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Teriflunomide provides protective properties after oxygen-glucose-deprivation in hippocampal and cerebellar slice cultures

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Neural Regeneration Research 2021年第11期16卷 2243-2249页

作者： Anna Wolters Judith Reuther philipp Gude Thomas Weber Carsten Theiss Heike Vogelsang Veronika Matschke Institute of Anatomy Department of CytologyMedical FacultyRuhr University BochumBochumGermany Department of Anaesthesiology and Intensive Care Medicine Ruhr University BochumSt.Josef HospitalBochumGermany

One of the major challenges in emergency medicine is out-of-hospital cardiac arrest(OHCA).Every year,about 53–62/100000 people worldwide suffer an out-of-hospital cardiac arrest with serious consequences,whereas persistent brain injury is a major cause of morbidity and mortality of those surviving a cardiac ***,only few and insufficient strategies are known to limit neurological damage of ischemia and reperfusion *** aim of the present study was to investigate whether teriflunomide,an approved drug for treatment of relapsing-remitting-multiple-sclerosis,exerts a protective effect on brain cells in an in vitro model of ***,organotypic slice cultures from rat hippocampus and cerebellum were exposed to oxygen-glucose-deprivation and subsequently treated with *** administration of teriflunomide in the reperfusion time on both hippocampal and cerebellar slice cultures significantly decreased the amount of detectable propidium iodide signal compared with an untreated culture,indicating that more cells survive after ***,hippocampal slice cultures showed a higher vulnerability to ischemic conditions and a more sensitive response to teriflunomide compared with cerebellar slice *** study suggests that teriflunomide,applied as a post-treatment after an oxygenglucose-deprivation,has a protective effect on hippocampal and cerebellar cells in organotypic slice cultures of *** procedures were conducted under established standards of the German federal state of North Rhine Westphalia,in accordance with the European Communities Council Directive 2010/63/EU on the protection of animals used for scientific purposes.

关键词： brain damage cardiac arrest cell death hypoxic chamber ischemia organotypic slice cultures post-treatment resuscitation

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拍卖行化身多元艺术空间——嘉德艺术中心

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设计家 2018年第1期 102-106页

作者： Marcel Holmberg Sun Ke Emily Liang Cecilia Lei Yingda Ahrens Mark Biemans Kim Bjarke Catarina Canas Alicia Casals Michael Cavander Jeffrey Cheng Patrick Conway Dyno Du Nicolaz Frez Brian Fung Daniel Hawkins Xinran Ji philipp kramer Emeline Laurencon Yuyang Lin Mavis Liu Wymen Lo Max Ma Rafael Merino John Murphey Marcin Olszowski Kevin Ou Kevin Park Yanyadech Phornphong Aaron Powers Klementina Savickaite Jim Shi Chiara Storino Joseph Tang Yang Tao Elena Yang Quentin Yiu Francis Young Lei Yu Danny Zhang Bruno Zhao Weiwei Zhang Yi Zhu Catarina Canas Brian Fung Paloma Hernaiz Marcel Holmberg Tait Kaplan Jaime Oliver Joseph Tang Beijing Institute of Architectural Design (BIAD) Beijing Buro Ole Scheeren MQ-Studio Shanghai(Hotel)

嘉德艺术中心紧邻紫禁城,作为一座全新的综合文化机构,将北京的古城韵味与现代大都会的蓬勃生机以及多元艺术融为一体.嘉德艺术中心是世界上第一个量身定制的拍卖行总部,在北京的中心创建了一个全新的多元艺术机构类型.建筑提供博物馆... 详细信息

嘉德艺术中心紧邻紫禁城,作为一座全新的综合文化机构,将北京的古城韵味与现代大都会的蓬勃生机以及多元艺术融为一体.嘉德艺术中心是世界上第一个量身定制的拍卖行总部,在北京的中心创建了一个全新的多元艺术机构类型.建筑提供博物馆硬件质量的展示空间和最先进的艺术品保护设施,同时也是一个灵活丰富的文化空间,与餐馆、酒店、公共交通基础设施结合在一起.

