 35.95% of all hospitalized patients, and occupying the 1st rank of tumors in urology in the Urology Department of the Pr Bocar Sidy Sall University Hospital in Kati. Bladder tumors were more common in men with 56.33%. The average age of our patients was 50 years ± 25.8 years and the extreme ages were 20 and 87 years. Urinary schistosomiasis, considered a predisposing factor, was found in 66.78% of cases in our patients as a history. Transurethral resection of the bladder was performed in 100% of our patients, nephrostomy in 1.90% of cases, ureterostomy in 1.58% of cases, Bricker type urinary diversion in 1.27% of cases, and a neobladder in 0.32% of cases. Squamous cell carcinoma is the dominant histological type (88.29%). The postoperative outcome was 99% favorable after resection. Conclusion: Bladder tumors were mainly tumors infiltrating the bladder muscle. The main risk factor was urinary bilharzia. Squamous cell carcinoma is the most common histological type with a diagnostic delay, thus limiting radical treatment after resection of the bladder tumor.

关键词： TURB Squamous Cell Carcinoma Urinary Schistosomiasis

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Telencephalic stab wound injury induces regenerative angiogenesis and neurogenesis in zebrafish:unveiling the role of vascular endothelial growth factor signaling and microglia

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Neural Regeneration Research 2025年第10期20卷 2938-2954页

作者： Danielle Fernezelian philippe Rondeau Laura Gence Nicolas Diotel Universitéde La Réunion INSERMUMR 1188Diabète athérothrombose Thérapies Réunion Océan Indien(DéTROI)Saint PierreLa RéunionFrance

After brain damage,regenerative angiogenesis and neurogenesis have been shown to occur simultaneously in mammals,suggesting a close link between these ***,the mechanisms by which these processes interact are not well *** this work,we aimed to study the correlation between angiogenesis and neurogenesis after a telencephalic stab wound *** this end,we used zebrafish as a relevant model of neuroplasticity and brain repair ***,using the Tg(fli1:EGFP×mpeg1.1:mCherry)zebrafish line,which enables visualization of blood vessels and microglia respectively,we analyzed regenerative angiogenesis from 1 to 21 days *** parallel,we monitored brain cell proliferation in neurogenic niches localized in the ventricular zone by using *** found that after brain damage,the blood vessel area and width as well as expression of the fli1 transgene and vascular endothelial growth factor(vegfaa and vegfbb)were *** the same time,neural stem cell proliferation was also increased,peaking between 3 and 5 days post-lesion in a manner similar to angiogenesis,along with the recruitment of ***,through pharmacological manipulation by injecting an anti-angiogenic drug(Tivozanib)or Vegf at the lesion site,we demonstrated that blocking or activating Vegf signaling modulated both angiogenic and neurogenic processes,as well as microglial ***,we showed that inhibition of microglia by clodronate-containing liposome injection or dexamethasone treatment impairs regenerative neurogenesis,as previously described,as well as injury-induced *** conclusion,we have described regenerative angiogenesis in zebrafish for the first time and have highlighted the role of inflammation in this *** addition,we have shown that both angiogenesis and neurogenesis are involved in brain repair and that microglia and inflammation-dependent mechanisms activated by Vegf signaling are important contributors to

关键词： angiogenesis cerebral damage inflammation neurogenesis stab wound telencephalon vascular endothelial growth factor zebrafish

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Epidemiological, Clinical and Therapeutic Aspects of Bladder Tumors in a Schistosomiasis-Endemic Country

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Open Journal of Urology（泌尿学期刊） 2024年第3期 151页

作者： Amadou Kassogue Idrissa Sissoko Alkadri Diarra Moussa Salifou Diallo Daouda Sangare Boureima Coulibaly philippe togo Albacaye Sember Mahamadou Traore Salia Coulibaly Mamadou Lamine Diakite

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A review of numerical analyses and experimental characterization methods for forming of textile reinforcements

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Chinese Journal of Aeronautics 2021年第8期34卷 143-163页

作者： Biao LIANG philippe BOISSE School of Mechanical Engineering Northwestern Polytechnical UniversityXi'an 710072China Universitede Lyon CNRSINSA-LyonLaMCoSF69621France

