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The Comparison of the Effect of Oat and Shiitake Mushroom Powder to Prevent Body Weight Gain in Rats Fed High Fat Diet

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Food and Nutrition Sciences 2012年第7期3卷 1009-1019页

作者： Dian Handayani Barbara J. Meyer Jiezhong Chen Patricia Tang philip chi lip kwok Hak-Kim Chan Xu-Feng Huang Department of Pharmacology and Pharmacy Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong Faculty of Pharmacy The University of Sydney Australia Faculty of Pharmacy The University of Sydney Sydney Australia Metabolic Research Centre School of Health Sciences and Illawarra Health and Medical Research Institute (IHMRI) University of Wollongong Wollongong Australia Metabolic Research Centre School of Health Sciences and Illawarra Health and Medical Research Institute (IHMRI) University of Wollongong Wollongong Australia

Preventing obesity could be done by lowering plasma TAG that inhibits adipogenesis. Oat and mushroom beta-glucans in the diet has been reported to lower plasma lipid;however the data focusing on their effects on TAG and obesity are insufficient. In the present study, lowering plasma triacylglycerol, fat deposition, body weight gain (BWG) in rats fed a high fat diet (HFD) was evaluated. Rats in the control group were given HFD only and rats in the treatment group fed HFD enriched with 0.2%, 0.6% and 1.8% (wt:wt) beta-glucan from oats (LD-O, MD-O, HD-O) or mushroom (LD-M, MD-M, HD-M). After 6 weeks dietary intervention, the rats fed HD-M showed significantly lower plasma TAG, total fat mass, white adipose tissue, inguinal fat and BWG level more than HD-O treated rats (p < 0.05). The underlying mechanism in lowering plasma TAG, fat pad masses and BWG in HD-M was increasing ratio of fat faecal to faecal weight which was significantly higher than HD-O (p < 0.05). This study demonstrated that the preventing obesity via lowering plasma TAG and fat deposition was different depending on beta-glucan origin, either from oats and Shiitake mushroom.

关键词： Beta-Glucan Triacylglycerol Fat Deposition Obesity Dietary Fibre

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Immersion Education in china:Teachers’Perspectives

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Frontiers of Education in china 2011年第1期6卷 68-91页

作者： Stella KONG philip HOARE chi Yanping Department of English Hong Kong Institute of EducationHong KongChina Department of Social Sciences Xi’an International Studies UniversityXi’an 710128China

This paper investigates the views of immersion teachers in Hong Kong and Xi’an towards the immersion curriculum they are *** are important stakeholders in any curriculum implementation and their views are significant in both evaluating progress and determining future *** teachers’views were gathered from questionnaires and *** include their understanding of the objectives of immersion education,their preparedness for their roles as immersion teachers,the main challenges in immersion teaching they identify and the support they receive from their *** responses are discussed to identify areas of concern which may be future priorities for professional development.

关键词： immersion education content-based language teaching teachers’perception

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聚合物有机光伏的电荷产生机理

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高分子学报 2023年第6期54卷 927-942页

作者：周慈勇香港大学工程学院机械工程系中国香港999077

聚合物有机光伏近年来已经获得长足的发展,最新的研究报道以Y6为代表的Y系列非富勒烯受体体系取得了接近20%的能量转换效率,然而其电荷产生的具体机制尚存在争议.本文回顾了近年来对基于富勒烯受体和非富勒烯受体的聚合物有机光伏体系... 详细信息

聚合物有机光伏近年来已经获得长足的发展,最新的研究报道以Y6为代表的Y系列非富勒烯受体体系取得了接近20%的能量转换效率,然而其电荷产生的具体机制尚存在争议.本文回顾了近年来对基于富勒烯受体和非富勒烯受体的聚合物有机光伏体系的电荷产生机理的研究报道,介绍了2种体系工作机理的异同,指出富勒烯体系虽然可以实现超快的电荷分离,却普遍存在较大的能量损失;非富勒烯体系大幅降低了器件的能量损失,但其电荷产生过程相对较慢,并且在一些情况下需要热能的辅助来实现.本文分析了Y系列体系实现高性能的可能原因,分析表明其具有的独特的分子堆积方式和电荷产生动力学均对其优异的性能有所贡献,并提出了进一步降低能量损失和提高器件性能的可能方法与展望.

