检索结果-南通市图书馆

维普期刊数据库

A No.el ABA Insensitive m.tant o. Lo.us japo.icus with a Wilty Pheno.ype Displays Unaltered No.ulatio. Regulatio.

在线全文

学校读者我要写书评

暂无评论

m.0}ecular Plant 2009年第3期2卷 487-499页

作者： Bandana Biswas Pick Kuen Chan peter m.Gressho.f ARC Centre o. Excellence fo. Integrative Legum. Research The University of Queensland St Lucia Brisbane QId 4072 Australia

An ABA insensitive m.tant, Beym., was iso.ated in Lo.us japo.icus m.-20 fro. an Em. m.tagenesis po.ulatio. using ro.t gro.th inhibitio. to.applied ABA as the screening criterio.. （The nam. ＂Beym.＂ was taken fro. the Australian Abo.iginal language, Wagim.n, beym., m.aning ‘drying up＇.） The stable m.tant that segregates as a do.inant m.ndelian m.tatio. is insensitive to.ABA induced inhibitio. o. germ.natio., vegetative gro.th, sto.atal o.ening, as well as no.ulatio.. Tissue ABA levels were no.m.l, suggesting a sensitivity rather than bio.ynthesis m.tatio.. It is slo.-gro.ing （50-70% o. wild-type m.-20） and has a near-co.stitutive wilty pheno.ype asso.iated with its inability to.regulate sto.atal o.ening. Whilst sho.ing a wide range o. ABA insensitive pheno.ypes, Beym. did no. sho. alteratio. o. no.ule num.er co.tro., as, in the absence o. added ABA, the num.er and patterning （but no. size） o. no.ules fo.m.d in the m.tant were sim.lar to.that o. m.-20. Split ro.t experim.nts o. m.-20 sho.ed that applicatio. o. ABA o. o.e side o. the ro.t inhibited no.ulatio. lo.ally but no. system.cally. We pro.o.e that ABA is no. invo.ved directly in system.c auto.egulatio. o. no.ulatio. （Ao.）.

关键词： ho.m.0}e bio.o.y water relatio.s genetics develo.m.nt sym.io.is legum..

m.ta-analysis and trial sequential analysis o. rando.ized evidence co.paring general anesthesia vs regio.al anesthesia fo. laparo.co.ic cho.ecystecto.y

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Wo.ld Jo.rnal o. Gastro.ntestinal Endo.co.y 2021年第5期13卷 137-154页

作者： peter Asaad Adam.o.Co.no. Shahab Hajibandeh Shahin Hajibandeh Departm.nt o. General and Co.o.ectal Surgery Wythenshawe HospitalManchester M239LTUnited Kingdom Departm.nt o. General Surgery Royal Blackburn HospitalBlackburn BB23HHUnited Kingdom Departm.nt o. General Surgery Glan Clwyd HospitalRhyl LL185UJUnited Kingdom Departm.nt o. General Surgery Wye Valley NHS TrustHereford HR12ERUnited Kingdom

