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Treatment strategies for colorectal carcinoma with synchronous liver metastases: Which way to go?

World Journal of Gastroenterology 2015年第22期21卷 7014-7021页

作者： Peter Ihnát petr vávra Pavel Zonca Department of Surgical Studies Faculty of MedicineUniversity of Ostrava Department of Surgery University Hospital Ostrava

AIM: To offer an up-to-date review of all availabletreatment strategies for patients with synchronous colorectal liver metastases(CLM).METHODS: A comprehensive literature search was performed to identify articles related to the management of patients with synchronous CLM. A search of the electronic databases PubMed, MEDLINE, and Google Scholar was conducted in September *** following search terms were used: synchronous colorectal liver metastases, surgery, stage Ⅳ colorectal cancer, liver-first approach, and up-front *** terms were employed in various combinations to maximize the search. Only articles written in English were included. Particular attention was devoted to studies and review articles that were published within the last six years(2009-2014). Additional searches of the cited references from primary articles were performed to further improve the review. The full texts of all relevant articles were accessed by two independent ***: Poor long-term outcomes of patients with synchronous CLM managed by a traditional treatment strategy have led to questions about the timing and sequence of possible therapeutic interventions. Thus,alternative paradigms called reverse strategies have been proposed. Presently, there are four treatment strategies available:(1) primary first approach(or traditional approach) comprises resection of the primary colorectal tumor followed by chemotherapy;subsequent liver resection is performed 3-6 mo after colorectal resection(provided that CLM are still resectable);(2) simultaneous resection of the primary colorectal tumor and CLM during a single operation presents intriguing options for a highly select group of patients, which can be associated with significant postoperative morbidity;(3) liver-first(or chemotherapy-first) approach comprises preoperative chemotherapy(3-6 cycles) followed by liver resection,adjuvant chemotherapy, and resection of the primary colorectal tumor(it is best suited for patient

关键词： Colorectal cancer Liver-first approach Reverse strategy Simultaneous resection Up-fronthepatectomy

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Machine Learning Techniques in Predicting Hot Deformation Behavior of Metallic Materials

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 713-732页

作者： petr Opela Josef Walek Jaromír Kopecek Department of Metallurgical Technologies Faculty of Materials Science and TechnologyVSB–Technical University of OstravaOstrava70800Czech Republic FZU—Institute of Physics of the Czech Academy of Sciences Prague18200Czech Republic

In engineering practice,it is often necessary to determine functional relationships between dependent and independent *** relationships can be highly nonlinear,and classical regression approaches cannot always provide sufficiently reliable ***,Machine Learning(ML)techniques,which offer advanced regression tools to address complicated engineering issues,have been developed and widely *** study investigates the selected ML techniques to evaluate their suitability for application in the hot deformation behavior of metallic *** ML-based regression methods of Artificial Neural Networks(ANNs),Support vector Machine(SvM),Decision Tree Regression(DTR),and Gaussian Process Regression(GPR)are applied to mathematically describe hot flow stress curve datasets acquired experimentally for a medium-carbon *** the GPR method has not been used for such a regression task before,the results showed that its performance is the most favorable and practically unrivaled;neither the ANN method nor the other studied ML techniques provide such precise results of the solved regression analysis.

关键词： Machine learning Gaussian process regression artificial neural networks support vector machine hot deformation behavior

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Application of comprehensive two-dimensional gas chromatography with masss pectrometric detection for the analysis of selected drug residues in wastewater and surface water

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Journal of Environmental Sciences 2013年第1期25卷 204-212页

作者： petr Lacina Ludmila Mravcov Milada vvrov Institute of Chemistry and Technology of Environmental Protection Faculty of ChemistryBrno University of Technology Geotest a.s.Smahova 1244/112Brno 62700Czech Republic

