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Updating digital elevation models via change detection and fusion of human and remote sensor data in urban environments

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International Journal of Digital Earth 2015年第2期8卷 153-171页

作者： Carolin Klonner Christopher Barron Pascal Neis bernhard Hofle Department of Geography University of HeidelbergHeidelbergGermany

OpenStreetMap(OSM)currently represents the most popular project of Volunteered Geographic Information(VGI):geodata are collected by common people and made available for public *** Laser Scanning(ALS)enables the acquisition of high-resolution digital elevation models that are used for many *** study combines the advantages of both ALS and OSM,offering a promising new approach that enhances data quality and allows change detection:the mainly up-to-date 2D data of OSM can be combined with the high-resolution–but rarely updated–elevation information provided by *** case study investigates building objects of OSM and ALS data of the city of Bregenz,*** quality of OSM is discerned by the comparison of building footprints using different true positive definitions(*** area).High quality of OSM data is revealed,yet also limitations of each method with respect to heterogeneous regions and building outlines are *** the first time,an up-to-date Digital Surface Model(DSM)combining 2D OSM and ALS data is achieved.A multitude of applications such as flood simulations and solar potential assessments can directly benefit from this data combination,since their value and reliability strongly depend on an up-to-date DSM.

关键词： OpenStreetMap airborne laser scanning change detection 3D modelling up-to-date digital surface models

Peptide self-assembly into lamellar phases and the formation of lipid-peptide nanostructures

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Nano Research 2018年第2期11卷 913-928页

作者： Karin Kornmueller bernhard Lehofer Gerd Leitinger Heinz Amenitsch Ruth Prassl Institute of Biophysics Medical University of Graz BioTechMed-Graz Graz Austria Institute of Cell Biology Histology and Embryology Research Unit Electron Microscopic Techniques Medical University of Graz Graz Austria Institute of Inorganic Chemistry Graz University of Technology Graz Austria

Lipids exhibit an extraordinary polymorphism in self-assembled mesophases, with lamellar phases as the most relevant biological representative. To mimic lipid lamellar phases with amphiphilic designer peptides, seven systematically varied short peptides were engineered. Indeed, four peptide candidates （V4D, V4WD, V4WD2, I4WD2） readily self-assembled into lamellae in aqueous solution. Small-angle X-ray scattering （SAXS） patterns revealed ordered lamellar structures with a repeat distance of 4-5 nm. Transmission electron microscopy （TEM） images confirmed the presence of stacked sheets. Two derivatives （V3D and V4D2） remained as loose aggregates dispersed in solution; one peptide （L4WD2） formed twisted tapes with internal lameUae and an antiparaUel -type monomer aligrtment. To understand the interaction of peptides with lipids, they were mixed with phosphatidylcholines. Low peptide concentrations （1.1 mM） induced the formation of a heterogeneous mixture of vesicular structures. Large multilamellar vesicles （MLV, d-spacing - 6.3 nm） coexisted with oligo- or unilamellar vesicles （- 50 nm in diameter） and bicelle-like structures （- 45 nm length, - 18 nm width）. High peptide concentrations （11 mM） led to unilamellar vesicles （ULV, diameter - 260-280 nm） with a homogeneous mixing of lipids and peptides. SAXS revealed the temperature-dependent fine structure of these ULVs. At 25 ℃ the bilayer is in a fully Interdigitated state （headgroup-to-headgroup distance dH, -2.9 nm）, whereas at 50 ℃this interdigitation opens up （dtm- 3.6 nm）. Our results highlight the versatility of self-assembled peptide superstructures. Subtle changes in the amino acid composition are key design elements in creating peptide- or lipid- peptide nanostructures with richness in morphology similar to that of naturally occurrin~ lioids.

关键词： amphiphilic designerpeptides lipids nanostructures lamellae small-angle X-rayscattering (SAXS) transmission electronmicroscopy (TEM)

Vitamin C and Vitamin D—friends or foes in modulating γδ T-cell differentiation?

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Cellular & Molecular Immunology 2022年第10期19卷 1198-1200页

作者： Christian peters Katharina Klein Dieter Kabelitz Institute of Immunology Christian-Albrechts UniversityKielGermany

The differentiation and functional plasticity of T cells are transcriptionally and epigenetically regulated by signals imposed by the local cytokine milieu and a variety of additional factors,including *** C has pleiotropic functions in the immune *** exerts antioxidant activity,can directly kill selected tumor targets,promotes early T-cell differentiation,and enhances Th1 cytokine production in mature T cells[1,2].

关键词： vitamin cytokine Vitamin

A High Order Sharp-Interface Method with Local Time Stepping for Compressible Multiphase Flows

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Communications in Computational Physics 2011年第1期9卷 205-230页

作者： Angela Ferrari Claus-Dieter Munz bernhard Weigand Institute of Aerodynamics and Gasdynamics University of StuttgartPfaffenwaldring 21D-70569 StuttgartGermany Institute of Aerospace Thermodynamics University of StuttgartPfaffenwaldring 31D-70569 StuttgartGermany

