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The effectiveness of different wear indicators in quantifying wear on railway wheels of freight wagons

Railway Engineering Science 2024年第3期32卷 307-323页

作者： philipe augusto de paula pacheco M.Magelli Matheus Valente Lopes Pedro Henrique Alves Correa N.Zampieri N.Bosso Auteliano Antunes dos Santos Federal Institute of the Southeast of Minas Gerais(IF Sudeste MG) Técnico PanamáStreet 45Santos DumontMG 36246-311Brazil Railway Laboratory(Lafer) Universidade Estadual de Campinas(UNICAMP)Mendeleyev Street 200CampinasSP 13083-872Brazil department of Mechanical and Aerospace Engineering Politecnico Di TorinoC.so Duca degli Abruzzi 2410129 TurinItaly

Railway infrastructure relies on the dynamic interaction between wheels and rails;thus,assessing wheel wear is a critical aspect of maintenance and *** paper focuses on the wheel-rail wear indicator T-gamma(Tγ).Amidst its use,it becomes apparent that Tγ,while valuable,fails to provide a comprehensive reflection of the actual material removal and actual contact format,which means that using only Tγas a target for optimization of profiles is not *** this work,three different freight wagons are evaluated:a meter-gauge and a broad-gauge heavy haul vehicles from South American railways,and a standard-gauge freight vehicle operated in Europe,with different axle loads and dissimilar new wheel/rail *** vehicles are subjected to comprehensive multibody simulations on various *** simulations aimed to elucidate the intricate relationship between different wear indicators:Tγ,wear index,material removal,and maximum wear depth,under diverse curves,non-compensated lateral accelerations(A_(nc)),and *** findings showed a correlation of 0.96 between Tγand wear depth and 0.82 between wear index and material removed for the outer *** the results,the Tγis better than the wear index to be used when analyzing wear depth while the wear index is more suited to foresee the material *** results also show the low influence of A_(nc)on wear index and Tγ.By considering these factors together,the study aims to improve the understanding of wheel-rail wear by selecting the best wear analysis approaches based on the effectiveness of each parameter.

关键词： Wear index Wear volume Wear modeling Dynamic simulation

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Systemic Inflammation Response Index and weight loss as prognostic factors in metastatic pancreatic cancer: A concept study from the PANTHEIA-SEOM trial

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 386-397页

作者： Vilma pacheco-Barcia Sara Custodio-Cabello Fatima Carrasco-Valero Magda Palka-Kotlowska Axel Mariño-Mendez Alberto Carmona-Bayonas Javier Gallego A J Muñoz Martín paula Jimenez-Fonseca Luis Cabezon-Gutierrez department of Medical Oncology Hospital Universitario de TorrejonMadrid 28850Spain department of Internal Medicine Hospital Universitario de TorrejonMadrid 28850Spain department of Medical Oncology Hospital Universitario Central de AsturiasOviedo 33011Spain department of Medical Oncology Hospital Universitario Morales MeseguerUniversity of MurciaMurcia 30001Spain department of Medical Oncology Hospital General Universitario de ElcheElche 03202Spain department of Medical Oncology Hospital General Universitario Gregorio MarañónUniversidad Complutense MadridMadrid 28007Spain Universidad Francisco de Vitoria Madrid 28223Spain

BACKGROUND The prognostic value of the Systemic Inflammation Response Index(SIRI)in advanced pancreatic cancer is recognized,but its correlation with patients´nutritional status and outcomes remains *** To study the prognostic significance of SIRI and weight loss in metastatic pancreatic *** The PANTHEIA-Spanish Society of Medical Oncology(SEOM)study is a multicentric(16 Spanish hospitals),observational,longitudinal,non-interventional initiative,promoted by the SEOM Real World-Evidence work *** pilot study sought to analyze the association between weight loss and inflammatory status as defined by *** cohort stems from a proof-of-concept pilot study conducted at one of the coordinating *** with pathologically confirmed metastatic pancreatic adenocarcinoma,treated from January 2020 to January 2023,were *** index was calculated using the product of neutrophil and monocyte counts,divided by lymphocyte counts,obtained within 15 days before initiation *** study evaluated associations between overall survival(OS),SIRI and weight *** A total of 50 patients were included.66%of these patients were male and the median age was 66 *** sites:36%liver,12%peritoneal carcinomatosis,10%lung,and 42%multiple *** the first line palliative chemotherapy treatments:50%received gemcitabine plus nab-paclitaxel;28%,modified fluorouracil,leucovorin,irinotecan and oxaliplatin,and 16%were administered gemcitabine.42%had a weight loss>5%in the three months(mo)preceding diagnosis.21 patients with a SIRI≥2.3×10^(3)/L exhibited a trend towards a lower median OS compared to those with a SIRI5%weight loss before diagnosis,the median OS was 6 mo,in contrast to 19 mo for those who did not experience such weight loss(P=0.003).Patients with a weight loss>5%showed higher SIRI *** difference was statistically significant(P<0.000).For pat

