检索结果-南通市图书馆

Healthy Donor Fecal Microbiota Transplantation for Recurrent Bacterial Cholangitis in Primary Sclerosing Cholangitis-A Single Case Report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2018年第4期6卷 438-441页

作者： Cyriac Abby philips philip augustine Nikhil Phadke The Liver Unit Cochin Gastroenterology GroupP.A.A.Ernakulam Medical CentreNational Highway Bypass(NH-66)PalarivattomKochiKeralaIndia Gastroenterology Cochin Gastroenterology GroupP.A.A.Ernakulam Medical CentreNational Highway Bypass(NH-66)PalarivattomKochiKeralaIndia Molecular Cellular and Developmental BiologyGenepath DxPhadke HospitalShivajinagarPuneMaharashtraIndia

Recurrent acute bacterial cholangitis is a unique indication for liver transplantation in primary sclerosing *** present the first report on utility of healthy donor fecal transplantation for management of recurrent acute bacterial cholangitis in a primary sclerosing cholangitis *** demonstrate the striking liver biochemistry,bile acid and bacterial community changes following intestinal microbiota transplantation associated with amelioration of recurrent cholangitis.

关键词： FMT Sclerosing cholangitis Stool transplant Gut microbiome Microbiota

Complementary and Alternative Medicine-related Drug-induced Liver Injury in Asia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2019年第3期7卷 263-274页

作者： Cyriac Abby philips philip augustine Sasidharan Rajesh Praveen Kumar Y Deepak Madhu The Liver Unit and Monarch Liver Lab Cochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia Gastroenterology Cochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia Interventional Radiology Cochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia Gastroenterology Government Medical CollegeThrissurKeralaIndia Gastroenterology Aster MIMSCalicutKeralaIndia

The use of complementary and alternative medicines(CAMs)for treatment of acute and chronic diseases is on the rise world over,especially in Asian countries,and mostly in China and ***-induced liver injury(DILI)due to CAM is increasingly reported in the literature from multiple centers all around the world and with large-number patient series published from the West,mostly based on nation-wide DILI networks and multicenter *** DILI networks are lacking among major Asian countries with high incidence of CAM *** medical societies dealing with drug toxicity,CAM practice and hepatobiliary disease have adopted an integrated approach to establishing identification,diagnosis and treatment of CAM-related DILI,representing a systematic approach that could be iterated by other countries for improving patient *** this exhaustive review,we provide published data on CAM-related DILI in Asia,with detail on incidences along with analysis of patient population and their clinical *** and clear discussion on commonly implicated CAM agents in major Asian countries and associated chemical and toxicology analyses as well as descriptions of liver biopsy findings are discussed with future directions.

关键词： CAM Herbals Ayurveda Chinese DILI Hepatitis Cirrhosis ACLF Liver biopsy

Outcomes and Toxicology of Herbal Drugs in Alcoholic Hepatitis-A Single Center Experience from India

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2019年第4期7卷 329-340页

作者： Cyriac Abby philips Sasidharan Rajesh Tom George Rizwan Ahamed Sandeep Kumbar philip augustine The Liver Unit and Monarch Liver Lab Cochin Gastroenterology GroupErnakulam Medical CenterKochiKeralaIndia Interventional Radiology Department of Gastroenterology and HepatologyCochin Gastroenterology GroupErnakulam Medical CenterKochiKeralaIndia Gastroenterology and Advanced G.I.Endoscopy Cochin Gastroenterology GroupErnakulam Medical CenterKochiKeralaIndia

Background and Aims:We aimed to study clinical out-comes and liver biopsy features of alcoholic hepatitis(AH)patients on complementary and alternative medicines(CAMs)and to analyze the retrieved drugs for chemical and toxic components linked to drug-induced liver ***:We retrospectively assessed clinical,biochemical and liver bi-opsy features of AH patients on CAM with drug-induced liver injury(AH-CAM,n=27)and compared them to a control group(classical AH,n=29)on standard of *** without liver biopsy evaluation and other causes for liver dis-ease were *** of the CAMs(n=42)from pa-tients were retrieved and assessed for chemical and ***:All were males,and significantly worse clinical pre-sentation,biochemical severity,and liver disease scores were notable in patients with *** Ayurve-dic-polyherbal formulations were the most commonly used *** liver histology,varying grades of severe-necrosis,severe hepatocellular,canalicular,cholangiolar cholestasis with predominant lymphocytic-portal-inflammation and varying grades of interface-hepatitis were noted in *** of CAMs revealed presence of heavy metals up to 100,000 times above detectable range and adulter-ants,such as antibiotics,chemotherapy agents,nonsteroi-dal anti-inflammatory drugs,alcohols,antidepressants,anxiolytics,and recreational *** follow up,a signifi-cantly higher number of patients with AH on CAM died at end of 1,3-and-6-months compared to controls(37%vs.83%,29%vs.62%,18%vs.52%respectively;p<0.001).Conclusions:Patients with AH and CAM-related drug-induced liver injury have extremely poor short-term survival in the absence of liver transplantation compared to those patients with AH on evidence-based *** transplant referral and educating on and curbing of CAM use in severe liver disease through strict monitoring of unregulated traditional health practices can help ease the burden of liver-related death.

