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Optimizing surface-engineered ultra-small gold nanoparticles for highly efficient miRNA delivery to enhance osteogenic differentiation of bone mesenchymal stromal cells

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Nano Research 2017年第1期10卷 49-63页

作者： Meng Yu Bo Lei Chuanbo Gao Jin Yan peter x. ma Frontier Institute of Science and Technology Xi'an Jiaotong University Xi'an 710054 China State Key Laboratory for manufacturing Systems Engineering Xi'an Jiaotong University Xi'an 710054 China State Key Laboratory for Mechanical Behavior of materials Xi'an Jiootong University Xi'an 710054 China Department of Biomedical Engineering University of Michigan Ann Arbor M148109-2009 USA macromolecular Science and Engineering Center University of Michigan Ann Arbor M148109-1055 USA Department of materials Science and Engineering University of Michigan Ann Arbor M148109-1078 USA

Regulation of osteogenic differentiation of bone mesenchymal stromal cells （BMSCs） plays a critical role in bone regeneration. As small non-coding RNAs, microRNAs （miRNAs） play an important role in stem cell differentiation through regulating target-mRNA ex.ression. Unfortunately, highly efficient and safe delivery of miRNAs to BMSCs to regulate their osteogenic differentiation remains challenging. Conventional inorganic nanocrystals have shown increased tox.city owing to their larger size precluding renal clearance. Here, we developed novel, surface-engineered, ultra-small gold nanoparticles （USAuNPs, 〈10 nm） for use as highly efficient miR-5106-delivery systems to enable regulation of BMSC differentiation. We ex.loited the effects of AuNPs coated layer-by-layer with polyethylenimine （PEI） and liposomes （Lipo） to enhance miR-5106-delivery activity and subsequent BMSC differentiation capacity. The PEI- and Lipo-coated AuNPs （Au@PEI@Lipo） showed negligible cytotox.city, good miRNA-5106-binding affinity, highly efficient delivery of miRNAs to BMSCs, and long-term miRNA ex.ression （21 days）. Additionally, compared with commercial Lipofectamine 3000 and 25 kD PEI, the optimized Au@PEI@Lipo-miR-5106 nanocomplex.s significantly enhanced BMSC differentiation into osteoblast-like cells through activation of the Sox. transcription factor. Our findings reveal a promising strategy for the rational design of ultra-small inorganic nanoparticles as highly efficient miRNA-delivery platforms for tissue regeneration and disease therapy.

关键词： ultra-small goldnanoparticles surface engineering microRNA (miRNA)delivery bone mesenchymalstromal cells osteogenic differentiation

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Achieving strength-ductility synergy in novel paramagnetic Fe-based medium-entropy alloys through deep cryogenic deformation

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Rare Metals 2024年第9期43卷 4493-4507页

作者： Hu-Wen ma Yan-Chun Zhao Li Feng Tian-Zeng Liu Zhi-Qi Yu Bo Jin Wang-Chun Duan peter K.Liaw Dong ma State Key Laboratory of Advanced Processing and Recycling of Non-Ferrous Metals Lanzhou University of TechnologyLanzhou 730050China Wenzhou Pump and Valve Engineering Research Institute Lanzhou University of TechnologyWenzhou 325105China Iron and Steel Research Institute Jiuquan Iron and Steel CorporationJiayuguan 735100China Lanzhou Resources and Environment Voc-Tech University Lanzhou 730123China Department of materials Science and Engineering The University of TennesseeKnoxvilleTN 37996-2200USA Neutron Science Center Songshan Lake Materials LaboratoryDongguan 523808China

Cryogenic pre-deformation treatment has been widely used to effectively improve the comprehensive mechanical properties of steels and novel ***,the dislocation evolution and phase transformation induced by different degrees of deep cryogenic deformation are not yet fully *** this study,the effects of multiple cryogenic pre-treatments on the mechanical properties and deformation mechanisms of a paramagnetic Fe_(63.3)Mn_(14-)Si_(9.1)Cr_(9.8)C_(3.8)medium-entropy alloy(MEA)were investigated,leading to the discovery of a pretreated MEA that ex.ibits ex.eptional mechanical properties,including a fracture strength of 3.0 GPa,plastic strain of 26.1%and work-hardening index.of *** addition,x.ray diffraction(x.D)and transmission electron microscopy(TEM)analyses revealed that multiple cryogenic pre-deformation treatments significantly increased the dislocation density of the MEA(from 9×10^(15)to 4×10^(16)m^(-2)after three pretreatments),along with a transition in the dislocation type from predominantly edge dislocations to mix.d dislocations(including screw-and edge-type dislocations).Notably,this pretreated MEA retained its paramagnetic properties(μ_(r)x.mately four(i.e.,from 9.7 to2.6 m J·m^(-2)),thereby activating the synergistic effects of transformation-induced plasticity,twinning-induced plasticity and dislocation strengthening *** synergistic effects lead to simultaneous strength and ductility enhancement of the MEA.