关键词：聚合物有机光伏非富勒烯受体电荷产生电荷复合能量损失

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Analysis of dynamic smile and upper lip curvature in young chinese

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International Journal of Oral Science 2013年第1期5卷 49-53页

作者： Ling-Zhi Liang Wen-Jie Hu Yan-Ling Zhang kwok-Hung Chung Department of Periodontology Peking University School & Hospital of Stomatology Department of Restorative Dentistry University of Washington

During smile evaluation and anterior esthetic construction,the anatomic and racial variations should be considered in order to achieve better matching *** aims of this study were to validate an objective method for recording spontaneous smile process and to categorize the smile and upper lip curvature of chinese Han-nationality *** hundred and eighty-eight chinese Han-nationality youths(88 males and 100 females) ranged from 20 to 35 years of age were *** smiles were elicited by watching comical movies and the dynamics of the spontaneous smile were captured continuously with a digital video *** subjects’ smiles were categorized into three types:commissure,cuspid and gummy smile based on video editing software and final ***’ upper lip curvatures were also measured and divided into three groups:upward,straight and *** analysis was conducted to obtain intra-rater reliabilities on twice *** Pearson chi-square test was used to compare differences for each parameters(α=0.05).In smile classification,60.6%commissure smile,33.5%cuspid smile and 5.9%gummy smile were *** upper lip measurement,26.1%upward,39.9%straight and 34.0%downward upper lip curvature were *** commissure smile group showed statistically significant higher percentage of straight(46.5%) and upward(40.4%) in upper lip curvatures(Plip curvature(Plip curvature and smile classification exist based on race,when comparing chinese subjects with those of Caucasian descent,and gender.

关键词： chinese Han nationality image processing smiles upper lip curvature

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The interplay of aging,genetics and environmental factors in the pathogenesis of Parkinson’s disease

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Translational Neurodegeneration 2019年第1期8卷 279-289页

作者： Shirley Yin-Yu Pang philip Wing-Lok Ho Hui-Fang Liu chi-Ting Leung Lingfei Li Eunice Eun Seo Chang David Boyer Ramsden Shu-Leong Ho Division of Neurology Department of MedicineQueen Mary HospitalUniversity of Hong KongHong KongPeople’s Republic of China Institute of Metabolism and Systems Research University of BirminghamBirminghamUK

Background:Parkinson’s disease(PD)is characterized by dopaminergic neuronal loss in the substantia nigra pars compacta and intracellular inclusions called Lewy bodies(LB).During the course of disease,misfoldedα-synuclein,the major constituent of LB,spreads to different regions of the brain in a prion-like fashion,giving rise to successive non-motor and motor *** is likely multifactorial,and involves interplay among aging,genetic susceptibility and environmental *** body:The prevalence of PD rises exponentially with age,and aging is associated with impairment of cellular pathways which increases susceptibility of dopaminergic neurons to cell ***,the majority of those over the age of 80 do not have PD,thus other factors in addition to aging are needed to cause *** of neurotoxins which can result in parkinsonism led to efforts in identifying environmental factors which may influence PD ***,the causality of most environmental factors is not conclusively established,and alternative explanations such as reverse causality and recall bias cannot be *** lack of geographic clusters and conjugal cases also go against environmental toxins as a major cause of *** mutations as well as common variants in genes such as SNCA,LRRK2 and GBA are associated with risk of PD,but Mendelian causes collectively only account for 5%of PD and common polymorphisms are associated with small increase in PD *** of PD has been estimated to be around 30%.Thus,aging,genetics and environmental factors each alone is rarely sufficient to cause PD for most ***:PD is a multifactorial disorder involving interplay of aging,genetics and environmental *** has implications on the development of appropriate animal models of PD which take all these factors into *** converging pathways likely include mitochondrial dysfunction,impaired autophagy,oxidative stress and neuroinflammation,which are

