检索结果-南通市图书馆

CuSbS_(2)薄膜光阴极的电子结构及其在光电催化分解水制氢的应用

在线全文

学校读者我要写书评

暂无评论

中国科学:材料科学(英文版) 2023年第9期66卷 3530-3538页

作者：钱静雯赵宇赵鹏举程浩然 Jan philipp Hofmann 张洪良 State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional MaterialsHubei Key Laboratory of Polymer Materials(Hubei University)School of Materials Science and EngineeringHubei UniversityWuhan 430062China Surface Science Laboratory Department of Materials and Earth SciencesTechnical University of DarmstadtOtto-Berndt-Strasse 3Darmstadt 64287Germany

硫化锑铜(CuSbS_(2))是一种p型半导体,带隙为1.5 eV,同时拥有较大的光吸收系数(>105cm-1),因此在光电催化领域拥有广阔的应用前景.但是目前国内外的研究还缺乏对CuSbS_(2)电子结构以及其如何影响PEC性能的深入理解.为了进一步改善CuSbS_... 详细信息

硫化锑铜(CuSbS_(2))是一种p型半导体,带隙为1.5 eV,同时拥有较大的光吸收系数(>105cm-1),因此在光电催化领域拥有广阔的应用前景.但是目前国内外的研究还缺乏对CuSbS_(2)电子结构以及其如何影响PEC性能的深入理解.为了进一步改善CuSbS_(2)的PEC性能,对其电子结构进行一系列表征分析是非常重要的.本文中,我们利用同步辐射技术揭示了CuSbS_(2)的电子结构.结果表明,CuSbS_(2)的价带(VB)由S 3p和Cu 3d的强杂交态组成,同时Sb 5p/5s也有部分影响.基于以上理论指导,我们设计了一种高质量Cu Sb S_(2)薄膜的制备技术,并使用FTO/CuSbS_(2)/CdS/Pt光电阴极在0.0 V下实现了CuSbS_(2)基材料的高光电流密度(6.3 mA cm^(-2)).

关键词：光吸收系数光电阴极同步辐射技术光电催化光阴极硫化锑光电流密度

Machine perfusion strategies in liver transplantation

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2019年第5期8卷 490-501页

作者： Andrea Schlegel Xavier Muller philipp Dutkowski Liver Unit Queen Elizabeth HospitalUniversity Hospitals Birmingham NHS Foundation TrustBirminghamUK Centre for Liver and Gastrointestinal Research Institute of Immunology and ImmunotherapyCollege of Medical and Dental SciencesUniversity of BirminghamBirminghamUK Department of Surgery and Transplantation University Hospital ZurichZurichSwitzerland

Machine perfusion is a hot topic in liver transplantation and several new perfusion conceptsare currently *** to introduction into routine clinical practice,however,such perfusionapproaches need to demonstrate their impact on liver function,post-transplant complications,utilizationrates of high-risk organs,and cost ***,based on results of experimental and clinical studies,the community has to recognize the limitations of this *** this review,we summarize currentperfusion concepts and differences between protective mechanisms of ex-and in-situ perfusion ***,we discuss which graft types may benefit most from perfusion techniques,and highlight the currentunderstanding of liver viability ***,we present results from recent clinical trials involvingmachine liver perfusion,and analyze the value of different outcome parameters,currently used as endpointsfor randomized controlled trials in the field.

关键词： Machine perfusion clinical trials viability assessment

High-resolution ex vivo analysis of the degradation and osseointegration of Mg-xGd implant screws in 3D

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2022年第7期7卷 37-52页

作者： Diana Krüger Silvia Galli Berit Zeller-Plumhoff D.C.Florian Wieland Niccolo Peruzzi Bjorn Wiese philipp Heuser Julian Moosmann Ann Wennerberg Regine Willumeit-Romer Institute of Metallic Biomaterials Helmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht21502Germany University of Malmo Faculty of OdontologyDepartment of ProsthodonticsCarl Gustafs vag 34Klerken20506MalmoSweden Lund University Department of Clinical Sciences LundMedical Radiation PhysicsBarngatan 422242LundSweden Deutsches Elektronen-Synchrotron(DESY) Notkestrasse 8522607HamburgGermany Institute of Materials Physics Helmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht21502Germany University of Gothenburg Institute of OdontologyDepartment of ProsthodonticsMedicinaregatan 12 f41390GoteborgSweden