关键词： Pancreatic cancer Nutrition Prognostic factor Inflammation Advanced cancer Systemic inflammatory response index Weight loss

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Genoprotection and metabolic benefits of marine macroalgae-Insights into the concept of functional foods through direct and indirect consumption

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Food Bioscience 2022年第3期47卷 524-533页

作者： Ana Marques João Ferreira Ana Cerqueda-pacheco Vitória Pereira Helena Abreu Rui Pereira Maria João Pires Fernanda Seixas paula Oliveira Isabel Gaivão Mário pacheco Laboratory of Physiotoxicology CESAM-Centre for Environmental and Marine StudiesDepartment of BiologyUniversity of AveiroCampus Universitário de Santiago3810-193AveiroPortugal CECAV-Animal and Veterinary Research Center AL4AnimalsUniversity of Trás-os-Montes and Alto DouroQuinta de Prados5000-801Vila RealPortugal department of Genetics and Biotechnology University of Trás-os-Montes and Alto DouroQuinta de Prados5000-801Vila RealPortugal department of Biology and Environment University of Trás-os-Montes and Alto DouroQuinta de Prados5000-801Vila RealPortugal CITAB-Centre for the Research and Technology of Agro-Environmental and Biological Sciences Inov4AgroUniversity of Trás-os-Montes and Alto DouroQuinta de Prados5000-801Vila RealPortugal department of Veterinary Sciences University of Trás-os-Montes and Alto DouroQuinta de Prados5000-801Vila RealPortugal ALGAplus Lda.Travessa Alexandre da Conceição s/n3830-196ÍlhavoPortugal

The consumption of marine macroalgae has been linked with health benefits,albeit some actions,including genoprotection,remain ***,we evaluated the genoprotective potential of a mixture of Ulva rigida,Fucus vesiculosus and Gracilaria gracilis,through direct consumption or via indirect intake using fish(Sparus aurata)as a vector of algal ***(Mus musculus)were subjected to a 1-month dietary supplementation with 5%of macroalgae mix or 10%of fillet of fish previously fed with an algae-supplemented aquafeed(for comparison purposes,10%supplementation with fillet of fish standardly fed was also considered).Thereafter,mice were challenged by the genotoxicant methyl methanesulfonate(MMS),and the genetic damage was evaluated through the micronuclei ***,a wider evaluation was carried out encompassing the assessment of energy metabolism,haematological and histological parameters,as well as growth *** unequivocally protected against MMS-induced *** activity profile of hepatic lactate and isocitrate dehydrogenases promoted by the supplemented diets reflected an improved energy *** properties were not transferred via fish fed with the algae-supplemented aquafeed,though the transference of phytocomponents with beneficial properties(*** balance improvement)should not be ***,these findings highlighted the genoprotection afforded by marine macroalgae,likely promoted by desmutagenic factors,reinforcing their definition as functional *** possibility of using fish as an indirect source of algae-borne phytocomponents proved to be plausible and worthy of further investigations.

关键词： Antigenotoxicity desmutagens Fish consumption Functional food Marine macroalgae consumption Metabolic benefits

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Role of sex on psychological distress,quality of life,and coping of patients with advanced colorectal and non-colorectal cancer

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World Journal of Gastrointestinal Oncology 2022年第10期14卷 2025-2037页

作者： Vilma pacheco-Barcia David Gomez Berta Obispo Luka Mihic Gongora Raquel Hernandez San Gil Patricia Cruz-Castellanos Mireia Gil-Raga Vicente Villalba Ismael Ghanem paula Jimenez-Fonseca Caterina Calderon department of Medical Oncology School of MedicineAlcala University(UAH)Hospital Central de la Defensa Gómez UllaMadrid 28047Spain department of Medical Oncology Hospital Universitario de NavarraPamplona 31008Spain department of Medical Oncology Hospital Universitario Infanta LeonorMadrid 28031Spain department of Medical Oncology Hospital Universitario Central de AsturiasOviedo 33011Spain department of Medical Oncology Hospital Universitario de CanariasTenerife 38320Spain department of Medical Oncology Hospital Universitario La PazMadrid 28046Spain department of Medical Oncology Hospital General Universitario de ValenciaCIBERONCValencia 46014Spain department of Clinical Psychology and Psychobiology Faculty of PsychologyUniversity of BarcelonaBarcelona 08007Spain department of Medical Oncology Hospital Universitario Central de AsturiasISPAOviedo 33007Spain department of Clinical Psychology and Psychobiology University of BarcelonaBarcelona 08007Spain

