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Water limitation and rootstock genotype interact to alter grape berry metabolism through transcriptome reprogramming

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Horticulture Research 2015年第1期2卷 242-254页

作者： Mariam Berdeja philippe nicolas Christian Kappel Zhan Wu Dai Ghislaine Hilbert Anthony Peccoux Magali Lafontaine Nathalie Ollat Eric Gomès Serge Delrot Ecophysiologie et Génomique Fonctionnelle de la Vigne University BordeauxISVVUMR 1287Villenave d′Ornon F-33140France Department of General and Organic Viticulture Hochschule Geisenheim UniversityGeisenheimGermany Boyce Thompson Institute for Plant Research IthacaNY 14850USA Institut für Biochemie und Biologie Universität PotsdamKarl-Liebknecht-Str.24–25Potsdam 14476Germany

Grapevine is a perennial crop often cultivated by grafting a scion cultivar on a suitable *** influence scions,particularly with regard to water uptake and ***,one of the possibilities to adapt viticulture to the extended drought stress periods is to select rootstocks conferring increased tolerance to ***,the molecular mechanisms associated with the ability of rootstock/scion combination to influence grape berry metabolism under drought stress are still poorly *** transcriptomic changes induced by drought stress in grape berries(*** noir)from vines grafted on either 110R(drought-tolerant)or 125AA(drought-sensitive)rootstock were *** experiments were conducted in the vineyard for two years and two grape berry developmental stages(50%and 100%veraison).The genome-wide microarray approach showed that water stress strongly impacts gene expression in the berries,through ontology categories that cover cell wall metabolism,primary and secondary metabolism,signaling,stress,and hormones,and that some of these effects strongly depend on the rootstock ***,under drought stress,berries from vines grafted on 110R displayed a different transcriptional response compared to 125AA-concerning genes related to jasmonate(JA),phenylpropanoid metabolism,and pathogenesis-related *** data also suggest a link between JA and secondary metabolism in water-stressed ***,genes related to secondary metabolism and JA are more induced and/or less repressed by drought stress in the berries grafted on the drought-sensitive rootstock *** rootstock-dependent gene expression changes are relevant for berry composition and sensory properties.

关键词： metabolism drought programming

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Telencephalic stab wound injury induces regenerative angiogenesis and neurogenesis in zebrafish:unveiling the role of vascular endothelial growth factor signaling and microglia

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Neural Regeneration Research 2025年第10期20卷 2938-2954页

作者： Danielle Fernezelian philippe Rondeau Laura Gence nicolas Diotel Universitéde La Réunion INSERMUMR 1188Diabète athérothrombose Thérapies Réunion Océan Indien(DéTROI)Saint PierreLa RéunionFrance

After brain damage,regenerative angiogenesis and neurogenesis have been shown to occur simultaneously in mammals,suggesting a close link between these ***,the mechanisms by which these processes interact are not well *** this work,we aimed to study the correlation between angiogenesis and neurogenesis after a telencephalic stab wound *** this end,we used zebrafish as a relevant model of neuroplasticity and brain repair ***,using the Tg(fli1:EGFP×mpeg1.1:mCherry)zebrafish line,which enables visualization of blood vessels and microglia respectively,we analyzed regenerative angiogenesis from 1 to 21 days *** parallel,we monitored brain cell proliferation in neurogenic niches localized in the ventricular zone by using *** found that after brain damage,the blood vessel area and width as well as expression of the fli1 transgene and vascular endothelial growth factor(vegfaa and vegfbb)were *** the same time,neural stem cell proliferation was also increased,peaking between 3 and 5 days post-lesion in a manner similar to angiogenesis,along with the recruitment of ***,through pharmacological manipulation by injecting an anti-angiogenic drug(Tivozanib)or Vegf at the lesion site,we demonstrated that blocking or activating Vegf signaling modulated both angiogenic and neurogenic processes,as well as microglial ***,we showed that inhibition of microglia by clodronate-containing liposome injection or dexamethasone treatment impairs regenerative neurogenesis,as previously described,as well as injury-induced *** conclusion,we have described regenerative angiogenesis in zebrafish for the first time and have highlighted the role of inflammation in this *** addition,we have shown that both angiogenesis and neurogenesis are involved in brain repair and that microglia and inflammation-dependent mechanisms activated by Vegf signaling are important contributors to

