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Long-Lasting Stretching Induces Muscle Hypertrophy:A Meta-Analysis of Animal Studies

Journal of Science in Sport and Exercise 2023年第4期5卷 289-301页

作者： Konstantin Warneke philipp alexander freund Stephan Schiemann Institute for Exercise Sport and HealthLeuphana UniversityUniversitätsallee 1LüneburgGermany Institute of Psychology Leuphana UniversityLüneburgGermany

Muscular hypertrophy depends on metabolic exhaustion as well as mechanical load on the *** tension seems to be the crucial factor to stimulate protein *** present meta-analysis was conducted to determine whether stretching can generate adequate mechanical tension to induce muscle *** used PubMed,Web of Science,and Scopus to search for literature examining the effects of long-term stretching on muscle mass,muscle cross-sectional area,fiber cross-sectional area,and fiber *** there was no sufficient number of studies investigating long-lasting stretching in humans,we only included original animal studies in the current ***,we identified 16 studies meeting the inclusion criteria(*** of at least 15 min per day).The 16 studies yielded 39 data points for muscle mass,11 data points for muscle cross-sectional area,20 data points for fiber cross-sectional area,and 10 data points for fiber *** all designs and categories,statistically significant increases were found for muscle mass(d=8.51;95%CI 7.11-9.91),muscle cross-sectional area(d=7.91;95%CI 5.75-10.08),fiber cross-sectional area(d=5.81;95%CI 4.32-7.31),and fiber number(d=4.62;95%CI 2.54-6.71).The findings show an(almost)continuous positive effect of long-term stretching on the listed parameters,so that it can be assumed that stretch training with adequate intensity and duration leads to hypertrophy and hyperplasia,at least in animal studies.A general transferability to humans-certainly with limited effectiveness-can be hypothesized but requires further research and training studies.

关键词： Muscle mass Static stretching Hyperplasia Chronic stretching

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Energy Disaggregation of Industrial Machinery Utilizing Artificial Neural Networks for Non-intrusive Load Monitoring

Energy and AI

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Energy and AI 2024年第3期17卷 342-356页

作者： philipp Pelger Johannes Steinleitner alexander Sauer Fraunhofer Institute for Manufacturing Engineering and Automation IPA Stuttgart 70569Germany Institute for Energy Efficiency in Production(EEP) University of StuttgartStuttgart 70569Germany

This paper explores the application of non-intrusive load monitoring techniques in the industrial sector for disaggregating the energy consumption of machinery in manufacturing processes. With an increasing focus on energy efficiency and decarbonization measures, achieving energy transparency in production becomes crucial. Utilizing non-intrusive load monitoring, energy data analysis and processing can provide valuable insights for informed decision-making on energy efficiency improvements and emission reductions. While non-intrusive load monitoring has been extensively researched in the building and residential sectors, the application in the industrial manufacturing domain needs to be further explored. This paper addresses this research gap by adapting established non-intrusive load monitoring techniques to an industrial dataset. By employing artificial neural networks for energy disaggregation, the determination of energy consumption of industrial machinery is made possible. Therefore, a generally applicable cross-energy carrier method to disaggregate the energy consumption of machinery in manufacturing processes is developed using a design science research approach and validated through a practical case study utilizing a compressed air demonstrator. The results show that the utilization of artificial neural networks is well-suited for energy disaggregation of industrial data, effectively identifying on and off states, multi-level states and continuously variable states. Non-intrusive load monitoring should be further considered in the research of emerging artificial intelligence technologies in energy consumption evaluation. It can be a viable alternative for intrusive load monitoring and is a prerequisite to installing energy meters for every machine.

关键词： Non-intrusive load monitoring Energy transparency Energy consumption evaluation Industrial manufacturing Artificial neural networks

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＂Fluidic Diode＂ for Passive Unidirectional Liquid Transport Bioinspired by the Spermathecae of Fleas

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Journal of Bionic Engineering 2018年第1期15卷 42-56页

作者： Gerda Buchberger alexander Kogler Agnes Weth Richard Baumgartner philipp Comanns Siegfried Bauer Werner Baumgartner Institute of Biomedical Mechatronics Johannes Kepler University Linz Altenberger Str. 69 A-4040 Linz Austria institute of Experimental Physics Department of Soft Matter Physics Johannes Kepler University Linz Altenberger Str. 69 A-4040 Linz Austria Institute of Biology II RWTH Aachen University Worringerweg 3 D-52074 Aachen Germany