关键词： Hepatitis Alcohol CAM DILI Ayurveda

Critical Update on the Diagnosis and Management of COVID-19 in Advanced Cirrhosis and Liver Transplant Recipients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2021年第6期9卷 947-959页

作者： Cyriac Abby philips Mohamed Rela Arvinder Singh Soin Subhash Gupta Sudhindran Surendran philip augustine Department of Clinical and Translational Hepatology and The Monarch Liver Laboratory The Liver InstituteCenter of Ex-cellence in Gastrointestinal SciencesRajagiri HospitalAluvaKeralaIndia Institute of Liver Disease and Liver Trans-plantation Dr.Rela Institute&Medical CentreBharath Institute of Higher Education and ResearchChennaiIndia In-stitute of Liver Transplantation and Regenerative Medicine MedantaThe MedicityGurgaonIndia Max Centre for Liver and Biliary Sciences Max Saket HospitalNew DelhiIndia Gastrointestinal Surgery and Solid Organ Transplantation Amrita Institute of Medical Sciences and Research CentreAmrita Vishwa VidyapeethamKochiKeralaIndia Gastroen-terology and Advanced GI Endoscopy Center of Excellence in Gastrointestinal SciencesRajagiri HospitalAluvaKeralaIndia

The novel coronavirus disease 2019(COVID-19)pandemic has impacted health care worldwide,with specific patient populations,such as those with diabetes,cardiovascular disease,and chronic lung disease,at higher risk of infection and others at higher risk of disease *** with decompensated cirrhosis fall into the latter category and are a unique group that require specific treatment and management decisions because they can develop acute-on-chronic liver *** liver transplant recipients,the atypical immunity profile due to immunosuppression protects against downstream inflammatory responses triggered by *** exhaustive review discusses the outcomes associated with COVID-19 in patients with advanced cirrhosis and in liver transplant *** focus on the immunopathogenesis of COVID-19,its correlation with the pathogenesis of advanced liver disease,and the effect of immunosuppression in liver transplant recipients to provide insight into the outcomes of this unique patient population.

关键词： Coronavirus Cirrhosis Portal hypertension Acute-on-chronic liver failure Sepsis Hepatic encephalopathy Multiple-organ failure Critical care

Identification and Analysis of Gut Microbiota and Functional Metabolism in Decompensated Cirrhosis with Infection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2023年第1期11卷 15-25页

作者： Cyriac Abby philips Rizwan Ahamed Jinsha K.P.Abduljaleel Sasidharan Rajesh philip augustine Clinical and Translational Hepatology Monarch Liver LaboratoryThe Liver InstituteCenter of Excellence in GI SciencesRajagiri HospitalAluvaKeralaIndia Gastroenterology and Advanced GI Endoscopy Center for Excellence in Gastrointestinal SciencesRajagiri HospitalAluvaKeralaIndia Diagnostic and Interventional Gastroenterology and Hepatology Center for Excellence in Gastrointestinal SciencesRajagiri HospitalAluvaKeralaIndia

Background and Aims:Intestinal dysbiosis play a role in the adverse outcomes of sepsis and septic ***,variations in bacterial diversity and microbiota-related functional metabolic alterations within the gut microbiome in decompensated cirrhosis(DC)patients with infection remain ***:We conducted 16-srRNA sequencing on stool samples(n=51:sepsis,27/no sepsis,24)collected from consecutive DC patients upon *** diversity,significant taxa,and respective metabolic profiling were performed based on subgroup ***/Cytoscape was utilized to identify significant non-random patterns of bacterial copresence and mutual exclusion for clinical ***:Genera associated with pathogenicity in conditions of immune exhaustion(Corynebacterium,Lautropia)were predominant in patients with *** pathways associated with oxidative stress and endotoxemia[lipopolysaccharide(LPS)synthesis and sulfur relay]were significantly upregulated in *** taxa were associated with sites of infection in DC *** oxidant pathways that increase glutathione were upregulated in those without *** family of sulfur-metabolizing bacteria,exaggeration of orally predominant pathogens(Prevotella),and pathways of severe LPS-related hyperinflammatory stress were notable in those with interleukin-6 levels>1,000 pg/*** genera related to an immune deficient state was significant in DC with≥2 infection *** was associated with survival during the same ***:Specific gut microbiota and their metabolites were associated with sepsis and related events in patients with *** beneficial strains that reduce immune exhaustion and supplementation of favorable metabolites could improve therapeutics for DC and sepsis,for which larger prospective,well controlled population-based studies remain an unmet need.

