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Molecular basis of inherited calcium channelopathies:role of mutations in pore-forming subunits

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Acta Pharmacologica Sinica 2006年第7期27卷 799-812页

作者： Lynn MCKEOWN philip ROBIN Owen T jones Faculty of Life Sciences the University of ManchesterManchesterUK

The pore-forming alpha subunits of voltage-gated calcium channels contain theessential biophysical machinery that underlies calcium influx in response to *** combination with requisite auxiliary subunits,these pore sub-units form calcium channel complexes that are pivotal to the physiology andpharmacology of diverse cells ranging from sperm to *** surprisingly,mutations in the pore subunits generate diverse pathologies,termedchannelopathies,that range from failures in excitation-contraction coupling tonight *** the last decade,major insights into the mechanisms ofpathogenesis have been derived from animals showing spontaneous or *** parallel,there has been considerable growth in our understandingof the workings of voltage-gated ion channels from a structure-function,regula-tion and cell biology *** we document our current understandingof the mutations underlying channelopathies involving the voltage-gated calciumchannel alpha subunits in humans and other species.

关键词： calcium channels channelopathies mutation

Magnetic nanowires fabricated by anodic aluminum oxide template—a brief review

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Science China(Physics,Mechanics & Astronomy) 2011年第7期54卷 1181-1189页

作者： LI WuXia ZHANg Jun SHEN TieHan jones grenville A gRUNDY philip J Institute of Physics Chinese Academy of Sciences Beijing 100190 China Faculty of Physics and Electronic Technology Hubei University Wuhan 430062 China Joule Physics Laboratory College of Science and Technology University of Salford Salford M5 4WT UK

Anodic aluminum oxide （AAO） with highly ordered nanoscale pores which are monodisperse and mutually parallel can be produced through a self-organized electrochemical process. Subsequent deposition of materials into the nanopores produces AA0 embedded nanowire arrays. Whilst the templates can be further removed to obtain free individual nanowires, the em- bedded nanowires form an interesting nanocomposite structure. Recent research activities on the fabrication and characteriza- tion of AAO template based magnetic nanowires are reviewed in this article. Studies of specific systems are given as an exam- ple of the research in the area.

关键词： anodic aluminum oxides electrochemical deposition magnetic nanowires templates magneto-optical properties

Empirical Wavelet Transform Based Method for Identification and Analysis of Sub-synchronous Oscillation Modes Using PMU Data

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 34-40页

作者： Joice g.philip Jaesung Jung Ahmet Onen the Department of Energy Systems Research Ajou UniversitySuwonSouth Korea the Department of Electrical and Electronic Engineering Abdullah Gul UniversityKayseri38080Turkey the Department of Electrical and Computer Engineering College of EngineeringSultan Qaboos UniversityAl-KhoudMuscatOman

This paper proposes an empirical wavelet transform(EWT)based method for identification and analysis of sub-synchronous oscillation(SSO)modes in the power system using phasor measurement unit(PMU)*** phasors from PMUs are preprocessed to check for the presence of *** the presence is established,the signal is decomposed using EWT and the parameters of the mono-components are estimated through Yoshida *** superiority of the proposed method is tested using test signals with known parameters and simulated using actual SSO signals from the Hami Power grid in Northwest *** show the effectiveness of the proposed EWT-Yoshida method in detecting the SSO and estimating its parameters.

关键词： Empirical wavelet transform(EWT) sub-synchronous oscillation Prony-based method Yoshida algorithm variational mode decomposition phasor measurement unit(PMU)

Denitrification and the challenge of scaling microsite knowledge to the globe

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mLife 2023年第3期2卷 229-238页

作者： g.philip Robertson W.K.Kellogg Biological Station Michigan State UniversityHickory CornersMichiganUSA Department of Plant Soiland Microbial SciencesMichigan State UniversityEast LansingMichiganUSA great Lakes Bioenergy Research Center Michigan State UniversityEast LansingMichiganUSA

