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Retinal microvascular signs and recurrent vascular events in patients with TIA or minor stroke

Stroke & Vascular Neurology 2023年第5期8卷 379-386,I0001-I0007页

作者： philipp Klyscz Thomas Ihl Inga Laumeier Maureen Steinicke Matthias Endres Georg Michelson Heinrich J Audebert Neurology Charité-Universitätsmedizin BerlinBerlinGermany Center for Stroke Research Berlin Charité-Universitätsmedizin BerlinBerlinGermany Berlin Institute of Health BerlinGermany Excellence Cluster NeuroCure Charité-Universitätsmedizin BerlinBerlinGermany German Center for Neurodegenerative Diseases partner site BerlinGermany German Center for Cardiovascular Research partner site BerlinGermany Ophthalmology Friedrich-Alexander-Universität Erlangen-Nürnberg Medizinische FakultätErlangenGermany Talkingeyes&More GmbH ErlangenGermany

Background and purpose Retinal pathologies are an independent risk factor for ischaemic stroke,but research on the predictive value of retinal abnormalities for recurrent vascular events in patients with prior stroke is *** investigated the association of retinal pathologies with subsequent vascular *** In a substudy of the Intensified secondary prevention intending a reduction of recurrent events in TIA and minor stroke patients(INSPiRE-TMS)trial,we enrolled patients with recent transient ischaemic attack(TIA)or minor stroke with at least one modifiable risk *** outcome was the composite of subsequent vascular *** photographs were taken at baseline and categorised into three different fundus groups by a telemedically linked *** 722 patients participated in the current study and 109 major vascular events *** multivariable adjustments,we did not find a significant association between fundus categories and risk for subsequent vascular events(HRs for moderate vascular retinopathy and vascular retinopathy with vessel rarefaction in comparison to no vascular retinopathy 1.03(95%CI 0.64 to 1.67),p=0.905 and 1.17(95%CI 0.62 to 2.20),p=0.626).In a selective post hoc analysis in patients with diabetes mellitus and hypertension,patients with vascular retinopathy with vessel rarefaction had a higher risk for recurrent stroke(HR 24.14(95%CI 2.74 to 212.50),p=0.004).Conclusions Retinal changes did not predict major subsequent vascular events in patients with recent TIA or minor *** studies are needed to examine the utility of fundus photography in assessing the risk of stroke recurrence in patients with diabetes mellitus and hypertension.

关键词： patients Retinal prevention

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Intelligent indoor metasurface robotics

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National Science Review 2023年第8期10卷 20-32页

作者： Hanting Zhao Shengguo Hu Hongrui Zhang Zhuo Wang Hao Dong philipp del Hougne Tie Jun Cui Lianlin Li State Key Laboratory of Advanced Optical Communication Systems and Networks School of Electronics Peking University Center on Frontiers of Computing Studies School of Computer Science Peking University The French National Centre for Scientific Research(CNRS) University of Rennes 4. State Key Laboratory of Millimeter WavesSoutheast University

Intelligent indoor robotics is expected to rapidly gain importance in crucial areas of our modern society such as at-home health care and factories. Yet, existing mobile robots are limited in their ability to perceive and respond to dynamically evolving complex indoor environments because of their inherently limited sensing and computing resources that are, moreover, traded off against their cruise time and payload. To address these formidable challenges, here we propose intelligent indoor metasurface robotics(I2MR),where all sensing and computing are relegated to a centralized robotic brain endowed with microwave perception; and I2MR’s limbs(motorized vehicles, airborne drones, etc.) merely execute the wirelessly received instructions from the brain. The key aspect of our concept is the centralized use of a computation-enabled programmable metasurface that can flexibly mold microwave propagation in the indoor wireless environment, including a sensing and localization modality based on configurational diversity and a communication modality to establish a preferential high-capacity wireless link between the I2MR’s brain and limbs. The metasurface-enhanced microwave perception is capable of realizing low-latency and high-resolution three-dimensional imaging of humans, even around corners and behind thick concrete walls, which is the basis for action decisions of the I2MR’s brain. I2MR is thus endowed with real-time and full-context awareness of its operating indoor environment. We implement, experimentally, a proof-of-principle demonstration at ～2.4 GHz, in which I2MR provides health-care assistance to a human inhabitant. The presented strategy opens a new avenue for the conception of smart and wirelessly networked indoor robotics.

