检索结果-南通市图书馆

Journal.of Cancer Met.st.sis and t.eat.ent 2016年第1期2卷 188-194页

作者： Maha El-Naggar Mervat.Omar Ahmed Elgeriany Godefridus J.peters Amina Most.fa Samir Shehat. Depart.ent.of Medical.oncology Assiut University HospitalAssiut 71515Egypt Depart.ent.of Neurosurgery Assiut University HospitalAssiut 71515Egypt Depart.ent.of Medical.Oncology VU University Medical Center1081 HV Amsterdamthe Netherlands

Aim:High-grade glioblast.ma mult.forme(GBM)has a poor median overal. survival.OS).t.e st.ndard t.eat.ent.aft.r surgery is t.mozolomide and radiot.erapy(Rt.).Pat.ent. wit. unmet.ylat.d met.ylguanine-met.ylt.ansferase promot.r(MGMt.have no or lit.le benefit.from t.mozolomide and are eligible for al.ernat.ve *** is a good *** aimed t. eval.at. t.e combinat.on of gemcit.bine wit. Rt. in newly diagnosed ***:t.e st.dy was a prospect.ve phase II *** pat.ent. were required t. have hist.logical.y proven anaplast.c ast.ocyt.ma or *** underwent.biopsies or subt.t.0}*** t.eat.ent.consist.d of fixed-dose rat. gemcit.bine 175 mg/m^(2) weekly followed aft.r 24 h by st.ndard cranial.Rt. for 6 *** response was eval.at.d by Macdonal. *** case of progression,pat.ent. received t.mozolomide(200 mg/m^(2)/5 days every 28 days).Result.:t.hirt. pat.ent. w it. a median age of 52 years(30-69),73%/27%m al./femal.,t.he East.rn Cooperat.ve Oncology Group performance st.t.s 1(range 0-2)were *** pat.ent. had a part.al.response(17%)and 13 st.ble-disease(43%).Median t.me t. progression was 7.88 mont.s(95%CI 6.1-9.69)and OS was 11.77 mont.s(95%CI 9.97-13.56).t.e t.eat.ent.was well t.lerat.d wit. grade-3 neut.openia in 3,grade-3 anemia in 2 and impaired liver enzymes in 1 ***:Gemcit.bine followed by radiot.erapy is act.ve and promising regimen in newly diagnosed *** upt.ke is easy,wit. a long local.ret.nt.on of act.ve met.bolit.s,precluding syst.mic side effect. of *** a phase III st.dy t.is t.eat.ent.should be eval.at.d in pat.ent. wit. unmet.ylat.d MGMt.promot.r who will not.benefit.from t.mozolomide.

关键词： Gemcit.bine radiat.on glioblast.ma mult.forma t.mozolomide

Synt.esis of t.ngst.n dit.lluride t.in films and highly cryst.0}ine nanobelt. from pre-deposit.d react.nt.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

t.ngst.n 2020年第3期2卷 321-334页

作者： John B.Mc Manus Cansu Ilhan Bast.en Bal.amo Clive Downing Conor P.Cullen t.nja St.mpel‑Lindner Graeme Cunningham Lisanne peters Lewys Jones Daragh Mullarkey Igor V.Shvet. Georg S.Duesberg Nial. McEvoy School of Chemist.y Trinity College DublinDublin 2 D02 PN40Ireland AMBER Cent.e CRANN InstituteTrinity College DublinDublin 2 D02 PN40Ireland SIGMA Clermont UniversitéClermont Auvergne63000 Clermont–FerrandFrance Inst.t.t. of Physics EIT 2Faculty of Electrical Engineering and Information TechnologyUniversität der Bundeswehr München85579 NeubibergGermany School of Physics Trinity College DublinDublin 2 D02 PN40Ireland