We present a device for passive unidirectional liquid transport. The capillary channels used are bioinspired by the shape of the spermathecae （receptaculum seminis） of rabbit fleas （Spilopsyllus cuniculi） and rat fleas （Xenopsytla cheopis）. The spermatheca is an organ of female fleas that stores sperm until suitable conditions to lay eggs are found. We translated and multiplied the natural form and function of a spermatheca to create a continuous capillary system from which we designed our microfluidic device based directly on the model from nature. Applying the Young-Laplace equation, we derived a theoretical description of local liquid transport, which enables model-guided design. We arranged the bioinspired capillaries in parallel and engraved them in poly（methyl methacrylate）（PMMA） plates by CO2 laser ablation. The fabricated structures transport soapy water passively （i.e., without external energy input） in the forward direction at velocities of about 1 mm＇s i while halting the liquid fronts completely in the backward direction. The bio- inspired capillary channels are capable of unidirectional liquid transport against gravity. Distance and velocity measurements prove the feasibility of the concept. Unidirectional passive liquid transport might be advantageous in technical surfaces for liquid man- agement, for instance, in biomedical microfluidics, lab-on-chip, lubrication, electronics cooling and in micro-analysis devices.

关键词： liquid diode wetting passive unidirectional liquid transport capillary bioinspired

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A novel temporary keratoprosthesis technique for vitreoretinal surgery

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International Journal of Ophthalmology(English edition) 2021年第11期14卷 1791-1795页

作者： Christos Skevas Eileen Bigdon alexander Steinhorst Toam Katz philipp Schindler Robert Kromer Martin Stephan Spitzer Department of Ophthalmology University Medical Center Hamburg-EppendorfHamburg 20246Germany

AIM:To investigate the safety of vitreoretinal surgery when using a soft contact lens as a temporary keratoprosthesis(TKP)in patients with severe corneal ***:Three patients with simultaneous corneal and vitreoretinal pathology were treated with a soft contact lens that was used as a TKP to facilitate vitreoretinal *** soft contact lens was fixated with sutures onto the globe so that no leakage was ***:Vitreoretinal surgery with excellent fundus view was possible in all *** soft contact lens allowed safe central and peripheral *** was successful in all ***:A soft contact lens properly fixated on the globe can successfully replace a *** surgical procedure has several advantages like one size fits all,low costs,and easy access to the material.

关键词： temporary keratoprosthesis combined vitreoretinal surgery perforating keratoplasty keratoprosthesis

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Impact of exercise on markers of B cell-related immunity:A systematic review

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Journal of Sport and Health Science 2024年第3期13卷 339-352,I0002页

作者： David Walzik Sergen Belen Karen Wilisch Marie Kupjetz Silvana Kirschke Tobias Esser Niklas Joisten alexander Schenk Sebastian Proschinger philipp Zimmer Division of Performance and Health(Sports Medicine) Institute for Sport and Sport ScienceTU Dortmund UniversityDortmund 44227Germany

Background:B cells represent a crucial component of adaptive immunity that ensures long-term protection from infection by generating pathogen-specific *** alters B cell counts and immunoglobulin levels,but evidence-based conclusions on potential benefits for adaptive immunity are *** systematic review assessed current literatures on the impact of acute exercise and exercise training on B cells,immunoglobulins,and markers of secretory immunity in human ***:According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines,MEDLINE,Web of Science,and Embase were searched on March 8,***-randomized controlled trials and crossover trials investigating the impact of acute exercise or exercise training on B cell counts and proportions,immunoglobulin levels,salivary flow rate,or secretory immunoglobulin A secretion rate were *** and reporting of exercise training studies were assessed using the Tool for the Assessment of Study Quality and reporting in *** characteristics,outcome measures,and statistically significant changes were summarized ***:Of the 67 eligible studies,22 applied acute exercise and 45 applied exercise *** included outcomes revealed significant alterations over time in acute exercise and exercise training context,but only a few investigations showed significant differences compared to control *** and plasma immunoglobulin A levels were most consistently increased in response to exercise ***:B cell-related outcomes are altered by acute exercise and exercise training,but evidence-based conclusions cannot be drawn with high confidence due to the large heterogeneity in populations and exercise ***-designed trials with large sample sizes are needed to clarify how exercise shapes B cell-related immunity.