关键词： intelligent metasurfaces intelligent robotics edge devices IoT 6G

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Comparison of hyperthermic intraperitoneal chemotherapy regimens for treatment of peritoneal-metastasized colorectal cancer

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World Journal of Gastrointestinal Oncology 2020年第8期12卷 903-917页

作者： Julia Spiegelberg Hannes Neeff philipp Holzner Mira Runkel Stefan Fichtner-Feigl Torben Glatz Department of General and Visceral Surgery Medical Center–University of FreiburgFreiburg 79106Germany Department of Surgery Marien Hospital HerneRuhr-University BochumHerne 44625Germany

BACKGROUND Cytoreductive surgery(CRS)in combination with hyperthermic intraperitoneal chemotherapy(HIPEC)improves patient survival in colorectal cancer(CRC)with peritoneal carcinomatosis(PC).Commonly used cytotoxic agents include mitomycin C(MMC)and *** have reported varying results,and the evidence for the choice of the HIPEC agent and uniform procedure protocols is *** To evaluate therapeutic benefits and complications of CRS+MMC vs oxaliplatin HIPEC in patients with peritoneal metastasized CRC as well as prognostic *** One hundred and two consecutive patients who had undergone CRS and HIPEC for CRC PC between 2007 and 2019 at the Medical Center of the University Freiburg regarding interdisciplinary cancer conference decision were retrospectively *** and MMC were used in 68 and 34 patients,*** patient’s demographics and tumour characteristics,operative details,postoperative complications and survival were *** were stratified and graded using Clavien/Dindo *** outcome factors were identified using univariate and multivariate analysis of *** The two groups did not differ significantly regarding baseline *** found no difference in median overall survival between MMC and oxaliplatin *** postoperative complications,patients treated with oxaliplatin HIPEC suffered increased complications(66.2%vs 35.3%;P=0.003),particularly intestinal atony,intraabdominal infections and urinary tract infection,and had a prolonged intensive care unit stay compared to the MMC group(7.2 d vs 4.4 d;P=0.035).Regarding univariate analysis of survival,we found primary tumour factors,nodal positivity and resection margins to be of prognostic value as well as peritoneal cancer index(PCI)-score and the completeness of cytoreduction regarding peritoneal *** analysis of survival confirmed primary distant metastasis and primary tumour resec

关键词： Colorectal cancer Peritoneal carcinomatosis Cytoreductive surgery Hyperthermic intraperitoneal chemotherapy Chemotherapy Mitomycin

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Virtual reality for immersive multi-user firefighter-training scenarios

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Virtual Reality & Intelligent Hardware 2022年第5期4卷 406-417页

作者： philipp BRAUN Michaela GRAFELMANN Felix GILL Hauke STOLZ Johannes HINCKELDEYN Ann-Kathrin LANGE Hamburg University of Technology Hamburg 21073Germany

Background Virtual reality(VR)applications can be used to provide comprehensive training scenarios that are difficult or impossible to represent in physical *** includes team training for emergency services such as *** a high level of immersion is essential for achieving effective virtual *** this respect,motion-capture systems offer the possibility of creating highly immersive multi-user training experiences,including full-body *** This study presents a preliminary prototype that helps extin-guish a virtual fire on a container ship as a VR training *** prototype provides a full-body and multi-user VR experience based on the synthesis of position data provided by the motion-capture system and orientation data from the VR ***,the prototype facilitates an initial evaluation of the *** The results confirm the value of using VR for training procedures that are difficult to implement in the real ***,the results show that motion-capture-based VR technologies are particularly useful for firefighting training,in which participants can collaborate in difficult-to-access ***,this study also indicates that increasing the immersion in such training remains a *** This study presents a prototypical VR application that enables the multi-user training of maritime *** research should evaluate the initial results,provide more extensive training scenarios,and measure the training progress.