关键词： Deep cryogenic transformation Iron-based medium-entropy alloys Dislocation evolution Phase transformation Stacking fault energy

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Metal-Organic Frameworks Housing Active Molecules as Bioinspired Catalysts

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CCS Chemistry 2024年第6期6卷 1380-1402页

作者： Yin Zhang peter E.VanNatta Junyu Ren Shengqian ma Department of Chemistry University of North TexasDentonTexas 76201 Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117585

Optimization of activity,selectivity,and stability of catalysts for practical application is a long-soughtafter *** progress in the advancement of rational catalyst design routinely takes queues from ***,enzymes are renowned for their high efficiency and selectivity in diverse and significant reactions under mild *** the well-known merits of enzymes,they often remain unsuitable for industrial catalysis due to issues,including limited environment(solvent/temperature/pH)compatibility,considerable structural uncertainty,and highly specific reaction *** the contex. of bioinspired catalysis design,the development of synthetic heterogeneous catalyst analogs,which may not only mimic enzymes to reproduce or even surpass their performance but also bypass their intrinsic limitations,is thus,desirable and has been ex.ensively studied in the contex. of porous *** metal-organic framework(MOF)is a superior candidate for porous materials towards this goal,thanks to facile and modular preparation,ex.licit crystalline composition/structure,tunable pore size/environment,and ex.ellent *** introduction of active molecular species such as bioactive molecules(e.g.,proteins,enzymes,peptides,amino acids,porphyrins)and chemically active molecules(e.g.,frustrated Lewis pairs)into metal-organic frameworks(MOFs)via pore encapsulation,chemical postmodification,or bottom-up construction has been shown to facilitate the cooperative enhancement of catalysis through the enforcement of prox.mity,enhancement of control/activity,and even inducement of unex.ected *** this minireview,we sought to summarize the last 5 years of fruitful progress,ex.loiting MOFs housing active molecules for substantial catalysis applications,including asymmetric reactions,CO_(2)conversion(reduction,cycloaddition),biocatalytic H_(2)O_(2)/dye degradation,and so on,and discuss challenges and opportunities in the prospective ex.loration of these system

关键词： metal-organic framework bioinspired catalyst active molecular species

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生物材料和再生医学

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国外科技新书评介 2016年第1期 12-12页

作者： peter x. ma 彭金平不详国家纳米科学中心

生物医用材料是指以医疗为目的，用于诊断、治疗、修复或替换人体组织器官或增进其功能的材料。再生医学是从20世纪80年代后期兴起并逐步发展起来的，但一直缺乏一个明确的定义。到90年代后期由于干细胞技术方面的突破，才把干细胞、组... 详细信息

生物医用材料是指以医疗为目的，用于诊断、治疗、修复或替换人体组织器官或增进其功能的材料。再生医学是从20世纪80年代后期兴起并逐步发展起来的，但一直缺乏一个明确的定义。到90年代后期由于干细胞技术方面的突破，才把干细胞、组织工程、组织器官代用品等纳入到再生医学里面来。

关键词：再生医学生物材料干细胞技术生物医用材料组织器官组织工程代用品后期

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Variable frequency deep brain stimulation of subthalamic nucleus to improve freezing of gait in Parkinson's disease

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National Science Review 2024年第6期11卷 102-104页

作者： Fumin Jia Aparna Wagle Shukla Wei Hu Yu ma Jianguo Zhang Leonardo Almeida Chris Kao Yi Guo Shizhong Zhang Yingqun Tao Zhipei Ling x.n x. Zhiquan Yang Fan-gang Meng x.nhua Wan Hesheng Liu peter E.Konard Luming Li National Engineering Laboratory for Neuromodulation Tsinghua University University of Florida Center for Movement Disorders and Neurorestoration Tsinghua University Yuquan Hospital Beijing Tiantan Hospital Capital Medical University School of Medicine Vanderbilt University Peking Union Medical College Hospital ZhuJiang Hospital of Southern Medical University The General Hospital of Shenyang Military Chinese PLA General Hospital x.angya Hospital Central South University Beijing Neurosurgical Institute Capital Medical University Athinoula A. martinos Center for Biomedical Imaging Harvard Medical School Precision Medicine & Healthcare Research Center Tsinghua-Berkeley Shenzhen Institute man-machine-Environment Engineering Institute School of Aerospace EngineeringTsinghua University Center of Epilepsy Beijing Institute for Brain Disorders