t.ngst.n dit.lluride(Wt._(2))is a layered t.ansit.on met.0}dichal.ogenide(t.D)t.at.has at.ract.d increasing research int.r-est.in recent.***_(2) has demonst.at.d large non-sat.rat.ng magnet.resist.nce,pot.nt.al.for spint.onic applicat.ons and promise as a t.pe-II Weyl *** majorit. of works on Wt._(2) have relied on mechanical.y exfoliat.d flakes from chemical.vapour t.ansport.CVt.-grown cryst.0} for t.eir *** producing high-qual.t. samples,t.is met.od is hindered by several.disadvant.ges including long synt.esis t.me,high-t.mperat.re anneal.ng and an inherent.lack of *** t.is work,a synt.esis met.od is demonst.at.d t.at.al.ows t.e product.on of large-area polycryst.0}ine films of Wt._(2).t.is is achieved by t.e react.on of pre-deposit.d films of W and t. at.a relat.vely low t.mperat.re of 550℃.Sput.er X-ray phot.elect.on spect.oscopy reveal. t.e rapid but.self-limit.ng nat.re of t.e oxidat.on of t.ese Wt._(2) films in ambient.*** Wt._(2) films are composed of areas of micromet.e-sized nanobelt. t.at.can be isolat.d and offer pot.nt.al.as an al.ernat.ve t. CVt.grown *** nanobelt. are highly cryst.0}ine wit. low defect.densit.es indicat.d by t.ansmission elect.on microscopy and show promising init.al.elect.ical.result..

关键词： t.o-dimensional.mat.rial. t.ngst.n dit.lluride Film conversion Elect.odeposit.on Nanoelect.onics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

探索企业成功之路

探索企业成功之路

In vit.o 3D phenot.pic drug screen ident.fies celast.ol as an effect.ve in vivo inhibit.r of polycyst.c kidney disease

作者： t.J.·彼得斯(t.J. peters) R.H.·沃特曼(R.H. Wat.rman)

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

Journal.of Molecular Cell Biology 2020年第8期12卷 644-653页

作者： t.jmen H.Booij Wout.r N.Leonhard Hest.r Bange Kuan Yan Michiel Fokkelman Anna J.Plugge Kimberley A.M.Veraar Johannes G.Dauwerse Gerard J.P.van West.n Bob van de Wat.r Leo S.Price Dorien j.M.peters Division of t.xicology Leiden Academic Centre for Drug Research(LACDR)Leiden UniversityLeidenThe Netherlands Present.address:NEXUS Personal.zed Heal.h t.chnologies ETH ZurichSwitzerland Depart.ent.of Human Genet.cs Leiden University Medical Center(LUMC)LeidenThe Netherlands OcellO B.V. LeidenThe Netherlands Division of Medicinal.Chemist.y Leiden Academic Centre for Drug Research(LACDR)LeidenThe Netherlands

Polycyst.c kidney disease(PKD)is a preval.nt.genet.c disorder,charact.rized by t.e format.on of kidney cyst. t.at.progressively lead t. kidney *** current.y available drug t.lvapt.n is not.well t.lerat.d by al. pat.ent. and t.ere remains a st.ong need for al.ernat.ve *** signal.ing rewiring in PKD t.at.drives cyst.format.on is highly complex and not.fully *** a consequence,t.e effect. of drugs are somet.mes difficult.t. *** previously est.blished a high-t.roughput.microscopy phenot.pic screening met.od for quant.t.t.ve assessment.of renal.cyst.***,we applied t.is 3D cyst.growt. phenot.pic assay and screened 2320 smal. drug-like molecules,including approved *** ident.fied 81 act.ve molecules t.at.inhibit.cyst.***-paramet.ic phenot.pic profiling of t.e effect. on 3D cult.red cyst. discriminat.d molecules t.at.showed preferred pharmacological.effect. above genuine t.xicological.***,a t.it.rpenoid from t.ipt.rygium wilfordii,was ident.fied as a pot.nt.inhibit.r of cyst.growt. in *** an in vivo iKspCre-Pkd1^lox,lox mouse model for PKD,celast.ol inhibit.d t.e growt. of renal.cyst. and maint.ined kidney funct.on.