关键词： Microbiome Portal hypertension Sepsis Acute-on-chronic liver failure Multidrug resistance

Critically Ill COVID-19 Patient with Chronic Liver Disease-Insights into a Comprehensive Liver Intensive Care

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2021年第4期9卷 576-586页

作者： Cyriac Abby philips Kamna Kakkar Moby Joseph Praveen Kumar Yerol Rizwan Ahamed Sasidharan Rajesh philip augustine Department of Clinical Hepatology The Liver InstituteCenter of Excellence in GI SciencesRajagiri HospitalChunangamvelyAluvaErnakulamKeralaIndia Department of Pulmonary and Critical Care Medicine Pt.B.D.Sharma Post Graduate Institute of Medical SciencesRohtakHaryanaIndia Great Western Hospitals NHS Foundation TrustSwindonUnited Kingdom Department of Gastroenterology State Government Medicine College and HospitalThrissurKeralaIndia Gastroenterology and Advanced G.I Endoscopy Center of Excellence in GI SciencesRajagiri HospitalChunangamvelyAluvaErnakulamKeralaIndia Interventional Hepatobiliary Radiology The Liver InstituteCenter of Excellence in GI SciencesRajagiri HospitalChunangamvelyAluvaErnakulamKeralaIndia

The novel coronavirus-related coronavirus disease 2019(COVID-19)pandemic has been relentless in disrupting and overwhelming healthcare the world *** outcomes of COVID-19 in patients with chronic comorbidities,especially in those with metabolic syndrome,are well *** liver disease and cirrhosis patients are a special subgroup,among whom the management of COVID-19 is *** the pathophysiology of COVID-19 in patients with cirrhosis and portal hypertension improves our identification of at-risk patients for disease progression that will further help compartmentalize generalized and specialized treatment options in this special patient *** this exhaustive review,we critically review the impact of COVID-19 on the liver and in chronic liver disease and cirrhosis *** further discuss common features associated with the pathophysiology of COVID-19 and cirrhosis,based on the renin-angiotensin system and deliberate current literature on guidelines for the treatment of COVID-19 and extrapolate the same to the cirrhosis population to provide a concise and stepwise,evidence-based management for cirrhosis patients with severe and critical *** are no specific management guidelines for cirrhosis patients with COVID-19 and current recommendations for treatment are as per guidelines for general ***,specific issues like avoiding corticosteroids in decompensated patients with variceal bleeding,suspected sepsis,high grade hepatic encephalopathy and acute kidney injury,use of early mechanical ventilation strategies in those with severe ascites and hepatopulmonary syndrome,avoidance of remdesivir in advanced liver disease,and application of liver-specific severity scores for prognostication and identification of futility need to be highlighted.

关键词： SARS-CoV-2 Coronavirus Pandemic ACLF Decompensation Portal hypertension Sepsis

Repurposing Pirfenidone for Nonalcoholic Steatohepatitis-related Cirrhosis:A Case Series

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2020年第1期8卷 100-105页

作者： Cyriac Abby philips Guruprasad Padsalgi Rizwan Ahamed Rajaguru Paramaguru Sasidharan Rajesh Tom George Pushpa Mahadevan philip augustine The Liver Unit and Monarch Liver Lab Cochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia Department of Gastroenterology Cochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia Department of Pathology Al Salam International HospitalBneid Al QarKuwaitIndia Department of Diagnostic and Interventional Radiology Department of Gastroenterology and The Liver UnitCochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia Department of Clinical Pathology VPS Lakeshore HospitalKochiKeralaIndia

We repurposed the antifibrotic drug pirfenidone—which is approved for treatment of idiopathic lung fibrosis—in a series of patients with nonalcoholic steatohepatitis-related *** report demonstrates the observed improvements in necroinflammation and regression of cirrhosis with pirfeni-done use for 12-weeks,associated with classical hepatic repair complex features on follow-up liver *** novel work could help stimulate further randomized trials of pirfe-nidone in patients with nonalcoholic steatohepatitis-related liver fibrosis or cirrhosis,for whom no recommended drug treatments exists currently.