关键词：艺术中心拍卖行艺术空间化身交通基础设施机构类型文化空间量身定制

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Applying ionic liquids as oil additives for gearboxes:Going beyond the state of the art by bridging the nano-scale and component level

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Friction 2023年第6期11卷 1057-1078页

作者： Azhaarudeen ANIFA MOHAMED FARUCK philipp G.GRÜTZMACHER Chia-Jui HSU Dominik DWORSCHAK Hsiu-Wei CHENG Markus VALTINER Kristof STAGEL philipp MIKSOVSKY Apurba Ranjan SAHOO Aitor SAINZ MARTINEZ Katharina BICA-SCHRODER Michael WEIGAND Carsten GACHOT Institut für Konstruktionswissenschaften und Produktentwicklung(IKP) Tribology Research DivisionTU WienVienna1060Austria Institut für Angewandte Physik(IAP) Applied Interface Physics research groupTU WienVienna1040Austria Institut für Angewandte Synthesechemie(IAS) Sustainable Organic Synthesis and Catalysis research groupTU WienVienna1060Austria

Ionic liquids(ILs)have been used effectively in many applications for reducing problems related to friction and *** this work,the potential of ILs as an anti-wear and extreme pressure lubricant additive for high load-carrying gearbox applications such as helicopter transmissions has been *** halide-free ILs:P_(8881)(BuO)_(2)PO_(2)^(-)(1)and P_(8881)(MeO)_(2)PO_(2)^(-)(2),which are blended at 5 wt%each into a standard non-additivated FVA2 base oil(BO)are *** solid-liquid interface,friction and load-carrying capacity,and wear(scuffing)behavior are studied on the nano-,lab-,and component-scale,respectively,at a different range of temperature and loading conditions by using the atomic force microscopy(AFM),Schwing-Reib-Verschleiβ(SRV)friction tests,and Brugger tests,as well as forschungsstelle für zahnrader und getriebebau(FZG)back-to-back gear test *** AFM analysis shows nearly no change of adhesion over the full range of studied temperature for the IL blends compared to the ***,IL blends demonstrate a very stable coefficient of friction(COF)of around 0.16,which even decreases with increasing test temperatures ranging from 40 to 120℃.A clear reduction in COF up to 25%is achieved by adding only 5 wt%of the investigated Ils in the BO,and the Brugger tests also show a pronounced enhancement of load-carrying ***,on the component-scale,a significant improvement in gear scuffing performance has been observed for both used IL blends.A detailed characterization of the wear tracks from the SRV friction tests via the transmission electron microscopy(TEM)revealed the formation of a phosphate(P-O)-based amorphous tribo-chemical layer of about 20 nm ***,this work may present an approach for Ils to be used as an additive in conventional lubricants due to their ability to enhance the lubrication properties,making them an alternative lubricant solution for high load-carrying gearbox applications.

关键词： ionic liquids(ILs) additives gears scuffing friction load-carrying capacity

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One-bit quantization is good for programmable coding metasurfaces

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Science China(Information Sciences) 2022年第7期65卷 225-239页

作者： Ya SHUANG Hanting ZHAO Menglin WEI Qiang CHENG Shi JIN Tiejun CUI philipp DEL HOUGNE Lianlin LI State Key Laboratory of Advanced Optical Communication Systems and Networks Department of ElectronicsPeking University Institute of Electromagnetic Space Southeast University State Key Laboratory of Millimeter Waves Southeast University Pazhou Laboratory University of Rennes

The information-carrying programmable metasurfaces have found widespread applications in communication, sensing, and other related areas. However, there is a fundamental but unresolved problem,i.e., the rigorous understanding of the quantization of metasurface coding. Here, we theoretically investigate the performance difference between one-bit and continuous information-encoding metasurfaces. To this end,we derive analytical representations of system responses in various cases(single-input single-output, singleinput multiple-output, and multiple-input multiple-output). We analyze the impact of one-bit coding(in contrast to continuous coding) in terms of the resulting channel cross-talk and reduction of information capacity in various representative scenarios from wireless communication and holography. Our main finding indicates that the one-bit coding yields a satisfactory performance in most practical scenarios; we also show that in many cases there are smart ways to mildly relax optimization constraints in order to reduce the performance gap between the one-bit and continuous coding. We expect that our results can provide theoretical guidance for a large variety of metasurface-assisted information systems for electromagnetic waves and other wave phenomena.

