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Analyses of fin ray types to detect strontium markers in juvenile blunt-snout bream megalobrama amblycephala

Ecological Processes 2024年第1期13卷 206-216页

作者： Yahua Zhu Tao Jiang Xiubao Chen Hongbo Liu Quinton phelps Jian Yang Wuxi Fisheries College Nanjing Agricultural University (WFCNAU) Laboratory of Fishery microchemistry Freshwater Fisheries Research Center Chinese Academy of Fishery Sciences (FFRCCAFS) Department of Biology Missouri State University (DBMSU)

Background Restocking by introducing hatchery-reared fish into wild habitats aids in the restoration of fishery aquatic ecosystems and reefs to increase the abundance of fish resources, restore the ecological balance of water bodies, and enhance ecosystem functioning. Accurately, rapidly, and effectively evaluating the success of restocking using chemical markers（e.g., strontium [Sr]） remains challenging for fisheries management. Consequently, for nonlethal fish sampling, hard tissues, such as fin rays, have received increasing attention as a target for marking method. However, data on the differences in marking different types of fin rays remain limited. Therefore, we exposed juvenile blunt snout bream individuals（megalobrama amblycephala） to 0（control group） or 800 mg/L of SrCl2·6H2O（marked group） for 5 days and transferred them into normal aerated water for post-immersion culture. We sampled their pectoral, dorsal, ventral, anal, and caudal fin rays. The Sr marks among the fin types were sampled at 0 and 20 days post-immersion and evaluated using an electron probe micro-analyzer（EPmA） for the five-day Sr/Ca ratios, along with line transect and Sr mapping *** Sr marking signatures were observed in all fin types in the marked group, with a success rate of up to 100%. Although marking efficiency varied among the different fin ray types, the highest Sr/Ca ratios were most often detected in the dorsal fin. Cross-sectional Sr concentration maps of all fin rays sampled showed high-Sr domains in the marked group; in contrast, the entire cross-sections of the control group displayed low Sr contents, indicating successful marking *** Fin ray Sr marking is a successful method for juvenile m. amblycephala, with the advantages of nonlethality and negligible sampling injuries, facilitating the rapid and effective evaluation of Sr marking in restocking m. amblycephala.

关键词： megalobrama amblycephala Juvenile Fin ray Strontium marking Electron probe micro-analyzer

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molecular and epidemiologic characterization of Wilms tumor from Baghdad, Iraq

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World Journal of Pediatrics 2018年第6期14卷 585-593页

作者： Hannah m.phelps mazin F.Al-Jadiry Natasha m.Corbitt Janene m.Pierce Bingshan Li Qiang Wei Raina R.Flores Hernan Correa Stefania Uccini Haydar Frangoul Adel R.Alsaadawi Safaa A.F.Al-Badri Amir F.Al-Darraji Raghad m.Al-Saeed Salma A.Al-Hadad Harold N.LovvornⅢ Vanderbilt University School of medicine 2215 Garland AvenueNashvilleTN 37232-9780USA Oncology Unit Children’s Welfare Teaching HospitalBaghdad University Medical CityBaghdadIraq Department of P ediatric Surgery Vanderbilt University Medical CenterNashvilleUSA Department of molecular Physiology and Bioph ysics Vanderbilt University School of MedicineNashvilleUSA Division of P ediatric Pathology Vanderbilt University Medical CenterNashvilleUSA Department of Clinical and molecular medicine Sapienza UniversityRomeItaly Division of P ediatric Hematology and Oncology Vanderbilt University Medical CenterNashvilleUSA Department of P athology Baghdad University Medical CityBaghdadIraq Oncology Unit Children’s Welfare Teaching HospitalWasit University College of MedicineWasitIraq

Background Wilms tumor (WT) is the most common childhood kidney cancer worldwide, yet its incidence and clinical behavior vary according to race and access to adequate healthcare resources. To guide and streamline therapy in the war-torn and resource-constrained city of Baghdad, Iraq, we conducted a first-ever molecular analysis of 20 WT specimens to characterize the biological features of this lethal disease within this challenged population. methods Next-generation sequencing of ten target genes associated with WT development and treatment resistance (WT1, CTNNB1, WTX, IGF2, CITED1, SIX2, p53, N-mYC, CRABP2, and TOP2A) was completed. Immunohistochemistry was performed for 6 marker proteins of WT (WT1, CTNNB1, NCAm, CITED1, SIX2, and p53). Patient outcomes were compiled. Results mutations were detected in previously described WT 'hot spots' (e.g., WT1 and CTNNB1) as well as novel loci that may be unique to the Iraqi population. Immunohistochemistry showed expression domains most typical of blastemal-predominant WT. Remarkably, despite the challenges facing families and care providers, only one child, with combined WT1 and CTNNB1 mutations, was confirmed dead from disease. median clinical follow-up was 40.5 months (range 6–78 months). Conclusions These data suggest that WT biology within a population of Iraqi children manifests features both similar to and unique from disease variants in other regions of the world. These observations will help to risk stratify WT patients living in this difficult environment to more or less intensive therapies and to focus treatment on cell-specific targets.

