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Evaluation of Emmer Wheat Genetic Resources Aimed at Dietary Food Production

Journal of Life Sciences 2011年第3期5卷 206-211页

作者： Zdenek Stehno Ivana Paulickova Jana Bradova petr Konvalina Ivana Capouchova Eva Maskova Dana Gabrovska Marie Holasova Vlasta Fiedlerova Renata Winterova Jarmila Ouhrabkova Ladislav Dotlacil Department of Gene Bank Crop Research Institute Praha 161 06 Czech Republic Department of Nutritive Substances Food Research Institute Praha 102 31 Czech Republic Faculty of Agriculture University of South Bohemia Ceskd Buddjovice 370 05 Czech Republic Faculty of Agrobiology Food and Natural Resources Czech University of Life Sciences Praha 165 21 Czech Republic

Emmer wheat cultivated by organic farmers is used as a component of some bio (organic) food products. Its positive influence on consumer health is caused by grain composition. With the aim of selecting varieties or landraces for their possible further use we tested selected emmer wheat accessions maintained in the Czech Gene Bank. In the set of 8 emmer wheat accessions, the main grain components, bread making characteristics and contents of health supporting chemical substances such as total dietary fibre content and its components, content of total polyphenols plus catechin and ferulic acid contents, vitamins of the B group and E plus total content of carotenoids were evaluated by standard methods. Tests of bread making quality confirmed a very well known fact that emmer wheat grain is much more suitable for other purposes as whole grain mixtures, cereal pure, etc. than for bread preparation. The results indicate the possibilities to select emmer wheat genotypes differing in grain composition and containing compounds with positive effects on human health. Among the tested emmer wheat accessions the Rudico variety had a complex of positive characteristics such as content of total dietary fibre, total polyphenol content with prevailing catechin and the highest amount of B group vitamins such as B1, B2, niacin, pantothenic acid and B6.

关键词：二粒小麦食品生产资源评价面包制作质量消费者健康组成部分饮食遗传

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Biodegradable zinc-iron alloys: Complex study of corrosion behavior,mechanical properties and hemocompatibility

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Progress in Natural Science:Materials International 2021年第2期31卷 279-287页

作者： Z.Orságová Králová R.Gorejová R.Orin?aková M.petra?ková A.Orin?ak M.Kupková M.Hrubov?a?ková T.Sop?ák M.Baláz? I.Maska?ová A.Kovalc?íková K.Kova? Department of Physical Chemistry Faculty of Science Pavol Jozef ?afa?rik University in Ko?ice Institute of Materials Research Slovak Academy of Sciences Institute of Geotechnics Slovak Academy of Sciences University of Veterinary Medicine and Pharmacy in Ko?ice Department of Animal Nutrition Dietetics and Animal Breeding

Zn-Fe alloys have been extensively investigated in this study with a view to their application as biodegradable bone implants. Biogenic element zinc is a very appropriate metal because of the ideal degradation rate compared to those of Mg and Fe. Studied alloys were made by compressing metallic powders in a content ratio of 100% Zn,Zn-1% Fe, Zn-2% Fe, Zn-5% Fe and Zn-10% Fe and sintering at 350°C for 1 h. Prepared samples were examined by optical microscopy, SEM and XRD. Corrosion behavior, mechanical testing and hemocompatibility were observed subsequently. The electrochemical performance of such materials was studied in the simulated body fluids. The enhanced corrosion rate was observed for all samples after iron addition due to the micro-galvanic effect between the pure Zn and Zn;Fe intermetallic phase. The corrosion rate of the Zn-5% Fe alloyed sample was more than 20-times higher（2.89 mmpy） compared to the pure Zn. However, alloying with more than 5 wt %of iron diminished the mechanical performance of the material. Therefore, the performed mechanical and hemocompatibility tests showed acceptable biocompatibility of zinc and Zn-1% Fe and Zn-2% Fe samples.

