检索结果-南通市图书馆

Catalytic synthesis of acetals and ketals with H3PW12O40/PAn

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2008年第1期27卷 89-94页

作者： YANG Shuijin ZHANG Yijun DU Xinxian philippe G. merle Hubei Key Laboratory of Bioanalytical Technique Department of Chemistry and Environmental Engineering Hubei Normal University Huangshi 435002 China Department of Chemistry and Biochemistry Concordia University Montreal H4B 1R6 Canada

A new environmental friendly catalyst H3PW12O40/PAn was prepared and identified by means of FT-IR,XRD,and TG/*** optimum conditions have been found;that is,the mass ratio of PAn to H3PW12O40 is 1：1.5,the volume of methanol is 20 mL,and the reflux reaction time is 3 *** structural identity of Keggin units is preserved after the incorporation into polyaniline *** activities of H3PW12O40/PAn in synthesizing 2-methyl-2-ethoxycarbonylmethyl-1,3-dioxolane,2,4-dimethyl-2-ethoxycarbonylmethyl-1,3-dioxolane,cyclohexanone ethylene ketal,cyclohexanone 1,2-propanediol ketal,butanone ethylene ketal,butanone 1,2-propanediol ketal,2-phenyl-1,3-dioxolane,4-methyl-2-phenyl-1,3-dioxolane,2-propyl-1,3-dioxolane,and 4-methyl-2-propyl-1,3-dioxolane were *** has been demon-strated that H3PW12O40/PAn is an excellent *** factors concerned in these reactions were *** optimum conditions are as follows：the molar ratio of aldehyde/ketone to glycol（r） is 1：1.5,the mass ratio of the catalyst used to the reactants is 0.6%,and the reaction time is 1.0 *** these conditions,the yield is as follows：2-methyl-2-ethoxycarbonylmethyl-1,3-dioxolane,69.0%;2,4-dimethyl-2-ethoxycarbonylmethyl-1,3-dioxolane,79.5%;cyclohexanone ethylene ketal,78.9%;cyclohexanone 1,2-propanediol ketal,85.3%;butanone ethylene ketal,56.9%;butanone 1,2-propanediol ketal,78.1%;2-phenyl-1,3-dioxolane,76.3%;4-methyl-2-phenyl-1,3-dioxolane,94.2%;2-propyl-1,3-dioxolane,70.7%;and 4-methyl-2-propyl-1,3-dioxolane,79.2%.

关键词： phosphotungstic acid acetal ketal polyaniline catalysis

Comparison and analysis of the efficacy of drug therapy for liver cancer

在线全文

学校读者我要写书评

暂无评论

Hepatoma Research 2020年第9期6卷 55-64页

作者： philippe merle Miroslava Subic Unitéd’Hépatologie et Gastroentérologie Hôpital de la Croix RousseHospices Civils de LyonLyon 69004France. Centre de Recherche en Cancérologie de Lyon INSERM U1052Lyon 69003France. UniversitéClaude Bernard Lyon 1 Villeurbanne 69100France

Hepatocellular carcinoma(HCC)is a poor prognosis tumor when not accessible to potentially curative treatments such as surgical resection,thermal ablations or liver *** cytotoxic chemotherapies have shown inconsistent clinical *** 2007,sorafenib,a tyrosine kinase inhibitor(TKI),was the first systemic therapy able to significantly improve the outcome of HCC patients non-eligible for curative or loco-regional therapies,despite a modest tolerance and low tumor objective response rate(ORR).Among the newer TKIs approved after 2017,lenvatinib was the first to show a striking ORR and demonstrate non-inferiority *** in the first-line ***,phase 3 trials showed the benefit of other TKIs,regorafenib and cabozantinib,and the anti-angiogenic ramucirumab monoclonal antibody,in systemic second-line *** checkpoint inhibitors targeting PD1,achieved striking tumor shrinkage in some patients in monotherapy,seeming to be associated with exciting ***,this occurred in too few patients to improve the median overall *** recently,the combination of anti-angiogenic drugs targeting the liver microenvironment with PD-1/PD-L1 inhibitors,such as the combination of bevacizumab and atezolizumab,proved to be substantially effective in phase 3,and other combinations of PD-1/PD-L1 and CTLA-4 inhibitors or TKIs have raised a lot of hopes for the systemic treatment of HCC.