Biodegradable magnesium(Mg)alloys can revolutionize osteosynthesis,because they have mechanical properties similar to those of the bone,and degrade over time,avoiding the need of removal ***,they are not yet routinely applied because their degradation behavior is not fully *** this study we have investigated and quantified the degradation and osseointegration behavior of two biodegradable Mg alloys based on gadolinium(Gd)at high ***-5Gd and Mg-10Gd screws were inserted in rat tibia for 4,8 and 12 ***,the degradation rate and degradation homogeneity,as well as bone-to-implant interface,were studied with synchrotron radiation micro computed tomography and ***(Ti)and polyether ether ketone(PEEK)were used as controls material to evaluate *** results showed that Mg-5Gd degraded faster and less homogeneously than *** alloys gradually form a stable degradation layer at the interface and were surrounded by new bone *** results were correlated to in vitro data obtained from the same material and *** average bone-to-implant contact of the Mg-xGd implants was comparable to that of Ti and higher than for *** results suggest that both Mg-xGd alloys are suitable as materials for bone implants.

关键词： Magnesium alloys Biodegradable implant Micro-computed tomography degradation rate Degradation homogeneity Ex vivo imaging Ex vivo histology Histology vs.tomography

Spatial metabolomics for evaluating response to neoadjuvant therapy in non-small cell lung cancer patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Communications 2022年第6期42卷 517-535页

作者： Jian Shen Na Sun philipp Zens Thomas Kunzke Achim Buck Verena M.Prade Jun Wang Qian Wang Ronggui Hu Annette Feuchtinger Sabina Berezowska Axel Walch Research Unit Analytical Pathology Helmholtz Zentrum Munchen-German Research Center for Environmental HealthNeuherberg 85764Germany Institute of Pathology University of BernBern 3008Switzerland Graduate School for Health Sciences University of BernMittelstrasse 43Bern 3012Switzerland Center for Excellence in Molecular Cell Science Chinese Academy of SciencesShanghai 200031P.R.China Department of Laboratory Medicine and Pathology Institute of PathologyLausanne University Hospital and University of LausanneLausanne 1011Switzerland

Background:The response to neoadjuvant chemotherapy(NAC)differs substantially among individual patients with non-small cell lung cancer(NSCLC).Major pathological response(MPR)is a histomorphological read-out used to assess treatment response and prognosis in patientsNSCLC *** spatial metabolomics is a promising tool for evaluating metabolic phenotypes,it has not yet been utilized to assess therapy responses in patients with *** evaluated the potential application of spatial metabolomics in cancer tissues to assess the response to NAC,using a metabolic classifier that utilizes mass spectrometry imaging combined with machine ***:Resected NSCLC tissue specimens obtained after NAC(n=88)were subjected to high-resolution mass spectrometry,and these data were used to develop an approach for assessing the response to NAC in patients with *** specificities of the generated tumor cell and stroma classifiers were validated by applying this approach to a cohort of biologically matched chemotherapy-naive patients with NSCLC(n=85).Results:The developed tumor cell metabolic classifier stratified patients into different prognostic groups with 81.6%accuracy,whereas the stroma metabolic classifier displayed 78.4%*** contrast,the accuracies of MPR and TNM staging for stratification were 62.5%and 54.1%,*** combination of metabolic and MPR classifiers showed slightly lower accuracy than either individual metabolic *** multivariate analysis,metabolic classifiers were the only independent prognostic factors identified(tumor:P=0.001,hazards ratio[HR]=3.823,95%confidence interval[CI]=1.716-8.514;stroma:P=0.049,HR=2.180,95%CI=1.004-4.737),whereasMPR(P=0.804;HR=0.913;95%CI=0.445-1.874)and TNM staging(P=0.078;HR=1.223;95%CI=0.977-1.550)were not independent prognostic *** Kaplan-Meier survival analyses,both tumor and stroma metabolic classifiers were able to further stratify patients as NAC responders(P<0.001)and non

关键词： cancer metabolism machine learning mass spectrometry imaging metabolic classifier Nonsmall cell lung cancer prognosis spatial metabolomics treatment response

Anisotropic brittle-ductile transition of monocrystalline sapphire during orthogonal cutting and nanoindentation experiments