关键词： Biodegradable materials Zinc Iron Alloy Corrosion behavior Hemocompatibility

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综合利用地球物理和地震资料进行北天山地震危险性研究(俄文)

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内陆地震 2006年第3期20卷 282-288页

作者：阿卢阿京.瑟德科夫阿拉.萨德科娃彼得.戈尔布诺夫哈萨克斯坦共和国科学教育部地震研究所

综合分析地震学、地球物理学资料及地壳深部构造信息,对北天山地震危险性进行评价。作为研究的数学基础采用了对正交归一函数系统进行多维随机抽样的定量分析方法。最后对分析结果的成因进行了解释。

关键词：地震地球物理综合地震危险性

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陆梁隆起断裂系统及其对油气运聚的控制作用

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新疆石油地质 2003年第4期24卷 281-283页

作者：张年富张越迁徐常胜王斌查明中国石油新疆油田分公司勘探开发研究院新疆克拉玛依834000 石油大学山东东营257061

准噶尔盆地陆梁隆起具深层断裂和中浅层断裂两大断裂系统。陆南、基东和基南3条区域大断裂是连接油源的主要断层,陆南和基东断裂均具上正下逆结构。基南断裂为逆断层,浅部未发育正断层。基东断裂上部正断层侧向封堵性较好,可形成断层侧... 详细信息

准噶尔盆地陆梁隆起具深层断裂和中浅层断裂两大断裂系统。陆南、基东和基南3条区域大断裂是连接油源的主要断层,陆南和基东断裂均具上正下逆结构。基南断裂为逆断层,浅部未发育正断层。基东断裂上部正断层侧向封堵性较好,可形成断层侧向封堵油气藏;陆南断裂上部正断层侧向封堵较差,纵向也是开启的。基南断裂活动期与风城组烃源岩主要生油期即第一次成藏期匹配较好,三叠纪该断裂为油气运移的通道。基东断裂和陆南断裂底部逆断层活动期与油气成藏匹配关系与基南断裂相似,而其上部正断层活动期与乌尔禾组主要生油期即第二次成藏期匹配关系较好,中侏罗世至早白垩世作为油气运移的良好通道。燕山运动期断裂对原生油藏保存、改造与破坏以及对次生油气藏的形成、保存、改造起着重大作用。

关键词：准噶尔盆地陆梁隆起断裂油气运移油气聚集

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经自然腔道取标本手术(NOSES)治疗结直肠癌的国际共识

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Gastroenterology Report 2019年第1期7卷 24-31,I0001页

作者： Xu Guan Zheng Liu Antonio Longo Jian-Chun Cai William Tzu-Liang Chen Lu-Chuan Chen Ho-Kyung Chun Joaquim Manuel da Costa Pereira Sergey Efetov Ricardo Escalante Qing-Si He Jun-Hong Hu Cuneyt Kayaalp Seon-Hahn Kim Jim S.Khan Li-Jen Kuo Atsushi Nishimura Fernanda Nogueira Junji Okuda Avanish Saklani Ali A.Shafik Ming-Yin Shen Jung-Tack Son Jun-Min Song Dong-Hui Sun Keisuke Uehara Gui-Yu Wang Ye Wei Zhi-Guo Xiong Hong-Liang Yao Gang Yu Shao-Jun Yu Hai-Tao Zhou Suk-Hwan Lee petr V.Tsarkov Chuan-Gang Fu Xi-Shan Wang The International Alliance of NOSES Department of Colorectal Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBejingChina Department of Coloproctology and Pelvic Diseases Humanitas GavazzeniBergamoItaly Department of Gastrointestinal Surgery Zhongshan Hospital of Xiamen UniversityXiamenChina Department of Surgery China Medical University HospitalTaichungTaiwanChina Department of Abdominal Surgery Fujian Medical University Cancer HospitalFuzhouChina Department of Surgery Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulSouth Korea Department of Surgery Hospital de BragaBragaPortugal Colorectal Surgery Department Sechenov First Moscow State Medical UniversityMoscowRussia Universidad Central de Venezuela Centro Medico LoiraCaracasVenezuela Department of General Surgery Shandong University Qilu HospitalJinanChina Department of General Surgery Huaihe Hospital of Henan UniversityKaifengChina Department of Gastrointestinal Surgery Inonu UniversityMalatyaTurkey Department of Surgery Korea University Anam HospitalKorea University College of MedicineSeoulSouth Korea Department of Colorectal Surgery Portsmouth Hospitals NHS TrustQueen Alexandra HospitalPortsmouthUK Division of Colorectal Surgery Taipei Medical University HospitalTaipeiTaiwanChina Department of Surgery Nagaka Chuo General HospitalNagaoka CityJapan Innovation Unit/Colorectal Cancer Osaka Medical College Hospital Cancer CenterOsakaJapan Department of GI Surgical Oncology Tata Memorial HospitalMumbaiIndia Department of Colorectal Surgery Cairo UniversityCairoEgypt Department of Anorectal Surgery First Affiliated HospitalZhengzhou UniversityZhengzhouChina Department of Gastric and Colorectal Surgery Jilin University First HospitalChangchunChina Division of Surgical Oncology Nagoya University Graduate School of MedicineNagoyaJapan Department of Colorectal Cancer Surgery The Second Affiliated Hospital of Harbin Medical

