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Gracilaria changii(Rhodophyta) alleviates bisphenol A-induced adverse reproductive abnormalities in mice

Asian Pacific Journal of Tropical Medicine 2021年第1期14卷 34-60页

作者： Chong Lee Ng Gim Cheong Tan Yoon-Yen Yow Mukesh Kumar Gupta phek jin kwong Department of Agricultural and Food Science Universiti Tunku Abdul Rahman31900Malaysia Department of Biomedical Science Universiti Tunku Abdul Rahman31900Malaysia Department of Biological Sciences School of Medical and Life SciencesSunway University47500Malaysia Department of Biotechnology and Medical Engineering National Institute of TechnologyRourkelaOdisha769008India

Objective:To evaluate the potential of Gracilaria changii extract in ameliorating the potential adverse effects of bisphenol ***:The antioxidant capacity of Gracilaria changii extracted using different solvents(methanol,ethanol,and aqueous)was *** mice were administered by oral gavage with bisphenol A(60 mg/kg body weight)for 6 weeks with or without Gracilaria changii aqueous ***,the mice were either euthanized for histology and immunohistochemistry studies or mated to evaluate the pregnancy ***:Gracilaria changii aqueous extract showed the highest antioxidant properties compared with extract using methanol and *** aqueous extract of Gracilaria changii improved the uterus index and uterine lipid peroxidation after bisphenol A exposure,although the uterine expressions of estrogen receptors and complement C3 were not *** evaluation of the uterus during the estrus stage has revealed that the extract could mitigate bisphenol A-induced adverse effects in the uterus as there was a lower percentage of mice showing abnormalities like decreased eosin staining in the myometrium,and decrease in the number of eosinophil and endometrial glands in the ***,Gracilaria changii aqueous extract improved the pregnancy rate of mice administered with bisphenol ***:Gracilaria changii extract protects against bisphenol A-induced female reproductive abnormalities in mice which may be mediated via modulation of eosinophil migration,endometrial gland formation,and protein expressions associated with prostaglandins in the myometrium.

关键词： Red seaweed Gracilaria changii Antioxidant Endocrine disruptor Bisphenol A Reproduction

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