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The Changing Cold Regions Network:Observation,diagnosis and prediction of environmental change in the Saskatchewan and Mackenzie River Basins,Canada

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Science China Earth Sciences 2015年第1期58卷 46-60页

作者： Chris M DEBEER Howard S WHEATER William L QUINTON Sean K CAREY Ronald E STEWART Murray D MACKAY philip marsh Global Institute for Water Security University of SaskatchewanNational Hydrology Research Centre Cold Regions Research Centre Wilfrid Laurier University School of Geography and Earth Sciences Mc Master University Department of Environment and Geography University of Manitoba Science and Technology Branch Environment Canada

Climate change is causing rapid and severe changes to many Earth systems and processes,with widespread cryospheric,ecological,and hydrological impacts globally,and especially in high northern *** is of major societal concern and there is an urgent need for improved understanding and predictive tools for environmental *** Changing Cold Regions Network(CCRN)is a Canadian research consortium with a focus to integrate existing and new experimental data with modelling and remote sensing products to understand,diagnose,and predict changing land,water,and climate,and their interactions and feedbacks over the geographic domain of the Mackenzie and Saskatchewan River Basins in *** network operates a set of 14 unique and focused Water,Ecosystem,Cryosphere and Climate(WECC)observatories within this region,which provide opportunities to observe and understand processes and their interaction,as well as develop and test numerical simulation models,and provide validation data for remote sensing *** paper describes this network and its observational,experimental,and modelling *** overview of many of the recent Earth system changes observed across the study region is provided,and some local insights from WECC observatories that may partly explain regional patterns and trends are *** of the model products being developed are discussed,and linkages with the local to international user community are reviewed—In particular,the use of WECC data towards model and remote sensing product calibration and validation is *** future activities and prospects for the network are also presented at the end of the paper.

关键词： climate change cryosphere hydrology atmospheric science ecology modelling Canada

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老街区的缤纷学堂

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设计家 2009年第11期 91-95,90页

作者： Alex de Rijke Jonas Lencer philip marsh 余丹 dRMM(de Rijke marsh Morgan Architects)

位于伦敦维多利亚区的这所学校建筑,由dRMM事务所负责对它进行更新和扩建设计。在紧密的周边城市环境中,这个具有多彩外观的建筑,赋予学校全新的个性之余,还提供了更多必需的学习空间和一个组织枢纽,并最大限度地拓展了师生游乐的场所。

关键词：学校建筑城市环境事务所学习空间外观维多利亚教学环境设计伦敦色彩

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中级学院单元04

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世界建筑导报 2004年第Z1期 30-31页

作者： Alex de Rilke,philip marsh,Sadie Morgan 单元主任单元主任单元主任

单层集合式住宅你能够从英特网的产品目录中订购家具,并可以在几天内将包装完好的货品通过运货车送达你手中,车上还有比你家里更好的椅子和音像设备。让我们试着用这种方式去建造一座住宅。目前在这个国家人们或许更喜欢用三个软木制... 详细信息

单层集合式住宅你能够从英特网的产品目录中订购家具,并可以在几天内将包装完好的货品通过运货车送达你手中,车上还有比你家里更好的椅子和音像设备。让我们试着用这种方式去建造一座住宅。目前在这个国家人们或许更喜欢用三个软木制的容器结束宜家式的生活,然而不幸的是这些容器仍在使用。有一种更好的途径:更轻、更便宜、更实用、更有趣……

关键词：产品目录住宅

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中级学院单元04

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世界建筑导报 2004年第1期19卷 30-31页

作者： Alex de Rilke philip marsh Sadie Morgan 单元主任

单层集合式住宅你能够从英特网的产品目录中订购家具，并可以在几天内将包装完好的货品通过运货车送达你手中，车上还有比你家里更好的椅子和吾像设备。让我们试着用这种方式去建造一座住宅。目前在这个国家人们或许更喜欢用三个软木制... 详细信息

单层集合式住宅你能够从英特网的产品目录中订购家具，并可以在几天内将包装完好的货品通过运货车送达你手中，车上还有比你家里更好的椅子和吾像设备。让我们试着用这种方式去建造一座住宅。目前在这个国家人们或许更喜欢用三个软木制的容器结束宜家式的生活，然而不幸的是这些容器仍在使用。有一种更好的途径：更轻、更便宜、更实用、更有趣……