关键词： Virtual reality Multi-user Motion capture Training Firefighting

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Cost-analysis of inpatient and outpatient parenteral antimicrobial therapy in orthopaedics: A systematic literature review

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World Journal of Clinical Cases 2019年第14期7卷 1825-1836页

作者： Christoph Kolja Boese philipp Lechler Michael Frink Michael Hackl Peer Eysel Christian Ries Department of Orthopaedic and Trauma Surgery University Hospital of CologneCologne 50931Germany Clinic for Trauma and Hand Surgery KreisklinikenAltotting 84503Germany Center for Orthopaedics and Trauma Surgery University Hospital Giessen and MarburgMarburg 35043Germany

BACKGROUND Increasing numbers of total joint arthroplasties and consecutive revision surgery are associated with the risk of periprosthetic joint infections (PPJI). Treatment of PPJI is complex and associated with immense socio-economic burden. One treatment aspect is parenteral antiinfective therapy, which usually requires an inpatient setting [Inpatient parenteral antibiotic therapy (IPAT)]. An alternative is outpatient parenteral treatment [Outpatient parenteral antibiotic therapy (OPAT)]. To conduct a health economic cost-benefit analysis of OPAT, a detailed cost analysis of IPAT and OPAT is required. So far, there is a lack of knowledge on the health economic effects of IPAT and OPAT for PPJI. AIM To review an economic comparison of IPAT and OPAT. METHODS A systematic literature review was performed through Medline following the PRISMA guidelines. RESULTS Of 619 identified studies, 174 included information of interest and 21 studies were included for quantitative analysis of OPAT and IPAT costs. Except for one study, all showed relevant cost savings for OPAT compared to IPAT. Costs for IPAT were between 1.10 to 17.34 times higher than those for OPAT. CONCLUSION There are only few reports on OPAT for PPJI. Detailed analyses to support economic or clinical guidelines are therefore limited. There is good clinical evidence supporting economic benefits of OPAT, but more high quality studies are needed for PPJI.

关键词： Antibiotic therapy Outpatient parenteral antibiotic therapy Inpatient parenteral antibiotic therapy Cost analysis Periprosthetic joint infection Parenteral

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The Contribution of the Gravitational Propagation Delay to Orbital and Center of Mass Motions

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Journal of Modern Physics 2016年第14期7卷 1909-1932页

作者： philipp Kornreich 1090 Wien Austria King of Prussia PA USA

Recent measurements have shown that gravitational waves and thus the gravitational interaction propagate with the speed of light. The propagation delay of the gravitational interaction in orbiting systems couples the orbital and center of mass motions. This causes the orbits to spiral out and the center of mass to accelerate. It is one of a number of small effects modifying the Kepler orbits. The calculations show that the analytical describable expansion of the semimajor axis started at a time that is less than the age of the systems. This could be caused by a collision of a system component in the past. The effect of this propagation delay on the motion of the Earth Moon and the Brown Dwarf 569Bab binary star system is analyzed. These systems were chosen because a considerable amount of measured astronomical data is available. The calculated results are in excellent agreement with the measured data. In galaxies, too, the energy transfer from the orbit of the star cloud to the center of mass motion causes the galaxies to ac-celerate. If galaxies are considered to be molecules of the universe, then the acceleration of the galaxies will cause the molecular gas to heat and expand. Alternatively, the loss in orbital internal energy of the galaxies should be included in the mass and energy in the calculation of the expanding Universe.

