检索结果-南通市图书馆

River management system development in Asia based on Data Integration and Analysis System(DIAS) under GEOSS

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2015年第1期58卷 76-95页

作者： Toshio KOIKE petra KOUDELOva Patricia Ann JARaniLLA-SANCHEZ Asif Mumtaz BHATTI Cho Thanda NYUNT Katsunori TAMAGAWA Department of Civil Engineering River and Environmental Engineering Laboratorythe University of Tokyo Department of Civil and Environmental Engineering Hydraulic Engineering LaboratoryHiroshima University

This paper introduces the process of development and practical use implementation of an advanced river management system for supporting integrated water resources management practices in Asian river basins under the framework of GEOSS Asia water cycle initiative （AWCI）. The system is based on integration of data from earth observation satellites and in-situ networks with other types of data, including numerical weather prediction model outputs, climate model outputs, geographical infor- mation, and socio-economic data. The system builds on the water and energy budget distributed hydrological model （WEB-DHM） that was adapted for specific conditions of studied basins, in particular snow and glacier phenomena and equipped with other functions such as dam operation optimization scheme and a set of tools for climate change impact assess- ment to be able to generate relevant information for policy and decision makers. In situ data were archived for 18 selected ba- sins at the Data Integration and Analysis System （DIAS） of Japan and demonstration projects were carded out showing poten- tial of the new system. It included climate change impact assessment on hydrological regimes, which is presently a critical step for sound management decisions. Results of such three case studies in Pakistan, Philippines, and Vietnam are provided here.

关键词： integrated water resources management tools climate change impact assessment Asian river basins Asian Water Cycle Initiative

Effects of Organic Matter-Rich Amendments on Selenium Mobility in Soils

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pedosphere 2019年第6期29卷 740-751页

作者： petra SMAZíKová Luká? PRAUS Jirina SZáKová Jana TREMLová Ale? HANC Pavel TLUSTOS Department of Agro-Environmental Chemistry and Plant Nutrition Faculty of Agrobiology Food and Natural Resources Czech University of Life Sciences Prague

Soil organic matter (SOM) plays an important role in the Se dynamics in soil. The potential effects of vermicompost and digestate as important sources of SOM on selenium (Se) mobility were assessed in this study. Three soils differing in their physicochemical parameters, fluvisol, chernozem, and luvisol, were chosen, and three types of vermicomposts based on various bio-waste materials as digestate (vermicompost 1), kitchen waste with woodchips (vermicompost 2), and garden bio-waste (vermicompost 3) were used due to their high organic matter content. Additionally, digestate samples alone were applied. To evaluate the potential effect of vermicompost application on sorption characteristics of soils, batch sorption experiments were performed. The results showed a predominant effect on Se species in the soils, where selenite sorbed more intensively compared to selenate, regardless of the soil and ameliorative material applied. In the control, the soil sorption ability of selenite tended to decrease in the order: fluvisol > luvisol > chernozem. However, these differences were not significant. Moreover, the effects of the ameliorative materials depended on both soil and amendment used. In fluvisol, all the amendment applications resulted in a decrease in distribution coefficient ( K d values) of Se, whereas in chernozem, this effect was observed only for the digestate-based vermicompost 1. Increasing K d levels were reported in luvisol treated with digestate;the application of garden bio-waste-based vermicompost 3 tended to decrease the K d values. Further studies are required on long-term effects of these amendments on Se mobility in soils and the role of individual organic matter fractions in this context.

关键词： Batch sorption experiments Bio-waste material Selenite Selenate Sorption isotherms Vermicompost

Importance of genetic polymorphisms in liver transplantation outcomes

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2020年第12期26卷 1273-1285页

作者： Tomislav Kelava petra Turcic Antonio Markotic Ana Ostojic Dino Sisl Anna Mrzljak Laboratory for Molecular Immunology Croatian Institute for Brain ResearchUniversity of ZagrebSchool of MedicineZagreb 10000Croatia Department of Pharmacology Faculty of Pharmacy and Biochemistry of University of ZagrebZagreb 10000Croatia Center for Clinical Pharmacology University Clinical Hospital MostarMostar 88000Bosnia and Herzegovina Department of Medicine Merkur University HospitalZagreb 10000Croatia Department of Medicine Merkur University HospitalSchool of MedicineUniversity of ZagrebZagreb 10000Croatia