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a welle-stablished therapy for patients with Parkinson’s disease (PD) presenting with medication refractory tremors, motor fluctuations and dyskinesias induced by dopaminergic medications [1]. However,traditional high-frequency stimulation(HFS) does not effectively control ax.al symptoms such as gait dysfunction,postural instability and freezing of gait(FOG)[2,3].

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Synthetic biodegradable functional polymers for tissue engineering:a brief review

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Science China Chemistry 2014年第4期57卷 490-500页

作者： GUO BaoLin ma peter x Center for Biomedical Engineering and Regenerative Medicine Frontier Institute of Science and Technology Xi'an Jiaotong University Department of Biomedical Engineering University of Michigan Department of Biologic and materials Sciences University of Michigan macromolecular Science and Engineering Center University of Michigan Department of materials Science and Engineering University of Michigan

Scaffolds play a crucial role in tissue engineering. Biodegradable polymers with great processing flex.bility are the predominant scaffolding materials. Synthetic biodegradable polymers with well-defined structure and without immunological concerns associated with naturally derived polymers are widely used in tissue engineering. The synthetic biodegradable polymers that are widely used in tissue engineering, including polyesters, polyanhydrides, polyphosphazenes, polyurethane, and poly(glycerol sebacate) are summarized in this article. New developments in conducting polymers, photoresponsive polymers, amino-acid-based polymers, enzymatically degradable polymers, and peptide-activated polymers are also discussed. In addition to chemical functionalization, the scaffold designs that mimic the nano and micro features of the ex.racellular matrix.ECM) are presented as well, and composite and nanocomposite scaffolds are also reviewed.

关键词： synthetic biodegradable polymers functional polymers scaffolds tissue engineering

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Cu含量对铁基中熵合金耐腐蚀及抗菌性能的影响

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稀有金属材料与工程 2024年第7期53卷 1817-1825页

作者：赵燕春宋海转马虎文胡若楠冯力段望春 Liaw peter K 兰州理工大学省部共建有色金属加工与再利用国家重点实验室甘肃兰州730050 兰州理工大学温州泵阀工程研究院浙江温州325105 兰州资源环境职业技术大学甘肃兰州730123 田纳西大学材料系美国诺克斯维尔TN 37996

采用水冷铜坩埚磁悬浮真空熔炼炉制备了(Fe_(63.3)Mn_(14)Si_(9.1)Cr_(9.8)C_(3.8))_(99.5-x.Cu_(x.Ag_(0.5)(x.1,2,3,4,5,at%)合金,并对合金试样进行抗菌时效处理,研究Cu含量对合金耐腐蚀性能以及抗菌性能的影响。结果表明,经过固溶时效处理后的中熵合金均为fcc结构,随着Cu含量的提高,fcc1富铁基体上逐渐析出了富Cu和富Ag的fcc2相。合金在3.5%(质量分数)NaCl溶液中的耐腐蚀性能优于AISI304。随Cu含量的增加,腐蚀电流密度先减小而后增加,容抗弧半径先增大后减小,表明合金的耐腐蚀性能先增强后减弱。合金在大肠杆菌悬浮液中的腐蚀速率呈现出先增大后减小的趋势,x.2合金的耐生物腐蚀能力最优,而抗菌性能和腐蚀性能存在倒置关系。富Cu和富Ag的fcc2相能有效提升合金的抗菌性能,x.5合金的抗菌性能最优,抗菌率达到99.94%.