关键词： Propagation Delay Gravitation Gravitational Waves Orbits Center of Mass Newtonian Mechanics

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Data analytics in the electricity sector – A quantitative and qualitative literature review

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能源与人工智能(英文) 2020年第1期1卷 145-167页

作者： Frederik vom Scheidt Hana Medinova Nicole Ludwig Bent Richter philipp Staudt Christof Weinhardt Institute for Information Systems and Marketing Karlsruhe Institute of TechnologyKaiserstr.8976133 KarlsruheGermany Institute for Automation and Applied Informatics Karlsruhe Institute of TechnologyHermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany

The rapid transformation of the electricity sector increases both the opportunities and the need for Data *** recent years,various new methods and fields of application have been *** research is growing and becoming more diverse and specialized,it is essential to integrate and structure the fragmented body of scientific *** therefore conduct a systematic review of studies concerned with developing and applying Data Analytics methods in the context of the electricity value ***,we provide a quantitative high-level overview of the status quo of Data Analytics research,and show historical literature growth,leading countries in the field and the most intensive international ***,we qualitatively review over 200 high-impact studies to present an in-depth analysis of the most prominent applications of Data Analytics in each of the electricity sector’s areas:generation,trading,transmission,distribution,and *** each area,we review the state-of-the-art Data Analytics applications and *** addition,we discuss used data sets,feature selection methods,benchmark methods,evaluation metrics,and model complexity and run *** the findings from the different areas,we identify best practices and what researchers in one area can learn from other ***,we highlight potential for future research.

关键词： Data analytics Electricity Machine learning Generation Price Transmission Distribution Consumption

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Yb-and Er concentration dependence of the upconversion luminescence of highly doped NaYF_(4):Yb,Er/NaYF_(4):Lu core/shell nanocrystals prepared by a water-free synthesis

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Nano Research 2022年第10期15卷 9639-9646页

作者： Christian Würth Bettina Grauel Monika Pons Florian Frenzel philipp Rissiek Kerstin Rücker Markus Haase Ute Resch-Genger Federal Institute for Materials Research and Testing(BAM) Division BiophotonicsRichard-Willstaetter-Str.1112489 BerlinGermany Institut für Chemie Neuer Materialien Fachbereich Biologie/ChemieUniversität OsnabrückBarbarastraße 749076 OsnabrückGermany

High sensitizer and activator concentrations have been increasingly examined to improve the performance of multi-color emissive upconversion(UC)nanocrystals(UCNC)like NaYF_(4):Yb,Er and first strategies were reported to reduce concentration quenching in highly doped *** luminescence(UCL)is,however,controlled not only by dopant concentration,yet by an interplay of different parameters including size,crystal and shell quality,and excitation power density(P).Thus,identifying optimum dopant concentrations requires systematic studies of UCNC designed to minimize additional quenching pathways and quantitative ***,we quantify the dopant concentration dependence of the UCL quantum yield(ΦUC)of solid NaYF_(4):Yb,Er/NaYF_(4):Lu upconversion core/shell nanocrystals of varying Yb3+and Er3+concentrations(Yb3+series:20%‒98%Yb3+;2%Er3+;Er3+series:60%Yb3+;2%‒40%Er3+).To circumvent other luminescence quenching processes,an elaborate synthesis yielding OH-free UCNC with recordΦUC of~9%and~25 nm core particles with a thick surface shell were *** Yb3+concentrations barely reduceΦUC from~9%(20%Yb3+)to~7%(98%Yb3+)for an Er3+concentration of 2%,thereby allowing to strongly increase the particle absorption cross section and UCNC *** an increased Er3+concentration reducesΦUC from~7%(2%Er3+)to 1%(40%)for 60%Yb3+.Nevertheless,at very high P(>1 MW/cm^(2))used for microscopic studies,highly Er3+-doped UCNC display a high brightness because of reduced *** findings underline the importance of synthesis control and will pave the road to many fundamental studies of UC materials.

