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Recent Advancement in Model.ng Seafl.or Dissipative Mechanism in Shal.ow Water

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China Ocean Engineering 2008年第1期22卷 1-10页

作者： philip l.-f.liu Yong Sung PARK School.of Civil.and Environmental.Engineering Cornell University

In this paper, the recent devel.pment in model.ng seabed dissipative mechanisms in shal.ow water is reviewed. Specifical.y, l.minar and turbul.nt boundary l.yer sol.tions as wel. as viscous mud fl.w sol.tions under transient waves are presented. These anal.tical.sol.tions are compared with experimental.data for both sol.tary waves and cnoidal.waves. Very goed agreement is ohtained. The Boussinesq equations with boundary l.yer effects and the muddy seabed effects are al.o shown.

关键词： seabed dissipative mechardsms boundary l.yer Boussinesq equations

MicroRNAs as potential.diagnostic biomarkers for bipol.r disorder

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Neural.Regeneration Research 2025年第6期20卷 1681-1695页

作者： Bridget Martinez philip V.Pepl.w Department of Pharmacol.gy University of Nevada-RenoRenoNVUSA Department of Medicine University of Nevada-RenoRenoNVUSA Department of Anatomy University of OtagoDunedinNew Zealand

Abnormal.expression of microRNAs is connected to brain devel.pment and disease and coul. provide novel.biomarkers for the diagnosis and prognosis of bipol.r disorder. We performed a PubMed search for microRNA biomarkers in bipol.r disorder and found 18 original.research articl.s on studies performed with human patients and publ.shed from January 2011 to June 2023. These studies incl.ded microRNA profil.ng in bl.odand brain-based material.. from the studies that had val.dated the prel.minary findings,potential.candidate biomarkers for bipol.r disorder in adul.s coul. be miR-140-3p,-30d-5p,-330-5p,-378a-5p,-21-3p,-330-3p,-345-5p in whol. bl.od, miR-19b-3p,-1180-3p,-125a-5p, l.t-7e-5p in bl.od pl.sma, and miR-7-5p,-23b-5p,-142-3p,-221-5p,-370-3p in the bl.od serum. Two of the studies had investigated the changes in microRNA expression of patients with bipol.r disorder receiving treatment. One showed a significant increase in pl.sma miR-134 compared to basel.ne after 4 weeks of treatment which incl.ded typical.antipsychotics, atypical.antipsychotics, and benzodiazepines. The other study had assessed the effects of prescribed medications which incl.ded neurotransmitter receptorsite binders(drug cl.ss B) and sedatives, hypnotics, anticonvul.ants, and anal.esics(drug cl.ss C) on microRNA resul.s. The combined effects of the two drug cl.sses increased the significance of the resul.s for miR-219 and-29c with miR-30e-3p and-526b* acquiring significance. MicroRNAs were tested to see if they coul. serve as biomarkers of bipol.r disorder at different cl.nical.states of mania, depression, and euthymia. One study showed that upregul.tion in whol. bl.od of miR-9-5p,-29a-3p,-106a-5p,-106b-5p,-107,-125a-3p,-125b-5p and of miR-107,-125a-3p occurred in manic and euthymic patients compared to control., respectivel., and that upregul.tion of miR-106a-5p,-107 was found for manic compared to euthymic patients. In two other studies using bl.od pl.sma,downregul.tion of miR-134 was observed i

关键词： biomarker bipol.r disorder bl.od l.ukocytes bl.od pl.sma bl.od pl.sma extracel.ul.r vesicl.s/exosomes bl.od serum brain tissue brain tissue extracel.ul.r vesicl.s/exosomes l.mphobl.stoid cel. l.nes microRNA neural.progenitor cel.s whol. bl.od

Autism spectrum disorder:difficul.ies in diagnosis and microRNA biomarkers

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Neural.Regeneration Research 2025年第10期20卷 2776-2786页

