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Impact of PD-1/PD-L1 inhibitors on survival in stage Ⅲ non-small-cell lung cancer:A systematic review

Cancer Pathogenesis and Therapy 2024年第3期2卷 155-163页

作者： petros Roussos Magdalini Migkou National and Kapodistrian University of Athens Medical SchoolAlexandra HospitalTherapeutic ClinicLeof.Vasilissis Sofias 80Athens 11528Greece

Background:Lung cancer is the leading cause of cancer-related death,and non-small-cell lung cancer(NsCLC)is the predominant *** death 1(PD-1)and programmed death-ligand 1(PD-L1)inhibitors are widely used to treat stage IV *** study systematically reviewed the literature to clarify the impact of PD1/PD-L1 inhibitor treatment on the survival of patients with stage Ⅲ ***:Randomized phase Ⅲ clinical trials of PD-1/PD-L1 inhibitors administered to patients with stage Ⅲ NsCLC that were written in English and published between November 2012 and November 2022 were eligible for *** sources of information were the MEDLINE database(last consulted on December 26,2022),scienceDirect website(last consulted on December 26,2022),and CENTRAL register(last consulted on December 27,2022).The outcomes of interest were overall survival(Os),progression-free survival(PFs),disease-free survival(DFs),and event-free survival(EFs).Risk of bias assessments were performed according to the Cochrane Handbook for systematic Reviews of Interventions version *** findings have been assessed for certainty according to the Grading of Recommendations,Assessment,Development,and Evaluations(GRADE)***:Fourteen eligible studies and 2788 participants were included in the *** key characteristics used to group the participants were disease histology,percentage of PD-L1 expression in cancer cells,and timeline of *** and PFs were improved(risk ratio[RR]:0.85;95%confidence interval[CI]:0.75–0.96 and RR:0.75;95%CI:0.70–0.86,respectively)based on the use of PD-L1 inhibitors after chemoradiation and Os was improved using first-line PD-1 inhibitors plus chemotherapy in non-squamous NsCLC(RR:0.40;95%CI:0.17–0.95),with the GRADE results indicating moderate quality of evidence.

关键词： Non-small cell lung cancer PD-1 inhibitors PD-L1 inhibitors Immunotherapy systematic review

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Revisiting Port Regulatory Governance & substance: Towards a Holistic supply Chain Approach

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Journal of Environmental science and Engineering(B) 2023年第4期12卷 206-210页

作者： Constantınos Chlomoudıs petros pallıs Theodore stylıadıs Department of Maritime studies University of PiraeusPiraeus 18532Greece

The evolution and integration of ports in global logistics chains has altered their traditional role while has initiated restructuring processes in many ports worldwide. While most of the research addresses this issue by highlighting the need for re-positioning and redefining the role of the port within the supply chains, not much attention has been given to the structure, scope and reach as well as to the tools of regulation hat competent authorities could exploit in order to avert potential abusive actions of global powerful actors along the containerized transport chain, that would affect the competitive functioning of distinct segment or the integrity of supply chains. In this context, we propose the reconceptualization and reinforcement of the regulatory governance structures of ports on a national and international level as well as the extension of the scope of ports’ regulations along the supply chain to counterbalance the globalization, consolidation and integration of containerized transport actors.

关键词： Ports concentration supply chain integration regulation

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Anatomical steps in the conceptualisation of the urethral ligament plication(ULP),a tape-free operation for stress urinary incontinence(sUI)cure

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Gynecology and Obstetrics Clinical Medicine 2024年第2期4卷 122-125页

作者： Peter petros Retired pelvic surgeon noneSydneyNew South WalesAustralia

INTRODUCTION It is not sufficient to describe an anatomical *** answer is required to the question,‘what is it for'.salvador Gil-Vernet(1892-1987)was a famous spanish anatomist and urologist and Nobel Prize *** anatomical structure in question is the role of the pubourethral ligament(PUL)in the cure of stress urinary incontinence(sUI).The 1990 Integral Theory,on which the tension-free vaginal tape(TVT)operation is based,described two separate closure mechanisms for the urethra,both reliant on the PUL,distally and at the bladder neck,with the bladder neck the most important.