The forming of textile reinforcements is an important stage in the manufacturing of textile composite parts with Liquid Composite Molding *** orientations and part geometry obtained from this stage have significant impact on the subsequent resin injection and final mechanical properties of composite *** simulation of textile reinforcement forming is in strong demand as it can greatly reduce the time and cost in the determination of the optimized processing parameters,which is the foundation of the low-cost application of composite *** review presents the state of the art of forming modeling methods for textile reinforcement and the corresponding experimental characterization methods developed in this *** microscopic,mesoscopic and macroscopic models are *** concerning the simulation of wrinkling are also presented since it is the most common defect occurred in the textile reinforcement ***,challenges and recommendations on the future research directions for textile reinforcement modeling and experimental characterization are provided.

关键词： Experimental characterization Forming Liquid Composite Molding Numerical analysis Textile reinforcements

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Advantages and Drawbacks of Quantum Mechanical Static and Dynamic Approaches to Modelling Infrared Spectra

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Chinese Journal of Chemical Physics 2009年第2期22卷 123-128页

作者： Claude Pouchan philippe Carbonniere Groupe Chimie Théorique et Réactivité ECP IPREM UMR CNRS 5254 Université de Pau et des Pays de I'Adour 2 Rue Jules Ferry F-54000 Pau France

We present quantum mechanical vibrational computations beyond the harmonic approximation from effective second order perturbative and variation perturbation treatments defined as static approaches, as well as vibrational analysis from density functional theory molecular dynamics trajectories at 300 and 600 K. The four schemes are compared in terms of prediction of fundamental transitions, and simulation of the corresponding medium infrared spectrum at the same level of theory using the B3LYP/6-31＋G（d,p） description of the electronic structure. We summarize conclusions about advantages and drawbacks of these two approaches and report the main results obtained for semi-rigid and flexible molecules.

关键词： Anharmonic vibrations Vibrational configuration interaction Perturbative approach Ab initio molecular dynamic treatment

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Ba promoter effect on cobalt-catalyzed ammonia decomposition kinetics: A theoretical analysis

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Journal of Energy Chemistry 2024年第12期99卷 182-192页

作者： Zahra Almisbaa philippe Sautet Department of Chemical and Biomolecular Engineering University of CaliforniaLos AngelesCA 90095United States Department of Chemistry and Biochemistry University of CaliforniaLos AngelesCA 90095United States

Ammonia decomposition is a key reaction in the context of hydrogen storage, transport, and release. This study combines density functional theory(DFT) calculations with microkinetic modeling to address the promotion mechanism of Ba species for ammonia decomposition on Co catalysts. The modified adsorption properties of Co upon the addition of metallic Ba or BaO suggest that the promoters play a role in alleviating the competitive adsorption of H. Calculating the full reaction pathway of ammonia decomposition shows that limiting the investigation to the N–N association step, as done previously, overlooks the effect of the promoter on the energy barriers of the NHxdehydrogenation steps. Challenges of modeling the ammonia decomposition reaction are addressed by understanding that the NH_(2) intermediate is stabilized on the step sites rather than the terrace sites. When the effect of H-coverage on the adsorption of NH_(3) is not considered in the microkinetic simulations, the results conflict with the ***, accounting for the effect of H-coverage, as performed here, shows that BaO-doped Co has higher rates than pristine Co and Ba-doped Co at the reaction temperature of 723.15 K. When H is adsorbed on the Ba-doped Co, the adsorption of ammonia becomes significantly endergonic, which makes the rates relatively slow. The superiority of the BaO-promoted catalyst is attributed to a lower energy for the transition state of the rate-determining step, coupled with a reduced impact of the hydrogen coverage on weakening the ammonia adsorption. The kinetic analysis of the influence of Ba and BaO on the Co surface shows that BaO-doped Co aligns more closely with experimental observations than Badoped Co. This implies that Ba on the Co surface is likely to be in an oxide form under reaction *** the kinetics of the ammonia decomposition reaction provides a foundation for developing highly effective catalysts to accelerate the industrial utilizatio

关键词： Cobalt catalyst Ammonia decomposition Hydrogen carrier DFT Microkinetic

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Intersectional gene inactivation: there is more to conditional mutagenesis than Cre

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Science China(Life Sciences) 2018年第9期61卷 1115-1117页

