检索结果-南通市图书馆

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** eMBASe,Ovid MeDLINe,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for english language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-english language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Multiple sclerosis is at a checkpoint: advancing the program

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

NecAB family of neuronal calcium-binding proteins in health and disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NecAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized c-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NecAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NecAB2 interacts with predominantly striatal G-protein-coupled receptors, while NecAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NecAB proteins exhibit distinct subcellular localizations: NecAB1 is found in the nucleus and cytosol, NecAB2 resides in endosomes and the plasma membrane, and NecAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NecAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NecAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

Ultra‑Transparent and Multifunctional IZVO Mesh electrodes for Next‑Generation Flexible Optoelectronics

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram D.Dongale Atul c.Khot chenjie Yao Nahyun Kim Tae Geun Kim School of electrical engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea computational electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

Quantitative characterization of polyacrylamide–shale interaction under various saline conditions

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2017年第3期14卷 586-596页

作者： Samyukta Koteeswaran Jack c.Pashin Josh D.Ramsey peter e.clark School of chemical engineering Oklahoma State UniversityStillwater OK 74078 USA Boone Pickens School of Geology Oklahoma State University Stillwater OK 74078 USA

Interaction of polymer-containing injected fluids with shale is a widely studied phenomenon, but much is still unknown about the interaction of charged polyacrylamides such as anionic and cationic polyacrylamides with shale. The nature of interaction of charged polyacrylamides with shale is not well understood, especially from the perspective of assessing the potential for polyacrylamides to cause formation damage. Zeta potential and rheological measurements were made for chattanooga and Pride Mountain shales suspended in polyacrylamide solutions with and without inorganic salts and tetramethyl ammonium chloride（TMAc）. The change in zeta potential and viscosity with time was recorded. The magnitude of decrease in the absolute value of zeta potential with time is indicative of adsorption of polymer on the surface of shale and serves as a measure of the extent of polymer interaction with shale. The salts that were used in this study are potassium chloride（Kcl）, sodium chloride（Na cl）. This study quantified the interaction of anionic and cationic polyacrylamide with different North American *** the experimental results, it was determined that the polyacrylamides can interact strongly with shale, particularly the cationic polyacrylamide. The objective of this study was to determine the extent of interaction of anionic and cationic polyacrylamide with each shale sample in the presence of additives such as salts.

关键词： Anionic and cationic polyacrylamides chattanooga shale Pride Mountain shale Zeta potentialSlurry rheology

AN AccURATe TWO-DIMeNSIONAL THeORY OF VIBRATIONS OF ISOTROPIc,eLASTIc PLATeS

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Solida Sinica 2011年第2期24卷 125-134页

作者： peter c.Y.Lee Department of civil and environmental engineering Princeton University

An infinite system of two-dimensional equations of motion of isotropic elastic plates with edge and corner conditions are deduced from the three-dimensional equations of elasticity by expansion of displacements in a series of trigonometrical functions and a linear function of the thickness coordinate of the plate. The linear term in the expansion is to accommodate the in-plane displacements induced by the rotation of the plate normal in low-frequency flexural motions. A system of first-order equations of flexural motions and accompanying boundary conditions are extracted from the infinite system. It is shown that the present system of equations is equivalent to the Mindlin＇s first-order equations, and the dispersion relation of straight-crested waves of the present theory is identical to that of the Mindlin＇s without introducing any corrections. Reduction of present equations and boundary conditions to those of classical plate theories of flexural motions is also presented.

关键词： isotropic elastic plates first-order equations boundary conditions flexural andthickness-shear vibrations

Recent Advancements in the Optimization capacity configuration and coordination Operation Strategy of Wind-Solar Hybrid Storage System

在线全文

学校读者我要写书评

暂无评论

energy engineering 2025年第1期122卷 285-306页

作者： Hongliang Hao caifeng Wen Feifei Xue HaoQiu Ning Yang Yuwen Zhang chaoyu Wang edwin e.Nyakilla Department of New energy Storage Peking University Ordos Research Institute of EnergyOrdos017010China School of energy and Power engineering Inner Mongolia University of TechnologyHohhot010080China Key Laboratory of Wind energy and Solar energy Utilization Technology Inner Mongolia University of TechnologyHohhot010051China