近年来,经自然腔道取标本手术(NOSES)治疗结直肠癌已引起了广泛关注。NOSES应用于结直肠手术的潜在优势包括减轻术后疼痛,减少伤口并发症,减少对术后镇痛的需求,加快肠道功能的恢复,缩短住院时间,更好的美容效果,以及给患者带来了更佳... 详细信息

近年来,经自然腔道取标本手术(NOSES)治疗结直肠癌已引起了广泛关注。NOSES应用于结直肠手术的潜在优势包括减轻术后疼痛,减少伤口并发症,减少对术后镇痛的需求,加快肠道功能的恢复,缩短住院时间,更好的美容效果,以及给患者带来了更佳的心理状态。尽管NOSES的手术创伤显著减轻,然而该技术也存在一些潜在问题。尤其随着这项新技术的兴起,人们对其无菌的把控、肿瘤学结果和病例选择等问题表示出关切。因此,迫切需要一部操作指南来规范NOSES手术在结直肠癌中的开展。经过国际NOSES联盟全体成员的三轮讨论,最终形成了该部共识。这一共识有助于NOSES在全球范围内的长远发展。

关键词： colorectal cancer natural orifice specimen extraction surgery(NOSES) laparoscopy natural orifice transluminal endoscopic surgery(NOTES) transanal total mesorectal excision(TaTME)

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FungalTraits:a user-friendly traits database of fungi and fungus-like stramenopiles

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Fungal Diversity 2020年第2期107卷 I0001-I0016页

