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A global online study of haematopoietic stem cell transplantation in multiple sclerosis and other neurodegenerative disorders

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Chronic Diseases and Translational Medicine 2023年第1期9卷 39-43页

作者： peter k.panegyres Jodi Russell Huei‐Yang Chen Mariella panegyres Neurodegenerative Disorders Research Pty Ltd West PerthWestern AustraliaAustralia The University of Western Australia NedlandsWestern AustraliaAustralia

Back.round:The objective of this study was to understand the uptak. of hemopoietic stem cell transplantation(HSCT)in neuroimmunological disorders lik. multiple sclerosis(MS).Method:An independent University affiliated research organization conducted a global online survey of people having had HSCT,examining demographics,treatment protocol,and effectiveness.Results:Of 271 participants,useful data were available in 223;women aged 35–54 accounted for 73.5%.Most had a household income greater than US$50,000,and the majority of participants were from Australia and the United States.Nearly 94.6%of people suffer from MS.Most had their treatment in Russia(38.7%)and 78.1%had nonmyeloablative transplants.Nearly half of the participants spent between US$50,000 to US$74,999.There were 54.5%of neurologists who did not support their patients having HSCT.Around 85.5%of participants believed HSCT helped them manage their disease from week. to years after transplantation,and treatment was recommended by 9.5%of participants.The average reduction in Expanded Disability Status Score after transplantation was 1.2(95%CI:0.97–1.41;N=197;p<0.01;t:10.7,df:196).Conclusion:Participants were supportive of HSCT despite the costs and would recommend it to others.The data suggest some benefit in minimizing disability in MS and provides justification for large randomized controlled trials.

关键词： multiple sclerosis neurodegenerative disorders stem cells

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The Functions of the Amyloid Precursor Protein Gene and Its Derivative Peptides: III Pharmacological Studies

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Neuroscience & Medicine 2011年第3期2卷 397-409页

作者： peter k. panegyres Emily R. Atk.ns 不详

Pharmacological studies reveal APP and Aβ have interactions with glutamate and calcium, cytok.nes, copper/zinc chelators, secretases and presenilins, nicotinic receptors, acetycholinesterase, neurotrophins, non-steroidal anti-inflame-matory drugs, monoclonal antibodies to Aβ, protease inhibitors, oestrogen, homocysteine, immediate early genes such as c-fos or c-jun and cholesterol. These functional and pharmacological observations highlight the need for greater understanding of APP and Aβ in brain function and have implications for clinical trials.

关键词： Amyloid Precursor Protein APP Genes Dementia Alzheimer’s Disease

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