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Accumulation of Flavonoids in an ntra ntrb Mutant Leads to Tolerance to UV-C

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Molecular Plant 2009年第2期2卷 249-258页

作者： Talaat Bashandy Ludivine Taconnat Jean-Pierre Renou Yves Meyer Jean-philippe Reichheld Laboratoire Genome et Developpement des Plantes Universite de Perpignan UMR CNRS 5096 52 avenue Paul Alduy 66860 Perpignan France Unite de Recherche en Genomique Vegetale 91057 Evry cedex France

NADPH-dependent thioredoxin reductases （NTRs） are key regulatory enzymes determining the redox state of thioredoxins. There are two genes encoding NTRs （NTRA and NTRB） in the Arabidopsis genome, each encoding a cytosolic and a mitochondrial isoform. A double ntra ntrb mutant has recently been characterized and shows slower plant growth, slightly wrinkled seeds and a remarkable hypersensitivity to buthionine sulfoximine （BSO）, a specific inhibitor of gluta- thione biosynthesis. In this paper, we demonstrate that this mutant also accumulates higher level of flavonoids. Analysis of transcriptome data showed that several genes of the flavonoid pathway are overexpressed in the ntra ntrb mutant. Accumulation of flavonoids is generally considered a hallmark of plant stress. Nevertheless, no elevation of the expression of genes encoding ROS-detoxification enzymes was observed, suggesting that the ntra ntrb plants do not suffer from oxidative disease. Another hypothesis suggests that flavonoids are specifically synthesized in the ntra ntrb mutant in order to rescue the inactivation of NTR. To test this, the ntra ntrb mutant was crossed with transparent testa 4 （tt4） plants with a mutation in the gene encoding the first enzyme in flavonoid biosynthesis. As ntra ntrb plants are more resistant to UV-C treatment than wild-type plants, this higher resistance was abolished in the ntra ntrb tt4 mutant, suggesting that accumulation of flavonoids in the ntra ntrb mutant protects plants against UV-light.

关键词： abiotic/environmental stress oxidative and photo-oxidative stress secondary metabolism - phenylpropanoidsand phenolics gene expression Arabidopsis.

妊娠早期丙泊酚麻醉诱导和苏醒时的预测效应室靶浓度

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麻醉与镇痛 2012年第1期8卷 34-39页

作者： Nicolas Mongardon, MD Frederique Servin, MD, phd Mathilde Perrin, MD Ennoufous Bedairia, MD Sylvie Retout, phd Chadi Yazbeck, MD, phd philippe Faucher, MD philippe Montravers, MD, phd Jean-Marie Desmonts, MD Jean Guglielminotti, MD 谢珺田（译） Departement d＇Anesthesie et de Reanimation Chirurgicale Departementd＇Epidemiologie Biostatistique et Recherche Clinique Service de Gynecologie et d＇Obstetrique Assistance Publique-Hopitaux de Paris Hopital Bichat-Claude Bernard Paris France

背景妊娠时孕妇对镇静药的需要量减少，据称与孕酮有关。然而，妊娠和孕酮对丙泊酚的需要量产生怎样的影响，至今没有人彻底的研究过。本研究的目的是确定在妊娠早期，麻醉诱导意识消失期间和麻醉苏醒睁眼时所用丙泊酚的剂量和预测效应... 详细信息