关键词： urinary bladder operation

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Grafts in Peyronie’s surgery without the use of prostheses:a systematic review and meta-analysis

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Asian Journal of Andrology 2024年第3期26卷 250-259页

作者： Anastasios Natsos Vasileios Tatanis stavros Kontogiannis sharon Waisbrod Kristiana Gkeka Mohamed Obaidad Angelis Peteinaris Konstantinos Pagonis Costas Papadopoulos Panagiotis Kallidonis Evangelos Liatsikos petros Drettas Department of Urology University of PatrasPatras 26500Greece Uroclinic Pfaeffikon 8808Switzerland Department of Medical Physics University of PatrasPatras26500Greece Department of Urology Medical University of ViennaVienna 1090Austria

Peyronie’s disease(PD)is characterized by abnormal penile curvature,and various surgical methods have been developed usingdifferent graft ***,there is currently no universal agreement on which type of graft is the *** objective of thisreview was to evaluate the available literature and identify the most effective graft material for penile curvature correction in PD.A literature search was conducted using electronic databases,including PubMed,scopus,and the Cochrane *** patients,intervention,comparison,and outcome(PICO)approach was used to define the eligibility of *** authors independentlyselected studies,evaluated them,and extracted ***-effect models using the Dersimonian–Laird method were *** were single-arm studies and had a high risk of *** mucosa grafts(BMG)were found to result in the highest penilestraightening rates and were associated with the least de novo erectile *** grafts demonstrated a high successrate in straightening despite a higher mean preoperative curvature,while Tutoplast grafts had a higher incidence of postoperativeerectile *** had the highest percentage of postoperative penile ***,the Tachosil graft showed thebest performance when preoperative curvature is taken into *** on the available literature,BMG appear to be the mosteffective for penile curvature correction in PD,but this is offset by the requirement for low preoperative *** Tachosilgraft shows the best overall performance when preoperative curvature is *** randomized clinical trials arestill needed to determine graft superiority.

关键词： erectile function penile curvature penile grafts Peyronie’s disease

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Artificial Intelligence and Computer Vision during surgery: Discussing Laparoscopic Images with ChatGPT4—Preliminary Results

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surgical science 2024年第3期15卷 169-181页

作者： savvas Hirides petros Hirides Kouloufakou Kalliopi Constantinos Hirides Department of surgery Medical School University of Nicosia Nicosia Cyprus Department of Laparoscopic & Robotic surgery Athens Medical Center Athens Greece Department of Laparoscopic & Robotic surgery IASO Maternity & Gynecology Clinic Athens Greece

Introduction: Ultrafast latest developments in artificial intelligence (ΑΙ) have recently multiplied concerns regarding the future of robotic autonomy in surgery. However, the literature on the topic is still scarce. Aim: To test a novel AI commercially available tool for image analysis on a series of laparoscopic scenes. Methods: The research tools included OPENAI CHATGPT 4.0 with its corresponding image recognition plugin which was fed with a list of 100 laparoscopic selected snapshots from common surgical procedures. In order to score reliability of received responses from image-recognition bot, two corresponding scales were developed ranging from 0 - 5. The set of images was divided into two groups: unlabeled (Group A) and labeled (Group B), and according to the type of surgical procedure or image resolution. Results: AI was able to recognize correctly the context of surgical-related images in 97% of its reports. For the labeled surgical pictures, the image-processing bot scored 3.95/5 (79%), whilst for the unlabeled, it scored 2.905/5 (58.1%). Phases of the procedure were commented in detail, after all successful interpretations. With rates 4 - 5/5, the chatbot was able to talk in detail about the indications, contraindications, stages, instrumentation, complications and outcome rates of the operation discussed. Conclusion: Interaction between surgeon and chatbot appears to be an interesting frontend for further research by clinicians in parallel with evolution of its complex underlying infrastructure. In this early phase of using artificial intelligence for image recognition in surgery, no safe conclusions can be drawn by small cohorts with commercially available software. Further development of medically-oriented AI software and clinical world awareness are expected to bring fruitful information on the topic in the years to come.

关键词： Artificial Intelligence surgery Image Recognition Autonomous surgery

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Automation 5.0: The Key to systems Intelligence and Industry 5.0

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IEEE/CAA Journal of Automatica sinica 2024年第8期11卷 1723-1727页