BACKGROUNDPatients with advanced gastrointestinal cancer must cope with the negative effects of cancer and *** To evaluate psychological distress,quality of life,and coping strategies in patients with advanced colorectal cancer compared to non-colorectal cancer based on *** A prospective,transversal,multicenter study was conducted in 203 patients;101(50%)had a colorectal and 102(50%)had digestive,non-colorectal advanced *** completed questionnaires evaluating psychological distress(Brief Symptom Inventory-18),quality of life(EORTC QLQ-C30),and coping strategies(Mini-Mental Adjustment to Cancer)before starting systemic cancer *** The study included 42.4%*** exhibited more depressive symptoms,anxiety,functional limitations,and anxious preoccupation than *** with non-colorectal digestive cancer and women showed more somatization and physical symptoms than subjects with colorectal cancer and *** with colorectal cancer reported the best health *** The degree of disease acceptance in gastrointestinal malignancies may depend on sex and location of the primary digestive *** interventions should specifically address sex and tumor site differences in individuals with advanced digestive cancer.

关键词： Anxiety Colorectal cancer depression Gastrointestinal cancer Sex

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Expression and activity of heterologous hydroxyisocaproate dehydrogenases in Synechocystis *** 6803ΔhoxYH

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Engineering Microbiology 2022年第1期2卷 1-7页

作者： Valentina Jurka Christoph K.Winkler Silvan Poschenrieder Paulo Oliveira Catarina C.pacheco Eunice A.Ferreira Florian Weissensteiner Piera de Santis Selin Kara Robert Kourist paula Tamagnini Wolfgang Kroutil a Institute of Chemistry University of GrazNAWI GrazHeinrichstrasse 288010 GrazAustria i3S–Instituto de Investigação e Inovação em Saúde Universidade do Porto4200-135 PortoPortugal IBMC–Instituto de Biologia Molecular e Celular Universidade do Porto4200-135 PortoPortugal departamento de Biologia Faculdade de CiênciasUniversidade do Porto4169-007 PortoPortugal ICBAS–Instituto de Ciências Biomédicas Abel Salazar Universidade do Porto4050-313 PortoPortugal Aarhus University Department of EngineeringBiological and Chemical Engineering SectionBiocatalysis and Bioprocessing GroupGustav Wieds Vej 10DK 8000 AarhusDenmark Institute of Molecular Biotechnology Graz University of Technology8010 GrazAustria Field of Excellence BioHealth University of Graz8010 GrazAustria BioTechMed Graz 8010 GrazAustria.

Exploiting light to drive redox reactions is currently a hot topic since light is considered as an environmentally friendly source of ***,cyanobacteria,which can use light e.g.,for generating NADPH,are in the focus of ***,it has been shown that various heterologous redox enzymes could be expressed in these *** we demonstrated the successful inducer-free expression of𝛼-keto-acid dehydroge-nases(L-HicDH and D-HicDH)from Lactobacillus confusus DSM 20196 and Lactobacillus paracasei DSM 20008 in Synechocystis *** 6803ΔhoxYH mutant using replicative *** the L-HicDH showed poor activity limited by the amount of expressed enzyme,the D-HicDH was applied both in vivo and in vitro,transforming the selected𝛼-keto acids to the corresponding optically pure(R)-𝛼-hydroxy acids(ee>99%)in up to 53%and 90%conversion,respectively.

关键词： Cyanobacteria Biocatalysis Photobiotransformation Synechocystis sp.PCC 6803 Hydroxyisocaproate dehydrogenase Ketoacid dehydrogenase

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Early Hepatic Encephalopathy after a Transjugular Intrahepatic Portosystemic Shunt Procedure: Case Report

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Open Journal of Gastroenterology 2021年第6期11卷 81-88页