关键词： Antibody B-lymphocyte Exercise Humoral immunity Immune system

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Minimally invasive surgery for inflammatory bowel disease: Review of current developments and future perspectives

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第2期7卷 217-226页

作者： philipp--alexander Neumann Emile Rijcken Department of General and Visceral Surgery University Clinic of Muenster

Patients with inflammatory bowel disease(IBD)com-prise a population of patients that have a high likelihood of both surgical treatment at a young age and repetitive operative *** surgical procedures need to aim at minimizing operative trauma with bestpostoperative *** invasive techniques have been one of the major advancements in surgery in the last decades and are nowadays almost routinely performed in colorectal resections irrespective of underlying *** due to special disease related characteristics such as bowel stenosis,interen-teric fistula,abscesses,malnutrition,repetitive sur-geries,or immunosuppressive medications,patients with IBD represent a special cohort with specific needs for *** review summarizes current evidence of minimally invasive surgery for patients with Crohn’s disease or ulcerative colitis and gives an outlook on the future perspective of technical advances in this highly moving field with its latest developments in single port surgery,robotics and trans-anal techniques.

关键词： Inflammatory bowel disease Minimally invasive surgery Laparoscopy Colorectal Robotic

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Radiotherapy-induced heart disease:a review of the literature

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Precision Clinical Medicine 2019年第4期2卷 270-282页

作者： Bingwen Zou Julius philipp Schuster Kerun Niu Qianyi Huang alexander Rühle Peter Ernst Huber Department of Radiation Oncology Heidelberg University HospitalIm Neuenheimer Feld 400Heidelberg 69120Germany Department of Molecular Radiation Oncology German Cancer Research CenterIm Neuenheimer Feld 280Heidelberg 69120Germany Heidelberg Institute for Radiation Oncology(HIRO)and National Center for Radiation Oncology(NCRO) Im Neuenheimer Feld 280Heidelberg 69120Germany

Radiotherapy as one of the four pillars of cancer therapy plays a critical role in the multimodal treatment of thoracic *** to significant improvements in overall cancer survival,radiotherapy-induced heart disease(RIHD)has become an increasingly recognized adverse reaction which contributes to major radiationassociated toxicities including non-malignant *** is especially relevant for patients suffering from diseases with excellent prognosis such as breast cancer or Hodgkin’s lymphoma,since RIHD may occur decades after *** studies have enriched our knowledge of many potential mechanisms by which thoracic radiotherapy induces heart *** findings in humans reveal that irradiation might increase the risk of cardiac disease at even lower doses than previously *** preclinical studies have identified non-invasive methods for evaluation of ***,potential options preventing or at least attenuating RIHD have been *** research may enrich our limited knowledge about biological mechanisms of RIHD,identify non-invasive early detection biomarkers and investigate potential treatment options that might attenuate or prevent these unwanted side ***,we present a comprehensive review about the published literature regarding clinical manifestation and pathological alterations in *** mechanisms and treatment options are outlined,and challenges in RIHD treatment are summarized.

关键词： Radiotherapy heart injury thoracic cancer radiation-induced heart injury cancer treatment

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Prospective observational multicenter study to define a diagnostic algorithm for biliary candidiasis

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World Journal of Gastroenterology 2014年第34期20卷 12260-12268页

作者： philipp Lenz Franziska Eckelskemper Thomas Erichsen Tim Lankisch alexander Dechêne Gabriele Lubritz Frank Lenze Torsten Beyna Hansjorg Ullerich Andre Schmedt Dirk Domagk Department of Medicine B University of MuensterD-48149 MuensterGermany Department of Gastroenterology Hepatology and EndocrinologyHannover Medical School30625 HannoverGermany Department of Gastroenterology and Hepatology University Hospital Essen45147 EssenGermany Institute of Medical Microbiology University Hospital MuensterD-48149 MuensterGermany