作者： Sergei Põlme Kessy Abarenkov RHenrik Nilsson Björn D.Lindahl Karina Engelbrecht Clemmensen Havard Kauserud Nhu Nguyen Rasmus Kjøller Scott T.Bates petr Baldrian Tobias Guldberg Frøslev Kristjan Adojaan Alfredo Vizzini Ave Suija Donald Pfister Hans-Otto Baral Helle Järv Hugo Madrid Jenni Nordén Jian-Kui Liu Julia Pawlowska Kadri Põldmaa Kadri Pärtel Kadri Runnel Karen Hansen Karl-Henrik Larsson Kevin David Hyde Marcelo Sandoval-Denis Matthew E.Smith Merje Toome-Heller Nalin N.Wijayawardene Nelson Menolli Jr Nicole K.Reynolds Rein Drenkhan Sajeewa S.N.Maharachchikumbura Tatiana B.Gibertoni Thomas Læssøe William Davis Yuri Tokarev Adriana Corrales Adriene Mayra Soares Ahto Agan Alexandre Reis Machado Andrés Argüelles-Moyao Andrew Detheridge Angelina de Meiras-Ottoni Annemieke Verbeken Arun Kumar Dutta Bao-Kai Cui C.K.Pradeep César Marín Daniel Stanton Daniyal Gohar Dhanushka N.Wanasinghe Eveli Otsing Farzad Aslani Gareth W.Griffith Thorsten H.Lumbsch Hans-Peter Grossart Hossein Masigol Ina Timling Inga Hiiesalu Jane Oja John Y.Kupagme József Geml Julieta Alvarez-Manjarrez Kai Ilves Kaire Loit Kalev Adamson Kazuhide Nara Kati Küngas Keilor Rojas-Jimenez Krišs Bitenieks Laszlo Irinyi LászlóGNagy Liina Soonvald Li-Wei Zhou Lysett Wagner M.Catherine Aime MaarjaÖpik María Isabel Mujica Martin Metsoja Martin Ryberg Martti Vasar Masao Murata Matthew PNelsen Michelle Cleary Milan C.Samarakoon Mingkwan Doilom Mohammad Bahram Niloufar Hagh-Doust Olesya Dulya Peter Johnston petr Kohout Qian Chen Qing Tian Rajasree Nandi Rasekh Amiri Rekhani Hansika Perera Renata dos Santos Chikowski Renato L.Mendes-Alvarenga Roberto Garibay-Orijel Robin Gielen Rungtiwa Phookamsak Ruvishika S.Jayawardena Saleh Rahimlou Samantha C.Karunarathna Saowaluck Tibpromma Shawn P.Brown Siim-Kaarel Sepp Sunil Mundra Zhu-Hua Luo Tanay Bose Tanel Vahter Tarquin Netherway Teng Yang Tom May Torda Varga Wei Li Victor Rafael Matos Coimbra Virton Rodrigo Targino de Oliveira Vitor Xavier de Lima Vladimir S.Mikryukov Yongzhong Lu Yosuke Matsuda Yumiko Miyamoto Urm Institute of Ecology and Earth Sciences University of Tartu14A Ravila50411 TartuEstonia Natural History Museum University of Tartu46 Vanemuise Str51003 TartuEstonia Gothenburg Global Biodiversity Centre Box 46140530 GothenburgSweden Department of Biological and Environmental Sciences University of GothenburgGothenburgSweden Department of Soil and Environment Swedish University of Agricultural SciencesBox 701475007 UppsalaSweden Department of Forest Mycology and Plant Pathology Swedish University of Agricultural SciencesBox 702675007 UppsalaSweden Section for Genetics and Evolutionary Biology(EvoGene) Department of BiosciencesUniversity of OsloP.O.Box 1066BlindernNO-0316 OsloNorway University of Hawaiʻi at Mānoa 3190 Maile WaySt.John 102HonoluluHIUSA Department of Biology University of CopenhagenUniversitetsparken 152100 CopenhagenØDenmark Purdue University Northwest WestvilleIN 46391USA Institute of Microbiology Czech Academy of SciencesVidenska 108314220 Praha 4Czech Republic GLOBE Institute University of CopenhagenØster Farimagsgade 5KH7.2.321353 CopenhagenDenmark Dipartimento di Scienze della Vita e Biologia dei Sistemi Universitàdi TorinoViale Mattioli 2510125 TorinoItaly Department of Organismic and Evolutionary Biology and Farlow Library and Herbarium Harvard University22 Divinity AveCambridgeMA 02138USA Blaihofstr.42 72074 TübingenGermany SYNLAB Estonia Veerenni 53aTallinn 11313Estonia Escuela de Tecnología Médica Universidad Santo TomásLos Carreras 753OsornoChile Centro de Genómica y Bioinformática Universidad MayorCamino La Pirámide 5750HuechurabaSantiagoChile Norwegian Institute for Nature Research(NINA) Sognsveien 680855 OsloNorway School of Life Science and Technology University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Evolutionary Biology Faculty of BiologyBiological and Chemical Research CentreUniversity of Warsawul.Zwirki i Wigury 10102-089 WarsawPoland Department of Botany Swedish Museum of

The cryptic lifestyle of most fungi necessitates molecular identification of the guild in environmental *** the past decades,rapid development and affordability of molecular tools have tremendously improved insights of the fungal diversity in all ecosystems and ***,in spite of the progress of molecular methods,knowledge about functional properties of the fungal taxa is vague and interpretation of environmental studies in an ecologically meaningful manner remains *** order to facilitate functional assignments and ecological interpretation of environmental studies we introduce a user friendly traits and character database FungalTraits operating at genus and species hypothesis *** the information from previous efforts such as FUNGuild and FunFun together with involvement of expert knowledge,we reannotated 10,210 and 151 fungal and Stramenopila genera,*** resulted in a stand-alone spreadsheet dataset covering 17 lifestyle related traits of fungal and Stramenopila genera,designed for rapid functional assignments of environmental *** order to assign the trait states to fungal species hypotheses,the scientific community of experts manually categorised and assigned available trait information to 697,413 fungal ITS *** the basis of those sequences we were able to summarise trait and host information into 92,623 fungal species hypotheses at 1%dissimilarity threshold.