关键词： highly doped upconversion nanocrystals core/shell nanoparticles upconversion luminescence efficiency NaYF_(4):Yb Er concentration quenching

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Influence of structural depth of laser-patterned steel surfaces on the solid lubricity of carbon nanoparticle coatings

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Friction 2023年第7期11卷 1276-1291页

作者： Timothy MACLUCAS Lukas DAUT philipp GRÜTZMACHER Maria Agustina GUITAR Volker PRESSER Carsten GACHOT Sebastian SUAREZ Frank MÜCKLICH Chair of Functional Materials Saarland UniversitySaarbrücken 66123Germany Institute for Engineering Design and Product Development TU WienWien 1060Austria INM–Leibniz Institute for New Materials Saarbrücken 66123Germany Department of Materials Science&Engineering Saarland UniversitySaarbrücken 66123Germany Saarene-Saarland Center for Energy Materials and Sustainability Saarbrücken 66123Germany

Carbon nanoparticle coatings on laser-patterned stainless-steel surfaces present a solid lubrication system where the pattern's recessions act as lubricant-retaining *** study investigates the influence of the structural depth of line patterns coated with multi-walled carbon nanotubes(CNTs)and carbon onions(COs)on their respective potential to reduce friction and *** laser interference patterning(DLIP)with a pulse duration of 12 ps is used to create line patterns with three different structural depths at a periodicity of 3.5μm on AISI 304 steel ***,electrophoretic deposition(EPD)is applied to form homogeneous carbon nanoparticle coatings on the patterned *** ball-on-disc experiments are conducted on the as-described surfaces with an alumina counter body at a load of 100 *** results show that the shallower the coated structure,the lower its coefficient of friction(COF),regardless of the particle ***,with a minimum of just below 0.20,CNTs reach lower COF values than COs over most of the testing *** resulting wear tracks are characterized by scanning electron microscopy,transmission electron microscopy,and energy-dispersive X-ray *** friction testing,the CNTs remain in contact,and the immediate proximity,whereas the CO coating is largely *** of structural depth,no oxidation occurs on CNT-coated surfaces,whereas minor oxidation is detected on CO-coated wear tracks.

关键词： solid lubricant coatings carbon nanotubes carbon onions direct laser interference patterning(DLIP)surface structuring electrophoretic deposition(EPD)

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Diarrhea after bariatric procedures:Diagnosis and therapy

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World Journal of Gastroenterology 2017年第26期23卷 4689-4700页

作者： Yves M Borbély Alice Osterwalder Dino Kroll philipp C Nett Roman A Inglin Clinic for Visceral Surgery and Medicine InselspitalBern University HospitalUniversity of Bern

Diarrhea after bariatric procedures, mainly those with malabsorptive elements including Roux-Y Gastric Bypass and Biliopancreatic Diversion, is common and an essential determinant of quality of life and microand macronutrient deficiencies. Bariatric surgery is the only sustainably successful method to address morbid obesity and its comorbidities, particularly gaining more and more importance in the specific treatment of diabetic patients. Approximately half a million procedures are annually performed around the world, with numbers expected to rise drastically in the near future. A multitude of factors exert their influence on bowel habits; preoperative comorbidities and procedure-related aspects are intertwined with postoperative nutritional habits. Diagnosis may be challenging owing to the characteristics of postbariatric surgery anatomy with hindered accessibility of excluded segments of the small bowel and restriction at the gastric level. Conventional testing measures, if available, generally yield low accuracy and are usually not validated in this specific population. Limited trials of empiric treatment are a practical alternative and oftentimes an indispensable part of the diagnostic process. This review provides an overview of causes for chronic post-bariatric surgery diarrhea and details the particularities of its diagnosis and treatment in this specific patient population. Topics of current interest such as the impact of gut microbiota and the influence of bile acids on morbid obesity and especially their role in diarrhea are highlighted in order to provide a better understanding of the specific problems and chances of future treatment in post-bariatric surgery patients.

关键词： Bariatric surgery Diarrhea Malnutrition Malabsorption Steatorrhea Dumping syndrome Bile acids and salts Gut microbiota Blind loop syndrome

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