关键词： Hepatocellular carcinoma therapy immune checkpoint inhibitors tyrosine kinase inhibitors

Combination therapy for advanced hepatocellular carcinoma:do we see the light at the end of the tunnel?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2021年第2期10卷 180-192页

作者： Ti Zhang philippe merle Huaqi Wang Haitao Zhao Masatoshi Kudo Department of Hepatic Surgery Fudan University Shanghai Cancer CenterShanghai Medical CollegeFudan UniversityShanghaiChina Department of Hepatology Hôpital de la Croix-RousseHospices Civils de LyonUniversitéLyon 1103 Grande rue de la Croix RousseLyonFrance Department of Hepatobiliary Surgery Tianjin Medical University Cancer Institute and HospitalTianjinChina Department of Liver Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical College(CAMS&PUMC)BeijingChina Department of Gastroenterology and Hepatology Kindai University Faculty of MedicineOsaka-SayamaJapan

Importance:Combination therapies of anti-PD-1 and anti-angiogenesis regimens are emerging rapidly and exhibit more promising anti-tumor efficacy for advanced hepatocellular carcinoma(HCC),and consistently it is the hotspot in clinical ***:To elaborate several issues which are warranted further consideration as more regimens are being investigated in combination *** Review:We searched PubMed,MEDLINE,Cochrane Library and Google Scholar by 2021 February for publications on combination therapies for ***:Several clinical issues are worth reconsidering,such as the evaluation on appropriate primary endpoints in phase III clinical trials as for different practical problems,the translation of surrogate endpoint objective response rate(ORR)benefits into overall survival(OS)benefits,and whether conversion surgery contributes to initial expectations of long-term survival or *** concepts in novel immunotherapy and targeted therapy in combination with loco-regional therapies may improve overall survival for *** and Relevance for Reviews:Comprehensive understanding of the mechanism of immunotherapy and targeted therapy contributes to better prognosis of advanced HCC and more explorative combination therapies are needed.

关键词： Hepatocellular carcinoma(HCC) angiogenesis immunotherapy combination therapy

Polyaniline Supported 12-Tungstosilicic Acid as the Catalyst for Acetals and Ketals Synthesis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2009年第3期24卷 371-375页

作者：杨永金 philippe G merle Hubei Key Laboratory of Pollutant Analysis & Reuse Technology College of Chemistry and Environmental Engineering Hubei Normal University Department of Chemistry and Biochemistry Concordia University

A novel environmental friendly catalyst, H4SiW12O40/PAn was prepared and identified by FT-IR, XRD and TG/DTA. The optimal synthetic protocol was a PAn to H4SiW12O40 mass ratio of 1 ： 1, a 20 mL of methanol and a reaction time of 2 h at reflux. It was used in catalytic synthesis of ten important ketals and acetals with a high catalytic activity. With an aldehyde/ketone to glycol molar ratio of 1 ： 1.5 and a 1 wt% catalyst loading, the yields of ketals and acetals could reach 60.0%- 93.8 % after 1 h.

关键词： 12-tungstosilicic acid polyaniline acetal ketal catalysis

硅钨酸掺杂聚苯胺催化合成2-异丙基-1,3-二氧环戊烷

在线全文

学校读者我要写书评

暂无评论

化学试剂 2007年第10期29卷 577-580,583页

作者：杨水金余协卿 philippe G.merle 湖北师范学院化学与环境工程系湖北黄石435002 Department of Chemistryand Biochemistry Concordia UniversityMontrealCanada

采用回流法自制了硅钨酸(H4SiW12O40)掺杂聚苯胺(PAn)催化剂H4SiW12O40/PAn。通过异丁醛和乙二醇为原料合成标题化合物,探讨了硅钨酸掺杂聚苯胺催化剂对缩醛反应的催化活性,较系统地研究了原料物质的量比、催化剂用量、反应时间诸因素... 详细信息

采用回流法自制了硅钨酸(H4SiW12O40)掺杂聚苯胺(PAn)催化剂H4SiW12O40/PAn。通过异丁醛和乙二醇为原料合成标题化合物,探讨了硅钨酸掺杂聚苯胺催化剂对缩醛反应的催化活性,较系统地研究了原料物质的量比、催化剂用量、反应时间诸因素对产率的影响。实验表明,硅钨酸掺杂聚苯胺催化剂是合成标题化合物的良好催化剂,在n(乙二醇)∶n(异丁醛)=1.5∶1,催化剂用量为反应物料总质量的1.2%,环己烷为带水剂,反应时间1.0h的优化条件下,标题化合物的收率可达88.8%。