Although,liver transplantation serves as the only curative treatment for patients with end-stage liver diseases,it is burdened with complications,which affect survival *** addition to clinical risk factors,contribution of recipient and donor genetic prognostic markers has been extensively studied in order to reduce the burden and improve the *** of single nucleotide polymorphisms(SNPs)is one of the most important tools in development of personalized transplant *** provide a better insight in recent developments,we review the studies published in the last three years that investigated an association of recipient or donor SNPs with most common issues in liver transplantation:Acute cellular rejection,development of new-onset diabetes mellitus and non-alcoholic fatty liver disease,hepatocellular carcinoma recurrence,and tacrolimus concentration *** studies confirmed previously established SNP prognostic factors,such as PNPLA3 rs738409 for nonalcoholic fatty liver disease development,or the role of CYP3A5 rs776746 in tacrolimus concentration *** also identified several novel SNPs,with a reasonably strong association,which have the potential to become useful predictors of post-transplant ***,as the studies were typically conducted in one center on relatively low-to-moderate number of patients,verification of the results in other centers is warranted to resolve these ***,of 29 reviewed studies,28 used gene candidate approach and only one implemented a genome wide association *** wide association multicentric studies are needed to facilitate the development of personalized transplant medicine.

关键词： Single nucleotide polymorphisms Liver transplantation Acute rejection Non-alcoholic fatty liver disease New-onset diabetes mellitus Hepatocellular carcinoma Tacrolimus

All Roads Lead to Susceptibility: The Many Modes of Action of Fungal and Oomycete Intracellular Effectors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plant Communications 2020年第4期1卷 1-12页

作者： Qin He Hazel McLellan petra C.Boevink Paul R.J.Birch Key Laboratory of Horticultural Plant Biology(HZAU) Ministry of EducationKey Laboratory of Potato Biology and Biotechnology(HZAU)Ministry of Agriculture and Rural AffairsHuazhong Agricultural UniversityWuhanHubei 430070China Division of Plant Sciences School of Life SciencesUniversity of Dundee(at JHI)InvergowrieDundee DD25DAUK Cell and Molecular Sciences James Hutton InstituteInvergowrieDundee DD25DAUK These authors contributed equally to this article.

The ability to secrete effector proteins that can enter plant cells and manipulate host processes is a key determinant of what makes a successful plant ***,we review intracellular effectors from filamentous(fungal and oomycete)phytopathogens and the host proteins and processes that are targeted to promote *** cover contrasting virulence strategies and effector modes of *** pathogen effectors alter the fates of host proteins that they target,changing their stability,their activity,their location,and the protein partners with which they *** effectors inhibit target activity,whereas others enhance or utilize it,and some target multiple host *** discuss the emerging topic of effectors that target negative regulators of immunity or other plant proteins with activities that support *** also highlight the commonly targeted host proteins that are manipulated by effectors from multiple pathogens,including those representing different kingdoms of life.

关键词： effectors fungi oomycete immunity defense susceptibility factor

Interferon-α response in chronic hepatitis B-transfected HepG2.2.15 cells is partially restored by lamivudine treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2007年第2期13卷 228-235页

作者： Shi-He Guan Mengji Lu petra Grünewald Michael Roggendorf Guido Gerken Joerg F Schlaak Department of Gastroenterology and Hcpatology University Hospital of Esscn Esscn Germany Institute of Virology University Hospital of Essen Essen Germany Department of Laboratory Medicine the first Affiliated Hospital of Anhui Medical University China

AIM：To characterize the IFN-response and its modulation by the antiviral compound lamivudine in HBV- transfected HepG2.2.15 cells. METHODS： HepG2.2.15 and HepG2 cells were stimulated with various concentrations of IFN-α 2a in the presence or absence of lamivudine. Then, total RNA was extracted and analysed by customised cDNA arrays and northern blot for interferon-inducible genes （ISGs）. In addition, cellular proteins were extracted for EMSA and western blot. HBV replication was assessed by southern blot or ELISAs for HBsAg and HBeAg. RESULTS： Two genes （MxA, CigS） with completely abolished and 4 genes （IFITM1, -2, -3, and 6-16） with partially reduced IFN-responses were identified in HepG2.2.15 cells. In 2 genes （IFITM1, 6-16）, the response to IFN-α could be restored by treatment with lamivudine. This effect could not be explained by a direct modulation of the Jak/Stat signalling pathway since EMSA and western blot experiments revealed no suppression of Statl activation and ISGF3 formation after stimulation with IFN-α in HepG2.2.15 compared to HepG2 cells. CONCLUSION： These results are consistent with the assumption that chronic hepatitis B may specifically modulate the cellular response to IFN by a selective blockage of some ISGs. Antiviral treatment with lamivudine may partially restore ISG expressionby reducing HBV gene expression and replication.

