检索结果-南通市图书馆

Dual-sugar tests of small intestinal permeability are poor predictors of bacterial infections and mortality in cirrhosis: a prospective study

引用

World Journal of Gastroenterology 2016年第11期22卷 3275-3284页

作者： Anika Vogt philipp A reuken Sven Stengel Andreas Stallmach Tony Bruns Department of Internal Medicine IV (Gastroenterology Hepatologyand Infectious Diseases)Jena University Hospital Center for Sepsis Control and Care Jena University Hospital

AIM: To prospectively analyze the impact of increased intestinal permeability (IP) on mortality and the occurrence of infections in patients with ***: IP was quantified using the lactulose/mannitol (L/M) test in 46 hospitalized patients with cirrhosis (25 Child-Pugh A/B, 21 Child-Pugh C) and in 16 healthy controls. Markers of inflammation [LPS-binding protein, Interleukin-6 (IL-6)] and enterocyte death [intestinal fatty-acid binding protein (I-FABP)] were determined in serum using enzyme-linked immunosorbent assays. Patients were followed for one year and assessed for survival, liver transplantation, the necessity of hospitalization and the occurrence of bacterial infections. The primary endpoint of the study was defined as differences in survival between patients with pathological and without pathological lactulose/mannitol ***: Thirty-nine (85%) patients with cirrhosis had a pathologically increased IP index (L/M ratio > 0.07) compared to 4 (25%) healthy controls (P < 0.0001). The IP index correlated with the Child-Pugh score (r = 0.484, P = 0.001) and with serum IL-6 (r = 0.342, P = 0.02). Within one year, nineteen (41%) patients developed a total of 33 episodes of hospitalization with bacterial or fungal infections. Although patients who developed spontaneous bacterial peritonitis (SBP) (n = 7) had a higher IP index than patients who did not (0.27 vs 0.14, P = 0.018), the baseline IP index did not predict time to infection, infection-free survival or overall survival, neither when assessed as linear variable, as tertiles, nor dichotomized using an established cut-off. In contrast, model for end-stage liver disease score, Child-Pugh score, the presence of ascites, serum IL-6 and I-FABP were univariate predictors of infection-free ***: Although increased IP is a frequent phenomenon in advanced cirrhosis and may predispose to SBP, it failed to predict infection-free and overall survival in this prospective coho

关键词： Intestinal permeability Liver cirrhosis Lactulose/mannitol ratio Spontaneous bacterial peritonitis Bacterial translocation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluation of Ultrasound-based Surveillance for Hepatocellular Carcinoma in Patients at Risk:Results From a German Multicenter Retrospective Cohort Study

引用

Journal of Clinical and Translational Hepatology 2023年第3期11卷 626-637页

作者： Johannes Gillessen philipp reuken Peter-Marton Hunyady Matthias Christian Reichert Lucian Lothschütz Fabian Finkelmeier Matthias Nowka Gabriel Allo Fabian Kütting Martin Bürger Dirk Nierhoff Hans-Michael Steffen Christoph Schramm University Hospital Cologne Department of Gastroenterology and HepatologyCologneGermany University Hospital Jena Department of Internal Medicine IV-GastroenterologyHepatologyInfectious DiseaseJenaGermany University Hospital Frankfurt Department of Internal Medicine 1-Gastroenterology und HepatologyPulmonology und AllergologyEndocrinologyFrankfurtGermany Department of Medicine II Saarland University Medical CenterHomburgGermany Department of Gastroenterology and Hepatology University Hospital of EssenEssenGermany

Background and Aims:Hepatocellular carcinoma(HCC)surveillance in patients at risk is strongly recommended and usually performed by ultrasound(US)semiannually with or without alfa-fetoprotein(AFP)*** pa-rameters except for surveillance intervals have not been strictly *** aimed to evaluate surveillance success and risk factors for surveillance ***:Patients with≥1 US prior to HCC diagnosis performed at four tertiary referral hospitals in Germany between 2008 and 2019 were retrospectively *** success was defined as HCC detection within Milan ***:Only 47%of 156 patients,median age 63(interquartile range:57-70)years,56%male,and 96%with cirrhosis,received recom-mended surveillance modality and *** fail-ure occurred in 29%and was significantly associated with lower median model for end-stage liver disease(MELD)score odds ratio(OR)1.154,95%confidence interval(CI):1.027-1.297,p=0.025)and HCC localization within right liver lobe(OR:6.083,95%CI:1.303-28.407,p=0.022),but not with AFP≥200μg/*** with surveillance failure had sig-nificantly more intermediate/advanced tumor stages(93%vs.6%,p<0.001),fewer curative treatment options(15%vs.75%,p<0.001)and lower survival at 1 year(54%vs.75%,p=0.041),2 years(32%vs.57%,p=0.019)and 5 years(0%vs.16%,p=0.009).Alcoholic and non-alcoholic fatty liver disease(OR:6.1,95%CI:1.7-21.3,p=0.005)and ascites(OR:3.9,95%CI:1.2-12.6,p=0.021)were in-dependently associated with severe visual limitations on ***:US-based HCC surveillance in patients at risk frequently fails and its failure is associated with unfavorable patient-related *** MELD score and HCC lo-calization within right liver lobe were significantly associated with surveillance failure.