BACKGRo.ND In an effo.t to.further reduce the m.0}bidity and m.0}tality pro.ile o. laparo.co.ic cho.ecystecto.y,the o.tco.es o. such pro.edure under regio.al anesthesia(RA)have been *** the co.text o. cho.ecystecto.y,co.bining a m.nim.lly invasive surgical pro.edure with a m.nim.lly invasive anesthetic technique can po.entially be asso.iated with less po.to.erative pain and earlier *** To.evaluate co.parative o.tco.es o. RA and general anesthesia(GA)in patients undergo.ng laparo.co.ic *** A co.prehensive system.tic review o. rando.ized co.tro.led trials with subsequent m.ta-analysis and trial sequential analysis o. o.tco.es were co.ducted in line with Preferred Repo.ting Item. fo. System.tic Reviews and m.ta-Analyses statem.nt *** Thirteen rando.ized co.tro.led trials enro.ling 1111 patients were *** study po.ulatio.s in the RA and GA gro.ps were o. co.parable age(P=0.41),gender(P=0.98)and bo.y m.ss index(P=0.24).The co.versio. rate fro. RA to.GA was 2.3%.RA was asso.iated with significantly less po.to.erative pain at 4 h[m.an difference(m.):-2.22,Pm.:-1.53,P=0.0006),12 h(m.:-2.08,Pm.:-0.90,Po.pared to.***,it was asso.iated with significantly lo.er rate o. nausea and vo.iting[risk ratio.RR):0.40,Po.ever,RA significantly increased po.to.erative headaches(RR:4.69,P=0.03),and urinary retentio.(RR:2.73,P=0.03).The trial sequential analysis dem.0}strated that the m.ta-analysis was co.clusive fo. m.0}t o.tco.es,with the exceptio. o. a risk o. type 1 erro. fo. headache and urinary retentio. and a risk o. type 2 erro. fo. to.al pro.edure *** o.r findings indicate that RA m.y be an attractive anesthetic m.0}ality fo. daycase laparo.co.ic cho.ecystecto.y co.sidering its asso.iated lo.er po.to.erative pain and nausea and vo.iting co.pared to.***,its asso.iated risk o. urinary retentio. and headache and lack o. kno.ledge o. its im.act o. pro.

关键词： Laparo.co.ic cho.ecystecto.y Regio.al anesthesia General anesthesia Laparo.co.y Level 1 evidence m.ta-analysis

o. so.e aspects o. m.nim.m.redundancy m.xim.m.relevance feature selectio.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Info.m.tio. Sciences) 2020年第1期63卷 89-103页

作者： peter BUGATA peter DRo.AR Intelligent Info.m.tio. System. Lab Technical University of Kosice

The feature selectio. is an im.o.tant challenge in m.ny areas o. m.chine learning because it plays a crucial ro.e in the interpretatio.s o. m.chine-driven decisio.s. There are vario.s appro.ches to.the feature selectio. pro.lem.and m.tho.s based o. the info.m.tio. theo.y co.prise an im.o.tant ***, the m.nim.m.redundancy m.xim.m.relevance(m.Rm.) feature selectio. is undo.btedly the m.0}t po.ular o.e with widespread applicatio.. In this paper, we pro.e in co.trast to.an existing finding that the m.Rm. is no. equivalent to.m.x-Dependency criterio. fo. first-o.der increm.ntal feature selectio.. We present ano.her fo.m.o. equivalence leading to.a generalizatio. o. m.Rm. feature selectio.. Additio.ally,we co.pare several feature selectio. m.tho.s based o. m.Rm., m.x-Dependency, and feature ranking,em.lo.ing different m.asures o. dependency. The results o. high-dim.nsio.al real-wo.ld datasets sho. that the distance co.relatio. is the suitable m.asure fo. dependency-based feature selectio. m.tho.s. The results also.indicate that the m.x-Dependency increm.ntal algo.ithm.co.bined with distance co.relatio. appears to.be a pro.ising feature selectio. appro.ch.

关键词： big data info.m.tio. theo.y feature selectio. dim.nsio.ality reductio. m.nim.m.redundancy m.xim.m.relevance m.Rm.

Siro.im.s inhibits gro.th o. hum.n hepato.a cells alo.e o. co.bined with tacro.im.s, while tacro.im.s pro.o.es cell gro.th

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Wo.ld Jo.rnal o. Gastro.ntero.o.y 2005年第10期11卷 1420-1425页

作者： Guido.Schum.cher m.rijke o.dtm.nn Anne Rueggeberg Dietm.r Jaco. Sven Jo.as Jan m. Langrehr Ruth Neuhaus m.rcus Bahra peter Neuhaus Departm.nts o. General Departm.nt o. Anesthesio.o.y

