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Leukocyte DNA methylation and colorectal cancer among male smokers

World Journal of Gastrointestinal Oncology 2012年第8期4卷 193-201页

作者： Keith Killian Stephanie Weinstein Jarmo Virtamo Margaret Tucker philip taylor Demetrius Albanes Paul Meltzer Neil Caporaso Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda MD 20852 United States Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of HealthBethesda MD 20852 United States National Public Health Institute Helsinki FI-00271 Finland

AIM: To explore the association between methylation in leukocyte DNA and colorectal cancer (CRC) risk in male smokers using the α-tocopherol, β-carotene cancer prevention study. METHODS: About 221 incident CRC cases, and 219 controls, frequency-matched on age and smoking intensity were included. DNA methylation of 1505 CpG sites selected from 807 genes were evaluated using Illumina GoldenGate Methylation Cancer Panel I in pre-diagnostic blood leukocytes of study subjects. Tertiles of methylation level classified according to the distribution in controls for each CpG site were used to analyze the association between methylation level and CRC risk with logistic regression. The time between blood draw to cancer diagnosis (classifying cases according to latency) was incorporated in further analyses using proportional odds regression. RESULTS: We found that methylation changes of 31 CpG sites were associated with CRC risk at P < 0.01 level. Though none of these 31 sites remained statistically significant after Bonferroni correction, the most statistically significant CpG site associated with CRC risk achieved a P value of 1.0 × 10-4. The CpG site is located in DSP gene, and the risk estimate was 1.52 (95% CI: 0.91-2.53) and 2.62 (95% CI: 1.65-4.17) for the second and third tertile comparing with the lowest tertile respectively. Taking the latency information into account strengthened some associations, suggesting that the methylation levels of corresponding sites might change over time with tumor progression. CONCLUSION: The results suggest that the methylation level of some genes were associated with cancer susceptibility and some were related to tumor development over time. Further studies are warranted to confirm and refine our results.

关键词： DNA methylation Colorectal cancer Susceptibility

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Voltage Unbalance Mitigation in Low Voltage Distribution Networks with Photovoltaic Systems

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Journal of Electronic Science and Technology 2012年第1期10卷 1-6页

作者： Kein Huat Chua Yun Seng Lim Jianhui Wong Ezra Morris Stella Morris philip taylor the Electrical and Electronics Engineering Department Universiti Tunku Abdul RahmanMalaysia. the School of Engineering Durham UniversityDurhamUK

This paper proposes a technique to mitigate the voltage unbalance issue caused by the high penetration of photovoltaic （PV） systems into the low voltage distribution networks （LVDN） using a single phase energy storage system （ESS）. The ESS comprises a hi-directional power flow inverter and a battery bank. The system is capable of absorbing the excess power and delivering power to the network in order to keep the voltage unbalance factor （VUF） below the statutory limit of 1%. Investigations are carried out in the experimental small-scale energy zone （SSEZ）. The experimental results demonstrate that the ESS is capable of mitigating the VUF of the network.

关键词： Energy storage system low voltagedistribution network photovoltaic voltage unbalance.

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欧洲老年劳动力公共政策和工作场所政策的发展(英文)

欧洲老年劳动力公共政策和工作场所政策的发展(英文)

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北京论坛（2006）文明的和谐与共同繁荣—对人类文明方式的思考

作者： philip taylor Professor of Employment Policy Faculty of Business and Enterprise Swinburne University of Technology

This paper is based largely on research completed recently by the author and a team of researchers for the European Foundation for the Improvement of Living and Working Conditions which considered trends in public policy towards older workers in 11 Member States of the European Union and developments in workplace policy in approximately 120 organisations,primarily larger and operating in the private *** were first examined in

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Caspase-8 promotes scramblase-mediated phosphatidylserine exposure and fusion of osteoclast precursors

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Bone Research 2024年第3期12卷 611-620页

