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Gemcitabine in elderly patients with advanced pancreatic cancer

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World Journal of Gastroenterology 2011年第30期17卷 3497-3502页

作者： Olivia Hentic Vinciane Rebours philippe Lévy philippe Ruszniewski Pascal Hammel Magaly Zappa Chantal Dreyer Eric Raymond Ple des maladies de l'Appareil Digestif Service de PancréatologieHpital Beaujon100 boulevard du général Leclerc92110 ClichyFrance Ple des maladies de l’Appareil Digestif Service de PancréatologieHpital Beaujon100 boulevard du général Leclerc92110 ClichyFrance Service de Radiologie Hpital Beaujon100 boulevard du général Leclerc92110 ClichyFrance Service de Cancérologie Hpital Beaujon100 boulevard du général Leclerc92110 ClichyFrance

AIM： TO assess feasibility, tolerability and efficacy of gemcitabine-based chemotherapy in patients ≥ 75 years old with advanced pancreatic cancer. METHODS： All consecutive patients ≥ 75 years old with advanced pancreatic adenocarcinoma were included in this retrospective study. Necessary criteria to receive chemotherapy were： performance status 0-2, adequate biological parameters and no serious comorbidities. Other patients received best supportive care （BSC）. RESULTS： Thirty-eight patients （53% women, median age 78 years, range 75-84） with pancreatic cancer （metastatic： n = 20, locally advanced： n = 18） were studied. Among them, 30 （79%） were able to receive chemotherapy [median number： 9 infusions （1-45）]. Six patients （23%） had at least one episode of grade 3 neutropenia and one patient developed a grade 3 hemolytic-uremic syndrome. No toxic death occurred. Three patients （11%） had a partial tumor response, 13 （46%） had a stable disease and 12 （43%） had a tumor progression. Median survival was 9.1 mo （metastatic： 6.9 too, locally advanced： 11.4 too）. CONCLUSION： Tolerance and efficacy of gemcitabinebased chemotherapy is acceptable in elderly patients in good condition, with similar results to younger patients.

关键词： Elderly Pancreas Cancer Gemcitabine

Prediction on temperature dependent elastic constants of “soft” metal Al by AIMD and QHA

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Journal of Materials Science & Technology 2020年第10期42卷 92-97页

作者： Haijun Zhang Chenhui Li philippe Djemia Rui Yang Qingmiao Hua Institute of Metal Research Chinese Academy of SciencesWenhua Road 72Shenyang110016China School of Materials Science and Engineering University of Science and Technology of ChinaJinzhai Road 96Hefei230026China LSPM-CNRS3407 Universite Paris 13Sorbonne Paris CiteVilletaneuse93430France

First-principles methods based on density functional theory(DFT)are nowadays routinely applied to calculate the elastic constants of materials at temperature of 0 ***,the first-principles calculations of elastic constants at finite temperature are not *** the present work,the feasibility of the ab initio molecular dynamic(AIMD)method in calculations of the temperature dependent elastic constants of relatively"soft"metals,taking face centered cubic(FCC)aluminum(Al)as example,is *** AIMD calculations are performed with carefully selected strain tensors and strain *** parallel with the AIMD calculations,first-principles calculations with the quasiharmonic approximation(QHA)are performed as *** show that all three independent elastic constant components(C11,C12 and C44)of Al from both the AIMD and QHA calculations decrease with increasing temperature T,in good agreement with those from experimental *** work allows us to quantify the individual contributions of the volume expansion,lattice vibration(excluding those contributed to the volume expansion),and electronic temperature effects to the temperature induced variation of the elastic *** Al with stable FCC crystal structure,the volume expansion effect contributes the major part(about 75%~80%)in the temperature induced variation of the elastic *** contribution of the lattice vibration is minor(about 20%~25%)while the electronic temperature effect is *** the elastic constants soften with increasing temperature,FCC Al satisfies the Born elastic stability criteria with temperature up to the experimental melting point.

关键词： Elastic constant First-principle Molecular dynamics Vibration Aluminum

Control Evaluation of Antagonistic Series Elastic Actuation for a Robotic Endoscope Joint

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Journal of Bionic Engineering 2022年第4期19卷 965-974页

作者： Lorin Fasel Nicolas Gerig philippe C.Cattin Georg Rauter BIROMED-Lab Department of Biomedical EngineeringUniversity of Basel4123AllschwilSwitzerland CIAN Department of Biomedical EngineeringUniversity of Basel4123AllschwilSwitzerland