Pharmaceutical residues have become tightly controlled environmental contaminants in recent years, due to their increasing concentration in environmental components. This is mainly caused by their high level of production and everyday consumption. Therefore there is a need to apply new and sufficiently sensitive analytical methods, which can detect the presence of these contaminants even in very low concentrations. This study is focused on the application of a reliable analytical method for the analysis of 10 selected drug residues, mainly from the group of non-steroidal anti-inflammatory drugs （salicylic acid, acetylsalicylic acid, ctofibric acid, ibuprofen, acetaminophen, caffeine, naproxen, mefenamic acid, ketoprofen, and dicofenac）, in wastewaters and surface waters. This analytical method is based on solid phase extraction, derivatization by N-methyl-N-（trimethylsilyl）trifluoroacetamide （MSTFA） and finally analysis by comprehensive two-dimensional gas chromatography with Time-of-Flight mass spectrometric detection （GC×GC- TOF MS）. Detection limits ranged from 0.18 to 5 ng/L depending on the compound and selected matrix. The method was successfully applied for detection of the presence of selected pharmaceuticals in the Svratka River and in wastewater from the wastewater treatment plant in Brno-Modrice, Czech Republic. The concentration of pharmaceuticals varied from one to several hundreds of ng/L in surface water and from one to several tens of μg/L in wastewater.

关键词： non-steroidal anti-inflammatory drugs solid phase extraction derivatization comprehensive two-dimensional gaschromatography surface water wastewater

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Classification of Spectra of Emission Line Stars Using Machine Learning Techniques

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International Journal of Automation and computing 2014年第3期11卷 265-273页

作者： Pavla Bromová petr koda Jaroslav vázn Faculty of Information Technology Brno University of Technology Astronomical Institute of the Academy of Sciences of the Czech Republic

Advances in the technology of astronomical spectra acquisition have resulted in an enormous amount of data available in world-wide telescope archives. It is no longer feasible to analyze them using classical approaches, so a new astronomical discipline,astroinformatics, has emerged. We describe the initial experiments in the investigation of spectral line profiles of emission line stars using machine learning with attempt to automatically identify Be and B[e] stars spectra in large archives and classify their types in an automatic manner. Due to the size of spectra collections, the dimension reduction techniques based on wavelet transformation are studied as well. The result clearly justifies that machine learning is able to distinguish different shapes of line profiles even after drastic dimension reduction.

关键词： Be star stellar spectrum feature extraction dimension reduction discrete wavelet transform classification support vector machines(SvM) clustering.

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High‑throughput sequencing view on the magnitude of global fungal diversity

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Fungal Diversity 2022年第3期114卷 539-547页

作者： petr Baldrian Tomášvětrovský Clémentine Lepinay petr Kohout Laboratory of Environmental Microbiology Institute of Microbiology of the Czech Academy of SciencesVídeňská108314220 Prague 4Czech Republic

High-throughput DNA sequencing has dramatically transformed several areas of biodiversity research including *** limitations,high-throughput sequencing is nowadays a predominant method to characterize the alpha and beta diversity of fungal *** the papers utilizing high-throughput sequencing approaches to study natural habitats in terrestrial ecosystems worldwide,>200 studies published until 2019 have generated over 250 million sequences of the primary mycological metabarcoding marker,the nuclear ribosomal internal transcribed spacer 2(ITS2).Here we show that at a 97%sequence similarity threshold,the total richness of non-singleton fungal taxa across the studies published so far is 1.08 million,mostly Ascomycota(56.8%of the taxa)and Basidiomycota(36.7%of the taxa).The Chao-1 estimate of the total extant fungal diversity based on this dataset is 6.28 million taxa,representing a conservative estimate of global fungal species *** and litter represent the habitats with the highest alpha diversity of fungi followed by air,plant shoots,plant roots and deadwood with Chao-1 predictions,for samples containing 5000 sequences,of 1219,569,392,228,215 and 140 molecular species,*** on the high-throughput sequencing data,the highest proportion of unknown fungal species is associated with samples of lichen and plant *** considering the use of high-throughput sequenc-ing for the estimation of global fungal diversity,the limitations of the method have to be taken into account,some of which are sequencing platform-specific while others are inherent to the metabarcoding approaches of species *** this respect,high-throughput sequencing data can complement fungal diversity predictions based on methods of traditional mycology and increase our understanding of fungal biodiversity.