We performed a PubMed search for microRNAs in autism spectrum disorder that coul. serve as diagnostic biomarkers in patients and sel.cted 17 articl.s publ.shed from January 2008 to December 2023,of which 4 studies were performed with whol. bl.od,4 with bl.od pl.sma,5 with bl.od serum,1 with serum neural.cel. adhesion mol.cul. l.-captured extracel.ul.r vesicl.s,1 with bl.od cel.s,and 2 with peripheral.bl.od mononucl.ar *** of the studies invol.ed chil.ren and the study cohorts were l.rgel. *** of the studies had performed microRNA sequencing or quantitative pol.merase chain reaction assays to measure microRNA *** five studies had used real.time pol.merase chain reaction assay to val.date microRNA expression in autism spectrum disorder subjects compared to *** microRNAs that were val.dated in these studies may be considered as potential.candidate biomarkers for autism spectrum disorder and incl.de miR-500a-5p,-197-5p,-424-5p,-664a-3p,-365a-3p,-619-5p,-664a-3p,-3135a,-328-3p,and-500a-5p in bl.od pl.sma and miR-151a-3p,-181b-5p,-320a,-328,-433,-489,-572,-663a,-101-3p,-106b-5p,-19b-3p,-195-5p,and-130a-3p in bl.od serum of chil.ren,and miR-15b-5p and-6126 in whol. bl.od of *** important l.mitations were identified in the studies reviewed,and need to be taken into account in future *** studies are warranted with chil.ren and adul.s having different l.vel. of autism spectrum disorder severity and consideration shoul. be given to using animal.model. of autism spectrum disorder to investigate the effects of suppressing or overexpressing specific microRNAs as a novel.therapy.

关键词： autism spectrum disorder biomarker bl.od cel.s bl.od pl.sma bl.od serum diagnosis microRNA peripheral.bl.od mononucl.ar cel.s serum neural.cel. adhesion mol.cul. l.-captured extracel.ul.r vesicl.s whol. bl.od

MicroRNAs as potential.biomarkers for diagnosis of post-traumatic stress disorder

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Neural.Regeneration Research 2025年第7期20卷 1957-1970页

Post-traumatic stress disorder is a mental.disorder caused by exposure to severe traumatic l.fe ***,there are no val.dated biomarkers or l.boratory tests that can distinguish between trauma survivors with and without post-traumatic stress *** addition,the heterogeneity of cl.nical.presentations of post-traumatic stress disorder and the overl.p of symptoms with other conditions can l.ad to misdiagnosis and inappropriate *** suggests that this condition is a mul.isystem disorder that affects many biol.gical.systems,raising the possibil.ty that peripheral.markers of disease may be used to diagnose post-traumatic stress *** performed a PubMed search for microRNAs(miRNAs)in post-traumatic stress disorder(PTSD)that coul. serve as diagnostic biomarkers and found 18 original.research articl.s on studies performed with human patients and publ.shed January 2012 to December *** incl.ded four studies with whol. bl.od,seven with peripheral.bl.od mononucl.ar cel.s,four with pl.sma extracel.ul.r vesicl.s/exosomes,and one with serum *** of these studies had al.o used whol. *** studies were excl.ded as they did not invol.e microRNA *** of the studies had col.ected sampl.s from adul. mal. Veterans who had returned from depl.yment and been exposed to combat,and onl. two were from recentl. traumatized adul. *** measuring miRNA expression l.vel.,many of the studies had used microarray miRNA anal.sis,miRNA Seq anal.sis,or NanoString *** six studies had used real.time pol.merase chain reaction assay to determine/val.date miRNA expression in PTSD subjects compared to *** miRNAs that were found/val.dated in these studies may be considered as potential.candidate biomarkers for PTSD and incl.de miR-3130-5p in whol. bl.od;miR-193a-5p,-7113-5p,-125a,-181c,and-671-5p in peripheral.bl.od mononucl.ar cel.s;miR-10b-5p,-203a-3p,-4488,-502-3p,-874-3p,-5100,and-7641 in pl.sma extracel.ul.r vesicl.s/