背景妊娠时孕妇对镇静药的需要量减少，据称与孕酮有关。然而，妊娠和孕酮对丙泊酚的需要量产生怎样的影响，至今没有人彻底的研究过。本研究的目的是确定在妊娠早期，麻醉诱导意识消失期间和麻醉苏醒睁眼时所用丙泊酚的剂量和预测效应室靶浓度是否减低。同时观察血孕酮的含量与使意识消失时丙泊酚剂量和效应室靶浓度有无相关性。方法我们研究了57例ASA1-2级拟行终止妊娠的患者和55例行经阴道卵泡穿刺体外受精的对照患者。浓度为1％的丙泊酚以200ml／min的输注速度实施麻醉。记录在诱导时意识丧失过程中所用丙泊酚的剂量和预测效应室靶浓度（Schnider模型）。同时预测在麻醉苏醒睁眼时的效应室靶浓度。血孕酮的量在手术结束时测定。结果在意识消失时，妊娠患者较非妊娠患者所用丙泊酚剂量的平均值（±1个标准差）显著减少（分别为108．57±20．04mg和117．59±17．98mg，P=0．014）。与之相似，意识消失时预计的丙泊酚效应室靶浓度在妊娠患者有显著的降低。在麻醉苏醒睁眼时丙泊酚的预计靶浓度没有差别。没有观察到血孕酮水平与意识消失时丙泊酚的剂量和效应室靶浓度的相关性。结论早期妊娠时使意识消失的丙泊酚的剂量和预计的效应室靶浓度减低。孕酮并不能解释这一结果。

关键词：效应室靶浓度妊娠早期麻醉诱导丙泊酚预测经阴道卵泡穿刺意识消失麻醉苏醒

具有抗超敏作用的镇痛剂奈福泮对大鼠手术后长期疼痛易感性的预防

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麻醉与镇痛 2011年第4期7卷 68-76页

作者： Emilie Laboureyras, MSc Jeremy Chateauraynaud, MSc philippe Richebe, MD, phd Guy Simonnet, phd 马艳霞(译) 郭政(校) Universite Bordeaux 2 Universite Bordeaux 1 CNRS UMR 5227 Bordeaux Cedex Department of Anesthesia and Intensive Care Ⅱ Hopital cardiologique Haut Leveque Service du Professeur Gerard Janvier Centre Hospitalier Universitaire de Bordeaux Bordeaux France 不详

背景与外科手术有关的组织损伤经常产生外周及中枢敏化，这可以延长刺激，导致手术后剧烈疼痛，矜持的是，阿片类药物的应用，对于手术后疼痛管理是必须的，但可能诱导疼痛敏化，导致手术后疼痛增强，并增加发展成为慢性疼痛的风险。我... 详细信息

背景与外科手术有关的组织损伤经常产生外周及中枢敏化，这可以延长刺激，导致手术后剧烈疼痛，矜持的是，阿片类药物的应用，对于手术后疼痛管理是必须的，但可能诱导疼痛敏化，导致手术后疼痛增强，并增加发展成为慢性疼痛的风险。我们通过评价3周后未损伤对侧足底的炎症反应所诱导的痛觉超敏，研究大鼠足底的手术切皮是否可以增加长期疼痛的感性。同时我们还评价了奈福泮的效果。奈福泮常用于手术后疼痛治疗，不仅可预防被放大的手术后疼痛，且能预防手术后预期疼痛的易感性。手术后1天评价吗啡的效果。方法手术当日切开大鼠足底，分为给予或不给予芬太尼（每次4×10μg／kg．每隔15分钟1次）。损伤前30分钟奈福泮（10mg／kg）或者生理盐水皮下注射。3周后，当疼痛测量值回到基础值时．对足底进行卡拉胶（carrageenan）注射，形成连续的疼痛刺激，评价手术切开及芬太尼治疗大鼠的疼痛敏感度。通过压爪发声试验（the paw—pressure vocalization test）和承重试验（the weight bearing test）测量疼痛程度。结果大鼠手术切皮引起的潜在、长期的痛觉氧化，表现为注射卡拉胶引起痛觉超敏。芬太尼联合外科切支诱导出放大的手术后疼痛．当切皮前注射奈福泮，可减轻芬太尼围手术期治疗所引起的强烈疼痛，并预防长期痛觉超敏的进展。手术前奈福泮注射也提高了吗啡在芬太尼引起的手术后痛觉超敏时的止痛效果。结论预先给予奈福泮在提高手术后疼痛管理，降低手术后慢性疼痛发生的危险方面可能是有效的，因为该药既有镇痛作用，又有抗超敏作用。