关键词： angiogenesis cerebral damage inflammation neurogenesis stab wound telencephalon vascular endothelial growth factor zebrafish

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Impedance spectroscopy of the cell/nanovolcano interface enables optimization for electrophysiology

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Microsystems & Nanoengineering 2023年第3期9卷 297-308页

作者： nicolas Maïno Arnaud Bertsch philippe Renaud Microsystems laboratory 4 Institute of Electrical and Micro EngineeringEcole Polytechique Fédérale de Lausanne(EPFL)LausanneSwitzerland

Volcano-shaped microelectrodes have demonstrated superior performance in measuring attenuated intracellular action potentials from cardiomyocyte cultures. However, their application to neuronal cultures has not yet yielded reliable intracellular access. This common pitfall supports a growing consensus in the field that nanostructures need to be pitched to the cell of interest to enable intracellular access. Accordingly, we present a new methodology that enables us to resolve the cell/probe interface noninvasively through impedance spectroscopy. This method measures changes in the seal resistance of single cells in a scalable manner to predict the quality of electrophysiological recordings. In particular, the impact of chemical functionalization and variation of the probe’s geometry can be quantitatively measured. We demonstrate this approach on human embryonic kidney cells and primary rodent neurons. Through systematic optimization, the seal resistance can be increased by as much as 20-fold with chemical functionalization, while different probe geometries demonstrated a lower impact. The method presented is therefore well suited to the study of cell coupling to probes designed for electrophysiology, and it is poised to contribute to elucidate the nature and mechanism of plasma membrane disruption by micro/nanostructures.

关键词： enable interface optimization

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Control Evaluation of Antagonistic Series Elastic Actuation for a Robotic Endoscope Joint

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Journal of Bionic Engineering 2022年第4期19卷 965-974页

作者： Lorin Fasel nicolas Gerig philippe C.Cattin Georg Rauter BIROMED-Lab Department of Biomedical EngineeringUniversity of Basel4123AllschwilSwitzerland CIAN Department of Biomedical EngineeringUniversity of Basel4123AllschwilSwitzerland

Haptic feedback is typically missing during telemanipulation of surgical robots in minimally invasive surgeries,i.e.,surgeons cannot feel the interaction forces between the instruments and ***,surgeons have to solely rely on visual feedback,which increases complexity of guiding the instruments and poses the safety threat of unperceivable contacts outside the field of *** propose a novel series elastic actuation design for articulated robotic endoscopes to overcome these limitations and evaluate an according device with one *** to the actuation of human fingers,the joint is driven by antagonistic *** are integrated in the transmission between the tendons and the motors outside of the endoscope *** estimated the joint angle and thereby the endoscope shape,measured spring deflection,estimated tendon forces from that deflection,and implemented force control for the endoscope *** torque control and impedance control were evaluated under application of both a continuous force and an impact force to the endoscope *** springs reduced impact forces at the tip of the endoscope through their inherent *** the same time,feeding back the estimated force resulted in a stable tendon force control and a tunable endoscope joint control:Zero torque control effectively reduced the external forces,while the endoscope joint showed the expected stiffness in impedance *** results show that antagonistic series elastic actuation is a promising concept for endoscope joint actuation and that it can lead towards safer robot–tissue interactions in surgical robotics.

关键词： Minimally invasive surgery RAMIS Robot-assisted surgery Haptic feedback Force control Tendon-driven robotics

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宝石雕刻的艺术与技术

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芭莎珠宝 2019年第4期 17-17页

作者： philippe nicolas 陈旭(采访) 吕新颖(整理) 不详

最近,卡地亚在北京国贸的精品店重新开业,掌握着雕刻和镌刻珍贵宝石、硬质玉石及其他贵重材质技艺的法国艺术大师philippe nicolas也难得地为此来到中国。他是卡地亚位于巴黎的宝石雕刻工坊的掌舵人,我们趁此机会与这位艺术大师深度地... 详细信息

最近,卡地亚在北京国贸的精品店重新开业,掌握着雕刻和镌刻珍贵宝石、硬质玉石及其他贵重材质技艺的法国艺术大师philippe nicolas也难得地为此来到中国。他是卡地亚位于巴黎的宝石雕刻工坊的掌舵人,我们趁此机会与这位艺术大师深度地聊了聊这门稀有独特手工艺的神奇力量。

关键词：艺术与技术雕刻宝石艺术大师卡地亚精品店手工艺石雕

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On the relevance of analytical film thickness EHD equations for isothermal point contacts: Qualitative or quantitative predictions?