关键词： 2-异丙基-1,3-二氧环戊烷硅钨酸聚苯胺催化缩醛反应

Catalytic synthesis of acetals and ketals with H3PW6Mo6O40/TiO2

在线全文

学校读者我要写书评

暂无评论

Journal of Chemistry and Chemical Engineering 2007年第1期1卷 8-11,39页

作者： YANG Shui-jin TONG Wen-long philippe G. merle Hubei Key Laboratory of Bioanalytical Technique Department of Chemistry and Environmental Engineering Hubei Normal University Huangshi 435002 China Department of Chemistry and Biochemistry Concordia University Montreal H4B 1R6 Canada

A new environmental friendly catalyst, H3PW6Mo6O40/TiO2 was prepared. The optimum conditions have been found, that is, mass ratio of m （TiO2）： m （H3PW6Mo6O40） is 1：2.0, volume of water is 30 mL, the reflux reaction time is 2 h, and activated temperature is 150 ℃. H3PW6Mo6O40/TiO2 was used as catalyst in catalytic synthesis ofacetals and ketals. Effects ofn （aldehyde（ketone））： n （glycol）, catalyst dosage and reaction time on yield were investigated. Optimal conditions were： n（aldehyde （ketone））： n （glycol）=1.0 ： 1.4; mass fraction of catalyst to reactants, 0.8%; reaction time, 1.0 h and cyclohexane as water-stripped reagent, 10 mL. Under these conditions, yields of acetals and ketals can reach 53.0% -86.9 0%

关键词： H3PW6Mo6O40 TiO2 acetalation ketalation catalysis

Acute liver failure:individualization of care and minimizing the need for liver transplantation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2024年第5期13卷 865-868页

作者： philippe Ichaï Faouzi Saliba Liver Intensive Care Unit AP-HP Hôpital Paul-BrousseCentre Hépato-BiliaireVillejuifFrance UniversitéParis-Saclay and INSERM Unit N°1193 VillejuifFrance

Acute liver failure(ALF)is a challenging condition that requires a rapid transfer and management in a specialized intensive care unit affiliated to a transplant *** outcome depends mainly on patient’s age,etiology of ALF,severity of the neurological damage at time of presentation,systemic and brain hemodynamic status and the possibility of a rapid access to liver transplantation(LT).Nevertheless,in recent years,the global survival rate improved and the number of patients with ALF who do not require LT have significantly *** 1998 and 2013,the gap of improvement was respectively 12%and 25%(1).

关键词： Acute liver failure(ALF) artificial liver support liver transplantation(LT)

The top-order energy of quasilinear wave equations in two space dimensions is uniformly bounded

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fundamental Research 2024年第2期4卷 270-283页

作者： Shijie Dong philippe G.LeFloch Zhen Lei Southern University of Science and Technology SUSTech International Center for Mathematicsand Department of MathematicsShenzhen 518055China Fudan University School of Mathematical Sciences220 Handan RoadShanghai 200433China Laboratoire Jacques-Louis Lions and Centre National de la Recherche Scientifique Sorbonne Université4 Place JussieuParis 75252France Shanghai Center for Mathematical Sciences Shanghai 200433China

Alinhac solved a long-standing open problem in 2001 and established that quasilinear wave equations in two space dimensions with quadratic null nonlinearities admit global-in-time solutions,provided that the initial data are compactly supported and sufficiently small in Sobolev *** this work,Alinhac obtained an upper bound with polynomial growth in time for the top-order energy of the solutions.A natural question then arises whether the time-growth is a true phenomenon,despite the possible conservation of basic *** the present paper,we establish that the top-order energy of the solutions in Alinhac theorem remains globally bounded in time.

关键词： Quasilinear wave equation Global-in-time solution Uniform energy bounds Quadratic null nonlinearity Hyperboloidal foliation method Vector field method

Recent Progress of the Solar Wind Magnetosphere Ionosphere Link Explorer (SMILE) Mission

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

空间科学学报 2024年第4期44卷 692-698页

作者： WANG Chi ESCOUBET philippe FORSYTH Colin LI Jing AGNOLON David State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190 European Space Agency/European Space Research and Technology Centre Noordwijk 2201 AZ Mullard Space Science Laboratory University College LondonLondon RH56 NT

The SMILE(Solar wind Magnetosphere Ionosphere Link Explorer)mission is a joint space science mission between the Chinese Academy of Sciences(CAS)and the European Space Agency(ESA),aiming to understand the interaction of the solar wind with the Earth’s magnetosphere in a global *** of May 2024,the SMILE mission is in phase-D with an expected launch date of September *** report summarizes developments in the mission during the past two years.

关键词： SMILE Soft X-ray Imager Ultra-Violet Imager Light Ion Analyzer Magnetometer