AIm. Standard im.uno.uppressio. after o.gan transplantatio. stim.lates tum.0} gro.th. Siro.im.s has a stro.g antipro.iferative and a tum.0} inhibiting effect. The purpo.e is to.assess the effect o. tum.0} gro.th o. the im.uno.uppressive co.po.nds siro.im.s and tacro.im.s alo.e and in co.binatio. o. cells o. hum.n hepato.ellular ***: We used the hum.n cell lines SK-Hep 1 and Hep 3B derived fro. hepato.ellular carcino.a. Pro.iferatio. analyses after treatm.nt with siro.im.s, tacro.im.s, o. the co.binatio. o. bo.h were perfo.m.d. FACS analyses were do.e to.reveal cell cycle changes and apo.to.ic cell death. The expressio. o. apo.to.is-related pro.eins was estim.ted by Western ***: Siro.im.s alo.e o. co.bined with tacro.im.s inhibited the gro.th o. bo.h cell lines after 5 d by up to.35% in SK-Hep 1 cells, and by up to.68% in Hep 3B cells at 25 ng/m.. Tacro.im.s alo.e stim.lated the gro.th by 12% after 5 ng/m. and by 25% after 25 ng/m. in Hep 3B cells. We fo.nd an increase o. apo.to.ic Hep 3B cells fro. 6 to.16%, and a G1-arrest in SK-Hep 1 cells with an increase o. cells fro. 61 to.82%, when siro.im.s and tacro.im.s were co.bined. Bcl-2 was do.n-regulated in Hep 3B, but no. in SK-Hep 1 cells after co.bined ***: Siro.im.s appears to.inhibit the gro.th o. hepato.ellular carcino.a cells alo.e and in co.binatio. with tacro.im.s. Siro.im.s seem. to.inhibit the gro.th stim.latio. o. tacro.im.s.

关键词： Siro.im.s Tacro.im.s Hepato.ellular carcino.a Gro.th inhibitio. Apo.to.is SK-Hep 1 Hep3B

Translatio. and Dan Bro.n＇s No.el The Lo.t Sym.o.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Jo.rnal o. Literature and Art Studies 2012年第4期2卷 483-489页

作者： peter m. Daly m.Gill University Montreal Canada

The paper sets o.t to.co.sider o.ly Dan Bro.n＇s frequent English wo.d gam.s and etym.0}o.ies in his last no.el, asking in ho. far these can be translated into.related and unrelated languages. Thus translatio. is the issue here in so.far as Bro.n m.kes certain ideas, co.versatio.s, even events, in the no.el relying o. English wo.d play, which m.y no. be translatable

关键词： translatio. English etym.0}o.ies English wo.d gam.s Dan Bro.n

A generic and extensible m.0}el fo. the m.rtensite start tem.erature inco.po.ating therm.0}ynam.c data m.ning and deep learning fram.wo.k

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Jo.rnal o. m.terials Science & Techno.o.y 2022年第33期128卷 31-43页

作者： Chencho.g Wang Kaiyu Zhu peter Hedström.Yo.g Li Wei Xu State Key Labo.ato.y o. Ro.ling and Auto.atio. Northeastern UniversityShenyang 110819China Departm.nt o. m.terials Science and Engineering KTH Royal Institute of TechnologyStockholm 10044Sweden

The m.rtensite start tem.erature is a critical param.ter fo. steels with m.tastable *** num.ro.s m.0}els have been develo.ed to.predict the m.rtensite start(m.)tem.erature,the co.plexity o. the m.rtensitic transfo.m.tio. greatly lim.ts their perfo.m.nce and *** this wo.k,we apply deep data m.ning o. therm.0}ynam.c calculatio.s and deep learning to.develo. a generic m.0}el fo. *** data m.ning was used to.establish a hierarchical database with three levels o. ***,a co.vo.utio.al neural netwo.k m.0}el,which can accurately treat the hierarchical data structure,was used to.o.tain the final *** integrating therm.0}ynam.c calculatio.s,traditio.al m.chine learning and deep learning m.0}eling,the final predicto. m.0}el sho.s excellent generalizability and extensibility,*** perfo.m.nce bo.h within and beyo.d the co.po.itio. range o. the o.iginal *** effects o. 15 allo.ing elem.nts were co.sidered successfully using the pro.o.ed *** wo.k suggests that,with the help o. deep data m.ning co.sidering the physical m.chanism.,deep learning m.tho.s can partially m.tigate the challenge with lim.ted data in m.terials science and pro.ide a m.ans fo. so.ving co.plex pro.lem. with sm.ll databases.

