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The Hippo Tumor Suppressor Pathway(YAP/TAZ/TEAD/MST/LATS)and EGFR-RAS-RAF-MEK in cancer metastasis

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Genes & Diseases 2021年第1期8卷 48-60页

作者： Mohammad Reza Zinatizadeh Seyed Rouhollah Miri peyman Kheirandish Zarandi Ghanbar Mahmoodi Chalbatani Catarina Raposo Hamid Reza Mirzaei Mohammad Esmaeil Akbari Habibollah Mahmoodzadeh Cancer Research Center Shahid Beheshti University of Medical SciencesTehranIran Cancer Research Center Cancer Institute of IranTehran University of Medical ScienceTehranIran Department of Immunology School of MedicineTehran University of Medical SciencesTehranIran Department of Immunology Medical SchoolShahid Beheshti University of Medical SciencesTehranIran Faculty of Pharmaceutical Sciences State University of Campinas-UNICAMP Campinas SPBrazil Cancer Research Center Shohadae Tajrish HospitalDepartment of Radiation OncologyShahid Beheshti University of Medical SciencesTehranIran

Hippo Tumor Suppressor Pathway is the main pathway for cell growth that regulates tissue enlargement and organ size by limiting cell *** pathway is activated in response to cell cycle arrest signals(cell polarity,transduction,and DNA damage)and limited by growth factors or mitogens associated with EGF and *** major pathway consists of the central kinase of Ste20 MAPK(Saccharomyces cerevisiae),Hpo(Drosophila melanogaster)or MST kinases(mammalian)that activates the mammalian AGC kinase dmWts or LATS effector(MST and LATS).YAP in the nucleus work as a cofactor for a wide range of transcription factors involved in proliferation(TEA domain family,TEAD1-4),stem cells(Oct4 mononuclear factor and SMAD-related TGFb effector),differentiation(RUNX1),and Cell cycle/apoptosis control(p53,p63,and p73 family members).This is due to the diverse roles of YAP and may limit tumor progression and *** also coordinates various signal transduction pathways such as Hippo,WNT,TGFb and EGFR,and effects on lack of regulation of TEAD cancerous genes,such as KRAS,BRAF,LKB1,NF2 and MYC,which play essential roles in tumor progression,metastasis,cancer metabolism,immunity,and drug ***,RAS signaling is a pivotal factor in the inactivation of Hippo,which controls EGFR-RAS-RAF-MEK-ERKmediated interaction of Hippo ***,the loss of the Hippo pathway may have significant consequences on the targets of RAS-RAF mutations in cancer.

关键词： Cancer Hippo pathway Metastasis Signaling Tumor suppressor

The Role and Function of Ras-association domain family in Cancer:A Review

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Genes & Diseases 2019年第4期6卷 378-384页

作者： Mohammad Reza Zinatizadeh Seyed Ali Momeni peyman Kheirandish Zarandi Ghanbar Mahmoodi Chalbatani Hassan Dana Hamid Reza Mirzaei Mohammad Esmaeil Akbari Seyed Rouhollah Miri Cancer Research Center Shahid Beheshti University of Medical SciencesTehranIran Cancer Research Center Cancer Institute of IranTehran University of Medical ScienceTehranIran Uro-Oncology Research Center Tehran University of Medical SciencesTehranIRIran Cancer Research Center Shohadae Tajrish HospitalDepartment of Radiation OncologyShahid Beheshti University of Medical SciencesTehranIran

Ras gene mutation has been observed in more than 30%of cancers,and 90%of pancreatic,lung and colon *** proteins(K-Ras,H-Ras,N-Ras)act as molecular switches which are activated by binding to *** play a role in the cascade of cell process control(proliferation and cell division).In the inactive state,transforming GTP to GDP leads to the activation of GTpase in Ras ***,the mutation in Ras leads to the loss of internal GTPase activity and permanent activation of the *** activated Ras can promote the cell death or stop cell growth,which are facilitated by Ras-association domain *** studies have been conducted to determine the importance of losing RASSF proteins in Rasinduced *** paper examines the role of Ras and RASSF *** general,RASSF proteins can be used as a suitable means for targeting a large group of Ras-induced tumors.

关键词： Cancer Colon H-Ras K-Ras Lung N-Ras Pancreatic

Effectiveness of Music Therapy on Aggressive Behavior of Visually Impaired Adolescents

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Journal of Behavioral and Brain Science 2015年第3期5卷 96-100页

作者： peyman Hashemian Norouz Mashoogh Lida Jarahi Psychiatry and Behavioral Sciences Research Center Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran Ghochan Azad University Ghochan Iran Addiction Research Center Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran

Objective: Aggression is one of the common social disorders in adolescence. Blindness is a disability, which can lead to immature and inappropriate behaviors in children, and increase aggression in teenagers. The present study was conducted to investigate the effect of music on aggressive behavior in visually impaired students. Methods: This research was an experimental pretest-posttest study with a control group and was conducted in 2012. The study population of this research was teenagers with visual impairments in Bojnord, northeast of Iran. For this purpose, Buss and Perry aggression questionnaire and Rutter behavior questionnaire for teachers were used. Twelve music therapy sessions were held, each lasting 90 minutes. T-tests and analysis of covariance (ANCOVA) were used for data analysis. Results: There were not significant differences between the two groups regarding age, socioeconomic status, and education level of parents, as ascertained prior to the pretest. In the intervention group, the declines of aggression scores were statistically significant. There were significant differences between the results of posttest in the intervention and control groups. Conclusion: Music therapy reduces aggression in teens with blindness and can be used as a non-pharmacological intervention to reduce emotional states in this group.