关键词： High-throughput sequencing Metabarcoding Internal transcribed spacer Alpha diversity Meta-analysis

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Physics and applications of charged domain walls

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npj Computational Materials 2018年第1期4卷 119-129页

作者： petr S.Bednyakov Boris I.Sturman Tomas Sluka Alexander K.Tagantsev petr v.Yudin Institute of Physics Czech Academy of SciencesNa Slovance 218221 Prague 8Czech Republic Institute of Automation and Electrometry SB RAS Koptyug ave.1Novosibirsk 630090Russia CREAL3D SA Chemin du Paqueret 1 ACH-1025 Saint-SulpiceSwitzerland Swiss Federal Institute of Technology(EPFL) CH-1015 LausanneSwitzerland Ioffe Institute 194021 St.PetersburgRussia

The charged domain wall is an ultrathin(typically nanosized)interface between two domains;it carries bound charge owing to a change of normal component of spontaneous polarization on crossing the *** contrast to hetero-interfaces between different materials,charged domain walls(CDWs)can be created,displaced,erased,and recreated again in the bulk of a *** of the bound charge with free carriers is often necessary for stability of CDWs,which can result in giant two-dimensional conductivity along the *** in nominally insulating ferroelectrics,the concentration of free carriers at the walls can approach metallic ***,CDWs can be viewed as ultrathin reconfigurable strongly conductive sheets embedded into the bulk of an insulating *** feature is highly attractive for future *** last decade was marked by a surge of research interest in *** resulted in numerous breakthroughs in controllable and reproducible fabrication of CDWs in different materials,in investigation of CDW properties and charge compensation mechanisms,in discovery of light-induced effects,and,finally,in detection of giant two-dimensional *** present review is aiming at a concise presentation of the main physical ideas behind CDWs and a brief overview of the most important theoretical and experimental findings in the field.

关键词： walls breakthrough nominal

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A Jacobi Collocation Method for the Fractional Ginzburg-Landau Differential Equation

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Advances in Applied Mathematics and Mechanics 2020年第1期12卷 57-86页

作者： Yin Yang Jianyong Tao Shangyou Zhang petr v.Sivtsev Hunan Key Laboratory for Computation and Simulation in Science and Engineering Key Laboratory of Intelligent Computing&Information Processing of Ministry of EducationSchool of Mathematics and Computational ScienceXiangtan UniversityXiangtanHunan 411105China Department of Mathematical Sciences University of DelawareNewarkDE 19716USA International Scientific and Research Laboratory of Multiscale Model Reduction and High Performance Computing Ammosov North Eastern UniversityKulakovskogo677013YakutskRussia

In this paper,we design a collocation method to solve the fractional Ginzburg-Landau equation.A Jacobi collocation method is developed and implemented in two ***,we space-discretize the equation by the Jacobi-Gauss-Lobatto collocation(JGLC)method in one-and two-dimensional *** equation is then converted to a system of ordinary differential equations(ODEs)with the time variable based on *** second step applies the Jacobi-Gauss-Radau collocation(JGRC)method for the time ***,we give a theoretical proof of convergence of this Jacobi collocation method and some numerical results showing the proposed scheme is an effective and high-precision algorithm.

关键词： The fractional Ginzburg-Landau equation Jacobi collocation method convergence

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Heavy rockbursts due to longwall mining near protective pillars:A case study

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International Journal of Mining Science and Technology 2018年第5期28卷 799-805页

作者： petr Konicek Jan Schreiber Department of Geomechanics and Mining Research Institute of Geonics Czech Academy of Science

Rockburst represents a very dangerous phenomenon in deep underground mining in unfavourable conditions such as great depth, high horizontal stress, proximity of important tectonic structures, and unmined pillars. The case study describes a recorded heavy rockburst in the Czech part of the Upper Silesian Coal Basin, which occurred during longwall mining near the protective pillar. The artificial dividing of geological blocks and creation of mining protective pillars(shaft pillars, crosscut pillars etc.) is a dangerous task in light of rockbursts occurring mainly due to overstressing of remaining pillars. A simple model of this situation is presented. Natural and mining conditions are analysed and presented in detail as well as registered seismicity during longwall mining in the area. Recorded rockbursts in the area of interest are described and their causes discussed. Many rockbursts near protective pillars were recorded in this mining region. Methodical instructions for rockburst prevention in proximity of protective pillars as well as for gates driving were devised based on the evaluation of rockburst causes. The paper presents these principles for prevention.