关键词： metasurfaces metamaterials information capacity signal representation one-bit coding meta-surface

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A new silicon phthalocyanine dye induces pyroptosis in prostate cancer cells during photoimmunotherapy

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Bioactive Materials 2024年第11期41卷 537-552页

作者： Isis Wolf Jonas Storz Susanne Schultze-Seemann philipp REsser Stefan FMartin Susan Lauw Peer Fischer Wolfgang Melchinger Robert Zeiser Oliver Gorka Olaf Groß Christian Gratzke Reinhard Brückner philipp Wolf Department of Urology Medical Center–University of Freiburg79106FreiburgGermany Faculty of Medicine University of Freiburg79106FreiburgGermany Faculty of Biology University of Freiburg79104FreiburgGermany Institute for Organic Chemistry University of Freiburg79104FreiburgGermany Allergy Research Group Department of DermatologyMedical Center–University of Freiburg79104FreiburgGermany Core Facility Signalling Factory&Robotics University of Freiburg79104FreiburgGermany BIOSS Centre for Biological Signalling Studies University of Freiburg79104FreiburgGermany Max Planck Institute for Medical Research 69120HeidelbergGermany Institute for Molecular Systems Engineering and Advanced Materials Heidelberg University69120HeidelbergGermany Department of Internal Medicine I Medical Center-University of Freiburg79106FreiburgGermany k Institute of Neuropathology Medical Center-University of Freiburg79106FreiburgGermany CIBSS Centre for Integrative Biological Signalling Studies University of Freiburg79104FreiburgGermany Received 12 Septembe

Photoimmunotherapy(PIT)combines the specificity of antibodies with the cytotoxicity of light activatable photosensitizers(PS)and is a promising new cancer *** designed and synthesized,in a highly convergent manner,the silicon phthalocyanine dye WB692-CB2,which is novel for being the first light-activatable PS that can be directly conjugated via a maleimide linker to *** the present study we conjugated WB692-CB2 to a humanized antibody with engineered cysteines in the heavy chains that specifically targets the prostate-specific membrane antigen(PSMA).The resulting antibody dye conjugate revealed high affinity and specificity towards PSMA-expressing prostate cancer cells and induced cell death after irradiation with red *** cells exhibited morphological characteristics associated with *** studies revealed the generation of reactive oxygen species,triggering a cascade of intracellular events involving lipid peroxidation,caspase-1 activation,gasdermin D cleavage and membrane rupture followed by release of pro-inflammatory cellular *** first in vivo experiments,PIT with our antibody dye conjugate led to a significant reduction of tumor growth and enhanced overall survival in mice bearing subcutaneous prostate tumor *** study highlights the future potential of the new phthalocyanine dye WB692-CB2 as PS for the fluorescence-based detection and PIT of cancer,including local prostate tumor lesions,and systemic activation of anti-tumor immune responses by the induction of pyroptosis.

关键词： Silicon phthalocyanine Photoimmunotherapy Cancer Pyroptosis Immunogenic cell death

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Fully-coupled simulations of thermally-induced cracking in pegmatite due to microwave irradiation

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第2期11卷 242-250页

作者： Jielin Li Rennie B.Kaunda Shrey Arora philipp Hartlieb Priscilla P.Nelson School of Resources and Safety Engineering Central South University Department of Mining Engineering Colorado School of Mines Mining Engineering and Mineral Economics Montanuniversitaet Leoben