Haptic feedback is typically missing during telemanipulation of surgical robots in minimally invasive surgeries,i.e.,surgeons cannot feel the interaction forces between the instruments and ***,surgeons have to solely rely on visual feedback,which increases complexity of guiding the instruments and poses the safety threat of unperceivable contacts outside the field of *** propose a novel series elastic actuation design for articulated robotic endoscopes to overcome these limitations and evaluate an according device with one *** to the actuation of human fingers,the joint is driven by antagonistic *** are integrated in the transmission between the tendons and the motors outside of the endoscope *** estimated the joint angle and thereby the endoscope shape,measured spring deflection,estimated tendon forces from that deflection,and implemented force control for the endoscope *** torque control and impedance control were evaluated under application of both a continuous force and an impact force to the endoscope *** springs reduced impact forces at the tip of the endoscope through their inherent *** the same time,feeding back the estimated force resulted in a stable tendon force control and a tunable endoscope joint control:Zero torque control effectively reduced the external forces,while the endoscope joint showed the expected stiffness in impedance *** results show that antagonistic series elastic actuation is a promising concept for endoscope joint actuation and that it can lead towards safer robot–tissue interactions in surgical robotics.

关键词： Minimally invasive surgery RAMIS Robot-assisted surgery Haptic feedback Force control Tendon-driven robotics

Structural characteristics of electrohydrodynamic jets induced by a blade-plane actuator subjected to highly non-uniform electric fields:Parametric investigation through the particle image velocimetry techniques

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High Voltage 2023年第1期8卷 183-195页

作者： Zelu Yan Christophe Louste philippe Traoré Jian Wu Jian'an Fang Logistics Engineering College Shanghai Maritime UniversityShanghaiChina Institut PPRIME Universitéde PoitiersPoitiersFrance Key Laboratory of Aerospace Thermophysics School of Energy Science and EngineeringHarbin Institute of TechnologyHarbinChina College of Information Science and Technology Donghua UniversityShanghaiChina

This study set out to systematically investigate the structural characteristics of plane electrohydrodynamic jets through the particle image velocimetry(PIV)*** to the wide range of applied voltages and electrode gaps under various experimental conditions,an assessment of the image quality and a statistical analysis of the velocity fields are first performed to ensure the validity of the PIV measurements,which were originally applied purely to fluid *** results indicate that the time interval between two consecutive images should be pre-adjusted to reduce the number of uncorrelated vector ***,the minimum number of instantaneous fields should be achieved for an accurate calculation of the time-averaged *** equivalent electric field criterion adapted to the asymmetric electrode configuration is defined to find similarities in flow structures under different voltage and electrode gap *** the applied electric field increases,three injection regimes are identified and the current increases almost linearly,indicating a large conduction current *** decrease in charge density due to recombination proves to be relevant in all cases of this *** to the parametric analysis approach for classical jets and thermal plumes,the evolution of the coefficients of axial velocity,half-width and turbulence intensity are investigated.

关键词： plane particle blade

The Fictitious Domain Method with Sharp Interface for Elasticity Systems with General Jump Embedded Boundary Conditions

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Advances in Applied Mathematics and Mechanics 2021年第1期13卷 119-139页

作者： Mohamed Kara Salim Mesbahi philippe Angot Applied Mathematics Laboratory Department of MathematicsFaculty of SciencesFerhat Abbas UniversitySetifAlgeria Fundamental and Numerical Mathematics Laboratory Department of MathematicsFaculty of SciencesFerhat Abbas UniversitySetifAlgeria Aix-Marseille Universit´e Institut de Math´ematiques de MarseilleCNRS UMR 7373MarseilleFrance

In framework of the fictitious domain methods with immersed interfaces for the elasticity problem,the present contribution is to study and numerically validate the jump-integrated boundary conditions method with sharp interface for the vector elasticity system discretized by a proposed finite volume *** main idea of the fictitious domain approach consists in embedding the original domain of study into a geometrically larger and simpler one called the fictitious ***,we present a cell-centered finite volume method to discretize the fictitious domain *** proposed method is numerically validated for different test *** work can be considered as a first step before more challenging problems such as fluid-structure interactions or moving interface problems.

关键词： Fictitious domain method sharp interface elasticity system jump embedded boundary conditions finite volume method

A Geometry-Preserving Finite Volume Method for Compressible Fluids on Schwarzschild Spacetime

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Communications in Computational Physics 2014年第3期15卷 827-852页

作者： philippe G.LeFloch Hasan Makhlof Laboratoire Jacques-Louis Lions&Centre National de la Recherche Scientifique Université Pierre et Marie Curie(Paris 6)4 Place Jussieu75252 ParisFrance

We consider the relativistic Euler equations governing spherically symmetric,perfect fluid flows on the outer domain of communication of Schwarzschild spacetime,and we introduce a version of the finite volume method which is formulated from the geometric formulation(and thus takes the geometry into account at the discretization level)and is well-balanced,in the sense that it preserves steady solutions to the Euler equations on the curved geometry under *** order to formulate our method,we first derive a closed formula describing all steady and spherically symmetric solutions to the Euler equations posed on Schwarzschild ***,we describe a geometry-preserving,finite volume method which is based from the family of steady solutions to the Euler *** scheme is second-order accurate and,as required,preserves the family of steady solutions at the discrete *** experiments are presented which demonstrate the efficiency and robustness of the proposed method even for solutions containing shock waves and nonlinear interacting wave *** an application,we investigate the late-time asymptotics of perturbed steady solutions and demonstrate its convergence for late time toward another steady solution,taking the overall effect of the perturbation into account.