作者： Brenda Krishnacoumar Martin Stenzel Hilal Garibagaoglu Yasunori Omata Rachel L.Sworn Thea Hofmann Natacha Ipseiz Magdalena A.Czubala Ulrike Steffen Antonio Maccataio Cornelia Stoll Christina Böhm Martin Herrmann Stefan Uderhardt Robert H.Jenkins philip R.taylor Anika Grüneboom Mario M.Zaiss Georg Schett Gerhard Krönke Carina Scholtysek Department of Internal Medicine 3-Rheumatology and Immunology Friedrich-Alexander University Erlangen-Nürnberg(FAU)and Universitätsklinikum Erlangen91054 ErlangenGermany Deutsches Zentrum für Immuntherapie(DZI) Friedrich-Alexander University Erlangen-Nürnberg(FAU)and Universitätsklinikum Erlangen91054 ErlangenGermany Department of Biopsectroscopy Leibniz Institut für Analytische Wissenschaften-ISAS-e.V.Bunsen-Kirchhoff-Str.11Dortmund 44227Germany Medical Faculty University HospitalUniversity Duisburg-EssenEssen 45147Germany Systems Immunity Research Institute Heath ParkCardiff UniversityCardiff CF144XNUK Optical Imaging Competence Centre(FAU OICE) Exploratory Research UnitFriedrich-Alexander University Erlangen-Nürnberg(FAU)ErlangenGermany Division of Infection&Immunity Heath ParkCardiff UniversityCardiff CF144XNUK Deutsches Rheuma-Forschungszentrum Berlin BerlinGermany Department of Rheumatology and Clinical Immunology Charité-Universitätsmedizin BerlinBerlinGermany

Efficient cellular fusion of mononuclear precursors is the prerequisite for the generation of fully functional multinucleated bone-resorbing ***,the exact molecular factors and mechanisms controlling osteoclast fusion remain incompletely *** we identify RANKL-mediated activation of caspase-8 as early key event during osteoclast fusion.

关键词： incomplete exact activation

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Total and cancer mortality following supplementation with vitamins and minerals:Post-intervention follow-up of the General Population Nutrition Intervention Trial in Linxian China

Total and cancer mortality following supplementation with vi...

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“全国老年营养学术研讨会”暨“四川省营养学会成立二十周年庆祝会”

作者： Sanford M Dawsey Farin Kamangar Christian C Abnet Laura LeeJohnson Steven D Mark philip R taylor Division of Cancer Epidemiology & Genetics NCI/NIHBethesdaMD 20892USA Division of Cancer Epidemiology & Genetics.NCI/NIH.Bethesda MD 20892USA

*** High rates of esophageal cancer,locally known as"hard swallowing disease"have been recognized in the Taihang mountain region of north central China since Han Dynasty(206 BC-220 AD).In this area,esophageal cancer has always been defined by its clinical course difficulty in swallowing,followed by wasting and death and has included both ESCC and cardia stomach *** this population,reflux symptoms are uncommon,Barrett’s esophagus has not yet been documented,and adenocarcinoma of the esophagus is extremely rare.

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PRELIMINARY REPORT ON THE RESULTS OF NUTRITION PREVENTION TRIALS OF CANCER AND OTHER COMMON DISEASES AMONG RESIDENTS IN LINXIAN,CHINA

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Chinese Medical Journal 1995年第10期108卷 780-780页

作者：黎钧耀李冰 William J.Blot philip R.taylor Cancer Institute Chinese Academy of Medical SciencesBeijing 100021 National Cancer Institute BethesdaMA 20892USA

To examine whether vitamin / mineral supplementation may lower mortality and incidence for human cancer and mortality from other diseases as well as to provide the scientific basis and feasible approach for human cancer prevention and control,from 1982 to 1991 scientists from China and USA conducted two randomized, double-blind,placebo-controlled nutrition intervention trials in Linxian,China,where the mortality rates of esophageal and gastric cardia cancer are among the highest in the world and there is suspicion that the population’s chronic deficiencies of multiple