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Friction 2016年第4期4卷 369-379页

作者： Jean-David WHEELER philippe VERGNE nicolas FILLOT David PHILIPPON Univ Lyon INSA Lyon CNRS LaMCoS-UMR5259 Villeurbanne F-69621 France

Thin film and elastohydrodynamic lubrication regimes are rather young domains of tribology and they are still facing unresolved *** they rely upon a full separation of the moving surfaces by a thin (or very thin) fluid film,the knowledge of its thickness is of paramount importance,as for instance to developing lubricated mechanisms with long lasting and efficient *** a consequence,a large collection of formulae for point contacts have been proposed in the last 40 ***,their accuracy and validity have rarely been *** purpose of this paper is to offer an evaluation of the most widespread analytical formulae and to define whether they can be used as qualitative or quantitative *** methodology is based on comparisons with a numerical model for two configurations,circular and elliptical,considering both central and minimum film thicknesses.

关键词： thin film lubrication elastohydrodynamic lubrication (EHL) film thickness prediction EHD analytical equation central film thickness minimum film thickness circular contacts elliptical contacts

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Monitoring stress and recovery states: Structural and external stages of the short version of the RESTQ sport in elite swimmers before championships

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Journal of Sport and Health Science 2019年第1期8卷 77-88页

作者： Michel nicolas philippe Vacher Guillaume Martinent Laurent Mourot Laboratory of Socio Psychology and Management of Sport (SPMS EA 4180) University of Burgundy Laboratory of Vulnerabilities and Innovation in Sport (L-ViS EA 7428) Univ Lyon University of Claude Bernard Lyon 1 University of Franche Comt-Prognostic Markers and Regulatory Factors of Heart and Vascular Diseases and Exercise Performance Health Innovation Platform

Background: Psychological stress and recovery monitoring is a key issue for increasing athletes' health, well-being, and performance. This multistudy report examined changes and the doseàresponse relationships between recoveryàstress psychological states, training load(TL), heart rate(HR), heart rate recovery(HRR), and heart rate variability(HRV) while providing evidence for the factorial validity of a short French version of the RecoveryàStress Questionnaire for Athletes(RESTQ-36-R-Sport).Methods: Four hundred and seventy-three university athletes(Study 1), 72 full expert swimmers(Study 2), and 11 national to international swimmers(Study 3) participated in the study. Data were analyzed through confirmatory factor analyses(Study 1), repeated ANOVAs and correlational analyses(Study 2), t tests and correlational analyses(Study 3).Results: Multiple-group confirmatory factor analyses showed that the RESTQ-36-R-Sport scores were partially invariant across gender, type of sport, and practice level(Study 1). A doseàresponse relationship was performed between TL and RESTQ-36-R-Sport scores during an ecological training program(Study 2). Finally, relationships were found between physiological(HRR) and psychological(RESTQ-36-R-Sport) states during an ecological tapering period leading to a national championship(Study 3).Conclusion: As a whole, these findings provided evidence for the usefulness of the short version of the RESTQ-36-R-Sport for regular monitoring to prevent potential maladaptation due to intensive competitive sport practice.

关键词： Adaptation Confirmatory factor analysis Heart rate variability Monitoring Recovery Stress

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Benchmarks of 3D Laplace Equation Solvers in a Cubic Configuration for Streamer Simulation

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Plasma Science and Technology 2016年第5期18卷 538-543页

作者： Joseph-Marie PLEWA Olivier DUCASSE philippe DESSANTE Carolyn JACOBS Olivier EICHWALD nicolas RENON Mohammed YOUSFI Universite de Toulouse UPS INPT LAPLACE (Laboratoire Plasma et Conversion d'Energie) Toulouse Cedex 9 F-31062 France Group of Electrical Engineering-Paris (GeePs) UMR 8507 CNRS CentraleSupelec Universite Paris-Sud-UPMC 11 rue Joliot-Curie Plateau de Moulon 91192 Gif-sur-Yvette Cedex F-91192 France CALMIP Universite de Toulouse-CNRS-INPT-INSA-UPS UMS 3667 France CNRS LAPLACE Toulouse F-31062 France