作者： Miriam Viviane Baron Gabriela Di Lorenzo Garcia Scherer Michele paula dos Santos Andres Felipe Mantilla Santamaria Cristine Brandenburg Isabel Cristina Reinheimer Marcus Vinicius de Mello Pinto Aline Ronis Sampaio Alexandre Gomes Sancho Alexandre Gomes Sancho Esteban Fortuny pacheco Felice Picariello Danielle de Mello Florentino Joice Nedel Ott Carolina Gonçalves Pinheiro Nathália Ken Pereira Iketani Sonia Carvalho Patrícia Froes Meyer Bartira Ercília Pinheiro da Costa Postgraduate Program in Medicine and Health Sciences of the Pontifical Catholic University of Rio Grande do Sul (PUC/RS) Porto Alegre Rio Grande do Sul Brazil School of Medicine of the Pontifical Catholic University of Rio Grande do Sul (PUC/RS) Porto Alegre Rio Grande do Sul Brazil Industrial University of Santander (UIS) Bucaramanga Colombia University of Vale do Acaraú (IDJ/UVA) Ceará Brazil Celulare Institute Rio de Janeiro Brazil Unigranrio Rio de Janeiro Brazil Universidad Finis Terrae Santiago Chile Università degli Studi di Napoli Federico II Napoli Italy Uniredentor University Rio de Janeiro Brazil Postgraduate Program in Health Sciences of the Faculty of Medicine of ABC (FABC) S&#227o Paulo Brazil Hospital Beneficiente Portuguesa of Belém Pará Brazil Rigshospital Copenhagen East K&#248benhavn Denmark Centro Universitário do Rio Grande do Norte Natal Brazil

Patients with decompensated hepatic cirrhosis may present systemic alterations and dysfunction of multiple organs. Ascites, portal hypertension, esophageal varices, and hepatic encephalopathy are common complications arising from cirrhosis. The aim of this paper is to report a case of a patient with liver cirrhosis and the complications of a transjugular intrahepatic portosystemic shunt. Male, elderly, and ex-alcoholic, diagnosed with liver cirrhosis, ascites, and esophageal varices. He underwent transjugular intrahepatic portosystemic shunt due to portal hypertension and returned to the hospital after 24 hours with agitation and mental confusion. He had a bowel movement stop, neurological worsening, loss of renal function, hepatic hydrothorax, hepatic encephalopathy, hypernatremia, hypocalcemia, and hypophosphatemia. He underwent a new procedure to occlude the transjugular intrahepatic portosystemic shunt, showing improvement of the mental status and ascites. However, continued with decompensation and hydro-electrolytic disorders. He evolved with worsening of the ventilatory pattern, and neurological and renal function, with a fatal outcome. Esophageal varices due to portal hypertension can be corrected with the transjugular intrahepatic portosystemic shunt. However, complications such as hypernatremia, hepatic hydrothorax, and hepatic encephalopathy may occur. Therefore, there is a need for reintervention to shunt or reduce its caliber. Thus, for patients with advanced age and decompensated cirrhosis, the potential risks and benefits of this procedure should be carefully evaluated due to the risk of complications and death.

关键词： Ascites Hypernatremia Portasystemic Shunt Transjugular Intrahepatic Hepatic Encephalopathy

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Gross Chemical Profile and Calculation of Nitrogen-to-Protein Conversion Factors for Five Tropical Seaweeds

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American Journal of Plant Sciences 2011年第3期2卷 287-296页

作者： Graciela S.Diniz Elisabete Barbarino João Oiano-Neto Sidney pacheco Sergio O.Lourenco departamento de Biologia Marinha Universidade Federal FluminenseNiteróiBrazil Laboratório de Cromatografia Líquida Embrapa Agroindústria de AlimentosRio de JaneiroBrazil Instituto Virtual Internacional de Mudanças Globais Universidade Federal do Rio de Janeiro—UFRJ/IVIGRio de JaneiroBrazil

despite decades of research on marine algae, there are still significant gaps in basic knowledge about chemical composition of these organisms, especially in tropical environments. In this study, the amino acid composition and contents of total nitrogen, phosphorus, lipid, carbohydrate and protein were determined in Asparagopsis taxiformis, Centroceras clavulatum, Chaetomorpha aerea, Sargassum filipendula and Spyridia hypnoides. The seaweeds showed low lipid contents (lower than 5.5% d.w. in all species) and were rich in carbohydrates (more than 16% d.w. in all seaweeds). The percentage of nitrogen, phosphorus and protein varied widely among species, which red algae showed the highest con-centrations. The amino acid composition was similar among the seaweeds, which glutamic acid, aspartic acid and leu-cine as the most abundant. All species are poor in histidine. An average of 24.2% of the total nitrogen is non-proteinaceous. From data of total amino acid and total nitrogen, specific nitrogen-to-protein conversion factors were calculated for each species. The nitrogen-to-protein conversion factors calculated ranged from 4.51 to 5.21, with an overall average of 4.86. These findings show that the traditional conversion factor of 6.25 should be avoided for seaweeds, since it overestimates the actual protein content.

关键词： Nitrogen-to-Protein Conversion Factors Protein Amino Acid Seaweeds Element Composition Tropical Environment

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