关键词：集合式住宅单元学院中级产品目录英特网容器软木

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MicroRNAs as potential diagnostic biomarkers for bipolar disorder

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Neural Regeneration Research 2025年第6期20卷 1681-1695页

作者： Bridget Martinez philip V.Peplow Department of Pharmacology University of Nevada-RenoRenoNVUSA Department of Medicine University of Nevada-RenoRenoNVUSA Department of Anatomy University of OtagoDunedinNew Zealand

Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of bipolar disorder. We performed a PubMed search for microRNA biomarkers in bipolar disorder and found 18 original research articles on studies performed with human patients and published from January 2011 to June 2023. These studies included microRNA profiling in bloodand brain-based materials. From the studies that had validated the preliminary findings,potential candidate biomarkers for bipolar disorder in adults could be miR-140-3p,-30d-5p,-330-5p,-378a-5p,-21-3p,-330-3p,-345-5p in whole blood, miR-19b-3p,-1180-3p,-125a-5p, let-7e-5p in blood plasma, and miR-7-5p,-23b-5p,-142-3p,-221-5p,-370-3p in the blood serum. Two of the studies had investigated the changes in microRNA expression of patients with bipolar disorder receiving treatment. One showed a significant increase in plasma miR-134 compared to baseline after 4 weeks of treatment which included typical antipsychotics, atypical antipsychotics, and benzodiazepines. The other study had assessed the effects of prescribed medications which included neurotransmitter receptorsite binders(drug class B) and sedatives, hypnotics, anticonvulsants, and analgesics(drug class C) on microRNA results. The combined effects of the two drug classes increased the significance of the results for miR-219 and-29c with miR-30e-3p and-526b* acquiring significance. MicroRNAs were tested to see if they could serve as biomarkers of bipolar disorder at different clinical states of mania, depression, and euthymia. One study showed that upregulation in whole blood of miR-9-5p,-29a-3p,-106a-5p,-106b-5p,-107,-125a-3p,-125b-5p and of miR-107,-125a-3p occurred in manic and euthymic patients compared to controls, respectively, and that upregulation of miR-106a-5p,-107 was found for manic compared to euthymic patients. In two other studies using blood plasma,downregulation of miR-134 was observed i

关键词： biomarker bipolar disorder blood leukocytes blood plasma blood plasma extracellular vesicles/exosomes blood serum brain tissue brain tissue extracellular vesicles/exosomes lymphoblastoid cell lines microRNA neural progenitor cells whole blood

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Autism spectrum disorder:difficulties in diagnosis and microRNA biomarkers

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Neural Regeneration Research 2025年第10期20卷 2776-2786页

We performed a PubMed search for microRNAs in autism spectrum disorder that could serve as diagnostic biomarkers in patients and selected 17 articles published from January 2008 to December 2023,of which 4 studies were performed with whole blood,4 with blood plasma,5 with blood serum,1 with serum neural cell adhesion molecule L1-captured extracellular vesicles,1 with blood cells,and 2 with peripheral blood mononuclear *** of the studies involved children and the study cohorts were largely *** of the studies had performed microRNA sequencing or quantitative polymerase chain reaction assays to measure microRNA *** five studies had used real-time polymerase chain reaction assay to validate microRNA expression in autism spectrum disorder subjects compared to *** microRNAs that were validated in these studies may be considered as potential candidate biomarkers for autism spectrum disorder and include miR-500a-5p,-197-5p,-424-5p,-664a-3p,-365a-3p,-619-5p,-664a-3p,-3135a,-328-3p,and-500a-5p in blood plasma and miR-151a-3p,-181b-5p,-320a,-328,-433,-489,-572,-663a,-101-3p,-106b-5p,-19b-3p,-195-5p,and-130a-3p in blood serum of children,and miR-15b-5p and-6126 in whole blood of *** important limitations were identified in the studies reviewed,and need to be taken into account in future *** studies are warranted with children and adults having different levels of autism spectrum disorder severity and consideration should be given to using animal models of autism spectrum disorder to investigate the effects of suppressing or overexpressing specific microRNAs as a novel therapy.

