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Microneedle-based devices for point-of-care infectious disease diagnostics

Acta Pharmaceutica Sinica B 2021年第8期11卷 2344-2361页

作者： Rachael V.Dixon Eldhose Skaria Wing Man Lau Philip Manning Mark A.Birch-Machin S.Moein Moghimi Keng Wooi Ng School of Pharmacy Faculty of Medical SciencesNewcastle UniversityNewcastle Upon Tyne NE17RUUK Translational and Clinical Research Institute Faculty of Medical SciencesNewcastle UniversityNewcastle Upon Tyne NE24HHUK Wellcome Trust Centre for Cell-Matrix Research Faculty of BiologyMedicine and HealthUniversity of ManchesterManchester M139PTUK

Recent infectious disease outbreaks,such as COVID-19 and Ebola,have highlighted the need for rapid and accurate diagnosis to initiate treatment and curb transmission.Successful diagnostic strategies critically depend on the efficiency of biological sampling and timely analysis.However,current diagnostic techniques are invasive/intrusive and present a severe bottleneck by requiring specialist equipment and trained personnel.Moreover,centralised test facilities are poorly accessible and the requirement to travel may increase disease transmission.Self-administrable,point-of-care(PoC)microneedle diagnostic devices could provide a viable solution to these problems.These miniature needle arrays can detect biomarkers in/from the skin in a minimally invasive manner to provide(near-)real-time diagnosis.Few microneedle devices have been developed specifically for infectious disease diagnosis,though similar technologies are well established in other fields and generally adaptable for infectious disease diagnosis.These include microneedles for biofluid extraction,microneedle sensors and analyte-capturing microneedles,or combinations thereof.Analyte sampling/detection from both blood and dermal interstitial fluid is possible.These technologies are in their early stages of development for infectious disease diagnostics,and there is a vast scope for further development.In this review,we discuss the utility and future outlook of these microneedle technologies in infectious disease diagnosis.

关键词： Microneedle Infectious disease Point-of-care diagnostics(PoC) Biomarker detection Skin Biosensor COVID-19

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