关键词： Iraq Low- and middle-income countries Next-generation sequencing Pediatric cancer Wilms tumor

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电刺激膈神经横膈起搏

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国外医学.神经病学神经外科学分册 1987年第4期 193-196页

作者： Glenn W WL phelps m L 陈忠平

电刺激可兴奋组织在理论上已达到可以获得任何需求的生理反应的精确程度。本文旨在复习有关以电刺激治疗慢性换气功能减退方面的进展。

关键词：隔神经运动神经元隔肌呼吸中枢传出神经元电刺激起搏器

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因新型冠状病毒肺炎封锁前、中、后已确诊心血管病患者的全因死亡率:一项丹麦全国范围的队列研究

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中华高血压杂志 2021年第6期29卷 518-518页

作者：刘青(摘译) 郑武洪(审校) Butt JH FosbΦl EL Gerds TA Andersson C Kragholm K Biering-SΦrensen T Andersen J phelps m Andersen mP Gislason G Torp-Pedersen C KΦber L Schou m 不详

2020年3月13日,丹麦当局在全国范围内实施了广泛的封锁措施,以防止冠状病毒疾病2019(coronavirus disease 2019,COVID-19)的传播,并重新分配有限的医疗资源。研究者调查了在采取这些封锁措施之前、期间和之后,已确诊的心血管病患者的死... 详细信息

2020年3月13日,丹麦当局在全国范围内实施了广泛的封锁措施,以防止冠状病毒疾病2019(coronavirus disease 2019,COVID-19)的传播,并重新分配有限的医疗资源。研究者调查了在采取这些封锁措施之前、期间和之后,已确诊的心血管病患者的死亡率和不同地点的死亡率。

关键词：心血管病患者冠状病毒队列研究医疗资源封锁肺炎丹麦

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Evaluation of Stocking All Female Largemouth Bass (micropterus salmoides) in Alabama (USA) Ponds

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Natural Resources 2016年第6期7卷 315-325页

作者： michael J. maceina Steven m. Sammons Ronald P. phelps School of Fisheries Aquaculture and Aquatic Sciences Auburn University Auburn Alabama USA

Excessive largemouth bass ( micropterus salmoides ) recruitment in small impoundments leads to density-dependent growth depression, causing populations to have length distributions skewed towards smaller fish. To address this issue, we conducted three trials that evaluated stocking all female largemouth bass (F-LmB) in two small Alabama ponds (0.5 and 2.0 ha) where the drainage basin was isolated. Age-1 fish were individually identified for sex using a micro pipette inserted in the urogenital pore, tagged, and stocked at 38-40 F-LmB/ha into ponds that contained pre-established sunfish ( Lepomis spp.) populations. Female largemouth bass were collected with electrofishing, angling, and rotenone over a 2.5- to 5-year period among the three trials. Sex was correctly identified for 179 of the 180 F-LmB stocked. One male was detected in the first trial which resulted in successful largemouth bass reproduction and this trial was terminated after two years. Growth was rapid the first 2 years after stocking as 3-year-old fish reached an average of 429 to 459 mm and 1.37 to 1.66 kg in all 3 trials. However, 2 years after stocking, growth was nil in the second trial even though relative weights of F-LmB were generally greater than 100. In this second trial, removal of about 30% of the F-LmB inhabiting the pond and stocking small Nile tilapia Oreochromis niloticus (25 - 75 mm) resulted in average weights increasing from 1.30 to 2.34 kg in 1 year. Growth of F-LmB continued in the third trail, and average size approached 500 mm and 2.2 kg three years after stocking. Annual survival rates of F-LmB were high and ranged from 0.78 to 0.93 among the 3 trials. Stocking F-LmB offers an attractive alternative in ponds to create a low density largemouth bass population that displays fast growth and high survival when catch-and-release fishing is primarily practiced.