关键词：手术后疼痛剧烈疼痛奈福泮易感性敏作用大鼠预防镇痛剂

Australasian microtektites across the Antarctic continent: Evidence from the Sør Rondane Mountain range (East Antarctica)

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Geoscience Frontiers 2021年第4期12卷 202-214页

作者： Bastien Soens Matthias van Ginneken Stepan Chernonozhkin Nicolas Slotte Vinciane Debaille Frank Vanhaecke Herman Terryn philippe Claeys Steven Goderis Analytical Environmentaland Geo-ChemistryVrije Universiteit BrusselPleinlaan 2BE-1050 BrusselsBelgium Laboratoire G-Time UniversitéLibre de Bruxelles 50Av.F.D.Roosevelt CP 160/02BE-1050 BrusselsBelgium Centre for Astrophysics and Planetary Science University of KentCT27NZCanterburyKentUnited Kingdom Atomic&Mass Spectrometry–A&MS Research Unit Department of ChemistryGhent UniversityCampus SterreKrijgslaan 281–S12BE-9000 GhentBelgium Electrochemical and Surface Engineering Vrije Universiteit BrusselPleinlaan 2BE-1050 BrusselsBelgium

The~790 ka Australasian(micro)tektite strewn field is one of the most recent and best-known examples of impact ejecta emplacement as the result of a large-scale cratering event across a considerable part of Earth's surface(>10%in area).The Australasian strewn field is characterized by a tri-lobe pattern consisting of a large central distribution lobe,and two smaller side lobes extending to the west and ***,we report on the discovery of microtektite-like particles in sedimentary traps,containing abundant micrometeorite material,in the Sør Rondane Mountain(SRM)range of East *** thirty-three glassy particles display a characteristic pale yellowcolor and are predominantly spherical in shape,except for a single dumbbell-shaped *** vitreous spherules range in size from220 to 570μm,with an average diameter of~370μ*** compares relatively well with the size distribution(75–778μm)of Australasian microtektites previously recovered from the TransantarcticMountains(TAM)and located ca.2500–3000 km fromthe *** addition,the chemical composition of the SRM particles exhibits limited variation and is nearly identical to the‘normal-type’(i.e.,<6%MgO)TAM *** Sr and Nd isotope systematics for a single batch of SRM particles(n=26)strongly support their affiliation with TAMmicrotektites and the Australasian tektite strewn field in ***,Sr isotope ratios and Nd model ages suggest that the target material of the SRM particles was composed of a plagioclase-or carbonate-rich lithology derived from a Paleo-or Mesoproterozoic crustal *** affiliation to the Australasian strewn field requires long-range transportation,with estimated great circle distances of ca.11,600 km from the hypothetical source crater,provided transportation occurred along the central distribution *** is in agreement with the observations made for the Australasian microtektites recovered from Victoria Land(ca.11,000 km)and Larkman Nunatak(ca.12,000 km),w

关键词： Impact cratering Impact ejecta Target stratigraphy Volatilization Antarctica Microtektites

Predictors of Clostridium difficile infection severity in patients hospitalised in medical intensive care

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World Journal of Gastroenterology 2013年第44期19卷 8034-8041页

作者： Nagham Khanafer Abdoulaye Touré Cécile Chambrier Martin Cour Marie-Elisabeth Reverdy Laurent Argaud philippe Vanhems Laboratory of Epidemiology and Public Health CNRS UMR 5558 University of Lyon 69 373 Lyon France Epidemiology and Infection Control Unit Edouard Herriot Hospital Hospices Civils of Lyon 69437 Lyon France Clinical Nutrition Intensive Care Unit Croix Rousse Hospital Hospices Civils of Lyon69317 Lyon France INSERM Unit 1060 INRA 1235 University of Lyon 69921 Oullins France Medical Intensive Care Unit Edouard Herriot Hospital Hospices Civils of Lyon 69437 LyonFrance Microbiology Laboratory Hospices Civils of Lyon 69677 Bron France