AIM:To develop an algorithm to improve the diagnosis and treatment of patients with biliary ***:We performed a prospective study of 127patients who underwent endoscopic retrograde cholangiopancreatography,for various biliary disorders,at 3 tertiary referral centers in Germany from July 2011through July 2012(***:NCT01109550).Bile,buccal,and stool samples were *** indicated,endoscopic transpapillary bile duct biopsies were performed to clarify the etiology of bile duct strictures and to prove invasive fungal ***:Candida species were detected in 38 of the 127 bile samples(29.9%).By multivariate analysis patients’age and previous endoscopic sphincterotomy were independent risk factors for biliary candidiasis(P7 d)(P=0.089)tend to be at risk for biliary *** patient was negative in mycological culture of bile fluid but invasive biliary candidiasis was diagnosed *** Candida subspecies detected,36.7%were azole-resistant,such as C *** patients received anti-mycotic therapy,based on our *** these,3 had cancer with biliary tract involvement,2had secondary sclerosing cholangitis,1 had retroperitoneal fibrosis,and 5 had *** all patients contamination was ruled out by smears of the endoscope ***:Gastroenterologists should be aware of frequent candida colonization in patients with cholangitis and biliary *** suggested algorithm facilitates the further clinical management.

关键词： Cholangitis Biliary candidiasis Invasive fungal infection Biliary obstruction

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Improved training framework in a neural network model for disruption prediction and its application on EXL-50

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Plasma Science and Technology 2024年第5期26卷 29-39页

作者：蔡剑青梁云峰 alexander KNIEPS 齐东凯王二辉向皓明廖亮黄杰阳杰黄佳刘建文 philipp DREWS 徐帅顾翔高轶琛罗宇李直 the EXL-50 Team Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People’s Republic of China Forschungszentrum Jülich GmbH Institut für Energie-und Klimaforschung-PlasmaphysikPartner of the Trilateral Cluster(TEC)Jülich 52425Germany ENN Science and Technology Development Co. LtdLangfang 065001People’s Republic of China

A neural network model with a classical annotation method has been used on the EXL-50tokamak to predict impending ***,the results revealed issues of overfitting and overconfidence in predictions caused by inaccurate *** mitigate these issues,an improved training framework has been *** this approach,soft labels from previous training serve as teachers to supervise the further learning process;this has lead to a significant improvement in predictive model ***,this enhancement is primarily attributed to the coupling effect of the soft labels and correction *** improved training framework introduces an instance-specific label smoothing method,which reflects a more nuanced model assessment on the likelihood of a *** presents a possible solution to effectively address the challenges associated with accurate labeling across different machines.

关键词： neural network disruption soft label EXL-50 tokamak

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Arterial thrombosis in the context of HCV-associated vascular disease can be prevented by protein C

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Cellular & Molecular Immunology 2017年第12期14卷 986-996页

作者： philipp Blüm Joachim Pircher Monika Merkle Thomas Czermak Andrea Ribeiro Hanna Mannell Florian Krötz alexander Hennrich Michael Spannagl Simone Köppel Erik Gaitzsch Markus Wörnle Medizinische Klinik und Poliklinik IV InnenstadtKlinikum der Universität München80336 MünchenGermany Walter Brendel Centre of Experimental Medicine and Munich Heart Alliance Ludwig Maximilians University München80336 MünchenGermany Medizinische Klinik und Poliklinik I Klinikum der Universität München80336 MünchenGermany Abteilung für Transfusionsmedizin Zelltherapeutika und HämostaseologieKlinikum der Universität München80336 MünchenGermany

Hepatitis C virus(HCV)infection is a major problem *** is not limited to liver disease but is frequently complicated by immune-mediated extrahepatic manifestations such as glomerulonephritis or vasculitis.A fatal complication of HCV-associated vascular disease is ***:polyribocytidylic acid(poly(I:C)),a synthetic analog of viral RNA,induces a Toll-like receptor 3(TLR3)-dependent arteriolar thrombosis without significant thrombus formation in venules in *** procoagulant effects are caused by increased endothelial synthesis of tissue factor and PAI-1 without platelet *** addition to human umbilical endothelial cells(HUVEC),human mesangial cells(HMC)produce procoagulatory factors,cytokines and adhesion molecules after stimulation with poly(I:C)or HCV-containing cryoprecipitates from a patient with a HCV infection as *** protein C(APC)is able to prevent the induction of procoagulatory factors in HUVEC and HMC in vitro and blocks the effects of poly(I:C)and HCV-RNA on the expression of cytokines and adhesion molecules in HMC but not in *** vivo,protein C inhibits poly(I:C)-induced arteriolar ***,endothelial cells are de facto able to actively participate in immune-mediated vascular thrombosis caused by viral ***,we provide evidence for the ability of protein C to inhibit TLR3-mediated arteriolar thrombosis caused by HCV infection.

关键词： hepatitis C thrombosis toll-like receptor 3

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