作者： philippe Soriano Department of Cell Developmental and Regenerative Biology Icahn School of Medicine at Mount Sinai

The efforts of many laboratories worldwide and large scale international mutagenesis consortia have resulted in mutagenesis of nearly all mouse genes, and present efforts are devoted to large scale phenotyping of germline null mutant mice (Ayadi et al., 2012). Although early lethality associated with loss of function of a given gene may prevent elucidating its function at a later stage or in a given tissue, conditional alleles in which a critical part of the gene is flanked by recombinase target sites provide an opportunity for addressing gene function at later stages (Branda and Dymecki,2004). Fortunately, many of the mutant alleles generated by the consortia allow for conditional mutagenesis using site directed recombinases.

关键词： there is more to conditional mutagenesis than Cre

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Impact of Drops on Non-wetting Biomimetic Surfaces

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Journal of Bionic Engineering 2009年第4期6卷 330-334页

作者： Alain Merlen philippe Brunet Institut d'Electronique de Microelectronique et Nanotechnologie IEMN Universite des sciences et technologies de Lille1UMR CNRS 8520Avenue Poincare BP 6006959652 Villeneuve d'Ascq cedexFrance

We have carried out an experimental study of liquid drop impact on superhydrophobic substrates covered by a carpet of chemically coated *** micro-structure of the surface is similar to some biological ones(Lotus leaf for example).In this situation the contact angle can then be considered as equal to 180 degrees,with no *** to its initial inertia,the drop experiences a flattening phase after it hits the surface,taking the shape of a *** it reaches its maximal lateral extension,the drop begins to retract and bounces *** have extracted the lateral extension of the drop,and we propose a model that explains the *** find a limit initial velocity beyond which the drop protrudes into the nano-wire *** discuss the relevance of practical issues in terms of self-cleaning surfaces or spray-cooling.

关键词： superhydrophobic surfaces drop impact

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Reactive Extrusion(REx):Using Chemistry and Engineering to Solve the Problem of Ocean Plastics

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Engineering 2022年第7期8卷 15-18页

作者： philippe Dubois Center of Innovation and Research in Materials and Polymers&Materia Nova Research Center University of MonsMons B-7000Belgium

The reality of plastic pollution is no longer under debate:It has invaded our daily lives and is present all around us,with our oceans being no *** fact,a seventh“continent”has appeared in the oceans,composed of plastics and microplastics!Newspapers including Le Monde in France and The Guardian in United Kingdom recently headlined the record rate of microplastic accumulation in the Arctic *** headlines referred to an article published in Nature Communications[1]that reported the finding of up to 12000 plastic microparticles per liter of water frozen in the sea *** this finding,what future solutions can counteract this particularly insidious pollution?

关键词： Arctic continent pollution

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Global significance of oxygen and carbon isotope compositions of pedogenic carbonates since the Cretaceous

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Geoscience Frontiers 2021年第4期12卷 34-45页

作者： Marc Jolivet philippe Boulvais Géosciences Rennes CNRSUniv RennesUMR 6118F-35000RennesFrance

Few global syntheses of oxygen and carbon isotope composition of pedogenic carbonates have been attempted,unlike marine *** carbonates represent in-situ indicators of the climate conditions prevailing on *** δ^(18)O and δ^(13)C values of pedogenic carbonates are controlled by local and global factors,many of them not affecting the marine carbonates largely used to probe global climate *** compile pedogenic oxygen and carbon isotopic data(N=12,167)fromCretaceous to Quaternary-aged paleosols to identify potential trends through time and tie them to possible controlling *** discrete events such as the Paleocene-Eocene Thermal Maximum are clearly evidenced,our analysis reveals an increasing complexity in the distribution of the δ^(18)O vs δ^(13)C values through the *** could be expected,the rise of C4 plants induces a shift towards higherδ13C values during the Neogene and *** also show that the increase in global hypsometry during the Neogene plays a major role in controlling the δ^(18)O and δ^(13)C values of pedogenic carbonates by increasing aridity downwind of orographic ***,during the Quaternary,an increase of 3‰in δ^(18)O values is recorded both by the pedogenic carbonates and the marine foraminifera suggesting that both indicators may be used to track global climate signal.

关键词： Global isotopic signal Cretaceous–Quaternary Pedogenic carbonates Topography

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