AIM:To describe and analyse factors associated with Clostridium difficile infection(CDI)severity in hospitalised medical intensive care unit ***:We performed a retrospective cohort study of 40 patients with CDI in a medical intensive care unit(MICU)at a French university *** include patients hospitalised between January 1,2007and December 31,*** on demographics characteristics,past medical history,CDI description was *** to risk factors associated with CDI within 8 wk before CDI was recorded,including previous hospitalisation,nursing home residency,antibiotics,antisecretory drugs,and surgical ***:All included cases had their first episode of *** mean incidence rate was 12.94 cases/1000admitted patients,and 14.93,8.52,13.24,19.70,and8.31 respectively per 1000 admitted patients annually from 2007 to *** age was 62.9[interquartile range(IQR)55.4-72.40]years,and 13(32.5%)were *** length of MICU stay was 14.0d(IQR 5.0-22.8).In addition to diarrhoea,the clinical symptoms of CDI were fever(>38℃)in 23 patients,abdominal pain in 15 patients,and ileus in 1 *** duration of diarrhoea was 13.0(8.0-19.5)*** addition to diarrhoea,the clinical symptoms of CDI were fever(>38℃)in 23 patients,abdominal pain in 15 patients,and ileus in 1 *** to CDI,38patients(95.0%)were exposed to antibiotics,and 12(30%)received at least 4 ***,3rdgeneration cephalosporins,coamoxiclav and tazocillin were prescribed most frequently(65%,55%,40%and 37.5%,respectively).The majority of cases were hospital-acquired(n=36,90%),with 5 cases(13.9%)being *** patients had severe *** crude mortality rate within 30 d after diagnosis was 40%(n=16),with 9 deaths(9 over 16;56.3%)related to *** our 40 patients,15(37.5%)had severe *** logistic regression showed that male gender[odds ratio(OR):8.45;95%CI:1.06-67.16,P=0.044],rising serum C-reactive protein levels(OR=

关键词： Clostridium difficile Health-care associated infection Hospital-acquired infection Intensive care unit Nosocomial infection Severe Clostridium difficile infection

Bacteria may contribute to distant species recognition in ant-aphid mutualistic relationships

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Insect Science 2017年第2期24卷 278-284页

作者： Christophe Y. Fischer Claire Detrain philippe Thonart Eric Haubruge Frederic Francis Francois J. Verheggen Georges C. Lognay Laboratory of Analytical Chemistry University of Liege Gembloux Agro-Bio Tech Passage des Deportes 2 5030 Gembloux Unit of Social Ecology Universite Libre de Bruxelles CP231 50 avenue F. Roosevelt B-1050 Brussels Walloon Center of Industrial Biology University of Liege B40 Sart-Tilman 4000 Liege 4Functional and Evolutionary Entomology University of Liege Gembloux Agro-Bio Tech Passage des Deportes 2 5030 Gembloux Belgium

Mutualistic interactions between ant and aphid species have been the subject of considerable historical and contemporary investigations, the primary benefits being clean- ing and protection for the aphids and carbohydrate-rich honeydew for the ants. Questions remained, however, as to the volatile semiochemical factor influencing this relationship. A recent study highlighted the role of bacterial honeydew volatile compounds in ant at- traction. Here, ant＇s ability to distantly discriminate 2 aphid species was investigated based on bacterial honeydew semiochemicals emissions using a two-way olfactometer. Both the mutualistic aphid Aphis fabae L. and the nonmyrmecophilous aphid Acyrthosiphon pisum Harris were found to be attractive for the ant Lasius niger L. The level of attraction was similar in both assays （control vs. one of the aphid species）. However, when given a choice between these 2 aphid species, ants showed a significant preference for Aphis fabae. Honeydew volatiles, mostly from bacterial origins, are known to be a key element in ant attraction. Using the same olfactometry protocol, the relative attractiveness of volatiles emitted by honeydews collected from each aphid species and by bacteria isolated from each honeydew was investigated. Again, ants significantly preferred volatiles released by Aphis fabae honeydew and bacteria. This information suggests that microbial honeydew volatiles enable ants to distantly discriminate aphid species. These results strengthen the interest of studying the occurrence and potential impact of microorganisms in insect symbioses.