Our knowledge of microbial processes—who is responsible for what,the rates at which they occur,and the substrates consumed and products produced—is imperfect for many if not most taxa,but even less is known about how microsite processes scale to the ecosystem and thence the *** both natural and managed environments,scaling links fundamental knowledge to application and also allows for global assessments of the importance of microbial *** rarely is scaling straightforward:More often than not,process rates in situ are distributed in a highly skewed fashion,under the influence of multiple interacting controls,and thus often difficult to sample,quantify,and *** date,quantitative models of many important processes fail to capture daily,seasonal,and annual fluxes with the precision needed to effect meaningful management *** cycle processes are a case in point,and denitrification is a prime *** models based on machine learning can improve predictability and identify the best environmental predictors but are—by themselves—insufficient for revealing process-level knowledge gaps or predicting outcomes under novel environmental *** models that incorporate well-calibrated process models as predictors for machine learning algorithms can provide both improved understanding and more reliable forecasts under environmental conditions not yet *** trait-based models into such efforts promises to improve predictions and understanding still further,but much more development is needed.

关键词： ecosystems microsites N_(2) N_(2)O modeling

稳定性冠心病患者对选择性经皮冠状动脉介入治疗的理解差异：横断面研究

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英国医学杂志中文版 2015年第1期18卷 4-4页

作者： Faraz Kureshi NIH T-32 philip g jones Donna M Buchanan Mouin S Abdallah John A Spertus 袁建松乔树宾 Saint Luke's Mid America Heart Institute Kansas City MO 64111 USA University of Missouri- Kansas City Kansas City MO USA 中国医学科学院北京协和医学院阜外心血管病医院冠心病诊治中心

目的评价稳定性冠心病患者对于选择性经皮冠状动脉介入治疗（PCI）紧迫性和受益的理解程度，并评估各治疗中心和提供者之间的差异。

关键词：冠状动脉疾病介入治疗横断面稳定性

Connexin 30 controls the extension of astrocytic processes into the synaptic cleft through an unconventional non-channel function

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Neuroscience Bulletin 2014年第6期30卷 1045-1048页

作者： Jerome Clasadonte philip g.Haydon Department of Neuroscience Tufts University School of MedicineBostonMA 02111USA

Neurons and glial cells, particularly astrocytes, are the two main cell populations in the central nervous system. While it is established that brain functions primarily rely on neuronal activity, an active contribution of astrocytes to information processing is only starting to be considered. There is growing evidence that astrocytes, as part of the tripartite synapse, participate in this challenge by receiving and integrating neuronal signals and, in turn, by sending signals that target neurons[1]. The involvement of astrocytes in information processing has mainly been studied at the level of the single astrocyte, often missing the role of astrocyte networks in this process.

关键词： Connexin 30 controls the extension of astrocytic processes into the synaptic cleft through an unconventional non-channel function

Predicting the mode of flow in pneumatic conveying systems—A review

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Particuology 2008年第5期6卷 289-300页

作者： Mark g.jones Kenneth C.Williams Centre for Bulk Solids and Particulate Technologies School of EngineeringUniversity of NewcastleNewcastle 2308Australia

An initial prediction of the particulate mode of flow in pneumatic conveying systems is beneficial as this knowledge can provide clearer direction to the pneumatic conveying design process. There are three general categories of modes of flow, two dense flows： fluidised dense phase and plug flow, and dilute phase oniy. Detailed in this paper is a review of the commonly used and available techniques for predicting mode of flow. Two types of predictive charts were defined： basic particle parameter based （e.g. particle size and density） and air-particle parameter based （e.g. permeability and de-aeration）. The basic particle techniques were found to have strong and weak areas of predictive ability, on the basis of a comparison with data from materials with known mode of flow capability. It was found that there was only slight improvement in predictive ability when the particle density was replaced by loose-poured bulk density in the basic parameter techniques. The air-particle-parameter-based techniques also showed well-defined regions for mode of flow prediction though the data set used was smaller than that for the basic techniques. Also, it was found to be difficult to utilise de-aeration values from different researchers and subsequently, an air-particle-based technique was developed which does not require any de-aeration parameter in its assessment.