Fully-coupled thermo-mechanical simulations are implemented in COMSOL Multiphysics to investigate micro-scale stress-strain variability in pegmatite specimens subjected to thermal loading using microwaves. Thermally-induced compressive and tensile stresses increase as the microwave irradiation duration increases. The dielectric constant, coefficient of expansion, and type and size of mineralogical boundary have significant impacts on the responses of the rock to microwave irradiation. The maximum principal stress of the chlorite is the smallest, indicating that the chlorite experiences the most damage under microwave irradiation, followed by the quartz. The maximum principal stress values of plagioclase and orthoclase are larger, indicating that they are likely to incur the least damage. Where quartz or chlorite is dominant, the resulting von Mises stresses are consistently higher after 120 s of microwave irradiation. The rate of generation of von Mises stresses increases most rapidly along the interface between quartz and plagioclase, and the interface between quartz and orthoclase, followed by the interface between quartz and chlorite, and finally the interface between plagioclase and orthoclase. The presented modeling approach provides a practical method to investigate stress-strain relationships within mineralogical boundaries inside a rock thin section.

关键词： Microwave irradiation Thermo-mechanical loading Pegmatite Numerical modeling

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Model based decision support system for land use changes and socio-economic assessments

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Journal of Arid Land 2018年第2期10卷 169-182页

作者： YU Yang CHEN Xi philipp HUTTNER Marie HINNENTHAL Andreas BRIEDEN SUN Lingxiao Markus DISSE Xinjiang Institute of Ecology and Geography Chinese Academy of Sciences Chair of Hydrology and River Basin Management Technical University of Munich Chair of Statistics and Risk Management Universitaet der Bundeswehr Muenchen

Hydrological models are often linked with other models in cognate sciences to understand the interactions among climate, earth, water, ecosystem, and human society. This paper presents the development and implementation of a decision support system（DSS） that links the outputs of hydrological models with real-time decision making on social-economic assessments and land use management. Discharge and glacier geometry changes were simulated with hydrological model, water availability in semiarid environments. Irrigation and ecological water were simulated by a new commercial software MIKE HYDRO. Groundwater was simulated by MODFLOW. All the outputs of theses hydrological models were taken as inputs into the DSS in three types of links： regression equations, stationary data inputs, or dynamic data inputs as the models running parallel in the simulation periods. The DSS integrates the hydrological data, geographic data, social and economic statistical data, and establishes the relationships with equations, conditional statements and fuzzy logics. The programming is realized in C＋＋. The DSS has four remarkable features：（1） editable land use maps to assist decision-making;（2） conjunctive use of surface and groundwater resources;（3） interactions among water, earth, ecosystem, and humans; and（4） links with hydrological models. The overall goal of the DSS is to combine the outputs of scientific models, knowledge of experts, and perspectives of stakeholders, into a computer-based system, which allows sustainability impact assessment within regional planning; and to understand ecosystem services and integrate them into land and water management.

关键词： decision support system hydrological modeling ecosystem services land management socio-economic indicator Tarim River Basin

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Variable optofluidic slit aperture

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Light(Science & Applications) 2016年第1期5卷 869-875页

作者： Stefan Schuhladen Kaustubh Banerjee Moritz Stürmer philipp Müller Ulrike Wallrabe Hans Zappe Gisela and Erwin Sick Chair of Micro-optics Department of Microsystems EngineeringUniversity of FreiburgGeorges-Köhler-Allee 10279110 FreiburgGermany Laboratory for Microactuators Department of Microsystems EngineeringUniversity of FreiburgGeorges-Köhler-Allee 10279110 FreiburgGermany

The shape of liquid interfaces can be precisely controlled using electrowetting,an actuation mechanism which has been widely used for tunable optofluidic micro-optical components such as lenses or *** have expanded the considerable flexibility inherent in electrowetting actuation to realize a variable optofluidic slit,a tunable and reconfigurable two-dimensional aperture with no mechanically moving *** optofluidic slit is formed by precisely controlled movement of the liquid interfaces of two highly opaque ink *** 1.5mmlong slit aperture,with controllably variable discrete widths down to 45 mm,may be scanned across a length of 1.5mmwith switching times between adjacent slit positions of less than 120 *** addition,for a fixed slit aperture position,the width may be tuned to a minimum of 3 mmwith high uniformity and linearity over the entire slit *** compact,purely fluidic device offers an electrically controlled aperture tuning range not achievable with extant mechanical alternatives of a similar size.

