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Ivermectin as an adjunct treatment for hospitalized adult COVID-19 patients: A randomized multi-center clinical trial

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Asian Pacific Journal of Tropical Medicine 2021年第6期14卷 266-273页

作者： Morteza Shakhsi Niaee peyman namdar.abbas allami Leila Zolghadr Amir Javadi Amin Karampour Mehran Varnaseri Behzad Bijani Fatemeh Cheraghi Yazdan Naderi Fatemeh Amini Masoumeh Karamyan Mohammad Jafar YadYad Ramin Jamshidian Nematollah Gheibi Sciences and Technology Park QazvinIran Department of Surgery Qazvin University of Medical SciencesQazvinIran Department of Infectious Diseases Clinical Research Development UnitBouAliSina HospitalQazvin University of Medical SciencesQazvinIran Department of Chemistry Imam Khomeini International University QazvinIran Department of Social Sciences School of Medicine Qazvin University of Medical SciencesQazvinIran Infectious and Tropical Diseases Research Center Ahvaz Jundishapur University of Medical SciencesAhvazIran Department of Infectious Diseases Qazvin University of Medical SciencesQazvinIran Cellular and Molecular Research Center Research Institute for Prevention of Non-Communicable DiseasesQazvin University of Medical SciencesQazvinIran Department of Persian Medicine School of MedicineShiraz University of Medical SciencesShirazIran

Objective: To evaluate different doses of ivermectin in adult patients with mild COVID-19 and to evaluate the effect of ivermectin on mortality and clinical ***: A randomized, double-blind, placebo-controlled, multicenter clinical trial was performed at five hospitals. A total of 180 mild hospitalized patients with COVID-19 confirmed by PCR or chest image tests were enrolled and allocated to six arms including hydroxychloroquine 200 mg twice per day, placebo plus hydroxychloroquine 200 mg twice per day, single dose ivermectin(200 μg/kg), three low interval doses of ivermectin(200, 200, 200 μg/kg), single dose ivermectin(400 μg/kg), and three high interval doses of ivermectin(400, 200, 200 μg/kg). The primary endpoint of this trial was all-cause of mortality or clinical recovery. The radiographic findings, hospitalization and low O_2 saturation duration, and hematological variables of blood samples were analyzed. Results: A total of 16.7%(5/30) and 20.0%(6/30) patients died in arms treated with hydroxychloroquine 200 mg twice per day and placebo plus hydroxychloroquine 200 mg twice per day, respectively, and a reduction in mortality rate in patients receiving ivermectin treatment to 0%, 10%, 0% and 3.3% for arms 1-4 were observed. Risk of mortality was also decreased about 15% in the ivermectin treated arms. Conclusions: Ivermectin as an adjunct reduces the rate of mortality, time of low O_2 saturation, and duration of hospitalization in adult COVID-19 patients. The improvement of other clinical parametersshows that ivermectin, with a wide margin of safety, had a high therapeutic effect on COVID-19.

关键词： SARS-COV-2 Ivermectin Randomized controlled trial Dose-respond relationship

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碳酸盐岩储集层岩石物性变化与结构变形实验

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石油勘探与开发 2019年第3期46卷 542-551页

作者： SALIMIDELSHAD Yaser MORADZADEH Ali KAZEMZADEH Ezatallah POURAFSHARY peyman MAJDI abbas School of Mining Engineering College of Engineering University of Tehran Faculty of Research and Development in Upstream Petroleum Industry Research Institute of Petroleum IndustryTehran Department of Petroleum Engineering School of Mining and Geosciences Nazarbayev University

为研究压力对碳酸盐岩孔隙结构、岩石物理性质等方面的影响,在压力循环加载条件下对伊朗西南部South-Pars气田下三叠统Kangan组2个碳酸盐岩柱状岩心样品进行孔隙度、渗透率、CT扫描、扫描电子显微镜(SEM)、弹性波速度等分析。在2个岩心... 详细信息