关键词： Parkinson’s disease Genetics Aging Environmental toxins

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LRRK2 mutant knock-in mouse models: therapeutic relevance in Parkinson’s disease

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Translational Neurodegeneration 2022年第1期11卷 790-808页

作者： Eunice Eun Seo Chang philip Wing-Lok Ho Hui-Fang Liu Shirley Yin-Yu Pang chi-Ting Leung Yasine Malki Zoe Yuen-Kiu Choi David Boyer Ramsden Shu-Leong Ho Division of Neurology Department of MedicineQueen Mary HospitalUniversity of Hong KongPok Fu LamHong KongChina Institute of Metabolism and Systems Research University of BirminghamBirminghamUK.

Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) are one of the most frequent genetic causes of both familial and sporadic Parkinson’s disease (PD). Mounting evidence has demonstrated pathological similarities between LRRK2-associated PD (LRRK2-PD) and sporadic PD, suggesting that LRRK2 is a potential disease modulator and a thera-peutic target in PD. LRRK2 mutant knock-in (KI) mouse models display subtle alterations in pathological aspects that mirror early-stage PD, including increased susceptibility of nigrostriatal neurotransmission, development of motor and non-motor symptoms, mitochondrial and autophagy-lysosomal defects and synucleinopathies. This review provides a rationale for the use of LRRK2 KI mice to investigate the LRRK2-mediated pathogenesis of PD and implications from current findings from different LRRK2 KI mouse models, and ultimately discusses the therapeutic potentials against LRRK2-associated pathologies in PD.

关键词： Parkinson’s disease LRRK2 Knock-in mouse model Neurotransmission Motor dysfunction Autophagy Lysosome Mitochondrial dysfunction Synucleinopathy Hyperkinase activity LRRK2 inhibitor

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Simultaneous bilateral floating knee:A case report

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World Journal of Clinical Cases 2022年第28期10卷 10172-10179页

作者： chi-Ming Wu Hung-En Liao Shou-Jen Lan Department of Orthopaedic Jen-Ai HospitalTaichung 42481Taiwan Department of Orthopaedic National Defense Medical CenterTaipei 11490Taiwan Department of Healthcare Administration Asia UniversityTaichung 41354Taiwan Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung 40402Taiwan School of Medical Science Putian UniversityPutian 351100Fujian ProvinceChina

BACKGROUND The phrase “floating knee is a flail knee joint,” referring to ipsilateral femoral and tibial fractures,was first used by Blake and Mc Bryde in *** condition is often caused by a high-energy trauma with often extensive injury to the soft tissues,and is accompanied by life-threatening systemic complications,including head,chest or abdominal injuries and a high incidence of fat *** knee is a severe and uncommon injury *** SUMMARY A 27-year-old man sustained multiple injuries when the electric motorcycle he was riding was hit by a *** injuries included traumatic hypovolemic shock,comminuted and open type II fractures of the left femoral shaft,fracture of the right femoral shaft,comminuted fracture of the bilateral tibial and fibular shaft,and multiple lacerations and abrasions on his forehead,lower lip,neck and *** diagnosis was simultaneous bilateral floating knee complicated with soft tissue *** emergency treatment and the exclusion of life-threating complications,open reduction and internal fixation were successfully performed using plates and screws in the bilateral femoral and tibial *** Simultaneous bilateral floating knee is a rare and severe injury *** treatment is challenging,and *** present a case report of a young adult who suffered from bilateral floating knees during road traffic *** also offer our treatment experience of this complex injury and review past literature.

关键词： Floating knee Femoral and tibial fractures High-energy trauma Life-threatening complications Fat embolism syndrome Case report

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LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson’s disease

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Translational Neurodegeneration 2022年第1期11卷 869-882页

作者： Shirley Yin-Yu Pang Rachel Cheuk Nam Lo philip Wing-Lok Ho Hui-Fang Liu Eunice Eun Seo Chang chi-Ting Leung Yasine Malki Zoe Yuen-Kiu Choi Wing Yan Wong Michelle Hiu-Wai Kung David Boyer Ramsden Shu-Leong Ho Division of Neurology Department of MedicineQueen Mary HospitalUniversity of Hong KongHong KongChina School of Biomedical Sciences Li Ka Shing Faculty of MedicineUniversity of Hong KongHong KongChina Institute of Metabolism and Systems Research University of BirminghamBirminghamUK.