关键词： electrowetting on dielectrics(EWOD) optofluidics scanning slit aperture tunable

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Evaluating Performance of Different RNA Secondary Structure Prediction Programs Using Self-cleaving Ribozymes

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Genomics, Proteomics & Bioinformatics 2024年第3期22卷 29-41页

作者： Fei Qi Junjie Chen Yue Chen Jianfeng Sun Yiting Lin Zipeng Chen philipp Kapranov State Key Laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life SciencesXiamen UniversityXiamen 361102China Institute of Genomics School of MedicineHuaqiao UniversityXiamen 361021China Botnar Research Centre University of OxfordOxfordOX37LDUnited Kingdom

Accurate identification of the correct,biologically relevant RNA structures is critical to understanding various aspects of RNA biology since proper folding represents the key to the functionality of all types of RNA molecules and plays pivotal roles in many essential biological ***,a plethora of approaches have been developed to predict,identify,or solve RNA structures based on various computational,molecular,genetic,chemical,or physicochemical *** computational approaches hold distinct advantages over all other strategies in terms of the ease of implementation,time,speed,cost,and throughput,but they strongly underperform in terms of accuracy that significantly limits their broader ***,the advantages of these methods led to a steady development of multiple in silico RNA secondary structure prediction approaches including recent deep learning-based ***,we compared the accuracy of predictions of biologically relevant secondary structures of dozens of self-cleaving ribozyme sequences using seven in silico RNA folding prediction tools with tasks of varying *** found that while many programs performed well in relatively simple tasks,their performance varied significantly in more complex RNA folding ***,in general,a modern deep learning method outperformed the other programs in the complex tasks in predicting the RNA secondary structures,at least based on the specific class of sequences tested,suggesting that it may represent the future of RNA structure prediction algorithms.

关键词： RNA secondary structure RNA secondary structure prediction Ribozyme Deep learning Pseudoknot

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Preprotein Import into Chloroplasts via the Toc and Tic Complexes Is Regulated by Redox Signals in Pisum sativum

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Molecular Plant 2009年第6期2卷 1181-1197页

作者： Anna Stengel J. philipp Benz Bob B. Buchanan Jurgen Soil Bettina Bolter Munich Center for Integrated Protein Science CiPS^M Ludwig-Maximilians-Universitat Munchen Feodor-Lynen-Strasse 25 D-81377 Munich Germany Department of Biology I Botany Ludwig-Maximilians-Universitat Munchen Groβhaderner Strasse 2-4 D-82152 Planegg-Martinsried Germany Department of Plant and Microbial Biology University of California 411 Koshland Hall Berkeley CA 94720 USA

The import of nuclear-encoded preproteins is necessary to maintain chloroplast function. The recognition and transfer of most precursor proteins across the chloroplast envelopes are facilitated by two membrane-inserted protein complexes, the translocons of the chloroplast outer and inner envelope （Toc and Tic complexes, respectively）. Several signals have been invoked to regulate the import of preproteins. In our study, we were interested in redox-based import regulation mediated by two signals： regulation based on thiols and on the metabolic NADP＋/NADPH ratio. We sought to identify the proteins participating in the regulation of these transport pathways and to characterize the preprotein subgroups whose import is redox-dependent. Our results provide evidence that the formation and reduction of disulfide bridges in the Toc receptors and Toc translocation channel have a strong influence on import yield of all tested preproteins that depend on the Toc complex for translocation. Furthermore, the metabolic NADP＋/NADPH ratio influences not only the composition of the Tic complex, but also the import efficiency of most, but not all, preproteins tested. Thus, several Tic subcomplexes appear to participate in the translocation of different preprotein subgroups, and the redox-active compo- nents of these complexes likely play a role in regulating transport.

关键词： Metabolic regulation molecular transport transport processes/kinetics chloroplast biology protein targeting.

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