为研究压力对碳酸盐岩孔隙结构、岩石物理性质等方面的影响,在压力循环加载条件下对伊朗西南部South-Pars气田下三叠统Kangan组2个碳酸盐岩柱状岩心样品进行孔隙度、渗透率、CT扫描、扫描电子显微镜(SEM)、弹性波速度等分析。在2个岩心样品中,一个样品为方解石,另一个为含硬石膏结核的白云石,分别以6个阶段循环施加13.79 MPa和27.58 MPa的负载压力,统计分析2个样品在不同压力加载/卸载阶段下的物性变化特点。结果表明,方解石样品的孔隙度和渗透率随压力载荷的增加而减小,这与纵波和横波速度测试的结果一致。在白云石样品中则没有观察到这种趋势。在纵波和横波速度分析中可观察到压力加载阶段速度发生起伏,这可能是由于孔隙具有不同几何形状和样品中的孔隙发生变化所致。研究碳酸盐岩物性随压力的变化有助于优化调整油气藏开发方案。

关键词：压力循环加载岩石物性碳酸盐岩储集层 CT扫描 South-Pars气田下三叠统Kangan组结构变形

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Improving performance of open-pit mine production scheduling problem under grade uncertainty by hybrid algorithms

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Journal of Central South University 2020年第9期27卷 2479-2493页

作者： Kamyar TOLOUEI Ehsan MOOSAVI Amir Hossein BANGIAN TABRIZI peyman AFZAL abbas AGHAJANI BAZZAZI Department of Petroleum and Mining Engineering South Tehran BranchIslamic Azad UniversityTehranIran Department of Mining Engineering University of KashanKashanIran

One of the surface mining methods is open-pit mining,by which a pit is dug to extract ore or waste downwards from the earth’s *** the mining industry,one of the most significant difficulties is long-term production scheduling(LTPS)of the open-pit *** and uncertainty-based approaches are identified as the main strategies,which have been widely used to cope with this *** the last few years,many researchers have highly considered a new computational type,which is less costly,i.e.,meta-heuristic methods,so as to solve the mine design and production scheduling *** the optimality of the final solution cannot be guaranteed,they are able to produce sufficiently good solutions with relatively less computational *** the present paper,two hybrid models between augmented Lagrangian relaxation(ALR)and a particle swarm optimization(PSO)and ALR and bat algorithm(BA)are suggested so that the LTPS problem is solved under the condition of grade *** is suggested to carry out the ALR method on the LTPS problem to improve its performance and accelerate the ***,the Lagrangian coefficients are updated by using PSO and *** presented models have been compared with the outcomes of the ALR-genetic algorithm,the ALR-traditional sub-gradient method,and the conventional method without using the Lagrangian *** results indicated that the ALR is considered a more efficient approach which can solve a large-scale problem and make a valid ***,it is more effectual than the conventional ***,the time and cost of computation are diminished by the proposed hybrid *** CPU time using the ALR-BA method is about 7.4%higher than the ALR-PSO approach.

关键词： open-pit mine long-term production scheduling grade uncertainty augmented Lagrangian relaxation particle swarm optimization algorithm bat algorithm

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Experimental investigation of changes in petrophysical properties and structural deformation of carbonate reservoirs

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Petroleum Exploration and Development 2019年第3期46卷 565-575页

作者： SALIMIDELSHAD Yaser MORADZADEH Ali KAZEMZADEH Ezatallah POURAFSHARY peyman MAJDI abbas School of Mining Engineering College of Engineering University of Tehran Tehran *** Iran Faculty of Research and Development in Upstream Petroleum Industry Research Institute of Petroleum Industry Tehran *** Iran Department of Petroleum Engineering School of Mining and Geosciences Nazarbayev University Astana 010000 Kazakhstan

To examine the effect of pressure on pore structure and petrophysical properties of carbonate rock, the porosity, permeability, CT scanning, SEM and elastic wave velocity of two carbonate core plug samples from an oilfield in Southwest Iran were analyzed under cyclic pressure. One of the plugs was calcite and the other was dolomite with anhydrite nodules. The cyclic pressure exerted on the samples increased from 13.79 MPa to 27.58 MPa in six steps, and the variations in petrophysical properties of the two samples at different pressure loading and unloading steps were counted and analyzed. The results show that the calcite sample decreases in porosity and permeability with the increase of pressure, which is consistent with the results from compression and shear wave velocity tests. In the dolomite sample, the decreasing trend was not observed;fluctuations of compressive and shear velocities were observed during the loading stage, which may be due to different geometries of the pores and the porosity variation in the sample. Understanding the variation of carbonate petrophysical properties with pressure is helpful for optimizing reservoir development scheme.