The aim of this paper is to test a developed SOR R＆B method using the Chebyshev accelerator algorithm to solve the Laplace equation in a cubic 3D configuration. Comparisons are made in terms of precision and computing time with other elliptic equation solvers proposed in the open source LIS library. The first results, obtained by using a single core on a HPC, show that the developed SOR R＆B method is efficient when the spectral radius needed for the Chebyshev acceleration is carefully pre-estimated. Preliminary results obtained with a parallelized code using the MPI library are also discussed when the calculation is distributed over one hundred cores.

关键词： numerical methods for elliptic equations high performance computing 3Dstreamer simulation SOR IDR BiCGSTAB

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Vascular invasion in pancreatic cancer:Imaging modalities,preoperative diagnosis and surgical management

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World Journal of Gastroenterology 2010年第7期16卷 818-831页

作者： nicolas C Buchs Michael Chilcott Pierre-Alexandre Poletti Leo H Buhler philippe Morel Clinic for Visceral and Transplantation Surgery Department of SurgeryUniversity Hospitals of GenevaGeneva1211Switzerland Department of Radiology University Hospitals of GenevaGeneva1211Switzerland

Pancreatic cancer is associated with a poor prognosis,and surgical resection remains the only chance for curative *** the absence of metastatic disease,which would preclude resection,assessment of vascular invasion is an important parameter for determining resectability of pancreatic cancer.A frequent error is to misdiagnose an involved major ***,surgical exploration with pathological examination remains the"gold standard"in terms of evaluation of resectability,especially from the point of view of vascular ***,current imaging modalities have improved and allow detection of vascular invasion with more accuracy.A venous resection in pancreatic cancer is a feasible technique and relatively ***,a survival benefit is not achieved by curative resection in patients with pancreatic cancer and vascular *** the discovery of an arterial invasion during the operation might require an aggressive management,discovery before the operation should be considered as a *** of vascular invasion remains one of the most important challenges in pancreatic *** aim of this article is to provide a complete review of the different imaging modalities in the detection of vascular invasion in pancreatic cancer.

关键词： Vascular invasion Cancer Pancreas Management

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CO2-induced destabilization of pyrite-structured FeO2Hx in the lower mantle

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National Science Review 2018年第6期5卷 870-877页

作者： Eglantine Boulard Franois Guyot nicolas Menguy Alexandre Corgne Anne-Line Auzende Jean-philippe Perrillat Guillaume Fiquet Synchrotron SOLEIL Sorbonne Universit Musum National d’Histoire Naturelle Sorbonne Universit Musum National d’Histoire Naturelle Instituto de Ciencias de la Tierra Universidad Austral de Chile ISTerre Universit Grenoble Alpes Laboratoire de Gologie de Lyon UMR CNRS 5276Universit Claude Bernard Lyon 1—ENS de Lyon

Volatiles, such as carbon and water, modulate the Earth’s mantle rheology, partial melting and redox state,thereby playing a crucial role in the Earth’s internal dynamics. We experimentally show the transformation of goethite FeOOH in the presence of CO2into a tetrahedral carbonate phase, Fe4C3O12, at conditions above 107 GPa—2300 K. At temperatures below 2300 K, no interactions are evidenced between goethite and CO2, and instead a pyrite-structured FeO2Hx is formed as recently reported by Hu et al.(2016; 2017)and Nishi et al.(2017). The interpretation is that, above a critical temperature, FeO2Hx reacts with CO2and H2, yielding Fe4C3O12and H2O. Our findings provide strong support for the stability of carbon-oxygen-bearing phases at lower-mantle conditions. In both subducting slabs and lower-mantle lithologies, the tetrahedral carbonate Fe4C3O12would replace the pyrite-structured FeO2Hx through carbonation of these phases. This reaction provides a new mechanism for hydrogen release as H2 O within the deep lower mantle. Our study shows that the deep carbon and hydrogen cycles may be more complex than previously thought, as they strongly depend on the control exerted by local mineralogical and chemical environments on the CO2and H2thermodynamic activities.

关键词： deep carbon cycle FeOOH high pressure

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