关键词： Pneumatic conveying Mode of flow Dense phase Permeability De-aeration

Clinical impact of an anti-biofilm Hydrofiber dressing in hard-to-heal wounds previously managed with traditional antimicrobial products and systemic antibiotics

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Burns & Trauma 2020年第1期8卷 388-396页

作者： Daniel g.Metcalf philip g.Bowler Science&Technology Research&DevelopmentConvaTec Ltd.DeesideFlintshireUK

Background:Hard-to-heal wounds are often compromised by the presence of *** presents an infection risk,yet traditional antimicrobial wound care products and systemic antibiotics are often used despite the uncertainty of therapeutic success and wound *** aim of this study was to investigate the clinical impact of a next-generation anti-biofilm Hydrofiber wound dressing(AQUACEL Ag+Extra[AQAg+E])in hard-to-heal wounds that had previously been treated unsuccessfully with traditional silver-,iodine-or polyhexamethylene biguanide(PHMB)-containing dressings and products and/or systemic ***:Clinical case study evaluations of the anti-biofilm dressing were conducted,where deteriorating or stagnant wounds were selected by clinicians and primary dressings were replaced by the anti-biofilm dressing for up to 4 weeks,or as deemed clinically appropriate,with monitoring via case report *** data was stratified for cases where traditional silver-,iodine-or PHMBcontaining products,or systemic antibiotics,had been used prior to the introduction of the antibiofilm ***:Sixty-five cases were identified for inclusion,wounds ranging in duration from 1 week to 20 years(median:12 months).In 47(72%)cases the wounds were stagnant,while 15(23%)were deteriorating;3 wounds were not *** an average of 4.2 weeks of management with the anti-biofilm dressing(range:1–11 weeks),in 11(17%)cases the wounds had healed(*** wound closure),40(62%)wounds improved,9(14%)wounds remained the same and 5(8%)wounds ***:The introduction of this anti-biofilm dressing into protocols of care that had previously involved wound management with traditional antimicrobial products and/or antibiotics was shown to facilitate improvements in the healing status of most of these hard-to-heal *** containing proven anti-biofilm technology,in combination with antimicrobial silver and exudate management technology,appear to b

关键词： Antibiotics Antimicrobials AQUACEL Ag+Extra Biofilm Dressings Iodine Hard-to-heal wounds Polyhexamethylene biguanide Silver

Projections of the Advance in the Start of the growing Season during the 21st Century Based on CMIP5 Simulations

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Advances in Atmospheric Sciences 2015年第6期32卷 831-838页

作者： XIA Jiangjiang YAN Zhongwei JIA gensuo ZENg Heqing philip Douglas jones ZHOU Wen ZHANg Anzhi Key Laboratory of Regional Climate-Environment for East Asia Institute of Atmospheric PhysicsChinese Academy of Sciences Ministry of Environmental Protection of Jiuzhaigou Country Climatic Research Unit University of East Anglia Center of Excellence for Climate Change Research and Department of Meteorology King Abdulaziz University guy Carpenter Asia-Pacific Climate Impact Centre School of Energy and EnvironmentCity University of Hong Kong

It is well-known that global warming due to anthropogenic atmospheric greenhouse effects advanced the start of the vegetation growing season （SOS） across the globe during the 20th century. Projections of further changes in the SOS for the 21st century under certain emissions scenarios （Representative Concentration Pathways, RCPs） are useful for improving understanding of the consequences of global warming. In this study, we first evaluate a linear relationship between the SOS （defined using the normalized difference vegetation index） and the April temperature for most land areas of the Northern Hemisphere for 1982-2008. Based on this relationship and the ensemble projection of April temperature under RCPs from the latest state-of-the-art global coupled climate models, we show the possible changes in the SOS for most of the land areas of the Northern Hemisphere during the 21st century. By around 2040-59, the SOS will have advanced by -4.7 days under RCP2.6, -8.4 days under RCP4.5, and -10.1 days under RCPS.5, relative to 1985-2004. By 2080-99, it will have advanced by -4.3 days under RCP2.6, -11.3 days under RCP4.5, and -21.6 days under RCP8.5. The geographic pattern of SOS advance is considerably dependent on that of the temperature sensitivity of the SOS. The larger the temperature sensitivity, the larger the date-shift-rate of the SOS.

关键词： start of growing season (SOS) normalized difference vegetation index (NDVI) temperature sensitivity Repre-sentative Concentration Pathways (RCPs) CMIP5