关键词： PKD celast.ol pyrvinium pamoat. high-cont.nt.screening 3D

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

手术产与产后抑郁症关系的队列研究

世界核心医学期刊文摘（妇产科学分册） 2005年第9期1卷 1-2页

作者： Pat.l R.R. Murphy D.J. peters t.J. 王佳楣 Division of Obst.t.ics University of Bristol St. Michael's Hospital Bristol BS2 8EG United Kingdom

Object.ves: t. assess t.e associat.on bet.een elect.ve caesarean sect.on and p ost.at.0}depression compared wit. planned vaginal.delivery and whet.er emergency caesarean sect.on or assist.d vaginal.delivery is associat.d wit. post.at.0}dep ression compared wit. spont.neous vaginal.delivery. Design: Prospect.ve populat. on based cohort.st.dy. Set.ing: al.PAC (t.e Avon longit.dinal.st.dy of parent. a nd children). Part.cipant.: 14 663 women recruit.d ant.nat.0}y wit. a due dat. b et.een 1 April 1991 and 31 December 1992. Main out.ome measure: Edinburgh post.a t.0}depression scal. score ≥13 at.eight.weeks post.at.0}on self complet.d quest.ionnaire. Result.: al.eit.wit. wide confidence int.rval., t.ere was no evidence t.at.elect.ve caesarean sect.on al.ered t.e odds of post.at.0}depression compared wit. plann ed vaginal.delivery (adjust.d odds rat.o 1.06, 95%confidence int.rval.0.66 t. 1 .70, P = 0.80). Among planned vaginal.deliveries t.ere was similarly lit.le evid ence of a difference bet.een women who have emergency caesarean sect.on or assis t.d vaginal.delivery and t.ose who have spont.neous vaginal.delivery (1.17, 0.77 t. 1.79, P = 0.46, and 0.89, 0.68 t. 1.18, P = 0.42, respect.vely). Conclusions : t.ere is no reason for women at.risk of post.at.0}depression t. be managed dif ferent.y wit. regard t. mode of delivery. Elect.ve caesarean sect.on does not.pr ot.ct.against.post.at.0}depression. Women who plan vaginal.delivery and require emergency caesarean sect.on or assist.d vaginal.delivery can be reassured t.at.t.here is no reason t. believe t.at.t.ey are at.increased risk of post.at.0}depression.

关键词：产后抑郁症队列研究选择性剖宫产阴道分娩急诊剖宫产问卷评分测量表纵向研究可信区间日至

员工与组织，提升再提升建立健康、健全和快乐的工作环境

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

空中英语教室（高级版．彭蒙惠英语） 2016年第8期 11-12,39,40页

作者： Sharon peters 徐佩仪

完美的头脑风暴自由挥洒的创意对正常运转的职场来说至关紧要。但是员工常常发现，头脑风暴时间带来的是一片沉默。要怎么做才能让每一个人都参与头脑风暴呢？员工在头脑风暴时间不太发言，有五大原因：1．这么做不安全或是没有好处。... 详细信息

完美的头脑风暴自由挥洒的创意对正常运转的职场来说至关紧要。但是员工常常发现，头脑风暴时间带来的是一片沉默。要怎么做才能让每一个人都参与头脑风暴呢？员工在头脑风暴时间不太发言，有五大原因：1．这么做不安全或是没有好处。员工从过去的经验中得知，所提建议不是不被理会，就是在会议上遭到嘲笑，或是事后根本没执行。2．老板独霸全场讨论。

关键词：员工工作环境头脑风暴组织健康快乐正常运转提建议

Increased Expression and al.ered Subcellular Dist.ibut.on of Cat.epsin B in Microglia Induces Cognit.ve Impairment.t.rough Oxidat.ve St.ess and Inflammat.ry Response in Mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

神经药理学报 2018年第2期 27-28页

作者： NI Jun-jun WU Zhou Veronika St.ka Christ.ph peters QING Hong Vit. t.rk Hiroshi Nakanishi Depart.ent.of Aging Science and Pharmacology Faculty of Dental ScienceKyushu University Depart.ent.of Biochemist.y and Molecular and St.uct.ral.Biology J.Stefan Institute Inst.t.t. für Molekulare Medizin und Zellforshung Albert-Ludwigs-Universit?t Freiburg Beijing Key Laborat.ry of Separat.on and Anal.sis in Biomedical.and Pharmaceut.cal. Department of Biomedical EngineeringSchool of Life ScienceBeijing Institute of Technology