关键词： Largemouth Bass Relative Weight Growth Survival Ponds Program mARK

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外科病理取材图解指南 2版

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2009年

作者： WILLIAmH.WESTRARALPHH.HRUBANTImOTHYH.phelps等

本书共分十五篇，内容包括：总则和技术；转移性肿瘤的淋巴结；头颈部；消化系统；心血管和呼吸系统；骨、软组织和皮肤；乳腺；女性生殖系统；泌尿道和男性生殖系统；视觉系统；内分泌系统等。

ISBN: (纸本)9787810865821

关键词：外科学:病理学图解

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装甲抢救车和战斗工程车——需要进行变革的时代

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国外坦克 1996年第6期 30-37,41页

作者： Devron phelps 张国斌

传统上,装甲机动部队由以当代或前一代主战坦克为底盘的装甲抢救车和战斗工程车提供保障,由各种轻型装甲变型车提供辅助保障。随着m1“艾布拉姆斯”、“挑战者”2和“勒克莱尔”

关键词：主战坦克轻型装甲工程车变型车挑战者底盘部队布拉姆步兵战车装甲车

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PI-RADS 2.1版用于前列腺癌检测和多参数mRI衍生标志物研究的前瞻性评估

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国际医学放射学杂志 2023年第4期 483-483页

作者： E.C.Yilmaz J.H.Shih m.J.Belue S.A.Harmon T.E.phelps C.Garcia 宋雨桐

摘要单独的前列腺成像报告和数据系统（PI-RADS）2.1版以及PI-RADS 2.1与mRI定量特征相结合检测前列腺癌的前瞻性表现的数据是有限的。目的评估不同PI-RADS 2.1

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maser radiation from collisionless shocks: application to astrophysical jets

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High Power Laser Science and Engineering 2019年第1期7卷 120-127页

作者： D.C.Speirs K.Ronald A.D.R.phelps m.E.Koepke R.A.Cairns A.Rigby F.Cruz R.m.G.m.Trines R.Bamford B.J.Kellett B.Albertazzi J.E.Cross F.Fraschetti P.Graham P.m.Kozlowski Y.Kuramitsu F.miniati T.morita m.Oliver B.Reville Y.Sakawa S.Sarkar C.Spindloe m.Koenig L.O.Silva D.Q.Lamb P.Tzeferacos S.Lebedev G.Gregori R.Bingham Department of Physics SUPA University of Strathclyde Department of Physics West Virginia University School of mathematics and Statistics University of St.Andrews Department of Physics University of Oxford GoLP/Instituto de Plasmas e Fus?u Nuclear Instituto Superior T'ecnico Universidade de Lisboa STFC Rutherford Appleton Laboratory Laboratoire pour l’Utilisation de Lasers Intenses UMR7605 CNRS CEA Universit'e Paris VI Ecole Polytechnique Departments of Planetary Sciences and Astronomy University of Arizona AWE Aldermaston Reading West Berkshire Department of Physics National Central University Institute of Laser Engineering Osaka University School of mathematics and Physics Queen’s University Belfast Department of Astronomy and Astrophysics University of Chicago Imperial College London

This paper describes a model of electron energization and cyclotron-maser emission applicable to astrophysical magnetized collisionless shocks. It is motivated by the work of Begelman, Ergun and Rees [Astrophys. J. 625, 51(2005)] who argued that the cyclotron-maser instability occurs in localized magnetized collisionless shocks such as those expected in blazar jets. We report on recent research carried out to investigate electron acceleration at collisionless shocks and maser radiation associated with the accelerated electrons. We describe how electrons accelerated by lower-hybrid waves at collisionless shocks generate cyclotron-maser radiation when the accelerated electrons move into regions of stronger magnetic fields. The electrons are accelerated along the magnetic field and magnetically compressed leading to the formation of an electron velocity distribution having a horseshoe shape due to conservation of the electron magnetic moment. Under certain conditions the horseshoe electron velocity distribution function is unstable to the cyclotron-maser instability [Bingham and Cairns, Phys. Plasmas 7, 3089(2000); melrose, Rev. mod. Plasma Phys. 1, 5(2017)].

关键词： laboratory astrophysics plasma physics particle acceleration plasma-wave instabilities

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美国国立老化研究所与阿尔茨海默病协会诊断指南写作组：阿尔茨海默病临床前阶段的定义

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中华神经科杂志 2012年第5期45卷 336-344页

作者： Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan Am Iwatsubo T Jack CR Jr Kaye J montine TJ Park DC Reiman Em Rowe CC Siemers E Stern Y Yaffe K Carrillo mC Thies B morrison-Bogorad m Wagster mV phelps CH 贾建平（译）郭起浩（译）黄丽（译）陆璐（译）张逸驰（译）邢怡（译）不详首都医科大学宣武医院神经科北京100053 复旦大学附属华山医院神经内科

阿尔茨海默病（AD）的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会，但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生... 详细信息

阿尔茨海默病（AD）的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会，但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议，以确定能够预测由“正常”认知到轻度认知功能障碍（mCI）及AD痴呆的最佳预测指标。根据目前已有的主要科学证据，我们提出了一个概念性的框架和用于操作的研究标准，以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的，目前不涉及临床应用。我们希望这些建议能提供一个共识，以推进临床前AD的研究，最终推动更早期治疗干预的进展，使得一些疾病减缓药物的疗效发挥最大。

关键词：阿尔茨海默病诊断指南临床前研究所协会老化美国轻度认知功能障碍

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