关键词： Compressible fluid Euler system Schwarzschild spacetime geometry-preserving finite volume method steady state

Effect of an Internal Heat Exchanger on the Performances of a Double Evaporator Ejector Refrigeration Cycle

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Fluid Dynamics & Materials Processing 2023年第5期19卷 1115-1128页

作者： Rachedi Khadraoui Latra Boumaraf philippe Haberschill Mechanical Engineering Department Badji Mokhtar UniversityAnnabaAlgeria Center for Thermal Sciences of Lyon INSAVilleurbanneFrance

A theoretical investigation is presented about a double evaporator ejector refrigeration cycle(DEERC).Special attention is paid to take into account the influence of the sub-cooling and superheating effects induced by an internal heat exchanger(IHX).The ejector is introduced into the baseline cycle in order to mitigate the throttling process losses and increase the compressor suction ***,the IHX has the structure of a concentric counter-flow type heat exchanger and is intentionally used to ensure that the fluid at the compressor inlet is *** assess accurately the influence of the IHX on the DEERC performance,a mathematical model is derived in the frame of the dominant one-dimensional theory for *** model also accounts for the friction effect in the ejector mixing *** equations of this model are solved using an Engineering Equation Solver(EES)for different *** are:R134a as baseline fluid and other environment friendly refrigerants used for comparison,namely,R1234yf,R1234ze,R600,R600a,R290,R717 and *** simulation results show that the DEERC with an IHX can achieve COP(the coefficient of performance)improvements from 5.2 until 10%.

关键词： Refrigeration cycle double evaporator ejector IHX performance improvement environment-friendlyrefrigerants

Significance of progressive liver fibrosis in pediatric liver transplants: A review of current evidence

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World Journal of Gastroenterology 2020年第17期26卷 1987-1992页

作者： Mathew George philippe Paci Timucin Taner Departments of Surgery Mayo ClinicRochesterMN 55905United States Departments of Immunology Mayo ClinicRochesterMN 55905United States

This article reviews the current evidence and knowledge of progressive liver fibrosis after pediatric liver *** often-silent histologic finding is common in long-term survivors and may lead to allograft dysfunction in advanced *** through protocolized liver allograft biopsy remains the gold standard for diagnosis,and recent evidence suggests that chronic inflammation precedes fibrosis.

关键词： Allograft fibrosis Pediatric liver transplant Chronic rejection Immunosuppression Portal inflammation Liver allograft

Hepatocyte nuclear factor 4-alpha involvement in liver and intestinal inflammatory networks

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World Journal of Gastroenterology 2014年第1期20卷 22-30页

作者： Jean-philippe Babeu Franois Boudreau Département d’ Anatomie et de Biologie Cellulaire Faculté de Médecine et des Sciences de la SantéUniversité de SherbrookeSherbrooke J1E 4K8QuébecCanada

Hepatocyte nuclear factor 4-alpha (HNF4-α) is a nuclear receptor regulating metabolism, cell junctions, differentiation and proliferation in liver and intestinal epithelial cells. Mutations within the HNF4A gene are associated with human diseases such as maturity-onset diabetes of the young. Recently, HNF4A has also been described as a susceptibility gene for ulcerative colitis in genome-wide association studies. In addition, specific HNF4A genetic variants have been identified in pediatric cohorts of Crohn’s disease. Results obtained from knockout mice supported that HNF4-α can protect the intestinal mucosae against inflammation. However, the exact molecular links behind HNF4-α and inflammatory bowel diseases remains elusive. In this review, we will summarize the current knowledge about the role of HNF4-α and its isoforms in inflammation. Specific nature of HNF4-α P1 and P2 classes of isoforms will be summarized. HNF4-α role as a hepatocyte mediator for cytokines relays during liver inflammation will be integrated based on documented examples of the literature. Conclusions that can be made from these earlier liver studies will serve as a basis to extrapolate correlations and divergences applicable to intestinal inflammation. Finally, potential functional roles for HNF4-α isoforms in protecting the intestinal mucosae from chronic and pathological inflammation will be presented.

关键词： Hepatocyte nuclear factor 4-alpha Inflammatory bowel diseases Colitis-associated cancer Gastrointestinal tract Intestinal epithelium barrier Inflammation