关键词： Hepatocellular carcinoma Surveillance success Screening Ultra-sound.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

News on the physics potential of the reaction e^+e^-→ Zγ

引用

Science China(Physics,Mechanics & Astronomy) 2021年第2期64卷 27-28页

作者： philipp Roloff CERN CH-1211Geneva 23Switzerland

The next large project in particle physics is widely expected to be a high-energy electron-positron *** a facility could be realised as a circular collider,like the Circular Electron Positron Collider(CEPC)and the Future e^+e^-Circular Collider(FCC-ee)[1],or as a linear collider,like the International Linear Collider(ILC)and the Compact Linear Collider(CLIC)[2].

关键词： circular positron potential

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Plants against cancer:towards green Taxol production through pathway discovery and metabolic engineering

引用

aBIOTECH 2024年第3期5卷 394-402页

作者： philipp Zerbe Department of Plant Biology University of California DavisDavisCA 95616USA

The diversity of plant natural products presents a rich resource for accelerating drug discovery and addressing pressing human health ***,the challenges in accessing and cultivating source species,as well as metabolite structural complexity,and general low abundance present considerable hurdles in developing plant-derived *** in high-throughput sequencing,genome assembly,gene synthesis,analytical technologies,and synthetic biology approaches,now enable us to efficiently identify and engineer enzymes and metabolic pathways for producing natural and new-to-nature therapeutics and drug *** review highlights challenges and progress in plant natural product discovery and engineering by example of recent breakthroughs in identifying the missing enzymes involved in the biosynthesis of the anti-cancer agent Taxol^(®).These enzyme resources offer new avenues for the bio-manufacture and semi-synthesis of an old blockbuster drug.

关键词： Taxol Plant natural products Synthetic biology Pathway discovery Metabolic engineering

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Calibration-free speckle matrix imaging

引用

Light(Science & Applications) 2022年第3期11卷 1-3页

作者： philipp del Hougne Univ Rennes CNRSIETR-UMR 616435000RennesFrance

Unknown speckle patterns can be used to image targets embedded in complex scattering media 100 times faster than previous techniques based on carefully calibrated illuminations.

关键词： speckle illumination faster

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of nanoparticle concentration on zeta-potential measurement results and reproducibility

引用

Particuology 2010年第3期8卷 279-285页

作者： Ratna Tantra philipp Schulze Paul Quincey National Physical Laboratory Hampton Road Teddington Middlesex TW11 0LW UK Department of Physics University of Bath Bath BA2 7AY UK. National Physical Laboratory Hampton Road Teddington Middlesex TW11 0LW

The effect of nanoparticle concentration on zeta-potential measurement results at dilute concentrations was evaluated. The values of the zeta-potential for four different types of nanoparticles, Ludox （silica）, multi-walled carbon nanotubes （bamboo-shaped and hollow nanotubes） and gold, at various concentrations, were obtained using a laser Doppler electrophoresis instrument. The size of the nanoparticles on dilution was measured using dynamic light scattering （DLS）. The results show that there is a concentration range within which the zeta-potential, and particle size, are not affected by nanoparticle concentration. The lower concentration limit for the system to produce consistent results was dependent on the nature of the sample under study and ranged between 10-2 and 10-4 wt%. Below this concentration, there was an apparent shift in zeta-potential values to less negative values, which was accompanied by an increase in the particle size. The shift in zeta-potential was attributed to an increase in contribution of the signal from extraneous particulate matter. The increase in particle size was attributed to the nature of the homodyne optical configuration of the instrument. The aim of this study was to elucidate the range in nanoparticle concentration that allows for accurate and reliable measurement of the zeta-potential and DLS data.

关键词： Nanoparticles Zeta-potential Dynamic light scattering Reproducibility

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Entropy‑Conservative Discontinuous Galerkin Methods for the Shallow Water Equations with Uncertainty

引用

Communications on Applied Mathematics and Computation 2024年第3期6卷 1978-2010页

作者： Janina Bender philipp Öffner Institute of Mathematics University KasselMonchebergstraße 1934127 KasselGermany Institute of Mathematics Johannes Gutenberg UniversityStaudingerweg 955099 MainzGermany Mathematical Institute Technical University ClausthalErzstraße 138678 Clausthal ZellerfeldGermany

In this paper,we develop an entropy-conservative discontinuous Galerkin(DG)method for the shallow water(SW)equation with random *** of the most popular methods for uncertainty quantifcation is the generalized Polynomial Chaos(gPC)approach which we consider in the following *** apply the stochastic Galerkin(SG)method to the stochastic SW *** the SG approach in the stochastic hyperbolic SW system yields a purely deterministic system that is not necessarily hyperbolic *** lack of the hyperbolicity leads to ill-posedness and stability issues in numerical *** transforming the system using Roe variables,the hyperbolicity can be ensured and an entropy-entropy fux pair is known from a recent investigation by Gerster and Herty(***.27(3):639–671,2020).We use this pair and determine a corresponding entropy fux ***,we construct entropy conservative numerical twopoint fuxes for this augmented *** applying these new numerical fuxes in a nodal DG spectral element method(DGSEM)with fux diferencing ansatz,we obtain a provable entropy conservative(dissipative)*** numerical experiments,we validate our theoretical fndings.