关键词： NASH Fibrosis Antifibrotic Hepatitis Pirfenidone

Transjugular intrahepatic portosystemic shunt in cirrhosis: An exhaustive critical update

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2020年第37期26卷 5561-5596页

作者： Sasidharan Rajesh Tom George Cyriac Abby philips Rizwan Ahamed Sandeep Kumbar Narain Mohan Meera Mohanan philip augustine Division of Hepatobiliary Interventional Radiology Cochin Gastroenterology GroupErnakulam Medical CenterKochi 682028KeralaIndia The Liver Unit and Monarch Liver Lab Cochin Gastroenterology GroupErnakulam Medical CenterKochi 682028KeralaIndia Gastroenterology and Advanced GI Endoscopy Cochin Gastroenterology GroupErnakulam Medical CenterKochi 682028KeralaIndia Anesthesia and Critical Care Cochin Gastroenterology GroupErnakulam Medical CenterKochi 682028KeralaIndia

More than five decades after it was originally conceptualized as rescue therapy for patients with intractable variceal bleeding,the transjugular intrahepatic portosystemic shunt(TIPS)procedure continues to remain a focus of intense clinical and biomedical *** the impressive reduction in portal pressure achieved by this intervention,coupled with its minimally invasive nature,TIPS has gained increasing acceptance in the treatment of complications of portal *** early years of TIPS were plagued by poor long-term patency of the stents and increased incidence of hepatic ***,the diversion of portal flow after placement of TIPS often resulted in derangement of hepatic functions,which was occasionally *** the incidence of shunt dysfunction has markedly reduced with the advent of covered stents,hepatic encephalopathy and instances of early liver failure continue to remain a significant issue after *** has emerged over the years that careful selection of patients and diligent post-procedural care is of paramount importance to optimize the outcome after *** past twenty years have seen multiple studies redefining the role of TIPS in the management of variceal bleeding and refractory ascites while exploring its application in other complications of cirrhosis like hepatic hydrothorax,portal hypertensive gastropathy,ectopic varices,hepatorenal and hepatopulmonary syndromes,non-tumoral portal vein thrombosis and chylous *** has also been utilized to good effect before extrahepatic abdominal surgery to reduce perioperative morbidity and *** current article aims to review the updated literature on the status of TIPS in the management of patients with liver cirrhosis.

关键词： Early transjugular portosystemic shunt Preemptive transjugular intrahepatic portosystemic shunt Portal hypertension Esophageal varices Gastric varices Refractory ascites

One disease, many faces-typical and atypical presentations of SARS-CoV-2 infection-related COVID-19 disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2020年第18期8卷 3956-3970页

作者： Cyriac Abby philips Narain Mohan Rizwan Ahamed Sandeep Kumbar Sasidharan Rajesh Tom George Meera Mohanan philip augustine The Liver Unit and Monarch Cochin Gastroenterology GroupErnakulam Medical CenterCochin 682025KeralaIndia Gastroenterology and Advanced GI Endoscopy Cochin Gastroenterology GroupErnakulam Medical CenterCochin 682025KeralaIndia Division of Hepatobiliary Interventional Radiology Cochin Gastroenterology GroupErnakulam Medical CenterCochin 682025KeralaIndia Anesthesia and Critical Care Cochin Gastroenterology GroupErnakulam Medical CenterCochin 682025KeralaIndia

Since the appearance of the novel coronavirus(severe acute respiratory syndrome-coronavirus-2)and related coronavirus disease 2019(COVID-19)in China in December 2019,a very high number of small and large patient series have been published in literature from around the *** though the classical presentation of COVID-19 is one with respiratory symptoms with or without pneumonia that can be self-limiting or evolve into severe respiratory distress syndrome with multiple organ failure,and secondary bacterial sepsis,a large body of evidence suggests a plethora of other types of clinical *** this exhaustive review,we reviewed all of the published literature on COVID-19 to identify different types of clinical presentations affecting various organ systems,to provide an in-depth analysis that may prove useful for clinicians and health-workers on the frontline,battling the severe pandemic.

关键词： Adult respiratory distress syndrome Sepsis COVID-19 SARS-CoV-2 World Health Organization Centers for disease control