作者： Ljubo Vlacic Hailong Huang Mariagrazia Dotoli Yutong Wang petros A.Ioannou Lili Fan Xingxia Wang Raffaele Carli Chen Lv Lingxi Li Xiaoxiang Na Qing-Long Han Fei-Yue Wang Institute of Intelligent and Integrated systems and the school of Engineering and Built Environment Griffith UniversityNathanQLD 4111Australia Department of Aeronautical and Aviation Engineering The Hong Kong Polytechnic UniversityHong KongChina Department of Electrical and Information Engineering Polytechnic of Bari70126 BariItaly state Key Laboratory of Multimodal Artificial Intelligence systems Institute of AutomationChinese Academy of SciencesBeijing 100190and also with the Qingdao Academy of Intelligent IndustriesQingdao 266114China Department of Electrical Engineering-systems University of Southern CaliforniaLos AngelesCA 90007 USA school of Automation Beijing Institute of TechnologyBeijing 100081China state Key Laboratory of Multimodal Artificial Intelligence systems Institute of AutomationChinese Academy of SciencesBeijing 100190 school of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049 Beijing Huairou Academy of Parallel sensing Beijing 101499China school of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore Department of Electrical and Computer Engineering Purdue School of Engineering and TechnologyIndiana University-Purdue University IndianapolisIndianapolisIN 46202 USA Department of Engineering University of CambridgeCB21TN CambridgeU.K. school of science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia state Key Laboratory for Management and Control of Complex systems Chinese Academy of SciencesBeijing 100190 school of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Dazhou Artificial Intelligence Institute Dazhouand the Faculty of Innovation EngineeringMacao University of Science and TechnologyMacao 999078China

AUTOMATION has come a long way since the early days of mechanization,i.e.,the process of working exclusively by hand or using animals to work with *** rise of steam engines and water wheels represented the first generation of industry,which is now called Industry Citation:***,***,***,***,***,***,***,***,***,***,***,Q.-***,and F.-***,“Automation 5.0:The key to systems intelligence and Industry 5.0,”IEEE/CAA ***,vol.11,no.8,pp.1723-1727,Aug.2024.

关键词： Automation machinery intelligence

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Determinants of prognosis in metastatic urothelial carcinoma:a review of the literature

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 240-252页

作者： Gavin Hui Ali Raza Khaki petros Grivas Department of Medicine Stanford UniversityStanfordCA 94304USA Division of Oncology Department of MedicineStanford UniversityStanfordCA 94304USA Division of Medical Oncology Department of MedicineUniversity of WashingtonFred Hutchinson Cancer CenterSeattleWA 98109USA

The treatments for metastatic urothelial carcinoma(mUC)have advanced substantially since *** tools have been used to inform clinical trial designs and treatment ***,prognostic tools were developed for mUC based on older clinical trials involving cytotoxic *** novel therapies emerged,there are studies investigating prognostic factors in the era of immune checkpoint inhibitors(ICI),antibody-drug conjugates,and targeted *** review aims to highlight prognostic factors in mUC and their potential in clinical decision-making and *** the setting of chemotherapy,patient performance status,site of metastatic burden,and specific laboratory findings were found to have prognostic value in *** the era of ICI,newer models identified variables such as neutrophil to lymphocyte ratio,platelet count,and lactate dehydrogenase to also have potential prognostic *** addition to clinical biomarkers,molecular biomarkers,such as PD-L1 assay and fibroblast growth factor receptor 2 and 3 genomic testings,may have promising prognostic and predictive *** methods of identifying clinical and molecular prognostic factors involve clinician *** large complex datasets emerge,machine learning and artificial intelligence may help data analysis and detect important prognostic *** careful validation,such machine learning-based strategies may help create more robust prognostic and/or predictive models in the future.

关键词： Bladder cancer biomarkers health outcomes nomogram prediction prognosis urothelial carcinoma urinary tract cancers

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Minimally invasive Fothergill-Manchester operation with connective tissue conservation

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Gynecology and Obstetrics Clinical Medicine 2022年第2期2卷 52-56页

作者： Xiuli sun Ray Hodgson Jianliu Wang Peter petros Gynecologic Department Peking University People's HospitalBeijingChina University of NsW SydneyAustralia University of Western Australia school of Engineering and Mathematical sciences WA

Poor cure rates for prolapse repair reported by the PROsPECT TRIAL1 and total mesh bans after the Cumberlage Report,2 leave few options for vaginal surgery for urogynecologists *** remaining option,the Fothergill-Manchester Repair began as a modification of the Donald operation.3 Fothergill emphasized the role of cardinal ligament(CL)and uterosacral(UsL)ligaments in uterine prolapse repair.4 The classical Manchester operation involves full thickness inverted V-shaped vaginal excisions(Fig.1).The cervix is dilated and if elongated,it is *** are severed and sutured to the anterior part of *** may also be *** sutures bring vaginal flaps into the cervical *** is *** operation can be traumatic,some even reported a large quantity blood loss as high as 850 ml,5 possibly related to severing of CLs which contains uterine artery branches and also,failure of sturmdorf sutures to control bleeding from cervical amputation.