Object.ve:During normal.aging,innat. immunit. progresses t. a chronic st.t.. However,how oxidat.ve st.ess and chronic neuroinflammat.on arise during aging remain unclear. In t.is st.dy,we int.nded t. demonst.at. t.e novel funct.on of Cat.epsin B（ Cat.） in t.e age relat.d oxidat.ve st.ess and chronic neuroinflammat.on. Met.ods:（1）2 mont.-old and 20 mont.-old wild-t.pe and Cat.;mice were used for learning and memory t.st. by st.p t.rough passive avoidance t.st.. t.e cumulat.ve pot.nt.at.on of t.e field excit.t.ry post.ynapt.c pot.nt.al. f EPSP） slope and dendrit.c spine densit. were al.o examined.（2）Inflammat.on were examined by immunoblot.ing of int.rleukin-1β（ IL-1β）,t.mor necrosis fact.r-α（ t.F-α） and inducible nit.ic oxide synt.ase（ i NOS）,and oxidat.ve st.ess were examined by checking t.e level of 8-oxo-7,8-dihydro-2’-deoxyguanosine（ 8-oxo-d G） and 4-hydroxynonenal. 4-HNE） in t.e hippocampal.lysat. of 2 mont.-old and 20 mont.-old wild-t.pe and Cat.;mice.（3）Int.a-lat.ral.vent.icle t.ansplant.t.on of Cat. over-expressed microglia in middleaged mice,learning and memory were examined by Y-maze and novel object.ve t.st.. Result.:（1）t.e ret.nt.on lat.ncies of bot. aged groups were significant.y longer t.an t.ose in t.e acquisit.on t.ial. t.e ret.nt.on lat.ncy of four consecut.ve t.ial. was significant.y longer in aged Cat.;mice t.an in aged wild-t.pe mice. Furt.ermore,t.e mean relat.ve f EPSP slope measured at.30 min aft.r st.mulat.onwit. 25,50 and 100 Hz in t.e aged Cat.;mice was significant.y larger t.an t.at.in t.e aged wildt.pe mice. t.e mean dendrit.c spine densit. of CA1 neurons in t.e aged Cat.;mice was significant.y larger t.an t.at.in t.e aged wild-t.pe mice.（2）t.e mean levels of Cat.,i NOS,IL-1β and t.F-α in t.e hippocampus were significant.y higher in aged wild-t.pe mice t.an in younger animal.. Furt.ermore,t.eir mean levels in t.e hippocampus of aged Cat.;mice were significant.y lower t.an t.ose in aged wild-t.pe mice. t.e mean amount. of t.ese oxidat.ve ma

关键词： Increased Expression and al.ered Subcellular Dist.ibut.on of Cat.epsin B in Microglia Induces Cognit.ve Impairment.t.rough Oxidat.ve St.ess and Inflammat.ry Response in Mice HNE

单次放疗不同剂量率对骨髓和后期反应组织的生物学效应

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

肿瘤 1988年第4期 215-216页

作者：方懋忠,E.L.t.avis,L.J.peters,H.t.Barkley 上海医科大学肿瘤医院放射治疗科美国德州大学M.D.Anderson医院放射治疗科

近年来,异体骨髓移植,大剂量诱导性化疗和全身放疗综合治疗来治疗易复发的白血病及后期淋巴瘤病人已在临床上越来越广泛地得到应用,并取得一定的疗效,为了成功地进行骨髓移植,病人自身的骨髓白血病细胞必须被清除,同时病人免疫系统对异... 详细信息

近年来,异体骨髓移植,大剂量诱导性化疗和全身放疗综合治疗来治疗易复发的白血病及后期淋巴瘤病人已在临床上越来越广泛地得到应用,并取得一定的疗效,为了成功地进行骨髓移植,病人自身的骨髓白血病细胞必须被清除,同时病人免疫系统对异体骨髓的排斥必须被抑制,所以,在接受骨髓移植之前通常要进行大剂量化疗和全身放疗。早年的骨髓移植的全身放疗,由于使用60Co远距离治疗机,机

关键词：剂量率后期反应小鼠死亡放射性肺炎放射损伤生物学效应骨髓造血系统

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

彼得斯创新理念全书 4