关键词： Aggression Music Therapy Visually Impaired Student

The Effect of Neurofeedback Therapy in Primary Enuretic Children

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World Journal of Neuroscience 2015年第2期5卷 87-90页

作者： Mahmood Reza Khazaei Nasrin Aminifard peyman Hashemian Department of Pediatrics Mashhad Branch Islamic Azad University Mashhad Iran Department of Medicine Mashhad Branch Islamic Azad University Mashhad Iran Psychiatry Psychiatry and Behavioral Sciences Research Center Ibn-e-Sina Hospital Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran

Introduction:?Enuresis is one of the most common psychiatric disorders in children. Classical?treatments for primary enuretic children are conditioning (Bell and Pad method, and drug therapy). Neurofeedback is a kind of conditioning by changing amplitudes of brain waves. Method: Three?groups of 10 enuretic children were selected randomly. All three groups took imipramine. The?first group also took neurofeedback sessions with protocol of enhancement of?β/θ?wave ratio in occipital zone. The second group took non-real neurofeedback sessions beside the drug. The third?group just took the drug. Result:?All three groups showed significant remission (P < 0.0001) after treatment and a three-month follow-up. Conclusion:?Neurofeedback by this protocol was not any more efficient than imipramine therapy by itself.

关键词： Imipramine Neurofeedback Enuresis

The efficacy of a first aid training course for drivers： an experience from northern Iran

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Chinese Journal of Traumatology 2014年第5期17卷 289-292页

作者： Mohammad Ali Vakili Ali Mohjervatan Seyed Taghi Heydari Armin Akbarzadeh Nazanin Sadat Hosini Farideh Alizad peyman Arasteh Mohammad Javad Moghasemi Health Management and Social Development Research Center Golestan University of Medical Sciences Gorgan Iran Researcher Center for Disaster Management and Emergency Medicine Golestan University of Medical Sciences Gorgan Iran Research Center for Social Determinants of Health Jahrom University of Medical Sciences Jahrom Iran Student Research Committee Shiraz University of Medical Sciences Shiraz Iran

ObjectiveTo 评估急救训练课程的功效因为一组 *** 学习包括了 500 位司机，随机从道路运输公司选择了。他们经历了急救训练的一堂功课，结果在量的 *** 以后在 0-3 和 4-6 月被评估，质的改进在 drivers’ 被观察在给急救的功效。另外... 详细信息

ObjectiveTo 评估急救训练课程的功效因为一组 *** 学习包括了 500 位司机，随机从道路运输公司选择了。他们经历了急救训练的一堂功课，结果在量的 *** 以后在 0-3 和 4-6 月被评估，质的改进在 drivers’ 被观察在给急救的功效。另外正确干预的率比在 0-3 月在 4-6 月是更高的。在为驱动程序的 *** 急救训练课程为在道路交通事故的 prehospital 照顾系统有益、有用以后，异常是有利地没被改进的航线管理。

关键词：院前急救培训课程功效司机伊朗道路运输企业道路交通事故驱动程序

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管道周围液流的数值模拟

管道周围液流的数值模拟

Robust multi objective H2/H∞ Control of nonlinear uncertain systems using multiple linear model and ANFIS

2011年非开挖技术会议

作者： Abolghasem Pilechi peyman Badiei 杜晶

使用一个完整的动态二维(2DV)数值方法来研究水下管道周围的流动模式,该模型求解了纳维-斯托克斯控制方程(NSE)。该方程是在σ网络结构中用有限体积方法来解决的。湍流用实际的(k-ε)模型进行模拟。工程描述了在计算区域里实际的干元素... 详细信息

使用一个完整的动态二维(2DV)数值方法来研究水下管道周围的流动模式,该模型求解了纳维-斯托克斯控制方程(NSE)。该方程是在σ网络结构中用有限体积方法来解决的。湍流用实际的(k-ε)模型进行模拟。工程描述了在计算区域里实际的干元素。由若干干元素组成的圆形管道系统被认为是一个结果已经被实验室数据证实了的模型的例子。

关键词：管道流体数值模拟

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Robust multi objective H2/H∞ Control of nonlinear uncertain...

