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Food supply and the obesity scourge: Is there a relationship?

Health 2012年第12期4卷 1457-1463页

作者： Lillian Mwanri Wendy Foley John Coveney Robert Muller Fiona Verity Paul R. Ward Patricia Carter philip mohr Anne Taylor Department of Social Work Flinders University Adelaide Australia Discipline of Public Health Flinders University Adelaide Australia Health Promotion Branch SA Health Adelaide Australia Inala Indigenous Health Service Queensland Health Inala Australia Population Research and Outcome Studies Unit SA Health Adelaide Australia School of Psychology University of Adelaide Adelaide Australia

This paper reviews literature on the relationship between food supply and obesity. The focus is on the supply, cost, and variety of food through various types of food outlets and the impact of these factors on obesity in developed countries. The article reveals complex relationships between food supply factors and obesity. A numer of factors related to lifestyles including the mobility of populations and the use of motor vehicles greatly reduce the impact of the local environment on family and individual eating patterns. However, obesity is also affected by factors such as the type and density of food outlets, the cost of food, the travel distance and means of transport to the food outlet. While the relationship between food supply and obesity in the literature reveals complex and mixed findings, this paper concludes obesity is complex and food supply is only part of this phenomenon’s predictors. Because the relationship between food supply and obesity is mediated by such multiple and complex factors including population behaviours, beliefs, lifestyles, knowledge and both food and physical environments;multiple strategies including policy development and other strategies aimed at manipulating food environments, physical environments, populations’ beliefs, behaviours and practices must be considered in searching for evidence to effectively combat obesity.

关键词： Obesity Food Supply Food Outlets Socio Economic Status Complex Relationships

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A rat model of multicompartmental traumatic injury and hemorrhagic shock induces bone marrow dysfunction and profound anemia

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Animal Models and Experimental Medicine 2024年第3期7卷 367-376页

作者： Lauren S.Kelly Jennifer A.Munley Erick E.Pons Kolenkode B.Kannan Elizabeth M.Whitley Letitia E.Bible philip A.Efron Alicia M.mohr Department of Surgery and Sepsis and Critical Illness Research Center University of Florida College of MedicineGainesvilleFloridaUSA Pathogenesis LLCGainesvilleFloridaUSA

Background:Severe trauma is associated with systemic inflammation and organ *** rodent trauma models are the mainstay of postinjury research but have been criticized for not fully replicating severe human *** aim of this study was to create a rat model of multicompartmental injury which recreates profound traumatic ***:Male Sprague-Dawley rats were subjected to unilateral lung contusion and hemorrhagic shock(LCHS),multicompartmental polytrauma(PT)(unilateral lung contusion,hemorrhagic shock,cecectomy,bifemoral pseudofracture),or na?ve ***,plasma toll-l ike receptor 4(TLR4),hemoglobin,spleen to body weight ratio,bone marrow(BM)erythroid progenitor(CFU-GEMM,BFU-E,and CFU-E)growth,plasma granulocyte colony-stimulating factor(G-CSF)and right lung histologic injury were assessed on day 7,with significance defined as p values<0.05(*).Results:Polytrauma resulted in markedly more profound inhibition of weight gain compared to LCHS(p=0.0002)along with elevated plasma TLR4(p<0.0001),lower hemoglobin(p<0.0001),and enlarged spleen to body weight ratios(p=0.004).Both LCHS and PT demonstrated suppression of CFU-E and BFU-E growth compared to naive(p<0.03,p<0.01).Plasma G-CSF was elevated in PT compared to both na?ve and LCHS(p<0.0001,p=0.02).LCHS and PT demonstrated significant histologic right lung injury with poor alveolar wall integrity and interstitial ***:Multicompartmental injury as described here establishes a reproducible model of multicompartmental injury with worsened anemia,splenic tissue enlargement,weight loss,and increased inflammatory activity compared to a less severe *** may serve as a more effective model to recreate profound traumatic injury to replicate the human inflammatory response postinjury.

关键词： anemia i nflammation polytrauma pseudofracture shock

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