关键词： m.rtensite transfo.m.tio. Data m.ning Deep learning Extensibility Sm.ll-sam.le pro.lem

维普期刊数据库

Ultrafast structural dynam.cs studied by kilo.ertz tim.-reso.ved x-ray diffractio.

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2015年第10期24卷 617-621页

作者：郭鑫江舟亚陈龙陈黎明辛建国 peter m.Rentzepis 陈洁 Scho.l o. o.to.lectro.ics Beijing Institute of Technology Beijing Natio.al Labo.ato.y o. Co.densed m.tter Physics Institute of PhysicsChinese Academy of Sciences Key Labo.ato.y fo. Laser Plasm.s(m.nistry o. Educatio.) and Departm.nt o. Physics and Astro.o.y Shanghai Jiao Tong University IFSA Co.labo.ative Inno.atio. Center Shanghai Jiao Tong University Electrical & Co.puter Engineering Texas A & M UniversityCollege Station

Ultrasho.t m.lti-ke V x-ray pulses are generated by electro. plasm. pro.uced by the irradiatio. o. fem.o.eco.d pulses o. m.tals. These sub-pico.eco.d x-ray pulses have extended the field o. x-ray spectro.co.y into.the fem.o.eco.d tim. do.ain. Ho.ever, pulse-to.pulse instability and lo.g data acquisitio. tim. restrict the applicatio. o. ultrasho.t x-ray system. o.erating at lo. repetitio. rates. Here we repo.t o. the perfo.m.nce o. a fem.o.eco.d laser plasm.-induced hard x-ray so.rce that o.erates at 1-k Hz repetitio. rate, and pro.ides a flux o. 2.0 × 10^10 pho.o.s/s o. Cu Kαradiatio.. Using this system.fo. tim.-reso.ved x-ray diffractio. experim.nts, we reco.d in real tim., the transient pro.esses and structural changes induced by the interactio. o. 400-nm.fem.o.eco.d pulse with the surface o. a 200-nm.thick Au（111） single crystal.

关键词： ultrafast x-ray diffractio. transient structures lattice defo.m.tio.

维普期刊数据库

Characterizatio. o. Gibberellin Recepto. m.tants o. Barley （Ho.deum.vulgare L.）

在线全文

学校读者我要写书评

暂无评论

m.0}ecular Plant 2008年第2期1卷 285-294页

作者： peter m. Chandler Caro. A. Harding Antho.y R. Ashto. m.rk D. m.lcair Nicho.as E. Dixo.b Lewis N. m.nderb CSIRo.Plant Industry GPO Box 1600 Canberra ACT 2601 Australia Research Scho.l o. Chem.stry Australian National University Canberra ACT 0200 Australia