关键词： Fungal traits Trophic modes Function Guild Bioinformatics High-throughput sequencing Community ecology

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松辽盆地汪家屯东火山岩储层预测

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石油物探 2000年第2期39卷 36-43,14页

作者：张殿成何德友尚广弟孟宪禄大庆石油管理局物探公司研究所大庆163357

深层火成岩是当前地球物理、地质和地球化学研究的主要领域之一 ,因为在该地层中已发现储量可观的油气藏。我们从地震和地质方面对火山岩的特征和分布规律进行了研究 ,一方面通过火山岩相地震反射特征对储层进行细致的解释 ;另一方面从... 详细信息

深层火成岩是当前地球物理、地质和地球化学研究的主要领域之一 ,因为在该地层中已发现储量可观的油气藏。我们从地震和地质方面对火山岩的特征和分布规律进行了研究 ,一方面通过火山岩相地震反射特征对储层进行细致的解释 ;另一方面从钻井揭示的地质因素出发 ,对火山岩的分布规律进行探讨 ,并对汪家屯东深层天然气进行了评价。所取得的成果对松辽盆地深层火成岩储层的研究及天然气评价都具有十分重要的意义。

关键词：火山岩天然气勘探天然气成藏条件储集层预测

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经自然腔道取标本手术(NOSES)治疗胃癌的国际共识(2019)

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Gastroenterology Report 2020年第1期8卷 5-10,I0001页

作者： Xu Guan Zheng Liu Amjad Parvaiz Antonio Longo Avanish Saklani Ali AShafik Jian-Chun Cai Charles Ternent Lin Chen Cuneyt Kayaalp Fatih Sumer Fernanda Nogueira Feng Gao Fang-Hai Han Qing-Si He Ho-Kyung Chun Chang-Ming Huang Hai-Yang Huang Rui Huang Zhi-Wei Jiang Jim S Khan Joaquim Manuel da Costa Pereira JosephWNunoo-Mensah Jung Tack Son Liang Kang Keisuke Uehara Ping Lan Le-Ping Li Han Liang Bing-Rong Liu Juan Liu Dan Ma Ming-Yin Shen Mohammad Rashidul Islam Narimantas Evaldas Samalavicius Kai Pan petr Tsarkov Xin-Yu Qin Ricardo Escalante Sergey Efetov Seung Kyu Jeong Suk-Hwan Lee Dong-Hui Sun Li Sun Tatiana Garmanova Yan-Tao Tian Gui-Yu Wang Guo-Jun Wang Guo-Rong Wang Xiao-Qiang Wang William Tzu-Liang Chen Woo Yong Lee Su Yan Zu-Li Yang Gang Yu Pei-Wu Yu Dan Zhao Yun-Shi Zhong Jian-Ping Wang Xi-Shan Wang The International Alliance of NOSES Department of Colorectal Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China Poole Hospital NHS Trust PooleUK European Center of Coloproctology and Pelvic Diseases-Multimedica Hospital MilanItaly Department of GI Surgical Oncology Tata Memorial HospitalMumbaiIndia Department of Colorectal Surgery Cairo UniversityCairoEgypt Department of Gastrointestinal Surgery Zhongshan Hospital of Xiamen UniversityXiamenFujianP.R.China Section of Colon and Rectal Surgery Creighton University School of MedicineOmahaNEUSA Department of General Surgery Chinese People’s Liberation Army General HospitalBeijingP.R.China Department of Gastrointestinal Surgery Inonu UniversityMalatyaTurkey Department of Surgery Hospital de BragaBragaPortugal Department of Colorectal Cancer Surgery the Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangP.R.China Department of Gastroenterological Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of General Surgery Shandong University Qilu HospitalJinanShandongP.R.China Department of Surgery Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulSouth Korea Department of Gastric Surgery Fujian Medical University Union HospitalFuzhouFujianP.R.China Department of General Surgery Jiangsu Province Hospital of Traditional Chinese MedicineNanjingJiangsuP.R.China Department of Colorectal Surgery PortsmouthHospitals NHSTrustQueen Alexandra HospitalPortsmouthUK King’s College Hospital LondonUK Department of Colorectal Surgery The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Division of Surgical Oncology Department of SurgeryNagoya University School of MedicineNagoyaJapan Department of Gastrointestinal Surgery Shandong Provincial Hospital Affiliated to Shandong UniversityJinanShandongP.R.China Department of Gastric Cancer