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nanotechnology and Precision Engineering 2018年第3期1卷 157-171页

作者： philipp Maas Yuta Mizumoto Yasuhiro Kakinuma Sangkee Min Department of System Design Engineering Faculty of Science & TechnologyKeio University Department of Mechanical Engineering University of Wisconsin-Madison

Single-crystal sapphire is utilized as a high-performance engineering material,especially in extreme and harsh ***,due to its extreme hardness and brittleness,the machinability of sapphire is still a *** means of nanoindentation and plunge-cut experiments,the anisotropic brittle-ductile transition of the prismatic M-plane and rhombohedral R-plane is examined by analyzing crack morphologies and the critical depth-of-cut(CDC).The experimental results of the nanoindentation tests are correlated to the plunge-cut *** the prism plane and the rhombohedral crystal plane exhibit a two-fold symmetry of ductility with various crack patterns along the machined *** direction-dependent plasticity of the hexagonal sapphire crystal is mainly connected to a twinning process accompanied by slip dislocation.

关键词： Sapphire Anisotropy Brittle-ductile transition Orthogonal cutting

CFD–DEM simulation of fine particles in a spouted bed apparatus with a Wurster tube

在线全文

学校读者我要写书评

暂无评论

Particuology 2019年第1期17卷 114-125页

作者： Paul Breuninger Dominik Weis Isabell Behrendt philipp Grohn Fabian Krull Sergiy Antonyuk Institute of Particle Process Engineering University of KaiserslauternGottlieb Daimler Str.. KaiserslauternGermany

In this work, a coupled computational fluid dynamics–discrete element method (CFD–DEM) approach was employed to evaluate the spouting behavior of fine, cohesive powders in a cylindrical spouted bed with a conical base and equipped with a Wurster tube. The particle and gas dynamics inside the apparatus were simulated with 1.7 million spherical ZrO2 particles with a particle size of 100 μm. For an accurate prediction of the interactions of cohesive particles in the spouted bed, the adhesion forces according to JKR theory were included in the Hertz–Tsuji contact model. The surface energy of the particles was varied over a wide range to determine the effect of the adhesion on the spouting (the fountain shape and maximum height as well as the distribution of the concentrations and velocities of particles in different zones of the apparatus). A detailed analysis of the collision dynamics was conducted. The spouting behavior of a spouted bed with the same dimensions, particles, and processing parameters was recorded with a high-speed camera. The CFD–DEM simulations showed good agreement with the experimentally captured spouting behavior.

关键词： CFD–DEM Spouted bed Wurster tube Cohesive powder

Corneal Endothelial Cell Loss in Femtosecond Laser-assisted Descemet＇s Stripping Automated Endothelial Keratoplasty： A 12-month Follow-up Study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2017年第24期130卷 2927-2932页

作者： Yun Feng Hong-Qiang Qu Jing Ren philipp Prahs Jing Hong Department of Ophthalmology Peking University Third Hospital Peking University Eye Center Beijing 100191 China Department of Ophthalmology University of Regensburg Regensburg 93053 Germany

Background：Descemet＇s stripping automated endothelial keratoplasty （DSAEK） surgery offers a more standardized approach and reliable method to create corneal grafts with an instrument such as a *** the development of Descemet＇s membrane endothelial keratoplasty,an excellent clinical outcome is seen in the treatment of corneal endothelial dysfunctions,which indicates that thinner corneal graft results in better clinical *** the recent development of the femtosecond laser,ultrathin corneal graft preparation has become *** study aimed to report corneal graft endothelial cell loss （ECL） in a large series of cases undergoing DSAEK with femtosecond laser-assisted corneal graft preparation within a 12-month ***：This study was designed as a prospective,noncomparative,interventional case *** 126 consecutive eyes with endothelial failure of 120 patients,who had corneal endothelial decompensation and underwent femtosecond-assisted DSAEK using the VisuMax femtosecond laser system,were included in the *** endothelial cell density （ECD） was recorded postoperatively at 2 weeks （n =126）,1 month （n =126）,3 months （n =110）,6 months （n =101）,and 12 months （n =71） and then compared with the preoperative eye bank ***-and postoperative central ECDs were evaluated using Heidelberg retina tomography-Ⅲ confocal *** was calculated for each postoperative time *** thickness was examined using anterior segment-optical coherence ***：Mean preoperative cell count was 3383 ± 350 cells/mm^*** postoperative cell counts were 2382 ± 707 cells/mm^2,2179 ± 685 cells/mm^2,2074 ± 688 cells/mm^2,1884 ± 662 cells/mm^2,and 1723 ± 624 cells/mm^2 at 2 weeks,1,3,6,and 12 months,respectively;these represented the ECL of 29.7 ± 19.7%,35.4 ± 19.5%,38.6 ± 19.8%,44.3 ± 18.9%,and 48.9 ± 18.4% at the each corresponding time *** mean corneal graft thickness after surgery was 142 ± 48 μm,118 ± 41 μm,10