In this paper,a new sharp-interface approach to simulate compressible multiphase flows is *** new scheme consists of a high order WENO finite volume scheme for solving the Euler equations coupled with a high order pathconservative discontinuous Galerkin finite element scheme to evolve an indicator function that tracks the material *** the interface our method applies ghost cells to compute the numerical flux,as the ghost fluid ***,unlike the original ghost fluid scheme of Fedkiw et al.[15],the state of the ghost fluid is derived from an approximate-state Riemann solver,similar to the approach proposed in[25],but based on a much simpler *** formulation leads only to one single scalar nonlinear algebraic equation that has to be solved at the interface,instead of the system used in[25].Away from the interface,we use the new general Osher-type flux recently proposed by Dumbser and Toro[13],which is a simple but complete Riemann solver,applicable to general hyperbolic conservation *** time integration is performed using a fully-discrete one-step scheme,based on the approaches recently proposed in[5,7].This allows us to evolve the system also with time-accurate local time *** to the sub-cell resolution and the subsequent more restrictive time-step constraint of the DG scheme,a local evolution for the indicator function is applied,which is matched with the finite volume scheme for the solution of the Euler equations that runs with a larger time *** use of a locally optimal time step avoids the introduction of excessive numerical diffusion in the finite volume *** different fluids have been used,namely an ideal gas and a weakly compressible fluid modeled by the Tait *** tests have been computed to assess the accuracy and the performance of the new high order scheme.A verification of our algorithm has been carefully carried out using exact solutions as well as a comparison with other numerical re

关键词： Sharp interface capturing compressible multiphase flows one-step time-integration time-accurate local time stepping modified ghost fluid method WENO schemes discontinuous Galerkin methods

PD-L1 in the palm of your hand:palmitoylation as a target for immuno-oncology

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Signal Transduction and Targeted Therapy 2019年第1期4卷 528-529页

作者： Andreas von Knethen bernhard Brüne Institute of Biochemistry I-Pathobiochemistry Faculty of MedicineGoethe-University FrankfurtTheodor-Stern-Kai 760590 Frankfurt am MainGermany

A recent study by Yao et *** in Nature Biomedical Engineering showed the importance of palmitoylation in regulat-ing PD-L1 protein stability and trafficking.1 These researchers developed a competitive inhibitor that blocks PD-L1 palmitoyla-tion,which may provide a new strategy for targeting PD-L1 or other palmitoylated membrane proteins(Fig.1).

关键词： al. competitive traffic

Complementarity among species in horizontal versus vertical rooting space

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Journal of Plant Ecology 2008年第1期1卷 33-41页

作者： Stefanie von Felten bernhard Schmid Institute of Environmental Sciences University of Zurich8057 ZurichSwitzerland Institute of Plant Sciences ETH Zurich8092 ZurichSwitzerland

Aims Many experiments have shown a positive effect of species richness on productivity in grassland plant ***,it is poorly understood how environmental conditions affect this *** aimed to test whether deep soil and limiting nutrient conditions increase the complementarity effect(CE)of species richness due to enhanced potential for resource *** We grew monocultures and mixtures of four common grassland species in pots on shallow and deep soil,factorially combined with two nutrient *** volume was kept constant to avoid confounding soil depth and *** an additive partitioning method,we separated biodiversity effects on plant productivity into components due to species complementarity and *** findings Net biodiversity and complementarity effects were consistently higher in shallow pots,which was unexpected,and at the low nutrient *** two results suggest that although belowground partitioning of resources was important,especially under low nutrient conditions,it was not due to differences in rooting *** conclude that in our experiment(i)horizontal root segregation might have been more important than the partitioning of rooting depths and(ii)that the positive effects of deep soil found in other studies were due to the combination of deeper soil with larger soil volume.

关键词： biodiversity effects nutrient limitation resource partitioning root competition soil depth

A user perspective on future cloud-based services for Big Earth data

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International Journal of Digital Earth 2021年第12期14卷 1758-1774页

作者： Julia Wagemann Stephan Siemen bernhard Seeger Jörg Bendix Laboratory of Climatology and Remote Sensing(LCRS) Faculty of GeographyUniversity of Marburg Forecast Department European Centre for Medium-Range Weather Forecasts(ECMWF) Department of Mathematics and Computer Science University of Marburg

Cloud-based services introduce a paradigm shift in how users access,process and analyse Big Earth data.A key challenge is to align the current state of how users access,process and analyse the data with trends and roadmaps large data organisations *** addition,due to the increased availability of open data,a more diverse user base wants to take advantage of Earth science data leading to new user *** run a web-based survey among Big Earth data users to better understand the motivation to migrate to cloud-based services as well as the challenges and opportunities that might *** show an overall interest in moving to cloud-based services but air an insufficient literacy in cloud systems and a lack of trust due to security concerns and opacity of emerging *** gaps demand efforts on three ***,cloud services shall be targeted at intermediate users instead of policy-and decision-makers and over-engineered systems with a high level of abstraction should be ***,more substantial capacity-building efforts are required to decrease the existing gap in cloud skills and ***,a cloud certification mechanism could help in building up overall trust in cloud-based services.

关键词： User requirements cloudbased services Big Earth data open data

Drug treatment of male fertility disorders

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Asian Journal of Andrology 2000年第2期2卷 81-85页

作者： Gerhard Haidl Frank-Michael Kohn Wolf-bernhard Schill Department of Dermatology University of Bonn GermanyDepartment of Dermatology and Allergology Techological University of Munich GermanyCenter of Dermatology and Andrology University of Giessen Germany

Drug treatment remains an active domain in the therapy of male fertility disorders. Although there are only a fewconditions that allow causal treatment, rational approaches are possible in many cases. Best results are obtained in casesrequiring an anti-inflammatory treatment and in patients with an impaired sperm transport. High-dosage administrationof FSH is a promising new development, aimed particularly at improving the disturbed sperm structures. A careful di-agnostic work-up with elucidation of the underlying disease is essential to achieve a successful therapy.

关键词： male fertility agents drug therapy treatment recommendations

Trade Unions in Western Europe since 1945 1

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