关键词： Hepatitis B IFN-α Gene expression Larnivudine

Agriculture and Water Sources Protection Zones in the Czech Republic

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Agricultural Science and Technology(A) 2012年第10期2卷 1155-1161页

作者： petra Oppeltova Mendel University in Brno Zemedelska 1 Brno 61300 Czech Republic

The area of interest is located in the South Moravia Region at the confluence of the Jihlava, Oslava and Rokytn^i rivers. Ivan^ice spring area comprises a series of hydrologic boreholes, it is the main water source for water supply of Ivan^ice and Rosice towns and provides water for 30,000 inhabitants. The risk analysis was created on the basis of water quality monitoring, hydrogeological assessment and terrain exploration and a revision of protection zones was proposed. The spring area is situated in nitrate vulnerable zones and recently nitrate concentrations have been decreasing. Water quality evaluation results： high concentration of manganese and iron, sometimes higher concentration of ammonium and COD. This area is intensively used for agriculture and it is necessary to make a compromise solution during protection zones proposal, The regime in protection zones can not affect manganese and iron concentration （their origin is in the natural geological environment）. Therefore, water treatment plant is in operation and its modernization is proposed. Furthermore, the paper deals with spring area intensification construction of a new hydrologic borehole, and managed and unmanaged infiltration of surface water. The proposal of protection zones revision consists of reduction to a 2nd level protection zone.

关键词： Water quality ground water source of drinking water good agricultural practice nitrate vulnerable zones CzechRepublic.

Therapeutic drug monitoring in inflammatory bowel disease:The dawn of reactive monitoring

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第37期27卷 6231-6247页

作者： Farah Albader petra Anna Golovics Lorant Gonczi Talat Bessissow Waqqas Afif Peter Laszlo Lakatos Department of Internal Medicine McGill UniversityMontreal H3G1A4QuebecCanada Division of Gastroenterology Hungarian Defence ForcesMedical CentreBudapest H-1062Hungar Division of Gastroenterology McGill UniversityMontreal H3G 1A4QuebecCanada First Department of Medicine Semmelweis UniversityBudapest H-1083Hungary Division of Gastroenterology McGill University Health CentreMontreal H3G 1A4QuebecCanada

Inflammatory bowel disease(IBD)is a chronic condition that significantly affects the quality of life of its *** drugs have been the mainstay treatment in the management of IBD patients but despite their significant contribution,there remains a proportion of patients that do not respond or lose response to *** drug monitoring(TDM)involves measuring levels of serum drug concentrations and anti-drug *** of biologic drugs initially emerged to understand treatment failure in other immune mediated inflammatory *** was then introduced in IBD to rationalize primary non-response or secondary loss of response,given that low serum drug concentrations or the formation of anti-drug antibodies are variably associated with treatment *** aim of this narrative review is to provide an overview regarding the current use of TDM in clinical practice and to present the evidence available regarding its use in both proactive and reactive clinical settings in preventing and managing treatment *** review also presents the existing evidence regarding the association of various clinical outcomes with specific thresholds of drug concentrations,in everyday practice.A narrative review of published articles and conference abstracts regarding the use of TDM in IBD management,through an electronic search using PubMed and *** has proven to be superior and more cost effective in guiding management of patients with treatment failure compared to empiric dose escalation or change in *** a trend towards an association between clinical outcomes and drug concentrations,proactive TDM based strategies have not been shown to achieve clear benefit in long-term *** the clinical setting,TDM has proven to be useful in managing IBD patients,and its use in the reactive setting,as an additional tool to help manage patients with treatment failure,is being promoted as newer guidelines and consensus groups implement

关键词： Therapeutic drug monitoring Inflammatory bowel disease Biologic therapies Loss of response Reactive Proactive

Non-invasive prediction of persistent villous atrophy in celiac disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2020年第26期26卷 3780-3791页

作者： Barbora Packova petra Kovalcikova Zdenek Pavlovsky Daniel Bartusek Jitka Prokesova Jiri Dolina Radek Kroupa Department of Gastroenterology and Internal Medicine University Hospital BrnoFaculty of MedicineMasaryk UniversityBrno 62500Czech Republic Institute of Biostatistics and Analyses Faculty of MedicineMasaryk UniversityBrno 62500Czech Republic Department of Pathology University Hospital BrnoFaculty of MedicineMasaryk UniversityBrno 62500Czech Republic Department of Radiology and Nuclear Medicine University Hospital BrnoFaculty of MedicineMasaryk UniversityBrno 62500Czech Republic

