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Some worlds about postmortem blood atropine concentrations

Forensic Medicine and Anatomy Research 2013年第3期1卷 37-39页

作者： phak-rop pos pok INPS Laboratoire de Police Scientifique de Marseille Section Toxicologie Marseille France

Atropine is an anticholinergic drug, used in treatment of spasm and pain. postmortem blood atropine concentrations tend to be regionally dependent. We reported in this work the analytical findings of atropine in the peripheral and heart blood from a case of suspected death. Atropine was?determined in both peripheral and heart blood by liquid chromatography with tandem mass spectrometry. Towards the reference ranges, the concentration of atropine in the peripheral blood is therapeutic, and in the heart blood is lethal. The high concentration of atropine in the heart blood reflects postmortem redistribution rather than cardiotoxicity. The findings have great implications for forensic toxicology.

关键词： Atropine postmortem Redistribution

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An Intentional Poisoning by Lormetazepam in a Patient Treated with Nordiazepam

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Forensic Medicine and Anatomy Research 2014年第4期2卷 107-112页

作者： phak-rop pos pok Emilie Berland Michel Mauras Magali Valès Erika Kuhlmann Laboratoire de Police Scientifique de Marseille Section Toxicologie Institut National de Police Scientifique France

A case of suspected poisoning by benzodiazepines is presented in this paper. Toxicological analyses were applied on the blood collected 48 hours after the facts. GC-MS and HPLC-DAD have detected only nordiazepam which was prescribed in the treatment. Therefore, LC-MS/MS has detected lormetazepam and lorazepam (major metabolite of lormetazepam) in addition of nordiazepam. The concentrations of lormetazepam, lorazepam and nordiazepam measured in blood were 6.8, 6.3, and 16.2 ng/mL, respectively. The initial concentration of each drug at the relevant time, has been calculated from these residual concentrations, using an extrapolation approach. According to estimates, only lormetazepam (189 ng/mL) and lorazepam (68 ng/mL), were active at the target moment. A poisoning by lormetazepam was then considered. The more technology we have, the greater chance we have to get an outcome that is favorable to justice.

关键词： Benzodiazepines Discrimination between Poison and Medication LC-MS/MS

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