关键词：中熵合金微观组织腐蚀性能抗菌性能

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Pre-Cryogenian integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas

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Science China Earth Sciences 2024年第4期67卷 899-918页

作者： Peiyuan HU Qingguo ZHAI Guochun ZHAO peter A.CAWOOD Yue TANG Yiming LIU Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China Department of Earth Sciences University of Hong KongPokfulam RoadHong Kong 999077China State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi’an 710069China School of Earth Atmosphere&EnvironmentMonash UniversityMelbourneVIC 3800Australia

The composition and geological evolution of pre-Cryogenian material in the Tibetan Plateau and its surrounding areas have played an important role in studying the formation and evolution of early supercontinents on *** paper systematically summarizes the characteristics of pre-Cryogenian sedimentation,paleontology,magmatism,and metamorphism in the Tibetan Plateau and its surrounding *** on ex.sting data,the records of pre-Cryogenian sedimentation and paleontology are mainly concentrated in the Meso-Neoproterozoic,with relatively few records from the Paleoproterozoic or *** oldest geological record is the Hadean detrital zircons in the metamorphosed sedimentary rocks of the Himalaya and Qamdo areas(ca.4.0 Ga).The Tibetan Plateau and surrounding areas preserve records related to the formation and evolution of the Kenor supercraton,and the Columbia,Rodinia,and Gondwana ***-Cryogenian basements can be divided into three types:Tarim-,Yangtze-,and *** Tarim-type basement has a paleogeographic affinity with the northern margins of the Australian and Indian continents and lacks detrital zircon age peaks and magmatic-metamorphic records related to the Rodinia assembly(ca.1.3-0.9 Ga).The Yangtze-type basement records volcanic activity related to global cooling in the latest pre-Cryogenian period and contains Meso-Neoproterozoic stromatolite and micropaleoflora fossils,as well as magmaticmetamorphic records related to Rodinia assembly(ca.1.1-1.0 Ga).The Lhasa-type basement is characterized by Neoproterozoic rift-related sediment records(ca.900 ma)and high-pressure metamorphic events(ca.650 ma),with a prominent peak of detrital zircon ages of ca.1.2-1.1 *** is likely to have a paleogeographic affinity with the African continent.

关键词： Tibetan Plateau Pre-Cryogenian Sedimentation Fossils Paleogeographic evolution

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Doped microspheres for whispering gallery mode microlasing

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Science Bulletin 2024年第13期69卷 2021-2024页

作者： x.aox.an Wang Chaoyang Huang Chuansheng x.a Feifei Qin Gangyi Zhu Lingfeng mao Yi ma Zengliang Shi Qiannan Cui Chunx.ang x. State Key Laboratory of Digital Medical Engineering School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China School of Electronic Science and Engineering Southeast UniversityNanjing 210096China peter Grünberg Research Centre College of Telecommunications and Information EngineeringNanjing University of Posts and TelecommunicationsNanjing 210003China

Whispering gallery mode(WGM)optical microcavities,which are capable of light field confinement and manipulation in a relatively small volume,have gained considerable attention from fundamentals in enhanced light-matter interactions to laser applications[1].Undergoing decades of development,the improvement of lasing performance is always a significant issue,including low threshold and high quality(Q)factor[2].Increasing optical gain and reducing the losses are the key aspects towards the realization of a high-quality WGM laser.A perfect cavity structure and a smooth surface are the most crucial determinants to reduce optical losses and enhance light field confined abilities.

关键词： optical lasing mode

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Hybrid polymer biomaterials for bone tissue regeneration

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Frontiers of Medicine 2019年第2期13卷 189-201页

作者： Bo Lei Baolin Guo Kunal J.Rambhia peter x.ma Frontier Institute of Science and Technology Xi’an Jiaotong UniversityXi’an 710054China Department of Biomedical Engineering University of MichiganAnn ArborMI 48109USA Department of Biologic and materials Sciences University of MichiganAnn ArborMI 48109USA macromolecular Science and Engineering Center University of MichiganAnn ArborMI 48109USA Department of material Science and Engineering University of MichiganAnn ArborMI 48109USA

Native tissues possess unparalleled physiochemical and biological functions, which can be attributed to their hybrid polymer composition and intrinsic bioactivity. However, there are also various concerns or limitations over the use of natural materials derived from animals or cadavers, including the potential immunogenicity, pathogen transmission, batch to batch consistence and mismatch in properties for various applications. Therefore, there is an increasing interest in developing degradable hybrid polymer biomaterials with controlled properties for highly efficient biomedical applications. There have been efforts to mimic the ex.racellular protein structure such as nanofibrous and composite scaffolds, to functionalize scaffold surface for improved cellular interaction, to incorporate controlled biomolecule release capacity to impart biological signaling, and to vary physical properties of scaffolds to regulate cellular behavior. In this review, we highlight the design and synthesis of degradable hybrid polymer biomaterials and focus on recent developments in osteoconductive, elastomeric, photoluminescent and electroactive hybrid polymers. The review further ex.mplifies their applications for bone tissue regeneration.

关键词： hybrid polymer bone regeneration tissue engineering biomaterials

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