关键词： Shallow water(SW)equations Entropy conservation/dissipation Uncertainty quantification Discontinuous Galerkin(DG) Generalized Polynomial Chaos(gPC)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mode structure symmetry breaking of reversed shear Alfvén eigenmodes and its impact on the generation of parallel velocity asymmetries in energetic particle distribution

引用

Plasma Science and Technology 2022年第2期24卷 17-27页

作者： Guo MENG philipp LAUBER Xin WANG Zhixin LU Max-Planck-Institut fiir Plasmaphysik D-85748 GarchingGermany

In this work,the gyrokinetic eigenvalue code LIGKA,the drift-kinetic/MHD hybrid code HMGC and the gyrokinetic full-f code TRIMEG-GKX are employed to study the mode structure details of reversed shear Alfvén eigenmodes(RSAEs).Using the parameters from an ASDEXUpgrade plasma,a benchmark with the three different physical models for RSAE without and with energetic particles(EPs)is carried *** agreement has been found for the mode frequency and the growth *** structure symmetry breaking(MSSB)is observed when EPs are included,due to the EPs’non-perturbative *** is found that the MSSB properties are featured by a finite radial wave phase velocity,and the linear mode structure can be well described by an analytical complex Gaussian expressionФ(s)=e^(-σ(s-s_(0))^(2))with complex parametersσand s_(0),where s is the normalized radial *** mode structure is distorted in opposite manners when the EP drive shifted from one side of qminto the other side,and specifically,a non-zero average radial wave number with opposite signs is *** initial EP density profiles and the corresponding mode structures have been used as the input of HAGIS code to study the EP *** parallel velocity of EPs is generated in opposite directions,due to different values of the average radial wave number,corresponding to different initial EP density profiles with EP drive shifted away from the qmin.

关键词： reversed shear Alfvén eigenmode symmetry breaking energetic particles non-perturbative effects

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Realising Data-Centric Scientific Workflows with Provenance-Capturing on Data Lakes

引用

Data Intelligence 2022年第2期4卷 426-438页

作者： Hendrik Noltet philipp Wieder Gesellschaft fur wissenschaftliche Datenverarbeitung mbH Gottingen Gottingen Gottingen 37077Germany

Since their introduction by James Dixon in 2010,data lakes get more and more attention,driven by the promise of high reusability of the stored data due to the schema-on-read *** on this idea,several additional requirements were discussed in literature to improve the general usability of the concept,like a central metadata catalog including all provenance information,an overarching data governance,or the integration with(high-performance)processing *** the necessity for a logical and a physical organisation of data lakes in order to meet those requirements is widely recognized,no concrete guidelines are yet *** most common architecture implementing this conceptual organisation is the zone architecture,where data is assigned to a certain zone depending on the degree of *** paper discusses how FAIR Digital Objects can be used in a novel approach to organize a data lake based on data types instead of zones,how they can be used to abstract the physical implementation,and how they empower generic and portable processing capabilities based on a provenance-based approach.

关键词： Data lake Provenance Workflows FAIRDigital Objects CWFR

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Novel treatment options for portal hypertension

引用

Gastroenterology Report 2017年第2期5卷 90-103,I0001页

作者： philipp Schwabl Wim Laleman Division of Gastroenterology and Hepatology Department of Internal Medicine IIIMedical University of ViennaViennaAustria Department of Gastroenterology and Hepatology University Hospitals LeuvenKU LeuvenLeuvenBelgium

Portal hypertension is most frequently associated with cirrhosis and is a major driver for associated complications,such as variceal bleeding,ascites or hepatic *** such,clinically significant portal hypertension forms the prelude to decompensation and impacts significantly on the prognosis of patients with liver *** present,non-selective bblockers,vasopressin analogues and somatostatin analogues are the mainstay of treatment but these strategies are far from satisfactory and only target splanchnic *** contrast,safe and reliable strategies to reduce the increased intrahepatic resistance in cirrhotic patients still represent a pending *** recent years,several preclinical and clinical trials have focused on this latter component and other therapeutic *** this review,we highlight novel data in this context and address potentially interesting therapeutic options for the future.

关键词： portal hypertension hepatic venous pressure gradient non-selective b-blockers nitric oxide angiogenesis statins farnesoid X receptor renin-angiotensin-aldosterone

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：