BACKGROUND Celiac disease(CD)is an immune-mediated enteropathy that is primarily treated with a gluten-free diet(GFD).Mucosal healing is the main target of the ***,duodenal biopsy is the only way to evaluate mucosal healing,and noninvasive markers are *** elevation of anti-tissue transglutaminase antibodies(aTTG)is not an ideal predictor of persistent villous atrophy(va).Data regarding prediction of atrophy using anti-deamidated gliadin peptide antibodies(aDGP)and abdominal ultrasonography are *** To evaluate the ability of aTTG,aDGP,small bowel ultrasonography,and clinical and laboratory parameters in predicting persistent va determined using *** Patients with CD at least 1 year on a GFD and available follow-up duodenal biopsy,levels of aTTG and aDGP,and underwent small bowel ultrasonography were included in this retrospective cohort *** evaluated the sensitivity,specificity,and positive and negative predictive values of aTTG,aDGP,small bowel ultrasonography,laboratory and clinical parameters to predict persistent va.A receiver operating characteristic(ROC)curve analysis of antibody levels was used to calculate cut off values with the highest accuracy for atrophy *** Complete data were available for 82 patients who were followed up over a period of four years(2014-2018).Among patients included in the analysis,women(67,81.7%)were predominant and the mean age at diagnosis was 33.8 *** biopsy revealed persistent va in 19 patients(23.2%).The sensitivity and specificity of aTTG using the manufacturer’s diagnostic cutoff value to predict atrophy was 50%and 85.7%,respectively,while the sensitivity and specificity of aDGP(using the diagnostic cutoff value)was 77.8%and 75%,*** of an optimal cutoff value using ROC analysis(13.4 U/mL for aTTG IgA and 22.6 U/mL for aDGP IgA)increased the accuracy and reached 72.2%[95%confidence interval(CI):46.5-90.3]sensitivity and 90%(9

关键词： Celiac disease Villous atrophy Anti-tissue transglutaminase antibodies Antideamidated gliadin peptide antibodies Abdominal ultrasound Gluten-free diet

Viewpoints of the target population regarding barriers and facilitators of colorectal cancer screening in the Czech Republic

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2019年第9期25卷 1132-1141页

作者： Radek Kroupa Monika Ondrackova petra Kovalcikova Milan Dastych Tomas Pavlik Lumir Kunovsky Jiri Dolina Department of Gastroenterology and Internal Medicine University Hospital Brno and Faculty of Medicine Masaryk University Department of Hematology Oncology and Internal Medicine University Hospital Brno and Faculty of Medicine Masaryk University Institute of Biostatistics and Analyses Faculty of MedicineMasaryk University

BACKGROUND Public awareness of colorectal cancer(CRC) and uptake of CRC screening remain challenges. The viewpoints of the target population(asymptomatic individuals older than 50) regarding CRC screening information sources and the reasons for and against participation in CRC screening are not well known in the Czech Republic. This study aimed to acquire independent opinions from the target population independently on the health *** To investigate the viewpoints of the target population regarding the source of information for and barriers and facilitators of CRC *** A survey among relatives(aged 50 and older) of university students was conducted. Participants answered a questionnaire about sources of awareness regarding CRC screening, reasons for and against participation, and suggestions for improvements in CRC screening. The effect of certain variables on participation in CRC screening was *** Of 498 participants, 478(96%) respondents had some information about CRC screening and 375(75.3%) had participated in a CRC screening test. General practitioners(GPs)(n = 319, 64.1%) and traditional media(n = 166, 33.3%) were the most common information sources regarding CRC screening. A lack of interest or time and a fear of colonoscopy or positive results were reported as reasons for non-participation. Individuals aged > 60 years [adjusted odds ratio(aOR) = 2.30, 95% confidence interval(CI)(1.42-3.71), P = 0.001], females(aOR =1.95, 95%CI(1.26-3.01) P = 0.003), and relatives of CRC patients(aOR = 4.17,95%CI(1.82-9.58) P = 0.001) were more likely to participate in *** regarding screening provided by physicians-GPs:(aOR = 8.11,95%CI(4.90-13.41), P oviding better explanations regarding screening procedures and equipment for stool capturing could improve CRC screening *** GPs

关键词： Colorectal cancer Screening Colonoscopy General practitioner Patient compliance Fecal occult blood test