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Neoadjuvant sorafenib combined with gemcitabine plus oxaliplatin in advanced hepatocellular carcinoma

World Journal of Gastroenterology 2011年第17期17卷 2255-2258页

作者： Nicolas Williet Olivier Dubreuil Tarek Boussaha Isabelle Trouilloud Bruno Landi Martin Housset Muriel Botti philippe rougier Jacques Belghiti Julien Taieb Department of Gastroenterology Europeen Georges Pompidou HospitalMedical University75908 ParisFrance Department of Radiotherapy Europeen Georges Pompidou HospitalMedical University75908 ParisFrance Beaujon Hspital Medical University100boulevard du Général Leclerc92110 ClichyFrance

This paper reports the first case of a patient with hepatocellular carcinoma with lymph node metastasis treated by sorafenib combined with gemcitabine plus oxaliplatin,with a partial response and normalization of α fetoprotein,which allowed curative *** potential synergy between these three drugs needs to be confirmed,and is currently being investigated in a randomized phase Ⅱ trial.

关键词： Hepatocellular 癌 Gemcitabine Oxaliplatin Sorafenib Neoadjuvant 治疗

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Autoimmune pancreatitis with atypical imaging findings that mimicked an endocrine tumor

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World Journal of Gastroenterology 2010年第23期16卷 2954-2958页

作者： Cindy Neuzillet Céline Lepère Mostafa El Hajjam Laurent Palazzo Monique Fabre Hajer Turki Pascal Hammel philippe rougier Emmanuel Mitry Department of Digestive Surgery and Gastroenterology and Digestive Oncology Ambroise Paré Hospital9avenue Charles de Gaulle Radiology Unit Ambroise Paré Hospital9avenue Charles de Gaulle Medical off ice of Gastroenterology 30rue d'Astorg Pathology Unit Bicêtre Hospital78rue du Général Leclerc Department of Digestive Surgery and Gastroenterology PMADBeaujon Hospital100 boulevard du Général Leclerc EA 4340 Faculty of Medicine of West Paris University of Versailles Saint-Quentin9 boulevard d'Alembert

Autoimmune pancreatitis(AIP) is a rare cause of recurrent acute pancreatitis or chronic pancreatitis in middleaged patients,and is characterised by a marked infiltration of lymphocytes and plasma cells in pancreatic *** of focal forms can be diff icult as AIP may mimic pancreatic *** cases of AIP are *** report the case of a 15-yearold girl who had a focal AIP and associated cholangitis,with a very unusual vascularized mass that mimicked a pancreatic endocrine *** diagnosis was obtained by a pancreatic biopsy,thus avoiding surgical resection,and all the clinical,biological and radiological abnormalities resolved after steroid therapy with 6 mo of follow-up.

关键词： Pancreas Autoimmune pancreatitis Adolescent Endocrine tumor Biopsy

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Trastuzumab Re-Introduction with FOLFIRI for Treatment of HER2 Overexpression-Advanced Gastric Adenocarcinoma Following Failure of Other Trastuzumab-Based Chemotherapy Regimens

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Case Reports in Clinical Medicine 2015年第4期4卷 131-136页

作者： Olivier Dubreuil Aziz Zaanan Olivier Pellerin Jean-Baptiste Bachet philippe rougier Julien Taieb Gastro-Enterology and Digestive Oncology Unit Pitie Salpetriere Hospital Paris Farnce Digestive Oncology Unit European Georges Pompidou Hospital Paris France Paris-Descartes Medical University INSERM U970 Interventionnal Radiology European Georges Pompidou Hospital Paris France

A 67-year-old man diagnosed with HER2 overexpression advanced gastric adenocarcinoma and metastasis to liver and lungs was admitted for tertiary care. He received a third line chemotherapy that consists of trastuzumab combined with FOLFIRI regimen (irinotecan plus 5-FU/LV) following a disease relapse after an initial successful response to a combination of 5FU + oxaliplatin and trastuzumab. The patient showed a favorable and prolonged response to it. In addition the chemotherapy was well tolerated and devoid of remarkable side effects. The response to trastuzumab + FOLFIRI was assessed clinically and through CT scan imaging and upper gastrointestinal endoscopy. This case report shows that firstly the combination of FOLFIRI and trastuzumab could be tested as another regimen in metastatic gastric cancer, and, secondly, that in this disease, like in metastatic breast cancer, the continuation of trastuzumab after an initial progression under this antibody could be tested in order to improve the efficacy of the treatment Trastuzumab re-introduction with FOLFIRI for treatment of HER2 overexpression-advanced gastric adenocarcinoma following failure of other trastuzumab-based chemotherapy regimens.

关键词： Stomach Neoplasm Trastuzumab Treatment Reintroduction

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