Mutations in leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GBA) represent two most common genetic causes of Parkinson’s disease (PD). Both genes are important in the autophagic-lysosomal pathway (ALP), defects of which are associated with α-synuclein (α-syn) accumulation. LRRK2 regulates macroautophagy via activation of the mitogen activated protein kinase/extracellular signal regulated protein kinase (MAPK/ERK) kinase (MEK) and the calcium-dependent adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathways. Phosphorylation of Rab GTPases by LRRK2 regulates lysosomal homeostasis and endosomal trafficking. Mutant LRRK2 impairs chaperone-mediated autophagy, resulting in α-syn binding and oligomerization on lysosomal membranes. Mutations in GBA reduce glucocerebrosidase (GCase) activity, leading to glucosylceramide accumulation, α-syn aggregation and broad autophagic abnormalities. LRRK2 and GBA influence each other: GCase activity is reduced in LRRK2 mutant cells, and LRRK2 kinase inhibition can alter GCase activity in GBA mutant cells. Clinically, LRRK2 G2019S mutation seems to modify the effects of GBA mutation, resulting in milder symptoms than those resulting from GBA mutation alone. However, dual mutation carriers have an increased risk of PD and earlier age of onset compared with single mutation carriers, suggesting an additive deleterious effect on the initiation of PD pathogenic processes. Crosstalk between LRRK2 and GBA in PD exists, but its exact mechanism is unclear. Drugs that inhibit LRRK2 kinase or activate GCase are showing efficacy in pre-clinical models. Since LRRK2 kinase and GCase activities are also altered in idiopathic PD (iPD), it remains to be seen if these drugs will be useful in disease modification of iPD.

关键词： Parkinson’s disease Interaction LRRK2 GBA GCase Mutation Autophagy α-Synuclein

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Preface to the Focused Issue in Honor of Professor philip Roe on the Occasion of His 80th Birthday

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Communications on Applied Mathematics and Computation 2020年第3期2卷 319-320页

作者： Rémi Abgrall Jennifer K.Ryan chi-Wang Shu Institüt für Mathematik Universität ZürichWinterhurerstrasse 1908057ZurichSwitzerland Department of Applied Mathematics and Statistics Colorado School of MinesGoldenCO80401USA Division of Applied Mathematics Brown UniversityProvidenceRI02912USA

On July 3-4,2018,an international workshop was organised at the University of Cambridge,by ***,to mark the 80th anniversary of a young scientist,philip ***'s scientific achievements are numerous,and it is quite difficult to adequately address his accomplishments in a short *** began his journey at Cambridge,first for his Bachelor's degree and then obtaining his Master's degree in *** left for the Royal Aircraft Establishment(RAE)between 1962 to 1984 to work as an *** was a period of adventure,and the design of mature CFD codes for solving the Euler equations was far from being *** the Lax-Wendroff theorem was known(published in 1960),as for many novelties,it had taken some time before it became a gold *** the RAE,Phil was assigned by his manager to work in a direction that eventually led to Roe's Riemann solver and *** method is now standard in every specialised textbook,but the jump from generalizing the Murman scheme for Euler equations to what is now commonly known as the Roe flux is far from *** Roe relates this adventure,and others,in his"scientific autobiography",one of the papers of this focused issue.

关键词： eventually accomplishment assigned

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双栅FET放大器三阶互调失真的研究

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微纳电子技术 1982年第4期 61-63页

作者： philip T.Chen chi C.Hsieh 李浩模

本文描述了双栅GaAsFET放大器的三阶互调失真（IMD）积,它是直流偏压条件(VG1)和第二栅控制电压(VG2)的函数。提供了一个12GHz双栅FET放大器的线性特性,以证实对于最小三阶互调失真性能来说选择最佳偏压条件的重要性。

关键词：双栅放大器电子设备三阶互调失真 FET

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