关键词： operation suture Manchester

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Integrating omics technologies for improved quality and safety of seafood products

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Aquaculture and Fisheries 2023年第4期8卷 457-462页

作者： Deborah M Power petros Taoukis Dimitra Houhoula Theofania Tsironi Emmanouil Flemetakis Comparative Endocrinology and Integrative Biology Group Centro de Ciencias do MarUniversity of AlgarveFaroPortugal International Institution of Marine science Shanghai Ocean UniversityShanghaiChina Laboratory of Food Chemistry and Technology School of Chemical EngineeringNational Technical University of AthensGreece University of West Attica School of Food SciencesDepartment of Food Science&TechnologyGreece Agricultural University of Athens Department of Food Science and Human NutritionLaboratory of Food Process EngineeringGreece Agricultural University of Athens Department of BiotechnologyLaboratory of Molecular BiologyGreece

An essential aspect of product quality of aquatic foods is the rapid and accurate identification of bacterial *** this perspective omics technologies prove to be very useful in the assessment of the quality and safety of seafood *** technologies can identify and detect low levels of contamination by pathogenic and spoilage bacteria and can be used to study the effects caused by processing and storage of seafood *** integration of food processing with the monitoring of the microbial characteristics using conventional microbiological assays,coupled to molecular techniques may establish the baseline for the development of quicker and more sensitive and reliable methods for seafood safety *** use of combined omics technologies,including metagenomics,proteomics and metabolomics,coupled to conventional quality indices such as colour,texture and flavour offer a new tool for novel processing optimization to ensure seafood *** aim of this brief review is to outline how omics technologies can generate novel tools for integration into seafood processing and quality *** that the main aspect of the review is the improvement of safety and quality of the final product,from production to consumption,emphasis is given to microbial identification and metabolite detection,the evaluation of the allergenic capacity of fish and seafood and optimization of postharvest pro*** of omics for identification of potential microalgal products of relevance to seafood quality and safety is also considered.

关键词： Microbiome Proteome Fish Microalgae seafood Quality Molecular methods

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Model Reference Adaptive Control for Networked Distributed systems with strong Interconnections and Communication Delays

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Journal of systems science & Complexity 2018年第1期31卷 38-68页

作者： LYMPEROPOULOs Georgios IOANNOU petros Department of Electrical Engineering University of Southern California

在最近的年里，联网了系统(NDCs ) 收到了的分布式的控制研究注意。如此的系统面对的二主要挑战是在通讯网络和在代理人之间的强壮的互联的效果的可能的延期。这篇论文考虑在在它的代理人之间的通讯网络，以及强壮的互联有延期的 NDCs... 详细信息

在最近的年里，联网了系统(NDCs ) 收到了的分布式的控制研究注意。如此的系统面对的二主要挑战是在通讯网络和在代理人之间的强壮的互联的效果的可能的延期。这篇论文考虑在在它的代理人之间的通讯网络，以及强壮的互联有延期的 NDCs。控制目的是让每个代理人高效地由 attenuating 追踪一个引用模型经由反馈的强壮的互联的效果基于推迟的信息。首先，作者假设每个代理人知道它的自己的动力学，以及互联参数，但是与一些通讯延期在它的邻居的状态附近收到信息。作者建议一个分布式的控制计划并且证明如果互联能被削弱并且如果通讯延期是足够小的，那么，建议计划保证每个代理人的追踪的错误与取决于削弱的互联和延期的尺寸的界限被围住，并且作为这些无常还原剂归结为零到零。作者然后考虑尽管有合作，在代理人之间的互联是未知的并且州的信息分享的一种更现实主义的状况。为这个盒子，作者建议一个分布式的适应控制计划并且证明建议计划保证追踪的错误被围住并且在关于削弱的互联和延期的尺寸的吝啬的方形的意义小，如果削弱的互联和时间延期是足够小的。作者然后认为每个代理人也不知道的盒子是它的动力学也不互联矩阵。为这诉讼，作者建议一个分布式的适应控制计划并且证明建议计划保证追踪的错误被围住并且在提供的吝啬的方形的意义小削弱的互联和时间延期是足够小的。最后，在场的作者介绍建议计划的适用性和有效性的一个解说性的例子。

关键词：通讯网络适应控制分布式系统联网建模控制计划代理人

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