关键词： cyclic pressure loading petrophysical property carbonate reservoir, CT scan rock physical property structure deformation

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Depositional environments and sequence stratigraphy of the Bahram Formation(middleelate Devonian) in north of Kerman, south-central Iran

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Geoscience Frontiers 2016年第5期7卷 821-834页

作者： Afshin Hashmie Ali Rostamnejad Fariba Nikbakht Mansour Ghorbanie peyman Rezaie Hossien Gholamalian Department of Geology Faculty of Sciences University of Hormozgan

This study is focused on sedimentary environments, facies distribution, and sequence stratigraphy. The facies and sequence stratigraphic analyses of the Bahram Formation（middleelate Devonian） in southcentral Iran are based on two measured stratigraphic sections in the southern Tabas block. The Bahram Formation overlies red sandstones Padeha Formation in sections Hutk and Sardar and is overlain by Carboniferous carbonate deposits of Hutk Formation paraconformably, with a thickness of 354 and386 m respectively. Mixed siliciclastic and carbonate sediments are present in this succession. The field observations and laboratory studies were used to identify 14 micro/petrofacies, which can be grouped into 5 depositional environments： shore, tidal flat, lagoon, shoal and shallow open marine. A mixed carbonate-detrital shallow shelf is suggested for the depositional environment of the Bahram Formation which deepens to the east（Sardar section） and thins in southern locations（Hutk section）. Three 3rdorder cyclic siliciclastic and carbonate sequences in the Bahram Formation and one sequence shared with the overlying joint with Hutk Formation are identified, on the basis of shallowing upward patterns in the micro/pertofacies.

关键词： Bahram Formation Devonian Facies analysis Mixed carbonate-detrital shallow-shelf Sequence stratigraphy Tabas block

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Impact of spatiotemporal land-use and land-cover changes on surface urban heat islands in a semiarid region using Landsat data

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International Journal of Digital Earth 2021年第2期14卷 250-270页

作者： Ehsan Kamali Maskooni Hossein Hashemi Ronny Berndtsson peyman Daneshkar Arasteh Mohammad Kazemi Department of Watershed Management and Engineering University of HormozganBandar-AbbasIran Centre for Middle Eastern Studies&Division of Water Resources Engineering Lund UniversityLundSweden Water Science and Engineering Faculty of Agriculture and Natural ResourcesImam Khomeini International UniversityQazvinIran

Many factors are involved in urban heat island development,such as lack of green spaces,improper choice of building materials,densification,and other human *** aim of this research was to quantify the effects of land-use/land-cover(LU/LC)changes on urban land surface temperature(LST)during a 25-year period(1993–2018)for the semiarid Shiraz City in southern Iran using Landsat data(TM,ETM+,and OLI/TIRS)and machine learning *** main LU/LC classes,such as orchard,vegetation,bare surface,asphalt cover,and built-up areas,were identified using a support vector machine *** images were used to retrieve normalized difference vegetation index(NDVI)and normalized difference built-up index(NDBI).The results showed that the mean LST over the entire study domain increased considerably between 1993 and 2018,due to urbanization,decrease of green areas,and increasing industrial ***-up areas increased considerably by 25.8%from 80 to 100.6 km^(2) between 1993 and 2018,while vegetation cover decreased dramatically by 69.3%.Mean LST increased from 38.4 to 40.2℃ during the 25-year period with a significant increase of 3.9℃ between 2013 and *** addition,the Urban heat island Ratio Index(URI)displayed a substantial upward trend during the 25-year period.

关键词： Urbanization urban heat island land use land cover semiarid population density

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