玻璃体切割术联合人工晶状体巩膜固定术治疗眼外伤的疗效(英文)

2011 Chinese Control and Decision Conference（CCDC）

作者： Vahid Azimi peyman Akhlaghi Mohammad Hossein Kazemi graduate student of Islamic Azad University South Tehran Branch graduate student of Islamic Azad University South Tehran BranchTehranIran and member of Young Researchers Club from electrical engineering department of Shahed University

This paper considers the multi objective robust control for nonlinear systems using multiple model and adaptive neuro fuzzy inference system （ANFIS）.Nonlinear system divided to multiple linear model based on piecewise linearization around set *** each linear model multi objective robust controller is designed to guarantee both system performance and robust *** design the robust controller for each linear model,nonlinearity part of system consider as uncertainty of linear *** advantages of proposed method are that it can reduce the parameter perturbation and nonlinear uncertainty as well as increased the performance of the *** this work ANFIS is used to make decision and combine the designed controller for each linear *** result on a nonlinear benchmark plant shows the effectiveness of the proposed method.

关键词： Robust Nonlinear Multi objective ANFIS H infinity H2

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国际眼科杂志 2012年第6期12卷 1016-1018页

作者： Angela V PLoo Sujaya Singh Mohammadreza peyman Visvaraja Subrayan 马来西亚大学医学中心眼科马来西亚吉隆坡坡玛拉工艺大学眼科马来西亚吉隆

目的:探讨玻璃体切割术(pars plana vitrectomy,PPV)联合人工晶状体(intraocular lens,IOL)巩膜固定术治疗眼外伤的疗效。方法:系列病例回顾性分析。将马来西亚大学医学中心接受PPV联合IOL巩膜固定术的8例连续性病例纳入研究,其中1例患... 详细信息

目的:探讨玻璃体切割术(pars plana vitrectomy,PPV)联合人工晶状体(intraocular lens,IOL)巩膜固定术治疗眼外伤的疗效。方法:系列病例回顾性分析。将马来西亚大学医学中心接受PPV联合IOL巩膜固定术的8例连续性病例纳入研究,其中1例患者双眼均受伤,共有9眼。对现阶段视力,手术技巧,并发症及术后疗效进行分析。结果:9眼中有8眼(89%)视力提高。术后主要并发症是眼压升高,无缝线破裂。结论:PPV联合IOL巩膜固定术对有眼外伤病史的患者有非常好的疗效。

关键词：眼外伤玻璃体切割术人工晶状体巩膜固定术

Ivermectin as an adjunct treatment for hospitalized adult COVID-19 patients: A randomized multi-center clinical trial

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Asian Pacific Journal of Tropical Medicine 2021年第6期14卷 266-273页

作者： Morteza Shakhsi Niaee peyman Namdar Abbas Allami Leila Zolghadr Amir Javadi Amin Karampour Mehran Varnaseri Behzad Bijani Fatemeh Cheraghi Yazdan Naderi Fatemeh Amini Masoumeh Karamyan Mohammad Jafar YadYad Ramin Jamshidian Nematollah Gheibi Sciences and Technology Park QazvinIran Department of Surgery Qazvin University of Medical SciencesQazvinIran Department of Infectious Diseases Clinical Research Development UnitBouAliSina HospitalQazvin University of Medical SciencesQazvinIran Department of Chemistry Imam Khomeini International University QazvinIran Department of Social Sciences School of Medicine Qazvin University of Medical SciencesQazvinIran Infectious and Tropical Diseases Research Center Ahvaz Jundishapur University of Medical SciencesAhvazIran Department of Infectious Diseases Qazvin University of Medical SciencesQazvinIran Cellular and Molecular Research Center Research Institute for Prevention of Non-Communicable DiseasesQazvin University of Medical SciencesQazvinIran Department of Persian Medicine School of MedicineShiraz University of Medical SciencesShirazIran

Objective: To evaluate different doses of ivermectin in adult patients with mild COVID-19 and to evaluate the effect of ivermectin on mortality and clinical ***: A randomized, double-blind, placebo-controlled, multicenter clinical trial was performed at five hospitals. A total of 180 mild hospitalized patients with COVID-19 confirmed by PCR or chest image tests were enrolled and allocated to six arms including hydroxychloroquine 200 mg twice per day, placebo plus hydroxychloroquine 200 mg twice per day, single dose ivermectin(200 μg/kg), three low interval doses of ivermectin(200, 200, 200 μg/kg), single dose ivermectin(400 μg/kg), and three high interval doses of ivermectin(400, 200, 200 μg/kg). The primary endpoint of this trial was all-cause of mortality or clinical recovery. The radiographic findings, hospitalization and low O_2 saturation duration, and hematological variables of blood samples were analyzed. Results: A total of 16.7%(5/30) and 20.0%(6/30) patients died in arms treated with hydroxychloroquine 200 mg twice per day and placebo plus hydroxychloroquine 200 mg twice per day, respectively, and a reduction in mortality rate in patients receiving ivermectin treatment to 0%, 10%, 0% and 3.3% for arms 1-4 were observed. Risk of mortality was also decreased about 15% in the ivermectin treated arms. Conclusions: Ivermectin as an adjunct reduces the rate of mortality, time of low O_2 saturation, and duration of hospitalization in adult COVID-19 patients. The improvement of other clinical parametersshows that ivermectin, with a wide margin of safety, had a high therapeutic effect on COVID-19.

关键词： SARS-COV-2 Ivermectin Randomized controlled trial Dose-respond relationship