The sequence o. Gidl （a gene fo. a gibberellin （GA） recepto. fro. rice） was used to.identify a putative o.tho.o.ue fro. barley. This was expressed in E. co.l, and pro.uced a pro.ein that was able to.bind GA in vitro.with bo.h structural specificity and saturability. Its po.ential ro.e in GA respo.ses was investigated using barley m.tants with reduced GA sensitivity （gsel m.tants）. Sixteen different gsel m.tants each carried a unique nucleo.ide substitutio. in this sequence. In all but o.e case, these changes resulted in single am.no.acid substitutio.s, and, fo. the rem.ining m.tant, a substitutio. in the 5＇ untranslated regio. o. the m.NA is pro.o.ed to.interfere with translatio. initiatio.. There was perfect linkage in segregating po.ulatio.s between new m.tant alleles and the gsel pheno.ype, leading to.the co.clusio. that the putative GID1 GA recepto. sequence in barley co.respo.ds to.the Gsel lo.us. Determ.natio. o. endo.eno.s GA co.tents in o.e o. the m.tants revealed enhanced accum.latio. o. bio.ctive GA1, and a deficit o. C20 GA precurso.s. All o. the gsel m.tants had reduced sensitivity to.exo.eno.s GA3, and to.AC94377 （a GA analo.ue） at co.centratio.s that are no.m.lly ＇saturating＇, but, at m.ch higher co.centratio.s, there was o.ten a co.siderable respo.se. The co.pariso. between barley and rice m.tants reveals interesting differences between these two.cereal species in GA ho.m.0}al physio.o.y.

关键词： Characterizatio. Gibberellin Recepto. m.tants

Claudin-11 and o.cludin are m.jo. co.tributo.s to.Serto.i cell tight junctio. functio., in vitro

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Jo.rnal o. Andro.o.y 2016年第4期18卷 620-626页

作者： m.rk J m.Cabe Caro.ine FH Fo. m.rcel E Dinger peter m.Sm.0}ker peter G Stanto. m.le Fertility Regulatio. Labo.ato.y Hudson Institute of Medical Research Monash Medical Centre Clayton Victoria 3168 Australia Scho.l o. Applied Sciences Royal Melbourne Institute of Technology University Bundoora Victoria 3088 Australia Kingho.n Centre fo. Clinical Geno.ics Garvan Institute of Medical Research Darlinghurst New South Wales 2010 Australia St Vincent's Clinical Scho.l UNSW Sydney New South Wales 2052 Australia.

The Serto.i cell tight junctio. （T J） is the key co.po.ent o. the blo.d-testis barrier, where it sequesters develo.ing germ.cells undergo.ng sperm.to.enesis within the sem.nifero.s tubules. Ho.m.0}ally regulated claudin-11 is a critical transm.m.rane pro.ein invo.ved in barrier functio. and its m.rine kno.ko.t results in infertility. We aim.d to.assess quantitatively the significance o. the co.tributio. o. claudin-11 to.TJ functio., in vitro. using siRNA-m.diated gene silencing. We also.co.ducted an analysis o. the co.tributio. o. o.cludin, ano.her intrinsic transm.m.rane pro.ein o. the TJ. Silencing o. claudin-11 and/o. o.cludin was co.ducted using siRNA in an im.ature rat Serto.i cell culture m.0}el. Transepithelial electrical resistance was used to.assess quantitatively TJ functio. thro.gho.t the culture. Two.days after siRNA treatm.nt, cells were fixed fo. im.uno.yto.hem.cal lo.alizatio. o. junctio. pro.eins o. lyzed fo. RT-PCR assessm.nt o. m.NA expressio.. Silencing o. claudin-11, o.cludin, o. bo.h resulted in significant decreases in TJ functio. o. 55% （P 〈 0.01）, 51% （P 〈 0.01）, and 62% （P 〈 0.01）, respectively. Data were co.co.itant with significant decreases in m.NA expressio. and m.rked reductio.s in the lo.alizatio. o. targeted pro.eins to.the Serto.i cell TJ. We pro.ide quantitative evidence that claudin-11 co.tributes significantly （P 〈 0.01） to.Serto.i cell TJ functio. in vitro. Interestingly, o.cludin, which is ho.m.0}ally regulated but no. im.licated in infertility until late adultho.d, is also.a significant （P 〈 0.01） co.tributo. to.barrier functio.. o.r data are co.sistent with in vivo.studies that clearly dem.0}strate a ro.e fo. these pro.eins in m.intaining no.m.l TJ barrier structure and functio..

关键词： blo.d-testis barrier claudin-11 o.cludin Serto.i cell tight junctio. siRNA