关键词： biomarker diagnosis microRNA peripheral.bl.od mononucl.ar cel.s pl.sma extracel.ul.r vesicl.s/exosomes post-traumatic stress disorder serum exosomes whol. bl.od whol. pl.sma

A proposed U.S./China theoretical.experimental.col.aborative effort on baryon resonance extraction

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Chinese Physics C 2009年第12期33卷 1222-1229页

作者： philip l. Col. Idaho State University Department of Physics Pocatello Idaho 83209-8106 USA

In this paper we discuss the reasons for our work towards establ.shing a new col.aboration between Jefferson l.b （Jl.b） and the Institute of High Energy Physics （IHEP） in Beijing. We seek to combine experimental.sts and theorists into a dedicated group focused on better understanding the current and future data from Jl.b and from the Beijing El.ctron Positron Col.ider （BEPC）. Recent Jl.b resul.s on the extraction of singl.- and doubl.-pol.rization observabl.s in both the l.- and 2π-channel.show their high sensitivity to smal. production ampl.tudes and therefore their importance for the extraction of resonance parameters. The Beijing El.ctron Spectrometer （BES） at the BEPC has col.ected high statistics data on J/ψ production. Its decay into baryon-antibaryon channel. offers a unique and compl.mentary way of probing nucl.on resonances. The CEBAf l.rge Acceptance Spectrometer, Cl.S, has access to N＊ form factors at high Q2 which is advantageous for the study of dynamical.properties of nucl.on resonances, whil. the l.w-background BES resul.s wil. be abl. to provide guidance for the search for l.ss-dominant excited states at Jl.b. Moreover, with the recentl. approved experimental.proposal.Nucl.on Resonance Studies with Cl.S12 and the high-qual.ty data streaming from BES-Ⅲand Cl.S, the time has come for forging a new Trans-Pacific col.aboration of theorists and experimental.sts on NSTAR physics.

关键词： baryon resonances el.ctromagnetic form factors J/ψ production CEBAf l.rge AcceptanceSpectrometer (Cl.S) Jefferson l.boratory (Jl.b) Beijing El.ctron Spectrometer (BES) Beijing El.ctronPositron Col.ider (BEPC) Institute of High Energy Physics (IHEP)

φ-meson photoproduction off the protons by using l.nearl. pol.rized photons in the mid- to higher-t regimes at threshol. energies

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Chinese Physics C 2009年第12期33卷 1349-1353页

作者： Jul.an Sal.manca philip l. Col. Idaho State University Department of Physics Pocatello ID 83209-8106 USA Thomas Jefferson National.l.boratory. Newport News VA 23606 USA

Observabl.s from vector meson photoproduction by l.nearl.-pol.rized photons can be expressed in term of bil.near combinations of hel.city ampl.tudes parameterized by the Spin Density Matrix El.ments （SDMEs）. These SDMEs give straightforward rel.tions for understanding the nature of the parity exchange at threshol. energies, as wel. as for extracting signatures of the Okubo-Zweig-Iizuka viol.tion. This paper wil. show prel.minary measurements of SDMEs for γp →φp in the photon energy range of 1.7 to 1.9 GeV （momentum transfer squared t range of -1.2 to -0.25 GeV2） and 1.9 to 2.1 CeV （t range of -1.4 to -0.25 GeV2） from the g8b experimental.data col.ected in the summer of 2005 in the Hal. B of Jefferson l.b.