关键词： Rockburst Rockburst prevention Hardcoal longwall mining Induced seismicity Protective pillar

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A Comparison of Experimental and Numerical Studies Performed on a Low-Pressure Turbine Blade Cascade at High-Speed Conditions, Low Reynolds Numbers and various Turbulence Intensities

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Journal of Thermal Science 2013年第5期22卷 413-423页

作者： Jan Michalek petr Straka vZLU - Aerospace Research and Test Establishment Beranovych 130 19500 PragueCzech Republic

This paper focuses on a comparison of experimental and numerical investigations performed on a low-pressure mid-loaded turbine blade at operating conditions comprised of a wide range of Math numbers （from 0.5 - 1.1）, Reynolds numbers （from 0.4e＋5 - 3.0e＋5）, flow incidence （-15 - 15 degrees） and three levels of free-stream tur- bulence intensities （2, 5 and 10%）. The experimental part of the work was performed in a high-speed linear cas- cade wind tunnel. The increased levels of turbulence were achieved by a passive grid placed at the cascade inlet. A two-dimensional flow field at the center of the blade was traversed pitch-wise upstream and downstream the cascade by means of a five-bole probe and a needle pressure probe, respectively. The blade loading was measured using the surface pressure taps evenly deployed at the blade mid-span along the suction and the pressure side. The inlet turbulence was investigated using the constant temperature anemometer technique with a dual sensor probe. Experimentally evaluated values of turbulent kinetic energy and its dissipation rate were then used as inputs for the numerical simulations. An in-house code based on a system of the Favre-averaged Navier-Stokes equation closed by a two-equation k-co turbulence model was adopted for the predictions. The code utilizes an algebraic model of bypass transition valid both for attached as for separated flows taking in account the effect of free-stream turbulence and pressure gradient. The resulting comparison was carried out in terms of the kinetic en- ergy loss coefficient, distributions of downstream wakes and blade velocity. Additionally a flow visualization was performed by means of the Schlieren technique in order to provide a further understanding of the studied phe- nomena. A few selected cases with a particular interest in the attached and separated flow transition are compared and discussed.

关键词： low pressure turbine high-speed flow low Reynolds number flow separation transition RANS

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Hybrid LES/RANS Simulations of Compressible Flow in a Linear Cascade of Flat Blade Profiles

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Journal of Thermal Science 2024年第5期33卷 1839-1850页

作者： Jaromír PRIHODA petr STRAKA David SIMURDA petr SIDLOF Jan LEPICOvSKY Institute of Thermomechanics of the Czech Academy of Sciences Dolejskova 1402/518200 Prague 5Czech Republic Aerospace Research and Test Centre Beranovych 13019905 PragueCzech Republic Technical University of Liberec Faculty of MechatronicsStudentska 246117 Liberec 1Czech Republic

The paper reports on 3D numerical simulations of unsteady compressible airflow in a blade cascade consisting of flat profiles using a hybrid LES/RANS approach including a transition *** a first step towards simulation of blade flutter in turbomachinery,various incidence angle offsets of the middle blade were *** simulations were run for the flow regime characterized by outlet isentropic Mach number M_(is)=0.5and zero *** results of the LES/RANS simulations(pressure and Mach number distributions)were compared to a baseline RANS model,and to experimental data measured in a high-speed wind *** numerical results show that both methods overpredict flow separation taking place at the leading *** this regard,the hybrid LES/RANS method does not provide superior results compared to the traditional RANS ***,the LES/RANS results also capture vortex shedding from the blunt trailing *** frequency of the trailing edge vortex shedding in CFD simulations matches perfectly the spectral peak recorded during wind tunnel measurements.

关键词： numerical simulation blade cascade hybrid LES/RANS

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