关键词： Corneal Transplantation Descemet's Stripping Endothelial Keratoplasty Femtoseconds

Redundancy in Biology and Robotics:Potential of Kinematic Redundancy and its Interplay with Elasticity

在线全文

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2020年第4期17卷 695-707页

作者： Tom Verstraten Christian Schumacher Rapha(e)l Furnémont Andre Seyfarth philipp Beckerle Robotics and Multibody Mechanics Research Group(R&MM) Vrije Universiteit Brussel and Flanders MakePleinlaan 21050 ElseneBelgium Institute of Sports Science TU DarmstadtMagdalenenstraβe 2764289 DarmstadtGermany Elastic Lightweight Robotics Group Robotics Research InstituteTU DortmundOtto-Hahn-Straβe 844227 DortmundGermany Institüt fur Mechatronische Systeme im Maschinenbau TU DarmstadtOtto-Berndt-Straβe 264287 DarmstadtGermany

Redundancy facilitates some of the most remarkable capabilities of humans,and is therefore omni-present in our *** relationship between redundancy in robotics and biology is investigated in detail on the Series Elastic Dual-Motor Actuator(SEDMA),an actuator inspired by the kinematic redundancy exhibited by *** actuator consists of two motors coupled to a single spring at the *** a system has a redundant degree of freedom,which can be exploited to optimize aspects such as accuracy,impedance,fault-tolerance and energy *** test its potential for human-like motions,the SEDMA actuator is implemented in a hopping *** on a physical demonstrator show that the robot's movement patterns resemble human squat *** conclude that robots with bio-inspired actuator designs facilitate human-like movement,although current technical limitations may prevent them from reaching the same dynamic and energetic performance.

关键词： bioinspired redundant actuation series elastic actuation hopping robots energy efficiency human physiology

Ultra-sensitive bioanalysis of the therapeutic peptide exenatide for accurate pharmacokinetic analyses at effective plasma concentrations utilizing UPLC-MS/MS

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2020年第3期10卷 233-239页

作者： Max Sauter philipp Uhl Jürgen Burhenne Walter E.Haefeli Department of Clinical Pharmacology and Pharmacoepidemiology Heidelberg University HospitalIm Neuenheimer Feld 41069120HeidelbergGermany

Exenatide is the first approved glucagon-like peptide 1 receptor agonist subcutaneously or intramuscularly injected for the treatment of type 2 diabetes *** therapeutic plasma concentrations are in the low pg/mL range,therefore requiring ultra-sensitive *** enable the accurate evaluation of pharmacokinetic studies,we established a UPLC-MS/MS assay with a lower limit of quantification(LLOQ)of 5 pg/mL(1.2 pM)using 200μL of plasma,validated acco rding to FDA's and EMA's pertinent *** was isolated from plasma with solid phase extraction utilizing anionexchange *** was performed with positive electrospray ionization tandem mass spectrometry in the selected reaction monitoring *** calibrated concentration range of 5-10,000 pg/mL was linear showing co rrelation coefficients>*** and intraday accuracy ranged from 97.5%to 105.4%with corre sponding precision of<10.9%.Accuracy at the LLOQ ranged from 93.0%to 102.5%with corresponding precision of<15.9%.Because of the validity of a 10-fold dilution QC(accuracy 111.2%),the assay is suitable for exenatide quantification up to 100,000 pg/*** ultra-sensitive assay's applicability was demonstrated by the quantification of exenatide plasma concentrations and pharmacokinetics after intravenous and nasal administration to beagle dogs.

关键词： Exenatide Nasal Intravenous UPLC Tandem mass spectrometry Pharmacokinetics