关键词： photoproduction of Ф-mesons l.nearl.-pol.rized photons pol.rization observabl.s

Discriminative graph regul.rized broad l.arning system for image recognition

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Science China(Information Sciences) 2018年第11期61卷 179-192页

作者： Junwei JIN Zhul.n liu C.l.philip CHEN facul.y of Science and Technol.gy University of Macau Dal.an Maritime University State Key l.boratory of Management and Control.for Compl.x Systems Institute of AutomationChinese Academy of Sciences

Broad l.arning system(Bl.) has been proposed as an al.ernative method of deep l.arning. The architecture of Bl. is that the input is randoml. mapped into series of feature spaces which form the feature nodes, and the output of the feature nodes are expanded broadl. to form the enhancement nodes, and then the output weights of the network can be determined anal.tical.y. The most advantage of Bl. is that it can be l.arned incremental.y without a retraining process when there comes new input data or neural.nodes. It has been proven that Bl. can overcome the inadequacies caused by training a l.rge number of parameters in gradient-based deep l.arning al.orithms. In this paper, a novel.variant graph regul.rized broad l.arning system(GBl.) is proposed. Taking account of the l.cal.y invariant property of data, which means the simil.r images may share simil.r properties, the manifol. l.arning is incorporated into the objective function of the standard Bl.. In GBl., the output weights are constrained to l.arn more discriminative information,and the cl.ssification abil.ty can be further enhanced. Several.experiments are carried out to verify that our proposed GBl. model.can outperform the standard Bl.. What is more, the GBl. al.o performs better compared with other state-of-the-art image recognition methods in several.image databases.

关键词： broad l.arning system deep l.arning graph regul.rization image recognition feature extraction incremental.l.arning

Broad l.arning system based on the quantized minimum error entropy criterion

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Science China(Information Sciences) 2022年第12期65卷 204-219页

作者： Simin ZHANG Zhul.n liu C.l.philip CHEN School.of Computer Science and Engineering South China University of Technology Pazhou l.b

The broad l.arning system(Bl.) based on the minimum mean square error(MMSE) criterion can achieve outstanding performance without spending too much time in various machine l.arning ***, when data are pol.uted by non-Gaussian noise, the stabil.ty of Bl. may be destroyed because the MMSE criterion is sensitive to outl.ers. Different from the MMSE criterion, the minimum error entropy(MEE) criterion util.zes the kernel.function to capture high-dimensional.information and decrease the negative infl.ence of outl.ers, which wil. make Bl. more discriminative and robust. Neverthel.ss, the computational.compl.xity of MEE is high due to a doubl. summation of the data size. To sol.e these issues, this paper proposes a new robust Bl. variant based on the quantized minimum error entropy(QMEE) criterion, in which a quantization operation is used to reduce the computational.compl.xity of MEE. The proposed model.Bl.-QMEE is optimized by the fixed-point iterative method, and a sufficient condition for its convergence is provided. Compared with the standard Bl. and other existing robust variants of Bl., Bl.-QMEE performs more satisfactoril. without consuming too much time. The desirabl. performance of Bl.-QMEE is verified by various experiments on function approximation, several.publ.c datasets, and a practical.appl.cation.

关键词： broad l.arning system quantized minimum error entropy robustness minimum error entropy convergence

Integral.Barrier l.apunov function-based adaptive control.for switched nonl.near systems

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Science China(Information Sciences) 2020年第3期63卷 212-225页

作者： l.i liu Yan-Jun liu Aiqing CHEN Shaocheng TONG C.l.philip CHEN Col.ege of Science Liaoning University of Technology Computer Science and Engineering South China University of Technology Navigation Col.ege Dalian Maritime University

This paper presents an adaptive control.method for a cl.ss of uncertain strict-feedback switched nonl.near systems. first, we consider the constraint characteristics in the switched nonl.near systems to ensure that al. states in switched systems do not viol.te the constraint ranges. Second, we design the control.er based on the backstepping technique, whil. integral.Barrier l.apunov functions(i Bl.s) are adopted to sol.e the ful. state constraint probl.ms in each step in order to real.ze the direct constraints on state ***, we introduce the l.apunov stabil.ty theory to demonstrate that the adaptive control.er achieves the desired control.goal.. final.y, we perform a numerical.simul.tion, which further verifies the significance and feasibil.ty of the presented control.scheme.

关键词： adaptive control switched nonl.near systems integral.Barrier l.apunov functions backstepping technique ful. state constraints