关键词： In PRELIMINARY REPORT ON THE RESULTS OF NUTRITION PREVENTION TRIALS OF CANCER AND OTHER COMMON DISEASES AMONG RESIDENTS IN LINXIAN,CHINA

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Ecologic study of serum selenium and upper gastrointestinal cancers in Iran

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World Journal of Gastroenterology 2004年第17期10卷 2544-2546页

作者： Mehdi Nouarie Akram Pourshams Farin Kamangar Masood Sotoudeh Mohammad Hossein Derakhshan Mobammad Reza Akbari Hafez Fakheri Mohammad Javad Zahedi Kathleen Caldwell Christian *** philip R.taylor Reza Malekzadeh Sanford M.Dawsey Digestive Disease Research Center Tehran University of Medical SciencesTehranIran National Cancer Institute NIHBethesdaMD20895-8314USA Centers for Disease Control AtlantaGeorgiaUSA

AIM:Both observational and experimental studies have shown that higher selenium status reduces the risk of upper gastrointestinal cancers in selenium deficient populations. Recent cancer registry data have shown very different rates of esophageal cancer(EC)and gastric cancer(GC)in four Provinces of Iran,namely Ardabil,Mazandaran,Golestan, and *** aim of this study was to have a preliminary assessment of the hypothesis that high rates of EC in Golestan and high rates of GC in Ardabil may be partly attributable to selenium deficiency. METHODS:We measured serum selenium in 300 healthy adults from An:labil(n=100),Mazandaran(n=50),Golestan (n=100),and Kerman(n=50),using inductively coupled plasma,with dynamic reaction cell,mass spectrometry(ICP- DRC-MS)at the US Centers for Disease Control(Atlanta, Georgia). RESULTS:The median serum selenium concentrations were very different in the four *** medians(IQR)for selenium in Ardabil,Mazandarn,Golestan,and Kerman were 82(75-94),123(111-132),155(141-173),and 119 (110-128)μg/L,respectively(Ptaylor PR,Malekzadeh R,Dawsey *** study of serum

关键词： Adult Esophageal Neoplasms Female Humans Incidence Iran Linear Models Male Middle Aged Risk Factors Selenium Stomach Neoplasms

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新鲜水果可能降低男性吸烟人群中食管癌的长期死亡风险:林县营养干预试验30年随访研究

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中国肿瘤 2017年第12期26卷 953-959页

作者：梁赫王少明杨召于佩 philip R.taylor Christian *** 范金虎乔友林国家癌症中心/中国医学科学院北京协和医学院肿瘤医院北京100021 美国国立癌症研究所癌症流行病和基因研究部

[目的]探讨新鲜水果摄入是否可以降低吸烟人群食管癌的长期死亡风险。[方法]选取年龄为40~69岁8862名男性吸烟人群为研究对象,开展基线人口学特征、生活习惯、疾病史及饮食习惯的调查,随后对该人群进行随访至今约30年。以食管癌死亡病... 详细信息