Present of wind power is sporadically and cannot be utilized as the only fundamental load of energy *** paper proposes a wind-solar hybrid energy storage system(HeSS)to ensure a stable supply grid for a longer period.A multi-objective genetic algorithm(MOGA)and state of charge(SOc)region division for the batteries are introduced to solve the objective function and configuration of the system capacity,***/Simulink was used for simulation *** optimization results show that for a 0.5 MW wind power and 0.5 MW photovoltaic system,with a combination of a 300 Ah lithium battery,a 200 Ah lead-acid battery,and a water storage tank,the proposed strategy reduces the system construction cost by approximately 18,000 ***,the cycle count of the electrochemical energy storage systemincreases from4515 to 4660,while the depth of discharge decreases from 55.37%to 53.65%,achieving shallow charging and discharging,thereby extending battery life and reducing grid voltage fluctuations *** proposed strategy is a guide for stabilizing the grid connection of wind and solar power generation,capability allocation,and energy management of energy conservation systems.

关键词： electric-thermal hybrid storage modal decomposition multi-objective genetic algorithm capacity optimization allocation operation strategy

Drag reduction behavior of hydrolyzed polyacrylamide/xanthan gum mixed polymer solutions

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2017年第2期14卷 412-423页

作者： Mehdi Habibpour peter e. clark School of chemical engineering Oklahoma State University Stillwater OK 74078 USA

Partially hydrolyzed polyacrylamide（HPAM）as the main component of slickwater fracturing fluid is a shear-sensitive polymer,which suffers from mechanical degradation at turbulent flow *** different concentrations of HPAM as well as mixtures of polyacrylamide/xanthan gum were prepared to investigate the possibility of improving shear stability of *** reduction（DR）measurements were performed in a closed flow *** HPAM solutions,the extent of DR increased from 30%to67%with increasing HPAM concentration from 100 to1000 *** the HPAM solutions suffered from mechanical degradation and loss of DR efficiency over the shearing *** indicated that the resistance to shear degradation increased with increasing polymer *** efficiency of 600 wppm xanthan gum（XG）was 38%,indicating that XG was not as good a drag reducer as *** with only 6%DR decline,XG solution exhibited a better shear stability compared to HPAM *** HPAM/XG solutions initially exhibited greater DR（40%and 55%）compared to XG,but due to shear degradation,DR%dropped for HPAM/XG *** to 200 wppm HPAM solution,addition of XG did not improve the drag reduction efficiency of HPAM/XG mixed solutions though XG slightly improved the resistance against mechanical degradation in HPAM/XG mixed polymer solutions.

关键词： Slickwater Polyacrylamide Xanthan gum Drag reduction Shear stability

Merging bound states in the continuum in an open acoustic resonator

在线全文

学校读者我要写书评

暂无评论

Science china(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun Huang Bin Jia Artem S.Pilipchuk Sibo Huang chen Shen Almas F.Sadreev Yong Li Andrey e.Miroshnichenko School of Physics and electronic Sciences East China Normal University Institute of Acoustics Tongji University L.V.Kirensky Institute of Physics Department of Mechanical engineering Rowan University School of engineering and Technology University of New South Wales at Canberra

Bound states in the continuum （BIcs） are perfectly localized resonances despite embedding in the continuum ***,an isolated BIc is very sensitive to the structure ***,we report merging acoustic BIcs in a single open resonator,robust against the structure *** find that both symmetry-protected BIc and Friedrich-Wintgen BIc are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BIcs move toward each other and merge into a single one at a critical *** to an individual BIc,the merged BIc is robust against fabrication error because its Q-factor is proportional to ΔL-4,whereΔL embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective nonHermitian ***,we present direct experimental demonstrations of the moving and merging of BIcs in a coupled 3D waveguide-resonator,which are evidenced by the vanishing of the linewidth of Fano resonance in the transmission *** results may find exciting applications in designing high-quality acoustic sources,sensors and filters.

关键词： acoustic resonances bound state in the continuum high-Q resonances