关键词： ant aphid bacteria honeydew mutualism recognition VOC

Resolving impact volatilization and condensation from target rock mixing and hydrothermal overprinting within the Chicxulub impact structure

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Geoscience Frontiers 2022年第5期13卷 16-31页

作者： Thomas Déhais Stepan M.Chernonozhkin Pim Kaskes Sietze J.de Graaff Vinciane Debaille Frank Vanhaecke philippe Claeys Steven Goderis Analytical Environmental and Geo-ChemistryVrije Universiteit BrusselBrusselsBelgium Laboratoire G-Time UniversitécLibre de BruxellesBrusselsBelgium Department of Chemistry Atomic&Mass SpectrometryGhent UniversityGhentBelgium

This work presents isotopic data for the non-traditional isotope systems Fe,Cu,and Zn on a set of Chicxulub impactites and target lithologies with the aim of better documenting the dynamic processes taking place during hypervelocity impact events,as well as those affecting impact structures during the post-impact *** focus lies on material from the recent IODP-ICDP Expedition 364 Hole M0077A drill core obtained from the offshore Chicxulub peak *** ejecta blanket samples from the UNAM 5 and 7 cores were used to compare the crater lithologies with those outside of the impact *** datasets of bulk Fe,Cu,and Zn isotope ratios are coupled with petrographic observations and bulk major and trace element compositions to disentangle equilibrium isotope fractionation effects from kinetic *** observed Fe and Cu isotopic signatures,with δ^(56/54)Fe ranging from0.95‰to 0.58‰and δ^(65/63)Cu from0.73‰to 0.14‰,mostly reflect felsic,mafic,and carbonate target lithology mixing and secondary sulfide mineral formation,the latter associated to the extensive and long-lived(>105 years)hydrothermal system within Chicxulub *** the other hand,the stable Zn isotope ratios provide evidence for volatility-governed isotopic *** heavier Zn isotopic compositions observed for the uppermost part of the impactite sequence and a metamorphic clast(δ^(66/64)Zn of up to 0.80‰and 0.87‰,respectively)relative to most basement lithologies and impact melt rock units indicate partial vaporization of Zn,comparable to what has been observed for Cretaceous-Paleogene boundary layer sediments around the world,as well as for tektites from various strewn *** contrast to previous work,our data indicate that an isotopically light Zn reservoir(δ^(66/64)Zn down to0.49‰),of which the existence has previously been suggested based on mass balance considerations,may reside within the upper impact melt rock(UIM)*** observation is restricted to a few UIM sampl

关键词： Chicxulub impact structure Non-traditional stable isotopes Impact volatilization Impact condensation Hydrothermal alteration Target lithology mixing

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术前心率和焦虑对丙泊酚消除意识剂量的影响

麻醉与镇痛 2011年第5期7卷 63-67页

作者： Severine Gras, MD Frederique Servin, MD, phd Ennoufous Bedairia, MD philippe Montravers, MD, phd Jean-Marie Desmonts, MD Dan Longrois, MD, phd Jean Guglielminotti, MD 吴姗姗（译） Departement d＇Anesthdsie et de R6animation Chirurgicale Assistance Publique-Hopitaux de Paris Hopital Bichat-Claude Bernard Paris France. 不详