[目的]探讨新鲜水果摄入是否可以降低吸烟人群食管癌的长期死亡风险。[方法]选取年龄为40~69岁8862名男性吸烟人群为研究对象,开展基线人口学特征、生活习惯、疾病史及饮食习惯的调查,随后对该人群进行随访至今约30年。以食管癌死亡病例作为研究终点。利用Log-rank检验比较不同新鲜水果摄入频率受试人群中食管癌累积死亡率间的差异。风险比(HR)和95%可信区间(CI)则通过Cox等比例风险模型进行估计,用来表示受试者死于食管癌的相对风险。[结果]截至2015年12月31日,共计发生食管癌死亡病例891例。经过30年随访后,男性吸烟人群中,不同新鲜水果摄入频率受试人群中食管癌的30年累积死亡率分别为21.91%、16.48%、14.08%、11.03%和12.09%,且随着新鲜水果摄入频次的增加,食管癌30年累积死亡率呈下降趋势。与不食用新鲜水果受试人群相比,每月吃、1~3次/周、4~6次/周和每天吃的受试者食管癌的死亡风险分别降低27%(HR=0.73,95%CI:0.61~0.87)、39%(HR=0.61,95%CI:0.50~0.75)、49%(HR=0.51,95%CI:0.35~0.73)和49%(HR=0.51,95%CI:0.35~0.75)。在调整年龄、性别、地区、体重指数、教育水平、饮酒史和家族史、干预因素后,每周摄入新鲜水果1次以上仍可以降低食管癌的死亡风险(HR=0.87,95%CI:0.76~1.00),这种保护性效应在平原地区(HR=0.78,95%CI:0.63~0.96)和无饮酒史(HR=0.82,95%CI:0.68~1.00)的受试人群中尤为明显。[结论]新鲜水果的摄入可能降低男性吸烟人群中食管癌的长期死亡风险。

关键词：食管肿瘤水果吸烟前瞻性队列研究

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云锡矿工肺癌发现可疑到确诊时间分析

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中国肿瘤 2000年第5期9卷 210-211页

作者：姚树祥 philip taylor 乔友林晋萍罗学昌姜勇孙萍张建新杨兰云南锡业公司劳动防护研究所个旧661000 美国国立癌症研究所中国医学科学院肿瘤研究所

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血清B族维生素与食管癌和胃贲门癌发病风险关系的前瞻性研究

血清B族维生素与食管癌和胃贲门癌发病风险关系的前瞻性研究

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全国肿瘤流行病学和肿瘤病因学学术会议

作者：任建松 Gwen Murphy 范金虎 Sanford Dawsey philip taylor Jacob Selhub 乔友林 Christian Abnet 中国医学科学院肿瘤医院城市癌症早诊早治项目办公室 Division of Cancer Epidemiology and Genetics National Cancer InstituteNational Institutes of Health 中国医学科学院肿瘤医院流行病学研究室 Jean Mayer U.S.Department of Agriculture Human Nutrition Research Center on Aging at Tufts University

目的通过前瞻性的研究设计,探讨血清B族维生素水平与食管癌和胃贲门癌发病风险的关系。方法采用病例-队列研究设计,从中国林县营养干预试验一般人群队列中纳入研究对象。1985年3月至1991年5月,共有29584名40-69岁的健康成年人进入队列...

目的通过前瞻性的研究设计,探讨血清B族维生素水平与食管癌和胃贲门癌发病风险的关系。方法采用病例-队列研究设计,从中国林县营养干预试验一般人群队列中纳入研究对象。1985年3月至1991年5月,共有29584名40-69岁的健康成年人进入队列。经过5.25年的随访,从新诊断的病例中随机抽取498例食管癌病例和255例胃贲门癌病例组成各自病例组。经年龄与性别匹配,从全部队列人群中随机抽取947例研究对象组成亚队列组。对所有最终纳入的研究对象在进入队列时采集的血清进行B族维生素的检测,包括维生素B2（核黄素）、黄素单核苷酸（维生素B2的一种辅酶）、维生素B6、叶酸和维生素B12。利用多因素Cox比例风险模型估计血清B族维生素水平与食管癌和胃贲门癌发病风险的关系。结果与血清维生素B2最低组（＜9.9 nmol/L）相比,最高组（≥18.3nmol/L）食管癌发病风险低44%（HR:0.56,95%CI:0.41-0.75）。黄素单核苷酸增加食管癌（HR:1.08,95%CI:1.01-1.16）和胃贲门癌（HR:1.09,95%CI:1.00-1.20）的发病风险。结论多种B族维生素血清浓度与食管癌和胃贲门癌发病风险相关。其中,血清维生素B2浓度高对食管癌发病具有保护作用。

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