At present,natural orifice specimen extraction surgery(NOSES)has attracted more and more attention worldwide,because of its great advantages including minimal cutaneous trauma and post-operative pain,fast post-operative recovery,short hospital stay,and positive psychological ***,NOSES for the treatment of gastric cancer(GC)is still in its infancy,and there is great potential to improve its theoretical system and clinical ***,several key points including oncological outcomes,bacteriological concerns,indication selection,and standardized surgical procedures are raised with this innovative ***,it is necessary to achieve an international consensus to regulate the implementation of GC-NOSES,which is of great significance for healthy and orderly development of NOSES worldwide.

关键词： gastric cancer natural orifice specimen extraction surgery transanal specimen extraction transvaginal specimen extraction transoral specimen extraction consensus

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人源大麻素受体CB2的晶体结构

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科学新闻 2020年第2期 33-33页

作者：刘志杰 Xiaoting Li Tian Hua Kiran Vemuri Jo-Hao Ho Yiran Wu Lijie Wu petr Popov Othman Benchama Nikolai Zvonok K'ara Locke Lu Qu Gye Won Han Malliga R.Iyer Resat Cinar Nathan J.Coffey Jingjing Wang Meng Wu sevolod Katritch Suwen Zhao George Kunos Laura M.Bohn Alexandros Makriyannis Raymond C.Stevens 上海科技大学

文章简介大麻素受体CB2主要分布在人体的免疫系统,选择性调控大麻素受体CB2对炎症、纤维化及神经退行性疾病等具有较好的治疗潜力,同时可避免由大麻素受体CB1引起的精神活性。本研究报道了大麻素受体CB2与新型拮抗剂AM0257复合物2.8埃... 详细信息

文章简介大麻素受体CB2主要分布在人体的免疫系统,选择性调控大麻素受体CB2对炎症、纤维化及神经退行性疾病等具有较好的治疗潜力,同时可避免由大麻素受体CB1引起的精神活性。本研究报道了大麻素受体CB2与新型拮抗剂AM0257复合物2.8埃分辨率的晶体结构。经结构对比分析,发现同处于拮抗状态的CB2与CB1不但结构差别极大,拮抗状态的CB2-AM0257复合物结构

关键词：大麻素受体 CB2 晶体结构

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五羟色胺2C受体结构揭示GPCR多重药理学特性的结构基础

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科学新闻 2019年第2期 48-48页

作者：彭瑶 John D.McCorvy Kasper Harps?e Katherine Lansu Shuguang Yuan petr Popov Lu Qu Mengchen Pu Tao Che Louise F.Nikolajsen Xi-Ping Huang Yiran Wu Ling Shen Walden E.Bj?rn-Yoshimoto Kang Ding Daniel Wacker Gye Won Han Jianjun Cheng Vsevolod Katritch Anders A.Jensen Michael A.Hanson Suwen Zhao David E.Gloriam Bryan L.Roth Raymond C.Stevens 刘志杰上海科技大学iHuman研究所中国科学院生物物理研究所上海科技大学

文章简介有些药物往往需要作用于多个靶点,即多重药理学作用发挥其疗效。目前,针对多种血清素受体的药物,包括5-HT2C受体,对治疗肥胖、药物滥用和精神分裂症意义重大。开发具有针对5-HT2C受体选择性的配体或设计具有明确的多重药理学特... 详细信息

文章简介有些药物往往需要作用于多个靶点,即多重药理学作用发挥其疗效。目前,针对多种血清素受体的药物,包括5-HT2C受体,对治疗肥胖、药物滥用和精神分裂症意义重大。开发具有针对5-HT2C受体选择性的配体或设计具有明确的多重药理学特征的药物仍然是极其困

关键词：五羟色胺

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