关键词： autism spectrum disorder biomarker blood cells blood plasma blood serum diagnosis microRNA peripheral blood mononuclear cells serum neural cell adhesion molecule L1-captured extracellular vesicles whole blood

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MicroRNAs as potential biomarkers for diagnosis of post-traumatic stress disorder

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Neural Regeneration Research 2025年第7期20卷 1957-1970页

Post-traumatic stress disorder is a mental disorder caused by exposure to severe traumatic life ***,there are no validated biomarkers or laboratory tests that can distinguish between trauma survivors with and without post-traumatic stress *** addition,the heterogeneity of clinical presentations of post-traumatic stress disorder and the overlap of symptoms with other conditions can lead to misdiagnosis and inappropriate *** suggests that this condition is a multisystem disorder that affects many biological systems,raising the possibility that peripheral markers of disease may be used to diagnose post-traumatic stress *** performed a PubMed search for microRNAs(miRNAs)in post-traumatic stress disorder(PTSD)that could serve as diagnostic biomarkers and found 18 original research articles on studies performed with human patients and published January 2012 to December *** included four studies with whole blood,seven with peripheral blood mononuclear cells,four with plasma extracellular vesicles/exosomes,and one with serum *** of these studies had also used whole *** studies were excluded as they did not involve microRNA *** of the studies had collected samples from adult male Veterans who had returned from deployment and been exposed to combat,and only two were from recently traumatized adult *** measuring miRNA expression levels,many of the studies had used microarray miRNA analysis,miRNA Seq analysis,or NanoString *** six studies had used real time polymerase chain reaction assay to determine/validate miRNA expression in PTSD subjects compared to *** miRNAs that were found/validated in these studies may be considered as potential candidate biomarkers for PTSD and include miR-3130-5p in whole blood;miR-193a-5p,-7113-5p,-125a,-181c,and-671-5p in peripheral blood mononuclear cells;miR-10b-5p,-203a-3p,-4488,-502-3p,-874-3p,-5100,and-7641 in plasma extracellular vesicles/

关键词： biomarker diagnosis microRNA peripheral blood mononuclear cells plasma extracellular vesicles/exosomes post-traumatic stress disorder serum exosomes whole blood whole plasma

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A new twist on graphene: an interview with Pablo Jarillo-Herrero and Allan MacDonald

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National Science Review 2022年第4期9卷 186-191页

作者： philip Ball NSR from London

Graphene is the building block of graphite, made of carbon atoms bonded into sheets of hexagonal rings just a single atom thick. Although such isolated sheets had been predicted for many decades to exist, and had been grown on other surfaces, interest in this material exploded a?ter the discovery in 2004 that single sheets could be made easily and cheaply by separating them mechanically from graphite flakes(a process called exfoliation).

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The influence of airtightness on contaminant spread in MURBs in cold climates

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Building Simulation 2022年第2期15卷 249-264页

作者： philip Mckeen Zaiyi Liao Department of Architectural Science Ryerson UniversityTorontoM5B2K3Canada

Tall buildings in cold climates have unique challenges in maintaining indoor air quality due to stack *** the heating season,interior air buoyancy creates large pressure differentials in vertical shafts that can drive airflow from lower floors into upper *** pressure differential can result in the spread of contaminants throughout a *** recently,concern over COVID-19 has increased attention to the potential spread of airborne diseases in densely populated *** many multi-unit residential buildings,suite ventilation has traditionally relied upon fresh air supplied through a mechanically pressurized *** cold climates,large pressure differentials created by stack-effect can reduce the effectiveness of this *** and CFD simulations are employed to analyze airflow and contaminant spread due to stack *** are conducted on an idealized model of a 10-storey building using a range of experimentally derived airtightness *** demonstrate stack effect can reduce corridor ventilation to suites and even reverse the airflow for leakier *** airflow to suites can result in the accumulation of *** of the airflow can allow contaminants from a suite to spread throughout the *** spread is illustrated as a function of mechanical ventilation,building airtightness,and ambient *** to reduce the influence of stack effect on mechanically pressurized corridors are discussed.

关键词： MURBs ventilation contamination spread stack effect

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The search for charmed states of matter

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National Science Review 2021年第11期8卷 79-82页

作者： philip Ball NSR London

With the discovery of the Higgs boson in 2012, the Standard Model ofparticle physics was *** description encompasses all known subatomic particles and their *** of the public interest in high-energy physics now focuses on experimental searches for ’new physics’ beyond the Standard *** it would be a mistake to imagine that the Standard Model is now fully *** questions remain about the ways in which known fundamental particles interact and unite, especially at the very high energies needed to produce the most exotic varieties, such as heavy quarks (quarks are the constituents of hadrons, which include the ordinary nuclear particles protons and neutrons) and heavy leptons (leptons are members of the family that includes electrons).

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