背景关于焦虑对麻醉诱导时致意识消失（lossofconsciousness，LOC）所用丙泊酚剂量的影响，现有的研究得到了相矛盾的结果。焦虑对血流动力学的影响表现为增加心率（heartrate，HR）及心排血量，这些可能与上述的差异有关。因此，我们... 详细信息

背景关于焦虑对麻醉诱导时致意识消失（lossofconsciousness，LOC）所用丙泊酚剂量的影响，现有的研究得到了相矛盾的结果。焦虑对血流动力学的影响表现为增加心率（heartrate，HR）及心排血量，这些可能与上述的差异有关。因此，我们设计了如下研究来探讨：首先，术前HR对致LOC时丙泊酚剂量的影响；其次，术前焦虑对HR的影响。方法选择45例ASA分级为I-II级接受妇科手术的女性患者，在手术室用焦虑状态．特征量化表（State—TraitAnxietyInventorv，STAI）即***评分表进行焦虑评估。记录HR后，麻醉诱导用1％的丙泊酚以200ml／h的速度通过BasePrimea泵输注直至LOC，记录此时的丙泊酚剂量。对焦虑状态和HR与LOC时丙泊酚的剂量关系进行秩相关系数检验（P=0．01）。结果丙泊酚LOC时的剂量与HR有显著相关性（9=0．487，P=0．0012），而与焦虑状态无显著相关性（p=0．330，P=0．0306），但是焦虑状态与HR却有显著相关性（p=0．462，P=0．0054）。结论术前HR的增加与致LOC时的丙泊酚剂量增加相关，术前的焦虑导致了HR的增加。

关键词：术前焦虑丙泊酚剂量心率焦虑状态相关系数检验麻醉诱导血流动力学

Water limitation and rootstock genotype interact to alter grape berry metabolism through transcriptome reprogramming

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Horticulture Research 2015年第1期2卷 242-254页

作者： Mariam Berdeja philippe Nicolas Christian Kappel Zhan Wu Dai Ghislaine Hilbert Anthony Peccoux Magali Lafontaine Nathalie Ollat Eric Gomès Serge Delrot Ecophysiologie et Génomique Fonctionnelle de la Vigne University BordeauxISVVUMR 1287Villenave d′Ornon F-33140France Department of General and Organic Viticulture Hochschule Geisenheim UniversityGeisenheimGermany Boyce Thompson Institute for Plant Research IthacaNY 14850USA Institut für Biochemie und Biologie Universität PotsdamKarl-Liebknecht-Str.24–25Potsdam 14476Germany

Grapevine is a perennial crop often cultivated by grafting a scion cultivar on a suitable *** influence scions,particularly with regard to water uptake and ***,one of the possibilities to adapt viticulture to the extended drought stress periods is to select rootstocks conferring increased tolerance to ***,the molecular mechanisms associated with the ability of rootstock/scion combination to influence grape berry metabolism under drought stress are still poorly *** transcriptomic changes induced by drought stress in grape berries(*** noir)from vines grafted on either 110R(drought-tolerant)or 125AA(drought-sensitive)rootstock were *** experiments were conducted in the vineyard for two years and two grape berry developmental stages(50%and 100%veraison).The genome-wide microarray approach showed that water stress strongly impacts gene expression in the berries,through ontology categories that cover cell wall metabolism,primary and secondary metabolism,signaling,stress,and hormones,and that some of these effects strongly depend on the rootstock ***,under drought stress,berries from vines grafted on 110R displayed a different transcriptional response compared to 125AA-concerning genes related to jasmonate(JA),phenylpropanoid metabolism,and pathogenesis-related *** data also suggest a link between JA and secondary metabolism in water-stressed ***,genes related to secondary metabolism and JA are more induced and/or less repressed by drought stress in the berries grafted on the drought-sensitive rootstock *** rootstock-dependent gene expression changes are relevant for berry composition and sensory properties.

关键词： metabolism drought programming