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In vitro activity of moxifloxacin and piperacillin/sulbactam against pathogens of acute cholangitis

World Journal of Gastroenterology 2008年第20期14卷 3174-3178页

作者： Andreas Weber Wolfgang Huber Klaus Kamereck philipp winkle Petra Voland Hans Weidenbach Roland M Schmid Christian Prinz Department of Gastroenterology Klinikum rechts der Isar Technical University Munich Institute of Medical Microbiology Immunology and Hygiene Klinikum rechts der Isar Technical University Munich

AIM：To analyze the in vitro activity of moxifloxacin and piperacillin/sulbactam against pathogens isolated from patients with acute cholangitis. METHODS： In this prospective study a total of 65 patients with acute cholangitis due to biliary stone obstruction （n = 7）, benign biliary stricture （n = 16）, and malignant biliary stricture （n = 42） were investigated with regard to spectrum of bacterial infection and antibiotic resistance. Pathogens were isolated from bile cultures in all study patients. In 22 febrile patients, blood cultures were also obtained. In vitro activity of moxifloxacin and piperacillin/ sulbactam was determined by agar diffusion. RESULTS： Thirty-one out of 65 patients had positive bile and/or blood cultures. In 31 patients, 63 isolates with 17 different species were identified. The predominant strains were Enterococcus species （26/63）, Ecoli （13/63） and Klebsiella species （8/63）. A comparable in vitro activity of moxifloxacin and piperacillin/sulbactam was observed for *** and Klebsiella species. In contrast, Enterococcus species had higher resistances towards moxifloxacin. Overall bacteria showed antibiotic resistances in vitro of 34.9% for piperacillin/sulbactam and 36.5% for ***： Enterococcus species, ***/i and Klebsiella species were the most common bacteria isolated from bile and/or blood from patients with acute cholangitis. Overall, a mixed infection with several species was observed, and bacteria showed a comparable in vitro activity for piperacillin/sulbactam and moxifloxacin.

关键词： Cholangitis Acute cholangitis Endoscopy Antibiotics Moxifloxacin Piperacillin Sulbactam Biliarystricture Resistance Bacterial pathogens

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